Fortieth week by Sérgio Cavalheiro

“…A new multisystem inflammatory syndrome has recently been identified as a long-term effect of COVID-19, where, due to an imbalance of the inflammatory response, several tissues are affected, such as those of the gastrointestinal system as well as cardiovascular, hematological, cutaneous, respiratory, and neurological tissues. …”
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Efeitos agudos do exercício físico prolongado: avaliação após ultramaratona de 24 horas Acute effects of prolonged physical exercise: evaluation after a twenty-four-hour ultramarat... by Daniela Guinther Passaglia, Luiz Gustavo Marin Emed, Silvio Henrique Barberato, Surya Toledo Guerios, Andre Isolani Moser, Miguel Morita Fernandes Silva, Elissa Ishie, Luiz Cesar Guarita-Souza, Costantino Roberto Frack Costantini, José Rocha Faria-Neto

“…Runners showed weight loss (p < 0.001) and decrease in systolic (p < 0.001) and diastolic (p = 0.004) blood pressure. Hematological changes were compatible with the physiological stress. …”
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Crude propolis as an immunostimulating agent in broiler feed during the first stage<br>Própolis bruta como agente imunoestimulante na alimentação de frangos de corte na fase inicia... by Cinthia Eyng, Alice Eiko Murakami, Raissa Bochi Pedroso, Thais Gomes Verzignassi Silveira, Daniela Andressa Lino Lourenço, Ana Flávia Quiles Marques Garcia

“…The experiment herein was conducted to evaluate the efficacy of supplementing a broiler diet with crude propolis on the animals’ immune response (humeral and cellular), lymphoid organ weight and hematological profile. One hundred sixty-eight male broilers raised in metabolic cages until 21 days of age were used in the experiments. …”
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Assessment of the Mutation Profile of Tonsillar Squamous Cell Carcinomas Using Targeted Next-Generation Sequencing by Ha Young Park, Joong Seob Lee, Jee Hye Wee, Jeong Wook Kang, Eun Soo Kim, Taeryool Koo, Hee Sung Hwang, Hyo Jung Kim, Ho Suk Kang, Hyun Lim, Nan Young Kim, Eun Sook Nam, Seong Jin Cho, Mi Jung Kwon

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The RNA-Binding Protein ELAVL1 Regulates Hepatitis B Virus Replication and Growth of Hepatocellular Carcinoma Cells by Hiroaki Kanzaki, Tetsuhiro Chiba, Tatsuya Kaneko, Junjie Ao, Motoyasu Kan, Ryosuke Muroyama, Shingo Nakamoto, Tatsuo Kanda, Hitoshi Maruyama, Jun Kato, Yoh Zen, Ai Kotani, Kazuma Sekiba, Motoyuki Otsuka, Masayuki Ohtsuka, Naoya Kato

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Human Adipose Mesenchymal Stromal/Stem Cells Improve Fat Transplantation Performance by Maria Serena Piccinno, Tiziana Petrachi, Marco Pignatti, Alba Murgia, Giulia Grisendi, Olivia Candini, Elisa Resca, Valentina Bergamini, Francesco Ganzerli, Alberto Portone, Ilenia Mastrolia, Chiara Chiavelli, Ilaria Castelli, Daniela Bernabei, Mara Tagliazucchi, Elisa Bonetti, Francesca Lolli, Giorgio De Santis, Massimo Dominici, Elena Veronesi

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Fisiopatologia da deficiência de vitamina B12 e seu diagnóstico laboratorial Physiopathology of vitamin B12 deficiency and its laboratorial diagnosis by Clóvis Paniz, Denise Grotto, Gabriela Cristina Schmitt, Juliana Valentini, Karen Lílian Schott, Valdeci Juarez Pomblum, Solange Cristina Garcia

