In vitro clonal multilineage differentiation of distinct murine hematopoietic progenitor populations by Fatemeh Safi, Parashar Dhapola, Eva Erlandsson, Linda Geironson Ulfsson, Ariana S. Calderón, Charlotta Böiers, Göran Karlsson

“…Importantly, generation of all lineages from single long-term hematopoietic stem cells are described, following 21 days of culture. …”
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Gene Therapy for Primary Immunodeficiency by Benjamin C. Houghton, Claire Booth

“…Transduction of hematopoietic stem cells ex vivo using lentiviral vectors can now create a highly effective therapeutic product, capable of reconstituting many different immune system dysfunctions when reinfused into patients. …”
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Roles of non-coding RNA in megakaryocytopoiesis and thrombopoiesis: new target therapies in ITP by Wuquan Li, Yan Lv, Yeying Sun

“…Platelets are produced upon the differentiation of hematopoietic stem cells into megakaryocytes, 1011 per day, and are renewed every 8–9 days. …”
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Myelodysplastic neoplasms: An overview on diagnosis, risk-stratification, molecular pathogenesis, and treatment by Fabiana Kalina Marques, Adriano de Paula Sabino

“…Myelodysplastic neoplasms are clonal hematological malignancies arising from hematopoietic stem cells that accumulate various mutations. …”
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Cord-Blood-Derived Professional Antigen-Presenting Cells: Functions and Applications in Current and Prospective Cell Therapies by Sarah Cunningham, Holger Hackstein

“…Human umbilical cord blood (UCB) represents a valuable source of hematopoietic stem cells, particularly for patients lacking a matching donor. …”
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Congenital thrombocytopenia associated with a heterozygous variant in the MEIS1 gene encoding a transcription factor essential for megakaryopoiesis by Orna Steinberg-Shemer, Naama Orenstein, Tanya Krasnov, Sharon Noy-Lotan, Nathaly Marcoux, Orly Dgany, Joanne Yacobovich, Oded Gilad, Evelyn Shabad, Lina Basel-Salmon, Hannah Tamary

“…The transcription factor MEIS1 (myeloid ectotrophic insertion site 1) is crucial for the maintenance of hematopoietic stem cells and for megakaryopoiesis. Germline variants in MEIS1 are associated with restless-leg syndrome, but were not previously shown to cause cytopenias. …”
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Mechanical isolation of neonatal and adult mouse dura leukocytes for flow cytometry analysis by Chunxiao Niu, Hui Jiang, Mengyao Wu, Tao Zou, Xian Wu, Yuchen Lu, Lijiao Deng, Tingting Guo, Chuan-Yimu Si, Jiyan Zhang

“…Unlike the time-consuming enzymatic digestion isolation which makes dura hematopoietic stem cells (HSCs) undetectable, this rapid and simplified technique permits dura HSC identification.For complete details on the use and execution of this protocol, please refer to Niu et al. (2022).1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.…”
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Mesenchymal stromal cells in myeloid malignancies: Immunotherapeutic opportunities by Milica Vukotić, Suncica Kapor, Felipe Simon, Vladan Cokic, Juan F. Santibanez

“…Myeloid malignancies are clonal disorders of the progenitor cells or hematopoietic stem cells, including acute myeloid leukemia, myelodysplastic syndromes, myeloproliferative malignancies, and chronic myelomonocytic leukemia. …”
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Transient Leukemoid Reaction from T-Cell Large Granular Lymphocytes Post Autologous Stem Cell Transplant in a Patient Affected by Hodgkin Lymphoma by Andrea Duminuco, Marina Parisi, Giulio Antonio Milone, Alessandra Cupri, Salvatore Leotta, Giuseppe A. Palumbo, Nunziatina Laura Parrinello, Grazia Scuderi, Anna Triolo, Giuseppe Milone

“…T-cell lymphocytosis may also appear after the transplant of hematopoietic stem cells or solid organs. Rare cases have been reported in patients undergoing autologous stem cell transplant (ASCT) for hematological diseases (including multiple myeloma or non-Hodgkin’s lymphoma). …”
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Mucormycosis in children with hematological and oncological diseases in saint-petersburg by N. N. Klimko, S. N. Khostelidi, E. G. Boychenko, A. S. Kolbin, A. G. Volkova, M. O. Popova, T. S. Bogomolova, L. S. Zuborovskaya, M. B. Belogurova, N. V. Medvedeva, B. V. Afanasyev

“…The main underlying disease was acutel eukemia (70%), risk factors – prolong severe neutropenia (median – 31 d) and lymphocytopenia (median – 33 d) after cytostatic chemotherapy or hematopoietic stem cells transplantation. Etiology agents were Lichtheimia corуmbifera, Rhizopus spp. and Rhizomucor spp. …”
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Current advances of CRISPR-Cas technology in cell therapy by Hou-Yuan Qiu, Rui-Jin Ji, Ying Zhang

