Characterization of single amino acid substitutions in the β2 integrin subunit of patients with leukocyte adhesion deficiency (LAD)-1 by Guan, Siyu, Tan, Suet-Mien, Li, Yan, Torres, Jaume, Uzel, Gulbu, Xiang, Liming, Law, S.K. Alex

“…Integrins with the β2-G150D mutation fail to bind ligands, possibly due to the failure of the α1 segment of the βI domain to assume an α-helical structure. Integrins with the β2-G716A mutation are not maintained in their resting states, and the patient has the severe phenotype of LAD-1. …”
Get full text
Get full text

A Study of In-pipe Robots for Maintenance of Large-Diameter Sewerage Tunnel by Law, Wei-Chuan, Chen, I-Ming, Yeo, Song-Huat, Seet, Gim-Lee, Low, Kin-Huat

“…This kind of robots can be classified into 9 types of robotic system, namely PIG, Wheels, Crawler, Cylindrical, Legs, Inchworm, Helical, Snake and VVPIG type. This study implies that the research on pipeline and tunnel robot has been focusing only on single maintenance task and most of them just aim for small diameter pipelines. …”
Get full text
Get full text

Antenna systems for diversity in the next-generation mobile handphones by Hui, Hon Tat.

“…However, the commercial application of spatial antenna diversity in mobile phones is still very limited mainly due to the constraint of the small size of the modem handset In this project, the diversity performance of a dual helical antenna diversity system on a large ground plane and a mobile handset were investigated. …”
Get full text

Organogel formation by a cholesterol-stoppered bistable [2]rotaxane and its dumbbell precursor by Zhao, Yanli, Aprahamian, Ivan, Trabolsi, Ali, Erina, Natalia, Stoddart, J. Fraser

“…Direct evidence for the self-organization was obtained from AFM investigations which have shown that both of the [2]rotaxane and its dumbbell precursor form linear superstructures which we propose are helical in nature.…”
Get full text
Get full text

In vitro reconstitution of telomeric mono-nucleosomes by Tiu, Charles Kevin Dee

“…Reconstitution of telomeric DNA (telo-DNA) with human histone octamer, to form telomeric nucleosomes, was often quoted as challenging given that telo-DNA does not possess a positioning sequence and is out-of-sync with the helical periodicity of DNA. In this report, I endeavor to demonstrate telomeric mono-nucleosome reconstitution in vitro with a defined-length telomeric 145-bp DNA (telo-145) and in vitro refolded human histone octamer by salt-gradient deposition – a method currently being optimized in our laboratory. …”
Get full text

Post-buckling transition of compressed pipe strings in horizontal wellbores by Zhang, Qiang, Wang, Jiacheng, Cui, Wei, Xiao, Zhongmin, Yue, Qianbei

“…Based on the calculated post-buckling modes, the dimensionless critical loads for sinusoidal and helical buckling were identified. After sinusoidal buckling, it was observed that the compressed string was not in continuous contact with the horizontal wellbore, and two non-contact sections appeared near the string ends. …”
Get full text

OAM-based reconfigurable doppler shifts enable PAPR reduction for multi-carrier doppler diversity by Zhao, Yufei, Ge, Yao, Yang, Zhaojie, Ju, Gaohua, Ma, Lu, Lu, Yilong, Guan, Yong Liang

“…In a recent study, we discovered that even when the transceivers are stationary, a specific spatial Doppler shift can be generated by rotating the wavefront structure of the OAM helical beams. Furthermore, arbitrary integer rotational OAM Doppler shifts can be realized flexibly by using the recently popular digital encoding metasurfaces. …”
Get full text

Joint Recognition of Error Correcting Codes and Interleaver Parameters in a Robust Environment by Swaminathan, Ramabadran, Madhukumar, A. S.

“…Therefore, in this paper, innovative algorithms for automatic recognition of type of FEC codes along with the parameter estimation of helical scan interleaver are proposed considering both erroneous and non-erroneous scenarios without any prior knowledge about the encoding scheme used in the transmitter. …”
Get full text
Get full text

The recent development and applications of fluidic channels by 3D printing by Zhou, Yufeng

“…Finally, novel application of 3D printed channel in biology are reviewed, including pathogenic bacteria detection using magnetic nanoparticle clusters in a helical microchannel, cell stimulation by 3D chemical gradients, perfused functional vascular channels, 3D tissue construct, organ-on-a-chip, and miniaturized fluidic “reactionware” devices for chemical syntheses. …”
Get full text
Get full text

Filamentous oligomer structure reconstruction and a new filament picking method for Cryo-EM micrographs by Xu, Chenrui

“…Among various macromolecular complexes, the filamentous oligomer is a special category, which is assembled from identical subunits with helical symmetry. Protein filaments carry out unreplaceable roles in the cellular process. …”
Get full text

Study of islet amyloid polypeptide aggregation and its inhibition mechanisms. by Wei, Lei.