“…PHYSIOPATHOLOGY: The vitamin B12 deficiency leads to hematologic, neurophatologic and cardiovascular disorders, mainly by interfering in the homocysteine (Hcy) metabolism and in the methylation reactions of organism. …”
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Prevención de la isoinmunización materna al RhD, con gamma-globulina anti-D Prevention of maternal RhD isoimmunization with anti-D gamma globulin by Héctor Alfredo Baptista-González, Fany Rosenfeld-Mann, Teresita Leiss-Márquez

“…MATERIAL AND METHODS: Between 1982 and 1995, immunologic and hematologic data were collected from all Rh-negative women seen at Mexico's National Perinatology Institute. …”
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Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells by Ding YH, Zhou ZW, Ha CF, Zhang XY, Pan ST, He ZX, Edelman JL, Wang D, Yang ZX, Zhang XJ, Duan W, Yang TX, Qiu JX, Zhou SF

“…Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, has shown potent anticancer effects, and is under clinical investigation for the treatment of advanced solid tumor and hematologic malignancies. However, the role of ALS in the treatment of ovarian cancer remains unclear. …”
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Efficacy of single- and double-volume exchange transfusion for neonatal hyperbilirubinemia by Xiong Zhongzheng, Liu Xianchuan, Li Xiangzhu

“…Then, these newborns were divided into single volume group (80-110 mL/kg, n=48) and double volume group (150-180 mL/kg, n=48) by the exchange volume per unit body mass. The hematological indicators total serum bilirubin (TSB), peripheral blood red blood cell (RBC) count, white blood cell (WBC) count, platelet (PLT) count, serum albumin (ALB), prothrombin time (PT) and activated partial thromboplastin time (APTT), and changes in inner-environment indexes (blood gas, blood glucose, acid-base and electrolyte levels) were compared between the two groups of newborns before treatment and after once treatment. …”
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International evaluation of the psychometrics of health-related quality of life questionnaires for use among long-term survivors of testicular and prostate cancer by Marieke van Leeuwen, Jacobien M. Kieffer, Fabio Efficace, Sophie D. Fosså, Michel Bolla, Laurence Collette, Marc Colombel, Ugo De Giorgi, Bernhard Holzner, Lonneke V. van de Poll-Franse, Hendrik van Poppel, Jeff White, Ronald de Wit, Susanne Osanto, Neil K. Aaronson, for the European Organisation for Research and Treatment of Cancer Quality of Life Group, Genito-Urinary Cancers Group and Radiation Oncology Group, and the NCRN Testis Clinical Studies Group

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A Nomogram Model to Predict Post-Progression Survival in Esophageal Squamous Cell Carcinoma Patients With Recurrence After Radical Resection by Changsen Leng, Changsen Leng, Changsen Leng, Yingying Cui, Yingying Cui, Junying Chen, Junying Chen, Junying Chen, Kexi Wang, Hong Yang, Hong Yang, Hong Yang, Jing Wen, Jing Wen, Jianhua Fu, Jianhua Fu, Jianhua Fu, Qianwen Liu, Qianwen Liu, Qianwen Liu

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Increased expression of pendrin in eosinophilic chronic rhinosinusitis with nasal polyps by Taku Ito, Satoshi Ikeda, Tomoaki Asamori, Keiji Honda, Yoshiyuki Kawashima, Ken Kitamura, Keiko Suzuki, Takeshi Tsutsumi

“…Methods: A total of 68 patients were classified into eosinophilic chronic rhinosinusitis or non-eosinophilic chronic rhinosinusitis groups according to the degree of eosinophilic infiltration into the nasal polyps. Clinical, hematological, and immunohistochemical analyses were performed and statistically compared between both groups. …”
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Pathogenesis of nephro-and testiculopathies induced by the Malaysian isolate of Trypanosoma evansi in rabbits by Gumar, Yasameen Sahib

