Chapter 5 Long-Range Regulation of α-Globin Gene Expression by Higgs, D, Vernimmen, D, Wood, B

“…We have investigated in detail how the remote regulatory elements of the α-globin cluster become activated as hematopoietic stem cells (HSCs) undergo commitment, lineage specification, and differentiation to form red blood cells. …”

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21. by Roy, A, Cowan, G, Mead, A, Filippi, S, Bohn, G, Chaidos, A, Tunstall, O, Chan, J, Choolani, M, Bennett, P, Kumar, S, Atkinson, D, Wyatt-Ashmead, J, Hu, M, Stumpf, M, Goudevenou, K, O'Connor, D, Chou, S, Weiss, M, Karadimitris, A, Jacobsen, S, Vyas, P, Roberts, I

“…Here, we show that compared with primary disomic controls, primary T21 fetal liver (FL) hematopoietic stem cells (HSC) and megakaryocyte-erythroid progenitors are markedly increased, whereas granulocyte-macrophage progenitors are reduced. …”

Mouse development and cell proliferation in the absence of D-cyclins. by Kozar, K, Ciemerych, M, Rebel, V, Shigematsu, H, Zagozdzon, A, Sicinska, E, Geng, Y, Yu, Q, Bhattacharya, S, Bronson, RT, Akashi, K, Sicinski, P

“…Our analyses revealed that the D-cyclins are critically required for the expansion of hematopoietic stem cells. In contrast, cyclin D-deficient fibroblasts proliferate nearly normally but show increased requirement for mitogenic stimulation in cell cycle re-entry. …”

A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells. by van Riel, B, Pakozdi, T, Brouwer, R, Monteiro, R, Tuladhar, K, Franke, V, Bryne, J, Jorna, R, Rijkers, E, van Ijcken, W, Andrieu-Soler, C, Demmers, J, Patient, R, Soler, E, Lenhard, B, Grosveld, F

“…RUNX1 is known to be an essential transcription factor for generating hematopoietic stem cells (HSC), but much less is known about its role in the downstream process of hematopoietic differentiation. …”

Dysfunction of macrophages leads to diabetic bone regeneration deficiency by Yufeng Shen, Yufeng Shen, Yufeng Shen, Yifan Zhang, Yifan Zhang, Yifan Zhang, Zheng Zhou, Jinyu Wang, Jinyu Wang, Jinyu Wang, Dong Han, Dong Han, Dong Han, Jiwei Sun, Jiwei Sun, Jiwei Sun, Guangjin Chen, Guangjin Chen, Guangjin Chen, Qingming Tang, Qingming Tang, Qingming Tang, Wei Sun, Wei Sun, Wei Sun, Lili Chen, Lili Chen, Lili Chen

“…In diabetes mellitus, the proliferation of resident macrophages in bone microenvironment is limited, while enhanced myeloid differentiation of hematopoietic stem cells (HSCs) leads to increased and constant monocyte recruitment and thus macrophages shift toward the classic pro-inflammatory phenotype, which leads to the deficiency of bone regeneration. …”
Get full text

Multimodal cartography of human lymphopoiesis reveals B and T/NK/ILC lineages are subjected to differential regulation by Kutaiba Alhaj Hussen, Emna Chabaane, Elisabeth Nelson, Shalva Lekiashvili, Samuel Diop, Seydou Keita, Bertrand Evrard, Aurélie Lardenois, Marc Delord, Els Verhoeyen, Kerstin Cornils, Zeinab Kasraian, Elizabeth A. Macintyre, Ana Cumano, David Garrick, Michele Goodhardt, Guillaume P. Andrieu, Vahid Asnafi, Frederic Chalmel, Bruno Canque

“…While the differentiation of CD127- early lymphoid progenitors is mainly driven by Flt3 signaling, emergence of their CD127+ counterparts is regulated cell-intrinsically and depends exclusively on the divisional history of their upstream precursors, including hematopoietic stem cells. Further, transcriptional mapping of differentiation trajectories reveals that whereas myeloid granulomonocytic lineages follow continuous differentiation pathways, lymphoid trajectories are intrinsically discontinuous and characterized by sequential waves of cell proliferation allowing pre-commitment amplification of lymphoid progenitor pools. …”
Get full text

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation by Sarah E. Garnish, Katherine R. Martin, Maria Kauppi, Victoria E. Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C. Tovey Crutchfield, Komal M. Patel, Annette V. Jacobsen, Georgia K. Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R. Horne, Cathrine Hall, Samuel N. Young, Matthew Cook, Vicki Athanasopoulos, Carola G. Vinuesa, Kate E. Lawlor, Ian P. Wicks, Gregor Ebert, Ashley P. Ng, Charlotte A. Slade, Jaclyn S. Pearson, André L. Samson, John Silke, James M. Murphy, Joanne M. Hildebrand

“…In vivo, Mlkl S131P homozygosity reduces the capacity to clear Salmonella from major organs and retards recovery of hematopoietic stem cells. Thus, by dysregulating necroptosis, the S131P substitution impairs the return to homeostasis after systemic challenge. …”
Get full text

New insights into inflammatory memory of epidermal stem cells by Dapeng Cheng, Xiaochen Zhu, Xiaochen Zhu, Shaochen Yan, Linli Shi, Zhi Liu, Xin Zhou, Xinling Bi

“…Studies have identified that not only hematopoietic stem cells and fibroblasts have immune memory effects, but also stem cells from various barrier epithelial tissues generate and maintain inflammatory memory. …”
Get full text