“…Since the initiation of first-in-human trial in 2016, CRISPR-Cas has been tested in 57 cell therapy trials, 38 of which focusing on engineered CAR-T cells and TCR-T cells for cancer malignancies, 15 trials of engineered hematopoietic stem cells treating hemoglobinopathies, leukemia and AIDS, and 4 trials of engineered iPSCs for diabetes and cancer. …”
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Insights into Regulatory Factors in Megakaryocyte Development and Function: Basic Mechanisms and Potential Targets by Li Li, Rui Ni, Ziwei Li, Yue Ming, Li Liu, Dan Peng, Yongqing Cai, Yuanlin Wu, Tingting Jiang, Yanping Li, Yao Liu

“…The differentiation of megakaryocytes from hematopoietic stem cells in bone marrow and the development of megakaryocytes into platelets is a complex process. …”
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A System to Study Aneuploidy In Vivo by Pfau, Sarah Jeanne, Amon, Angelika B

“…By transplanting hematopoietic stem cells (HSCs) into recipient mice after ablation of recipient hematopoiesis by lethal irradiation, we can directly compare the fitness of HSCs derived from a range of aneuploid mouse models with that of euploid HSCs. …”
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Inflammatory signals directly instruct PU.1 in HSCs via TNF by Etzrodt, M, Ahmed, N, Hoppe, P, Loeffler, D, Skylaki, S, Hilsenbeck, O, Kokkaliaris, K, Kaltenbach, H, Stelling, J, Nerlov, C, Schroeder, T

“…The molecular mechanisms governing the transition from hematopoietic stem cells (HSCs) to lineage-committed progenitors remain poorly understood. …”

PB2700: ANXIETY AND DEPRESSION IN HEMATOLOGICAL MALIGNANCIES PATIENTS: FOCUS ON TREATMENT ADHERENCE by Dmitry E Vybornykh, Eduard Gemdzhian, Tatyana Moiseeva, Tatiana Gaponova, Daria Novikova

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EARLY T-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDHOOD by Hale Ören

“…ETPs are a subset of thymocytes representing recent immigrants from the bone marrow to the thymus, they retain multilineage differentiation potential, suggesting their direct derivation from hematopoietic stem cells (3). ETP-ALL, which was first reported by Coustan-Smith in 2009, largely overlaps with the pro-T subtype of the EGIL classification; its special diagnostic criteria in immunophenotypic screening are the absence of CD1a and CD8 expression, the absence or weak expression of CD5, and the presence of strong positive for at least one of CD34, CD117, HLADR, CD13, CD33, CD11b, and CD65 (2,4-6). …”
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Aging of Bone Marrow Mesenchymal Stromal Cells: Hematopoiesis Disturbances and Potential Role in the Development of Hematologic Cancers by Fulvio Massaro, Florent Corrillon, Basile Stamatopoulos, Nathalie Meuleman, Laurence Lagneaux, Dominique Bron

“…The results obtained in this field of research, year after year, underline the important role of cross-talk between hematopoietic stem cells and their close environment. In bone marrow, mesenchymal stromal cells (MSCs) are a major player in cell-to-cell communication, presenting a wide range of functionalities, sometimes opposite, depending on the environmental conditions. …”
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Invasive aspergillosis: results of multicenter study by N. N. Klimko, O. V. Shadrivova, S. N. Khostelidi, E. A. Desyatik, Yu. V. Borzova, R. M. Chernopyatova, E. V. Shagdileeva, A. G. Volkova, M. O. Popova, I. S. Zyuzgin, O. S. Ruzhinskaya, O. Ye. Ryabykina, N. V. Medvedeva, A. S. Kolbin, E. G. Boychenko, T. S. Bogomolova, S. M. Ignatieva, L. S. Zubarovskaya, B. V. Afanasiev

“…The risk factors: prolonged agranulocytosis (64 %), cytostatic chemotherapy (57 %), corticosteroid treatment (45 %), and allogeneic hematopoietic stem cells transplantation (29 %). The pathogens – A. fumigatus (42 %), A. niger (33 %), and A. flavus (21 %). …”
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Osteoclasts and Microgravity by John Kelly Smith

“…This review describes the ontogeny of osteoclast hematopoietic stem cells and the contributions macrophage colony stimulating factor, receptor activator of the nuclear factor-kappa B ligand, and the calcineurin pathways make in osteoclast differentiation and provides details of bone formation, the osteoclast cytoskeleton, the immune regulation of osteoclasts, and osteoclast mechanotransduction on Earth, in space, and under conditions of simulated microgravity. …”
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Immune Dysfunction, Cytokine Disruption, and Stromal Changes in Myelodysplastic Syndrome: A Review by Olivia F. Lynch, Laura M. Calvi

“…MDS represent complex and diverse diseases that evolve from malignant hematopoietic stem cells and involve not only the proliferation of malignant cells but also the dysfunction of normal bone marrow. …”
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