Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo by Sudo, K, Yamazaki, S, Wilkinson, A, Nakauchi, H, Nakamura, Y

“…Ex vivo expansion of hematopoietic stem cells (HSCs) is one of the most promising strategies to increase the availability of transplantable HSCs and improve bone marrow transplantation outcomes. …”

Allogeneic and xenogeneic lymphoid reconstitution in a RAG2−/−IL2RGy/− severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation by Renan B. Sper, Renan B. Sper, Jessica Proctor, Jessica Proctor, Odessa Lascina, Ling Guo, Ling Guo, Kathryn Polkoff, Kathryn Polkoff, Tobias Kaeser, Tobias Kaeser, Sean Simpson, Sean Simpson, Luke Borst, Luke Borst, Katherine Gleason, Katherine Gleason, Xia Zhang, Xia Zhang, Bruce Collins, Bruce Collins, Yanet Murphy, Jeffrey L. Platt, Jorge A. Piedrahita, Jorge A. Piedrahita

“…To address these limitations, we generated RAG2−/−IL2RGy/− immunodeficient pigs and demonstrate successful engraftment of SLA mismatched allogeneic D42 fetal liver cells, tagged with pH2B-eGFP, and human CD34+ hematopoietic stem cells after in utero cell transplantation. …”
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HSC-independent definitive hematopoiesis persists into adult life by Michihiro Kobayashi, Haichao Wei, Takashi Yamanashi, Nathalia Azevedo Portilho, Samuel Cornelius, Noemi Valiente, Chika Nishida, Haizi Cheng, Augusto Latorre, W. Jim Zheng, Joonsoo Kang, Jun Seita, David J. Shih, Jia Qian Wu, Momoko Yoshimoto

“…Summary: It is widely believed that hematopoiesis after birth is established by hematopoietic stem cells (HSCs) in the bone marrow and that HSC-independent hematopoiesis is limited only to primitive erythro-myeloid cells and tissue-resident innate immune cells arising in the embryo. …”
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Isolation of Diverse Simian Arteriviruses Causing Hemorrhagic Disease by Teressa M. Shaw, Samuel T. Dettle, Andres Mejia, Jennifer M. Hayes, Heather A. Simmons, Puja Basu, Jens H. Kuhn, Mitchell D. Ramuta, Cody J. Warren, Peter B. Jahrling, David H. O’Connor, Liupei Huang, Misbah Zaeem, Jiwon Seo, Igor I. Slukvin, Matthew E. Brown, Adam L. Bailey

“…We attempted to isolate 4 simarteriviruses, Kibale red colobus virus 1, Pebjah virus, simian hemorrhagic fever virus, and Southwest baboon virus 1, by inoculating an immortalized grivet cell line (known to replicate simian hemorrhagic fever virus), primary macaque cells, macrophages derived from macaque induced pluripotent stem cells, and mice engrafted with macaque CD34+-enriched hematopoietic stem cells. The combined effort resulted in successful virus isolation; however, no single approach was successful for all 4 simarteriviruses. …”
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Bone Tissue and the Nervous System: What Do They Have in Common? by Arianna Minoia, Luca Dalle Carbonare, Jens Christian Schwamborn, Silvia Bolognin, Maria Teresa Valenti

“…Bone is also associated with the generation of both hematopoietic stem cells (HSCs), and thus the generation of the immune system, and mesenchymal stem cells (MSCs). …”
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Crosstalk of Transcriptional Regulators of Adaptive Immune System and microRNAs: An Insight into Differentiation and Development by Maryam Boshtam, Ilnaz Rahimmanesh, Laleh Shariati, Malihe Najaflu, Hossein Khanahmad, Mina Mirian, Atefeh Zarepour, Ali Zarrabi, Shirin Kouhpayeh

“…In this review, we first discussed the origination process of common lymphocyte progenitors from hematopoietic stem cells, which further differentiate into various T-cell subsets under strict regulation of miRNAs and transcription factors. …”
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Immune therapy: a new therapy for acute myeloid leukemia by Chen Tian, Zehui Chen

“…However, one of the major difficulties in developing immune therapies against AML is that the target antigens are also significantly expressed on healthy hematopoietic stem cells; B-cell malignancies are different because CD20/CD19/healthy B-cells are readily replaceable. …”
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Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage Cells by Süleyman Coşkun, Hsu Chao, Hema Vasavada, Kartoosh Heydari, Naomi Gonzales, Xin Zhou, Benoit de Crombrugghe, Karen K. Hirschi

“…Hematopoietic stem cells (HSCs) reside within a specialized niche where interactions with vasculature, osteoblasts, and stromal components regulate their self-renewal and differentiation. …”
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Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells by Carlo Zimarino, William Moody, Sarah E. Davidson, Hafsa Munir, Jacqueline D. Shields

“…These adaptations could be recapitulated in vitro by exposing hematopoietic stem cells to tumor-derived factors. Engagement of CD47 with SIRPα on myeloid cells reduced their phagocytic capability, enhanced expression of immune checkpoints, increased reactive oxygen species production, and suppressed T cell proliferation. …”
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Diversified Treatment Options of Adult Stem Cells for Optic Neuropathies by Shaoying Tan, Yao Yao, Qichen Yang, Xiang-Ling Yuan, Ling-Ping Cen, Tsz Kin Ng

