Immune system rejuvenation—approaches and real achievements by Iryna Pishel

“…The review is devoted to replacement therapy using transplantation of hematopoietic stem cells (HSCs) and young lymphoid cells and tissues, cellular and systemic factor exchange in heterochronic parabiosis, and some other widely used life extension approaches. …”
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Retroviral transfer of donor MHC class I or MHC class II genes into recipient bone marrow cells can induce operational tolerance to alloantigens in vivo. by Wong, W, Billing, J, Stranford, SA, Hyde, K, Fry, J, Morris, P, Wood, K

“…We hypothesize that transfer of donor MHC gene(s) to recipient-type BM or hematopoietic stem cells would enable delivery of donor alloantigens to the recipient without the risk of graft-versus-host disease. …”

Treatment of cytomegalovirus retinitis by B. S. Pershin, A. B. Smirnova, S. L. Blagov

“…Patients suffering from acquired immunodeficiency syndrome and recipients of organs or hematopoietic stem cells are most susceptible to this disease. …”
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Basis of Gene Therapy by S. E. Ipatov, S. A. Roumiantsev

“…Approaches which can save or increase clinical efficacy of gene therapy with use as targets hematopoietic stem cells, thus significantly reduced risk of leukemia development and other side effects related to vectors including in genome, are presented.…”
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Safety issues of gene therapy by S. E. Ipatov, S. A. Roumiantsev

“…Approaches which can save or increase clinical efficacy of gene therapy with use as targets hematopoietic stem cells, thus significantly reduced risk of leukemia development and other side effects related to vectors including in genome, are presented.…”
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Regulation of myeloid and lymphoid cell development by O-glycans on Notch by Pamela Stanley, Ankit Tanwar

“…Canonical Notch ligands (DLL1, DLL4, JAG1, JAG2) expressed in stromal cells bind to the extracellular domain of Notch receptors expressed in hematopoietic stem cells and myeloid and lymphoid progenitors to activate Notch signaling. …”
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Interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms favorably impacts deregulation of oxidative stress genes and antioxidative defense mechanisms. by Vibe Skov, Mads Thomassen, Lasse Kjær, Christina Ellervik, Morten Kranker Larsen, Trine Alma Knudsen, Torben A Kruse, Hans C Hasselbalch

“…These genes have a major role for maintaining genomic stability, regulation of the oxidative stress response and in modulating migration or retention of hematopoietic stem cells. Therefore, their deregulation might give rise to increasing genomic instability, increased chronic inflammation and disease progression with egress of hematopoietic stem cells from the bone marrow to seed in the spleen, liver and elsewhere. …”
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Activation of the Arterial Program Drives Development of Definitive Hemogenic Endothelium with Lymphoid Potential by Mi Ae Park, Akhilesh Kumar, Ho Sun Jung, Gene Uenishi, Oleg V. Moskvin, James A. Thomson, Igor I. Slukvin

“…In the embryo, lymphoid progenitors and hematopoietic stem cells (HSCs) arise from hemogenic endothelium (HE) lining arteries but not veins. …”
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Seeking the “mother of blood” from human pluripotent stem cells: Are we there yet? by Fei Li

“…Incremental progress across the past three and half decades has brought us closer to making hematopoietic stem cells from iPSCs clinical solutions. A recent innovative two-step differentiation approach successfully generated transplantable HSCs from iPSC sources. …”
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A short history of hemogenic endothelium. by Swiers, G, Rode, C, Azzoni, E, de Bruijn, M

“…Ultimately, a better understanding of the processes controlling the transition of endothelium into blood will advance the generation and expansion of hematopoietic stem cells for therapeutic purposes.…”

Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment by Yongsheng Ruan, Hye Na Kim, Heather Ogana, Yong-Mi Kim

“…Canonical and noncanonical Wnt pathways play a critical role in the maintenance of normal hematopoietic stem cells (HSC) and LSCs. In this review, we summarize recent findings on the role of Wnt signaling in leukemia and its microenvironment and provide information on the currently available strategies for targeting Wnt signaling.…”
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Development of Cell Therapies for Renal Disease and Regenerative Medicine by Selene Torrico, Georgina Hotter, Soraya Játiva

“…Cell therapies using multipotent mesenchymal stromal cells, hematopoietic stem cells, macrophages, and other cell types have been used to induce regeneration and provide a cure for acute and chronic kidney disease in experimental models. …”
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Extracellular Vesicles and MicroRNA in Myelodysplastic Syndromes by Mathieu Meunier, David Laurin, Sophie Park

“…More specifically, mesenchymal stromal cells, which can secrete extracellular vesicles and their miRNA contents, modulate the fate of hematopoietic stem cells leading to leukemogenesis. Extracellular vesicles can mediate their miRNA and protein contents between nearby cells but also in the plasma of the patients, being potent tools for diagnosis and prognostic markers in MDS. …”
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Core-binding factors in hematopoiesis and immune function. by de Bruijn, M, Speck, N

“…This review describes the role of Runx1 and CBF beta in the initiation of hematopoiesis in the embryo, and in the emergence of hematopoietic stem cells. We also discuss the later stages of hematopoiesis for which members of the core binding factor family are required, as well as the recently described roles for these proteins in autoimmunity.…”

A short history of hemogenic endothelium by Swiers, G, Rode, C, Azzoni, E, De Bruijn, M

“…Ultimately, a better understanding of the processes controlling the transition of endothelium into blood will advance the generation and expansion of hematopoietic stem cells for therapeutic purposes. © 2013 Elsevier Inc.…”

490 A CTS team approach to Gold Nanorod (GNR) Theranostics in Adoptive Cell Therapy (ACT) by Matthew Frain, John Figg

“…GNRs have not been used to study hematopoietic stem cells in the context of ACT and brain malignancies. …”
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Precision Editing as a Therapeutic Approach for β-Hemoglobinopathies by Kiriaki Paschoudi, Evangelia Yannaki, Nikoletta Psatha

“…Allogeneic transplantation of hematopoietic stem cells (allo-HSCT) used to be the only curative option, although the indispensable need for an HLA-matched donor markedly restricted its universal application. …”
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Lentivirus vector in gene therapy of β-thalassemia by LIU Yize, CHAN Ying, ZHU Baosheng

“…Gene therapy mediated by lentiviral vector(LVV) is divided into gene-integration strategies using LVV to add fully functional β-hemoglobin(HBB) genes to chromosomes and gene-editing strategies using LVV to deliver specific ribozymes to hematopoietic stem cells for in situ repair of HBB genes. Improving viral titration and transduction efficiency, reducing target loss and advancing clinical trials are the main targets of these two strategies.…”
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Human herpes virus type 6 (Orthoherpesviridae: <i>Roseolovirus</i>): features of epidemiology and diagnosis by Inara S. Saydullayeva, Dmitry S. Tikhomirov, Mikhail Y. Drokov, Tatiana A. Tupoleva

“…This article addresses the epidemiology and diagnosis of infections caused by these viruses, including ones in patients after transplantation of solid organs and allogeneic hematopoietic stem cells.…”
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Lymphoid Genes Expression in Mouse Embryonic Stem Cells with Differentiation on Feeder Free Condition by Najmaldin Saki, Gholamreza Khamisipour, Saeid Abroun, Masoud Soleimani, Mina Soufizomorrod, Saeid Kaviani, Majid Mossahebimohammadi

“…Lymphocytes generated from hematopoietic stem cells. We designed a feeder free culture condition to generate lymphoid lineage cells from ESCs. …”
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