EMPLOYMENT OF A «SIDE POPULATION» APPROACH TO STEM CELL ISOLATION IN NORMAL AND TUMOR TISSUES by O. R. Tsinkalovsky, V. A. Zaidenov, A. S. Pakhotnykh, V. A. Andrianov

“…A combination of fluorescent staining with Hoechst 33342 dye, and flow cytometry of murine bone marrow cells may be used for separation of a side population (SP), which is highly enriched for hematopoietic stem cells capable of long-term hematopoietic reconstitution in lethally irradiated recipients. …”
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Put in a “Ca²⁺ll” to Acute Myeloid Leukemia by Clara Lewuillon, Marie-Océane Laguillaumie, Bruno Quesnel, Thierry Idziorek, Yasmine Touil, Loïc Lemonnier

“…Our purpose with this review is to raise awareness about this issue and to present (i) the role of calcium signaling in AML cell proliferation and differentiation and in the quiescence of hematopoietic stem cells; (ii) the interplay between mitochondria, metabolism, and oxidative stress; (iii) the effect of the BM microenvironment on AML cell fate; and finally (iv) the mechanism by which chemotherapeutic treatments modify calcium homeostasis in AML cells.…”
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G‐CSF/GM‐CSF‐induced hematopoietic dysregulation in the progression of solid tumors by Kai He, Xi Liu, Robert D. Hoffman, Rong‐Zhen Shi, Gui‐Yuan Lv, Jian‐Li Gao

“…As key factors in hematopoietic development, G‐CSF/GM‐CSF are well‐known facilitators of myelopoiesis and mobilization of hematopoietic stem cells (HSCs). In addition, these two cytokines can also promote or inhibit tumors, dependent on tumor type. …”
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Progression of Notch signaling regulation of B cells under radiation exposure by Xin Shu, Xin Shu, Jie Wang, Huihong Zeng, Lijian Shao, Lijian Shao, Lijian Shao

“…Although accumulating studies reported that Notch signaling contributes to the functionality of hematopoietic stem cells and T cells, its role in B cells is scarcely appreciated. …”
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Cellular enlargement - A new hallmark of aging? by Daniel M. Davies, Kim van den Handel, Soham Bharadwaj, Jette Lengefeld, Jette Lengefeld

“…Our recent study using hematopoietic stem cells (HSCs) in vivo indicates that cellular enlargement is causally associated with aging. …”
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Essentiality of Nfatc1 short isoform in osteoclast differentiation and its self-regulation by Yasuhiro Omata, Hideyuki Tachibana, Yoshimi Aizaki, Toshihide Mimura, Kojiro Sato

“…We developed a novel osteoclast culture system in which hematopoietic stem cells were cultured, proliferated, and then differentiated into osteoclasts in vitro. …”
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Role of reactive oxygen species in myelodysplastic syndromes by Qiangan Jing, Chaoting Zhou, Junyu Zhang, Ping Zhang, Yunyi Wu, Junyu Zhou, Xiangmin Tong, Yanchun Li, Jing Du, Ying Wang

“…OS caused by excessive ROS at physiological levels is likely to affect the functions of hematopoietic stem cells, such as cell growth and self-renewal, which may contribute to defective hematopoiesis. …”
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TELOMERE SHORTENING IN MONOCYTES OF THE PATIENTS WITH RHEUMATOID ARTHRITIS by V. I. Borisov, V. S. Kozhevnikov, V. V. Seniukov, A. E. Sizikov, L. P. Konenkova, O. V. Gerzog, V. A. Kozlov

“…The findings obtained may be considered as an additional argument confirming the hypothesis on genetic defects of hematopoietic stem cells determining RA development.…”
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Stress and non-stress roles of inflammatory signals during HSC emergence and maintenance by Thomas Clapes, Stylianos Lefkopoulos, Eirini Trompouki

“…Hematopoietic stem cells (HSCs) are a rare population that gives rise to almost all cells of the hematopoietic system, including immune cells. …”
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Role of Nitric Oxide in Megakaryocyte Function by Amir Asgari, Paul Jurasz

“…They are generated directly or through a multi-lineage commitment step from the most primitive progenitor or Hematopoietic Stem Cells (HSCs) in a process called “megakaryopoiesis”. …”
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Evaluation of the Possible Immuno-Protective Effect of Nigella Sativa Seed Oil on Cyclophosphamide- Induced Myelosuppression in Mice by Shahad A. Alsaad, Sarmed H. Kathem

