Directed sibling cord blood banking for transplantation: the 10-year experience in the national blood service in England. by Smythe, J, Armitage, S, McDonald, D, Pamphilon, D, Guttridge, M, Brown, J, Green, A, Brown, C, Warwick, R, Lankester, A, Fehily, D, Contreras, M, Navarrete, C, Watt, S

“…Umbilical cord blood (UCB) is an important source of hematopoietic stem cells for transplantation. Although UCB is often collected from unrelated donors, directed umbilical cord blood (DCB) from sibling donors also provides an important source of UCB for transplantation. …”

A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis. by Knezevic, K, Bee, T, Wilson, N, Janes, M, Kinston, S, Polderdijk, S, Kolb-Kokocinski, A, Ottersbach, K, Pencovich, N, Groner, Y, De Bruijn, M, Göttgens, B, Pimanda, J

“…The oncogenic transcription factor Runx1 is required for the specification of definitive hematopoietic stem cells (HSC) in the developing embryo. The activity of this master regulator is tightly controlled during development. …”

Single-cell approaches reveal novel cellular pathways for megakaryocyte and erythroid differentiation by Psaila, B, Mead, A

“…The classical model of hematopoiesis proposes a hierarchy in which a small number of multipotent hematopoietic stem cells (HSCs) maintain all blood lineages by giving rise to progeny that pass through discrete progenitor stages. …”

Angiocrine signals regulate quiescence and therapy resistance in bone metastasis by Singh, A, Veeriah, V, Xi, P, Labella, R, Chen, J, Romeo, S, Ramasamy, S, Kusumbe, A

“…Bone provides supportive microenvironments for hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) and is a frequent site of metastasis. …”

Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios by Hoppe, P, Schwarzfischer, M, Loeffler, D, Kokkaliaris, K, Hilsenbeck, O, Moritz, N, Endele, M, Filipczyk, A, Gambardella, A, Ahmed, N, Etzrodt, M, Coutu, D, Rieger, M, Marr, C, Strasser, M, Schauberger, B, Burtscher, I, Ermakova, O, Bürger, A, Lickert, H, Nerlov, C, Theis, F, Schroeder, T

“…We analyse individual hematopoietic stem cells (HSCs) throughout their differentiation into megakaryocytic/erythroid (MegE) and granulocytic/monocytic (GM) lineages. …”

Mesenchymal stromal cells in tumor microenvironment remodeling of BCR-ABL negative myeloproliferative diseases by Enrico La Spina, Sebastiano Giallongo, Cesarina Giallongo, Nunzio Vicario, Andrea Duminuco, Rosalba Parenti, Rosario Giuffrida, Lucia Longhitano, Giovanni Li Volti, Daniela Cambria, Francesco Di Raimondo, Giuseppe Musumeci, Alessandra Romano, Giuseppe Alberto Palumbo, Daniele Tibullo

“…In such a highly oxidative TME, the balance between Hematopoietic Stem Cells (HSCs) and Mesenchymal Stromal Cells (MSCs) has a crucial role in MPN development. …”
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Mdm2/p53 levels in bone marrow mesenchymal stromal cells are essential for maintaining the hematopoietic niche in response to DNA damage by Rasoul Pourebrahim, Rafael Heinz Montoya, Zoe Alaniz, Lauren Ostermann, Patrick P. Lin, Bin Liu, Edward Ayoub, Jared K. Burks, Michael Andreeff

“…Abstract Mesenchymal stromal cells (MSCs) are a key component of the bone marrow (BM) niche, providing essential support required for the maintenance of hematopoietic stem cells. To advance our understanding of physiological functions of p53 and Mdm2 in BM-MSCs, we developed traceable conditional mouse models targeting Mdm2 and/or Trp53 in vivo. …”
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Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation by Marc A Kerenyi, Zhen Shao, Yu-Jung Hsu, Guoji Guo, Sidinh Luc, Kassandra O'Brien, Yuko Fujiwara, Cong Peng, Minh Nguyen, Stuart H Orkin

“…Failure to fully silence HSPC genes compromised differentiation of hematopoietic stem cells as well as mature blood cell lineages. …”
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Establishment of Human Leukocyte Antigen-Mismatched Immune Responses after Transplantation of Human Liver Bud in Humanized Mouse Models by Akihiro Mori, Soichiro Murata, Nao Tashiro, Tomomi Tadokoro, Satoshi Okamoto, Ryo Otsuka, Haruka Wada, Tomoki Murata, Takeshi Takahashi, Ken-ichiro Seino, Hideki Taniguchi

“…After the transplantation of HLA-A2 human hematopoietic stem cells into NOG-HLA-A2Tg, we succeeded in achieving alloimmune responses after the HLA-mismatched human-induced pluripotent stem cell (hiPSC)-derived liver-like tissue transplantation. …”
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The Involvement of Macrophage Colony Stimulating Factor on Protein Hydrolysate Injection Mediated Hematopoietic Function Improvement by Shimiao Wang, Yuchong Zhang, Weiqi Meng, Yihao Dong, Sujie Zhang, Lesheng Teng, Yang Liu, Lanzhou Li, Di Wang

