The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies by Neha Sarodaya, Janardhan Karapurkar, Kye-Seong Kim, Seok-Ho Hong, Suresh Ramakrishna

“…Hematopoietic stem cells (HSCs) are responsible for the production of blood cells throughout the human lifespan. …”
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Yolk-sac-derived macrophages progressively expand in the mouse kidney with age by Shintaro Ide, Yasuhito Yahara, Yoshihiko Kobayashi, Sarah A Strausser, Kana Ide, Anisha Watwe, Shengjie Xu-Vanpala, Jamie R Privratsky, Steven D Crowley, Mari L Shinohara, Benjamin A Alman, Tomokazu Souma

“…Renal macrophages represent a highly heterogeneous and specialized population of myeloid cells with mixed developmental origins from the yolk-sac and hematopoietic stem cells (HSC). They promote both injury and repair by regulating inflammation, angiogenesis, and tissue remodeling. …”
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Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms by Peiwen Zhang, Na You, Yiyi Ding, Wenqi Zhu, Nan Wang, Yueqiao Xie, Wanling Huang, Qian Ren, Tiejun Qin, Rongfeng Fu, Lei Zhang, Zhijian Xiao, Tao Cheng, Xiaotong Ma

“…Gadd45g insufficiency in the murine hematopoietic system alone leads to significantly enhanced growth and self-renewal capacity of myeloid-biased hematopoietic stem cells, and the development of phenotypes resembling MPNs. …”
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NPM 1 Mutations in AML—The Landscape in 2023 by Naman Sharma, Jane L. Liesveld

“…Acute myeloid leukemia (AML) represents 80% of acute leukemia in adults and is characterized by clonal expansion of hematopoietic stem cells secondary to genomic mutations, rendering a selective growth advantage to the mutant clones. …”
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Long-acting interferon: pioneering disease modification of myeloproliferative neoplasms by Seug Yun Yoon, Sung-Yong Kim

“…Myeloproliferative neoplasms (MPNs) are clonal disorders of hematopoietic stem cells. The malignant clones produce cytokines that drive self-perpetuating inflammatory responses and tend to transform into more aggressive clones, leading to disease progression. …”
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Impact of oral microbiota on pathophysiology of GVHD by Akira Yamamoto, Yui Kambara, Hideaki Fujiwara

“…Allogeneic transplantation of hematopoietic cells is the only curative therapy for several hematopoietic disease in which patients receive cytotoxic conditioning regimens followed by infusion of hematopoietic stem cells. Although the outcomes have improved over the past decades, graft-versus-host-disease (GVHD), the most common life-threatening complication, remains a major cause of non-relapse morbidity and mortality. …”
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Targeting the alpha subunit of IL-3 receptor (CD123) in patients with acute leukemia by Ibrahim Aldoss, Mary Clark, Joo Y Song, Vinod Pullarkat

“…Notably, CD123 is preferentially overexpressed in leukemia stem cells (LSC) in contrast to normal hematopoietic stem cells, and this differential expression allows for the selective eradication of LSC and leukemic blasts through therapeutic targeting of CD123, with less impact on hematopoietic cells. …”
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Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells by Sicong He, Jiahao Chen, Yunyun Jiang, Yi Wu, Lu Zhu, Wan Jin, Changlong Zhao, Tao Yu, Tienan Wang, Shuting Wu, Xi Lin, Jianan Y Qu, Zilong Wen, Wenqing Zhang, Jin Xu

“…Here, using a laser-mediated temporal-spatial resolved cell labeling method, we demonstrated that most adult LCs originated from the ventral wall of the dorsal aorta (VDA), an equivalent to the mouse aorta, gonads, and mesonephros (AGM), where both hematopoietic stem cells (HSCs) and non-HSC progenitors are generated. …”
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ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma by Nadia Mensali, Hakan Köksal, Sandy Joaquina, Patrik Wernhoff, Nicholas P. Casey, Paola Romecin, Carla Panisello, René Rodriguez, Lene Vimeux, Asta Juzeniene, Marit R. Myhre, Anne Fåne, Carolina Castilla Ramírez, Solrun Melkorka Maggadottir, Adil Doganay Duru, Anna-Maria Georgoudaki, Iwona Grad, Andrés Daniel Maturana, Gustav Gaudernack, Gunnar Kvalheim, Angel M. Carcaboso, Enrique de Alava, Emmanuel Donnadieu, Øyvind S. Bruland, Pablo Menendez, Else Marit Inderberg, Sébastien Wälchli

“…T cells transduced with these CAR constructs mediate efficient and effective cytotoxicity against ALPL-positive cells in in vitro settings and in state-of-the-art in vivo orthotopic models of primary and metastatic OS, without unexpected toxicities against hematopoietic stem cells or healthy tissues. In summary, CAR-T cells targeting ALPL-1 show efficiency and specificity in treating OS in preclinical models, paving the path for clinical translation.…”
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MOBILIZATION OF STEM CELLS AFTER LIVER TRANSPLANTATION AND RESECTION by R. M. Kurabekova, O. M. Tsirulnikova, O. P. Shevchenko