“…NMR chemical shifts and 15N relaxation data indicate that the transiently populated helical structure in residues 11−18 is essential for interactions with insulin. …”
Get full text

Structural characterization of the full-length Hantaan virus polymerase by Keown, JR, Carrique, L, Nilsson-Payant, BE, Fodor, E, Grimes, JM

“…We observe motif E in four distinct conformations including β-sheet, two helical arrangements, and nucleotide primed arrangement. …”

Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT by Seddon, C, David, S, Wong, JLC, Ishimoto, N, He, S, Bradshaw, J, Low, WW, Frankel, G, Beis, K

“…The cryo-EM structures of TraTpKpQIL and TraTF reveal that they oligomerise into decameric champagne bottle cork-like structures, which are anchored to the outer membrane via a diacylglycerol and palmitic acid modified α-helical barrel domain. Unexpectedly, we identify chromosomal TraT homologues from multiple Gram-negative phyla which form numerous divergent lineages in a phylogenetic tree of TraT sequences. …”

Characterizing the conformational landscape of MDM2-binding p53 peptides using molecular dynamics simulations by Yadahalli, Shilpa, Li, Jianguo, Lane, David P., Gosavi, Shachi, Verma, Chandra Shekhar

“…Using our hypothesis, we suggest mutations to the 12/1 peptide that increase its helicity in simulations and may, in turn, shift the binding towards conformational selection. …”
Get full text
Get full text

Solvent effect on the folding dynamics and structure of E6-associated protein characterized from Ab initio protein folding simulations by Xu, Zhijun, Lazim, Raudah, Sun, Tiedong, Mei, Ye, Zhang, Dawei

“…On the basis of the close agreement between the calculated helix contents from AHBC simulations and experimental results, we observed based on the presented simulations that the two ends of the peptide may simultaneously take part in the formation of the helical structure at the early stage of folding and finally merge to form a helix with lowest backbone RMSD of about 0.9 Å in 40% 2,2,2-trifluoroethanol solution. …”
Get full text
Get full text

Molecular basis of selectivity and activity for the antimicrobial peptide Lynronne‐1 informs rational design of peptide with improved activity by Jayawant, Eleanor S., Hutchinson, Jack, Gašparíková, Dorota, Lockey, Christine, Pruñonosa Lara, Lidón, Guy, Ciaran, Brooks, Rhiannon L., Dixon, Ann M.

“…We translated our understanding of Lynronne‐1 structure to design peptides which varied in the size of their hydrophobic helical face. These peptides displayed the predicted continuum of membrane‐lysis activities in vitro and in vivo , and yielded a new AMP with 4‐fold improved activity against A. baumannii and 32‐fold improved activity against S. aureus .…”
Get full text

Procollagen Folding in Health and Disease by Yammine, Kathryn Marie

“…In Chapter 2, we explore the molecular basis of procollagen assembly, and uncover a new role for the triple helical domain sequence in guiding trimer assembly. …”
Get full text

Chiral phonons and giant magneto-optical effect in CrBr₃ 2D magnet by Yin, Tingting, Ulman, Kanchan Ajit, Liu, Sheng, Granados Del Águila, Andrés, Huang, Yuqing, Zhang, Lifa, Serra, Marco, Sedmidubsky, David, Sofer, Zdenek, Quek, Su Ying, Xiong, Qihua

“…Phonons with chirality determine the optical helicity of inelastic light scattering processes due to their nonzero angular momentum. …”
Get full text

Accelerated engineering of ELP-based materials through hybrid biomimetic-de novo predictive molecular design by Laakko, Timo, Korkealaakso, Antti, Yildirir, Burcu Firatligil, Batys, Piotr, Liljeström, Ville, Hokkanen, Ari, Nonappa, Penttilä, Merja, Laukkanen, Anssi, Miserez, Ali, Södergård, Caj, Mohammadi, Pezhman

“…This generalizable approach involves incorporating a series of de novo-designed sequences with α-helical conformation and genetically encoding them into biologically inspired intrinsically disordered repeating motifs. …”
Get full text

Indications of surface-dominated transport in single crystalline nanoflake devices of topological insulator Bi_{1.5}Sb_{0.5}Te_{1.8}Se_{1.2} by Xia, Bin, Ren, Peng, Sulaev, Azat, Liu, Peng, Shen, Shun-Qing, Wang, Lan

“…Our results open a path for realization of electric and spintronic devices based on the topological helical surface states.…”
Get full text
Get full text