The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice by Kerstin Schmidt, Qinyu Zhang, Alpaslan Tasdogan, Andreas Petzold, Andreas Dahl, Borros M Arneth, Robert Slany, Hans Jörg Fehling, Andrea Kranz, Adrian Francis Stewart, Konstantinos Anastassiadis

“…Hematopoietic stem cells require MLL1, which is one of six Set1/Trithorax-type histone 3 lysine 4 (H3K4) methyltransferases in mammals and clinically the most important leukemia gene. …”
Get full text

Identification of the Factor That Leads Human Mesenchymal Stem Cell Lines into Decellularized Bone by Anri Koyanagi, Iichiroh Onishi, Karin Muraoka, Ikue Sato, Shingo Sato, Tsuyoshi Kimura, Akio Kishida, Kouhei Yamamoto, Masanobu Kitagawa, Morito Kurata

“…Hematopoiesis is maintained by the interaction of hematopoietic stem cells (HSCs) and bone marrow mesenchymal stem cells (MSCs) in bone marrow microenvironments, called niches. …”
Get full text

Histone Acetyltransferases and Stem Cell Identity by Ruicen He, Arthur Dantas, Karl Riabowol

“…In this study we review functions of the HAT complexes active in pluripotent stem cells, hematopoietic stem cells, muscle satellite cells, mesenchymal stem cells, neural stem cells, and cancer stem cells.…”
Get full text

The road of NSCLC stem cells toward bone metastases by Giulia Bertolini, Ilaria Roato

“…The role of different cell types inside the bone metastatic niche, such as endothelial cells, bone cells, hematopoietic stem cells and immune cells will be discussed in regards of their impact in dictating the success of metastasis establishment by MICs.Finally, novel therapeutic options to target NSCLC MIC-induced bone metastases, increasing the survival of patients, will be presented.…”
Get full text

Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1 by Bo O Zhou, Lei Ding, Sean J Morrison

“…Hematopoietic stem cells (HSCs) are maintained by a perivascular niche in bone marrow but it is unclear whether the niche is reciprocally regulated by HSCs. …”
Get full text

Mitochondria: A Galaxy in the Hematopoietic and Leukemic Stem Cell Universe by Cristina Panuzzo, Aleksandar Jovanovski, Barbara Pergolizzi, Lucrezia Pironi, Serena Stanga, Carmen Fava, Daniela Cilloni

“…We investigated the pivotal role of mitochondria in the maintenance of hematopoietic stem cells (HSCs) and their main alterations that could induce malignant transformation, culminating in the generation of leukemic stem cells (LSCs). …”
Get full text

Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output by Marcel G.E. Rommel, Lisa Walz, Foteini Fotopoulou, Saskia Kohlscheen, Franziska Schenk, Csaba Miskey, Lacramioara Botezatu, Yvonne Krebs, Iris M. Voelker, Kevin Wittwer, Tim Holland-Letz, Zoltán Ivics, Veronika von Messling, Marieke A.G. Essers, Michael D. Milsom, Christian K. Pfaller, Ute Modlich

“…Irrespective of antiviral treatment or vaccination, at a certain threshold of IAV titer in the lung, CD41-positive hematopoietic stem cells (HSCs) enter the cell cycle while endothelial protein C receptor-positive CD41-negative HSCs remain quiescent. …”
Get full text

The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver by Sophia Y.Y. Mah, Sophia Y.Y. Mah, Hannah K. Vanyai, Hannah K. Vanyai, Yuqing Yang, Yuqing Yang, Anne K. Voss, Anne K. Voss, Tim Thomas, Tim Thomas

“…Mice lacking ING5 during development had decreased foetal liver cellularity, decreased numbers of hematopoietic stem cells and perturbed erythropoiesis compared to wild-type control mice. …”
Get full text

Lysosomes in Stem Cell Quiescence: A Potential Therapeutic Target in Acute Myeloid Leukemia by Vaibhav Jain, Swaroop Bose, Awadhesh K. Arya, Tasleem Arif

“…Recent research advancements have demonstrated that lysosomes also regulate the maintenance and hemostasis of hematopoietic stem cells (HSCs), which play a critical role in the progression of acute myeloid leukemia (AML) and other types of cancer. …”
Get full text

Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis by Yuhan Yan, Chao Chen, Zhiguo Li, Jing Zhang, Narin Park, Cheng-Kui Qu

“…Here we report that a continuous supply of exogenous arginine is required for the maintenance/function of normal hematopoietic stem cells (HSCs). Surprisingly, knockout of Slc7a3 (CAT3), a major L-arginine transporter, does not affect HSCs in steady-state or under stress. …”
Get full text

MicroRNA function in megakaryocytes by Sanjeev Raghuwanshi, Swati Dahariya, Syed Shahid Musvi, Usha Gutti, Ravinder Kandi, Ram Babu Undi, Itishri Sahu, Dushyant Kumar Gautam, Indira Paddibhatla, Ravi Kumar Gutti

“…Megakaryocytes (MKs), the largest cells in the bone marrow, are generated from hematopoietic stem cells (HSCs) in a sequential process called megakaryocytopoiesis in which HSCs undergo MK-progenitor (MP) commitment and maturation to terminally differentiated MK. …”
Get full text

Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1 by Xiaojing Cui, Cuiping Zhang, Fang Wang, Xinghui Zhao, Shuxia Wang, Jinpeng Liu, Daheng He, Chi Wang, Feng-Chun Yang, Sheng Tong, Ying Liang

“…Summary: Hematopoietic stem cells (HSCs) have the ability to self-renew and differentiate to all blood cell types. …”
Get full text