“…Recent investigations of mechanism of bone marrow stem cells mobiliza- tion into peripheral blood, role of the stem cells in recovery of injured liver and clinical studies of hematopoietic stem cells mobilization after liver transplantation and resection are discussed in the review. …”
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BCG-induced trained immunity: history, mechanisms and potential applications by Jingjing Chen, Li Gao, Xinya Wu, Yuxin Fan, Meixiao Liu, Li Peng, Jieqin Song, Bingxue Li, Aihua Liu, Fukai Bao

“…Mechanisms of trained immunity include epigenetic reprogramming, metabolic reprogramming, and long-term protection mediated by hematopoietic stem cells. Trained immunity has so far shown beneficial effects on cancer, viral-infections, autoimmune diseases, and a variety of other diseases, especially bladder cancer, respiratory viruses, and type 1 diabetes. …”
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Cerebrovascular Accident in a Patient with Polycythemia: a Case Report by O. M. Drapkina, I. I. Almazova, A. V. Smirnova, S. A. Berns, R. N. Shepel

“…Polycythemia vera is not only a clonal disease that causes hematopoietic stem cells, but also a pathology that often leads to thrombotic complications. …”
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Intrinsic and extrinsic factors determining natural killer cell fate: Phenotype and function by Lingtong Zhi, Xing Wang, Qing Gao, Wenhui He, Chongye Shang, Changjiang Guo, Zhiyuan Niu, Wuling Zhu, Xuan Zhang

“…Natural killer (NK) cells are derived from hematopoietic stem cells. They belong to the innate lymphoid cell family, which is an important part of innate immunity. …”
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Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis by Wang, Ying-Hua, Lee, Dongjun, Yu, Vionnie W.C., Jeanson, Nathaniel T., Clish, Clary B., Cantley, Lewis C., Scadden, David T., Israelsen, William James, Vander Heiden, Matthew G.

“…We find that deficiency in the M2 pyruvate kinase isoform (PKM2) reduces levels of metabolic intermediates important for biosynthesis and impairs progenitor function without perturbing hematopoietic stem cells (HSC), whereas lactate dehydrogenase-A (LDHA) deletion significantly inhibits the function of both HSC and progenitors during hematopoiesis. …”
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D-Cyclins Repress Apoptosis in Hematopoietic Cells by Controlling Death Receptor Fas and Its Ligand FasL by Choi, Yoon Jong, Saez, Borja, Anders, Lars, Hydbring, Per, Stefano, Joanna, Bacon, Nickolas A., Cook, Colleen, Kalaszczynska, Ilona, Signoretti, Sabina, Scadden, David T., Sicinski, Piotr, Young, Richard A.

“…We demonstrate that adult hematopoietic stem cells are particularly dependent on D-cyclins for survival and that they are especially sensitive to cyclin D loss. …”
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Transforming Growth Factor β drives haemogenic endothelium programming and the transition to haematopoietic stem cells by Monteiro, R, Pinheiro, P, Joseph, N, Peterkin, T, Koth, J, Repapi, E, Bonkhofer, F, Kirmizitas, A, Patient, R

“…Hematopoietic stem cells (HSCs) are self-renewing multipotent stem cells that generate mature blood lineages throughout life. …”

Humanized mouse model mimicking pathology of human tuberculosis for in vivo evaluation of drug regimens by Arrey, F, Loewe, D, Kuhlmann, S, Kaiser, P, Moura-Alves, P, Krishnamoorthy, G, Lozza, L, Maertzdorf, J, Skrahina, T, Skrahina, A, Gengenbacher, M, Nouailles, G, Kaufmann, SHE

“…We demonstrate that human immune system mice, generated by transplanted human fetal liver derived hematopoietic stem cells develop a continuum of pulmonary lesions upon Mycobacterium tuberculosis aerosol infection. …”

Stem cell culture on polyvinyl alcohol hydrogels having different elasticity and immobilized with ECM-derived oligopeptides by Muduli, Saradaprasan, Chen, Li-Hua, Li, Meng-Pei, Heish, Zhao-wen, Liu, Cheng-Hui, Kumar, Suresh, Alarfaj, Abdullah A., Munusamy, Murugan A., Benelli, Giovanni, Murugan, Kadarkarai, Wang, Han-Chow, Chen, Da-Chung, Hsu, Shih-Tien, Chang, Shih-Chang, Higuchi, Akon

“…We systematically investigated the morphologies and characteristics of several stem cell types, including human amniotic-derived stem cells, human hematopoietic stem cells, human induced pluripotent stem (iPS) cells, and embryonic stem (ES) cells on poly(vinyl alcohol) (PVA) hydrogels immobilized with and without extracellular matrix-derived oligopeptide. …”
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A female with classical paroxysmal nocturnal hemoglobinuria misdiagnosed as megaloblastic anemia by Sana D Jalal, Shahla M Saeed, Nawshirwan G Rashid, Abdulhamid S Saeed

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder of the hematopoietic stem cells, which manifests as bone marrow failure, hemolytic anemia, and thrombosis. …”
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Extramedullary hematopoiesis in cancer by Derek A. G. Barisas, Kyunghee Choi

“…To initiate EMH, hematopoietic stem cells (HSCs) are mobilized from the bone marrow into the circulation and to extramedullary sites such as the spleen and liver. …”
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