“…Adult stem cells, including mesenchymal stem cells and hematopoietic stem cells, have been applied in clinical trials based on their neuroprotective properties. …”
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Analysis of the differential expression and prognostic relationship of DEGs in AML based on TCGA database by Yue Gao, Yinnong Jia, Zhengmin Yu, Xinyu Ji, Xiaowen Liu, Lei Han, Hengdong Zhang, Baoli Zhu, Ming Xu

“…Abstract Background Acute myeloid leukemia (AML) is a common and lethal hematological malignant hyperplastic disease originating from hematopoietic stem cells. The purpose of this study is to obtain the key differentially expressed gene (DEG) related to the survival of AML by The Cancer Genome Atlas (TCGA) database and to verify these genes by a clinical follow-up investigation, in order to identify valuable predictive and prognostic biomarkers for early diagnosis of AML and predict the survival rates. …”
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Hepatic leukemia factor-expressing paraxial mesoderm cells contribute to the developing brain vasculature by Yuta Koui, Takako Ideue, Michael Boylan, Matthew J. Anderson, Motomi Osato, Toshio Suda, Tomomasa Yokomizo, Yoh-suke Mukouyama

“…Interestingly, the genetically marked E10.5 Hlf-expressing cells, which have been previously reported to contain embryonic hematopoietic stem cells, fail to contribute to the vascular cells. …”
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Linker histone H1.2 and H1.4 affect the neutrophil lineage determination by Gabriel Sollberger, Robert Streeck, Falko Apel, Brian Edward Caffrey, Arthur I Skoultchi, Arturo Zychlinsky

“…They acquire this antimicrobial potential during their maturation in the bone marrow, where they differentiate from hematopoietic stem cells in a process called granulopoiesis. …”
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An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: biology and treatment by Tiziana Grafone, Michela Palmisano, Chiara Nicci, Sergio Storti

“…Hematopoiesis, the process by which the hematopoietic stem cells and progenitors differentiate into blood cells of various lineages, involves complex interactions of transcription factors that modulate the expression of downstream genes and mediate proliferation and differentiation signals. …”
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The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies by Hengwei Zhang, Jane L. Liesveld, Laura M. Calvi, Brea C. Lipe, Lianping Xing, Michael W. Becker, Edward M. Schwarz, Shu-Chi A. Yeh

“…Recent advances in intravital imaging has suggested that the expansion of hematopoietic stem cells (HSCs) and acute myeloid leukemia cells is restricted to bone marrow microdomains during a distinct stage of bone remodeling. …”
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SLAM Family Receptors in B Cell Chronic Lymphoproliferative Disorders by Dominik Kľoc, Slavomír Kurhajec, Mykhailo Huniadi, Ján Sýkora, Tomáš Guman, Marek Šarišský

“…Individual SLAMF receptors are expressed on the surface of hematopoietic stem cells, hematopoietic progenitor cells, B cells, T cells, NK cells, NKT cells, monocytes, macrophages, dendritic cells, neutrophils, and platelets. …”
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Progressive disruption of hematopoietic architecture from clonal hematopoiesis to MDS by Michèle C. Buck, Lisa Bast, Judith S. Hecker, Jennifer Rivière, Maja Rothenberg-Thurley, Luisa Vogel, Dantong Wang, Immanuel Andrä, Fabian J. Theis, Florian Bassermann, Klaus H. Metzeler, Robert A.J. Oostendorp, Carsten Marr, Katharina S. Götze

“…Using computational modeling we analyzed differentiation and proliferation kinetics of cultured hematopoietic stem cells (HSC) from 8 healthy individuals, 7 CHIP, and 10 MDS patients. …”
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RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells by Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L. Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y. Q. Han, Aspen J. Pierson, Michael Xiao, Xuejing Yang, Lindsey M. Kuehm, Yuning Hong, Diu T. T. Nguyen, Gabriela Chiosis, Alex Kentsis, Christina Leslie, Ly P. Vu, Michael G. Kharas

“…Abstract Tissue homeostasis is maintained after stress by engaging and activating the hematopoietic stem and progenitor compartments in the blood. Hematopoietic stem cells (HSCs) are essential for long-term repopulation after secondary transplantation. …”
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TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry by Zhi Feng, Shengnan Liu, Ming Su, Chunyu Song, Chenyu Lin, Fangying Zhao, Yang Li, Xianyan Zeng, Yong Zhu, Yu Hou, Chunguang Ren, Huan Zhang, Ping Yi, Yong Ji, Chao Wang, Hongtao Li, Ming Ma, Lingfei Luo, Li Li

“…The conditional depletion or overexpression of TANGO6 in mouse hematopoietic stem cells results in compromised or expanded hematopoiesis. …”
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Insight into microRNAs’ involvement in hematopoiesis: current standing point of findings by Seyed Mahdi Nassiri, Neda Ahmadi Afshar, Parsa Almasi

“…Abstract Hematopoiesis is a complex process in which hematopoietic stem cells are differentiated into all mature blood cells (red blood cells, white blood cells, and platelets). …”
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