“…The data denotes that the pathogenesis of Malaysian isolate of trypanosomosis in rabbit model is associated with a pronounced biochemical and morphological changes in the kidneys and testicles, in addition to chronic hematological disorders such as anaemia. The T. evansi was demonstrated by an immunohistochemical technique in formalinfixed tissues of rabbits. …”
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Toxicity and Immunosuppressive Effects of Diazinon in Grass Carp, Ctenopharyngodon Idella (Cuvier and Valenciennes) by Poorgholam, Reza

“…The examination of hematological and tissue enzyme parameters indicated that diazinon at sublethal levels had caused an effect similar to anemia. …”
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Nutritional status among people living with HIV receiving antiretroviral medication at Hospital Sungai Buloh, Malaysia by Hejazi, Nazisa

“…Biochemical parameters including lipid profile,hematological and immunological parameters were measured using fasting blood samples. …”
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Effects of prebiotic, probiotic and synbiotic on performance and cecal microbiome of laying hens by Tang, Shirley Gee Hoon

“…Therefore, the present study was initiated to evaluate the in vivo effects of prebiotic IMO (PRE) and probiotic PrimaLac® (PRO), administered singly, and in combination as a synbiotic (SYN) (IMO + PrimaLac®), on performance, biochemical and hematological responses, egg quality and chemical compositions of egg yolks, and diversity and functional potential of cecal microbiome of laying hens. …”
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Effects of feeding raw and treated meskit [Prosopis juliflora (SW.) DC.] pods to Omani Sheep by Al-Khalasi, Said Shannan Ali

“…The collected blood samples were analysed for hematological and serum biochemistry levels, liver and kidney samples for histopathology to determine the health status of the animals. …”
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APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale by Barry I. Freedman, Marva M. Moxey-Mims, Amir A. Alexander, Brad C. Astor, Kelly A. Birdwell, Donald W. Bowden, Gordon Bowen, Jonathan Bromberg, Timothy E. Craven, Darshana M. Dadhania, Jasmin Divers, Mona D. Doshi, Elling Eidbo, Alessia Fornoni, Michael D. Gautreaux, Rasheed A. Gbadegesin, Patrick O. Gee, Giselle Guerra, Chi-yuan Hsu, Ana S. Iltis, Nichole Jefferson, Bruce A. Julian, David K. Klassen, Patrick P. Koty, Carl D. Langefeld, Krista L. Lentine, Lijun Ma, Roslyn B. Mannon, Madhav C. Menon, Sumit Mohan, J. Brian Moore, Barbara Murphy, Kenneth A. Newell, Jonah Odim, Mariella Ortigosa-Goggins, Nicholette D. Palmer, Meyeon Park, Afshin Parsa, Stephen O. Pastan, Emilio D. Poggio, Nishadi Rajapakse, Amber M. Reeves-Daniel, Sylvia E. Rosas, Laurie P. Russell, Deirdre Sawinski, S. Carrie Smith, Mitzie Spainhour, Robert J. Stratta, Matthew R. Weir, David M. Reboussin, Paul L. Kimmel, Daniel C. Brennan

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C18. Docetaxel como quimioterapia de 2ª linha nos doentes com CPNPC: estudo prospectivo multicêntrico. by A.S. Oliveira, P. Barradas, A. Costa, A. Figueiredo, A.P. Alves, M. Cristóvão, F. Barata, M.J. Melo

“…No relationships detected between first-line CT and response to docetaxel.Grade ¾ neutropenia(52 pts â 48%); 4 pts present with febrile neutropenia and one had a toxic death. Main non-hematologic adverse events: alopecia(59%), asthenia(28%) and peripheral neuropathy(22%).Survival results:overall median survivalâ12.7 months;median survival after docetaxelâ6.1 mo;median time to progression(TTP)â12 weeks;1 and 2-year survival rates-19 and 7%, respectively.We considered these results as interesting mainly because >70% pts were refractory to 1st-line CT and >80% were in stage IV.We conclude that for NSCLC pts with PS<2, docetaxel as a 2nd-line-CT is a worthwile treatment with acceptable toxicity that significantly prolongs survival. …”
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