“…Cyclophosphamide a widely used anticancer drugs, induces severe bone marrow suppression by damaging hematopoietic stem cells. As cancer incidence expands globally, the demand for an effective myeloprotective therapy during cancer treatment is also increasing.Nigella sativa seed oil, a well-known plant extract that widely used for various health conditions. …”
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B lymphocyte ontogeny by Juan Carlos Balandrán, Rosana Pelayo Camacho

“…The B cell development from hematopoietic stem cells is a continuous and highly regulated process where multiple differentiation potentials are gradually lost while acquiring lineage specialized functions. …”
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Experience with the use of bendamustine (Rozustin®): safety and efficacy by A. A. Semenova, A. V. Arakelyan, P. A. Zeynalova, G. S. Tumyan, V. B. Larionova, T. T. Valiev, F. M. Abbasbeyli, O. L. Timofeeva, A. S. Antipova, O. A. Lopuhova

“…The high effectiveness, acceptable toxicity profile compared to alternative “salvage” regimens, ease of implementation, and the possibility of a full collection of hematopoietic stem cells followed by high-dose chemotherapy and autologous stem cell transplant, confirm the good potential of the combined program with the inclusion of the drug bendamustine (Rozustin®).…”
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Identification of transcriptional regulators in the mouse immune system by Regev, Aviv

“…The differentiation of hematopoietic stem cells into cells of the immune system has been studied extensively in mammals, but the transcriptional circuitry that controls it is still only partially understood. …”
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Effect of recombinant Wnt protein on the Ex vivo expansion of umbilical cord blood hematopoietic cells. by Lim, Shy Ni.

“…Wnt gene pathway has shown to play an important role in the maintenance and development of hematopoietic stem cells (HSCs) compartment. The low number of HSCs in each umbilical cord blood (UCB) unit has limited its use in transplantation for adult patients. …”
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The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential by Luc, S, Luis, T, Boukarabila, H, Macaulay, I, Buza-Vidas, N, Bouriez-Jones, T, Lutteropp, M, Woll, P, Loughran, S, Mead, A, Hultquist, A, Brown, J, Mizukami, T, Matsuoka, S, Ferry, H, Anderson, K, Duarte, S, Atkinson, D, Soneji, S, Domanski, A, Farley, A, Sanjuan-Pla, A, Carella, C, Patient, R, De Bruijn, M

“…The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. …”

Scl is required for dorsal aorta as well as blood formation in zebrafish embryos. by Patterson, L, Gering, M, Patient, R

“…We conclude that scl is especially critical for the development of arteries where adult hematopoietic stem cells emerge, implicating scl in the formation of hemogenic endothelium.…”

Identification of transcriptional regulators in the mouse immune system. by Jojic, V, Shay, T, Sylvia, K, Zuk, O, Sun, X, Kang, J, Regev, A, Koller, D, Best, A, Knell, J, Goldrath, A, Joic, V, Koller, D, Shay, T, Regev, A, Cohen, N, Brennan, P, Brenner, M, Kim, F, Rao, T, Wagers, A, Heng, T, Ericson, J, Rothamel, K, Ortiz-Lopez, A

“…The differentiation of hematopoietic stem cells into cells of the immune system has been studied extensively in mammals, but the transcriptional circuitry that controls it is still only partially understood. …”

The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition by Azzoni, E, Frontera, V, Anselmi, G, Rode, C, James, C, Deltcheva, EM, Demian, AS, Brown, J, Barone, C, Patelli, A, Harman, JR, Nicholls, M, Conway, SJ, Morrissey, E, Jacobsen, SEW, Sparrow, DB, Harris, AL, Enver, T, de Bruijn, MFTR

“…Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the main embryonic arteries. …”

The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes. by Nilsson, L, Edén, P, Olsson, E, Månsson, R, Astrand-Grundström, I, Strömbeck, B, Theilgaard-Mönch, K, Anderson, K, Hast, R, Hellström-Lindberg, E, Samuelsson, J, Bergh, G, Nerlov, C, Johansson, B, Sigvardsson, M, Borg, A, Jacobsen, SE

“…Global gene expression profiling of highly purified 5q-deleted CD34+CD38(-)Thy1+ cells in 5q- myelodysplastic syndromes (MDSs) supported that they might originate from and outcompete normal CD34+CD38(-)Thy1+ hematopoietic stem cells. Few but distinct differences in gene expression distinguished MDS and normal stem cells. …”