“…PH restored peripheral blood cell concentrations and increased the numbers of hematopoietic stem cells and progenitor cells (HSPCs), B lymphocytes, macrophages, and granulocytes in the BM of CTX-treated mice. …”
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Detecting heterogeneity in single-cell RNA-Seq data by non-negative matrix factorization by Xun Zhu, Travers Ching, Xinghua Pan, Sherman M. Weissman, Lana Garmire

“…Here we investigate the performance of non-negative matrix factorization (NMF) method to analyze a wide variety of scRNA-Seq datasets, ranging from mouse hematopoietic stem cells to human glioblastoma data. In comparison to other unsupervised clustering methods including K-means and hierarchical clustering, NMF has higher accuracy in separating similar groups in various datasets. …”
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CD34 positive cells as endothelial progenitor cells in biology and medicine by Mehdi Hassanpour, Mehdi Hassanpour, Amankeldi A. Salybekov, Amankeldi A. Salybekov, Amankeldi A. Salybekov, Shuzo Kobayashi, Shuzo Kobayashi, Takayuki Asahara, Takayuki Asahara

“…CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known to be rich sources of EPCs. …”
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Mechanisms of Ataxia Telangiectasia Mutated (ATM) Control in the DNA Damage Response to Oxidative Stress, Epigenetic Regulation, and Persistent Innate Immune Suppression Following... by Laura A. Huff, Shan Yan, Mark G. Clemens

“…Herein we use sepsis as a model of an inflammatory pathophysiological condition that results in elevated oxidative stress, upregulation of the DDR, and epigenetic reprogramming of hematopoietic stem cells (HSCs) to discuss new evidence for interplay between the antioxidant response, the DNA damage response, and epigenetic status.…”
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Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia and in Normal Bone Marrow by Etienne Paubelle, Florence Zylbersztejn, Thiago Trovati Maciel, Caroline Carvalho, Annalisa Mupo, Meyling Cheok, Liesbet Lieben, Pierre Sujobert, Justine Decroocq, Akihiko Yokoyama, Vahid Asnafi, Elizabeth Macintyre, Jérôme Tamburini, Valérie Bardet, Sylvie Castaigne, Claude Preudhomme, Hervé Dombret, Geert Carmeliet, Didier Bouscary, Yelena Z. Ginzburg, Hughes de Thé, Marc Benhamou, Renato C. Monteiro, George S. Vassiliou, Olivier Hermine, Ivan C. Moura

“…In mice, the lack of Vdr results in increased numbers of hematopoietic and leukemia stem cells and quiescent hematopoietic stem cells. In addition, malignant transformation of Vdr−/− cells results in myeloid differentiation block and increases self-renewal. …”
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Case Report: Langerhans Cell Sarcoma With Intracranial and Extracranial Communication on the Left Frontal Bone by Shan Xie, Zhilin Shao, Dongqi Shao, Bang Du, Yi Han, Yu Li, Binbin Zhang, Xialin Zheng, Zhiquan Jiang

“…Treatment includes resection of lesions, radiotherapy, chemotherapy, immunotherapy, and transplantation of hematopoietic stem cells. However, a unified and optimized treatment plan is lacking, and individualized treatment is accepted.Case presentationWe report an 18-year-old man with intracranial and extracranial communicative LCS that occurred in only the left forehead without metastasis to other regions. …”
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Review of Dendritic Cells, Their Role in Clinical Immunology, and Distribution in Various Animal Species by Mohammed Yusuf Zanna, Abd Rahaman Yasmin, Abdul Rahman Omar, Siti Suri Arshad, Abdul Razak Mariatulqabtiah, Saulol Hamid Nur-Fazila, Md Isa Nur Mahiza

“…Dendritic cells (DCs) are cells derived from the hematopoietic stem cells (HSCs) of the bone marrow and form a widely distributed cellular system throughout the body. …”
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Isolation of Murine Myeloid Progenitor Populations by CD34/CD150 Surface Markers by Leonid Olender, Roshina Thapa, Roi Gazit

“…Myeloid progenitors are intermediates between Hematopoietic Stem Cells (HSCs) and Myeloid effector progeny. …”
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Autophagy a Close Relative of AML Biology by Carine Joffre, Charlotte Ducau, Laura Poillet-Perez, Charly Courdy, Véronique Mansat-De Mas

“…This review summarizes the recent findings that mechanistically show how autophagy favors leukemic transformation of normal hematopoietic stem cells, as well as AML progression and also recapitulates its ambivalent role in resistance to chemotherapies and targeted therapies.…”
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Resolution of otitis media in a humanized mouse model by Ye Lin Son, Kwang Pak, Nada Muradagha, Kyung Wook Heo, Anke Leichtle, Arwa Kurabi

“…This model has many potential uses in OM research, including using hematopoietic stem cells from patients with differing degrees of OM susceptibility, to understand the role of human immune responses in proneness to this common childhood disease.…”
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Inhibition of Notch Signaling Enhances Antitumor Activity of Histone Deacetylase Inhibitor LAQ824 by Qinglang Mei, Xiaohan Xu, Danling Gao, Yuting Xu, Jinbo Yang

“…Furthermore, LAQ has been shown to induce the activation of the Notch signaling pathway in hematopoietic stem cells, which is associated with tumor progression and drug resistance in colon and breast cancers. …”
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