Extracellular Vesicles as Biological Indicators and Potential Sources of Autologous Therapeutics in Osteoarthritis by Xin Zhang, Janet L. Huebner, Virginia Byers Kraus

“…In contrast, the CD34⁺ medium and small EVs, reflecting hematopoietic stem cells, progenitor cells, and endothelial cells, were the most significantly enriched subpopulations in plasma relative to SF (7.3- and 7.7-fold higher). …”
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Patients With Myeloproliferative Neoplasms Harbor High Frequencies of CD8 T Cell-Platelet Aggregates Associated With T Cell Suppression by Ana Micaela Carnaz Simões, Morten Orebo Holmström, Pia Aehnlich, Anne Rahbech, Marlies J. W. Peeters, Aneta Radziwon-Balicka, Carlos Zamora, Tobias Wirenfeldt Klausen, Vibe Skov, Lasse Kjær, Christina Ellervik, Christina Ellervik, Christina Ellervik, Daniel El Fassi, Daniel El Fassi, Silvia Vidal, Hans Carl Hasselbalch, Mads Hald Andersen, Mads Hald Andersen, Per thor Straten, Per thor Straten

“…Myeloproliferative neoplasms (MPN) are chronic cancers of the hematopoietic stem cells in the bone marrow, and patients often harbor elevated numbers of circulating platelets (PLT). …”
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Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis by Ayala Tovy, Jaime M Reyes, Linda Zhang, Yung-Hsin Huang, Carina Rosas, Alexes C Daquinag, Anna Guzman, Raghav Ramabadran, Chun-Wei Chen, Tianpeng Gu, Sinjini Gupta, Laura Ortinau, Dongsu Park, Aaron R Cox, Rachel E Rau, Sean M Hartig, Mikhail G Kolonin, Margaret A Goodell

“…DNA Methyltransferase 3 A (DNMT3A) is an important facilitator of differentiation of both embryonic and hematopoietic stem cells. Heterozygous germline mutations in DNMT3A lead to Tatton-Brown-Rahman Syndrome (TBRS), characterized by obesity and excessive height. …”
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A Pig-a conditional knock-out mice model mediated by Vav-iCre: stable GPI-deficient and mild hemolysis by Yingying Chen, Hui Liu, Lijie Zeng, Liyan Li, Dan Lu, Zhaoyun Liu, Rong Fu

“…Abstract Paroxysmal nocturnal hemoglobinuria is a clonal disease caused by PIG-A mutation of hematopoietic stem cells. At present, there is no suitable PNH animal model for basic research, therefore, it is urgent to establish a stable animal model. …”
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Mesenchymal Stromal Cells (MSCs): An Ally of B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells in Disease Maintenance and Progression within the Bone Marrow Hematopoietic Niche by Alessandra Fallati, Noemi Di Marzo, Giovanna D’Amico, Erica Dander

“…Mesenchymal stromal cells (MSCs) are structural components of the bone marrow (BM) niche, where they functionally interact with hematopoietic stem cells and more differentiated progenitors, contributing to hematopoiesis regulation. …”
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Auto-regeneration of mice testicle seminiferous tubules due to malnutrition based on stem cells mobilization using honey by Erma Safitri, Suzanita Utama, Thomas Valentinus Widiyatno, Willy Sandhika, R. Heru Prasetyo

“…Subsequently observation of Hematopoietic Stem Cells (HSCs) mobilization according to the CD34 and CD45 expressions performed using flowcytometry method was conducted. …”
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Emilin-2 is a component of bone marrow extracellular matrix regulating mesenchymal stem cell differentiation and hematopoietic progenitors by Francesco Da Ros, Luca Persano, Dario Bizzotto, Mariagrazia Michieli, Paola Braghetta, Mario Mazzucato, Paolo Bonaldo

“…Emilin-2 expression was monitored in vitro in primary and mesenchymal stem cell lines under undifferentiated and adipogenic conditions. Hematopoietic stem cells and progenitors in bone marrow of 3- to 10-month-old wild-type and Emilin-2 null mice were analyzed by flow cytometry. …”
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Contribution of the TIME in BCP-ALL: the basis for novel approaches therapeutics by Nathaly Poveda-Garavito, Nathaly Poveda-Garavito, Nathaly Poveda-Garavito, Alba Lucía Combita, Alba Lucía Combita, Alba Lucía Combita

“…The bone marrow (BM) niche is a microenvironment where both immune and non-immune cells functionally interact with hematopoietic stem cells (HSC) and more differentiated progenitors, contributing to the regulation of hematopoiesis. …”
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Sequential gene expression analysis of myelodysplastic syndrome transformation identifies HOXB3 and HOXB7 as the novel targets for mesenchymal cells in disease by Chunlai Yin, Yanqi Li, Cheng Zhang, Shizhu Zang, Zilong Wang, Xue Yan, Tonghui Ma, Xia Li, Weiping Li

“…Abstract Background Myelodysplastic syndrome (MDS) is known to arise through the pathogenic bone marrow mesenchymal stem cells (MSC) by interacting with hematopoietic stem cells (HSC). However, due to the strong heterogeneity of MDS patients, it is difficult to find common targets in studies with limited sample sizes. …”
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Acquired and hereditary bone marrow failure: A mitochondrial perspective by Waseem Nasr, Waseem Nasr, Marie-Dominique Filippi, Marie-Dominique Filippi

“…BMFs and MDS are caused by decreased fitness of hematopoietic stem cells (HSC) and poor hematopoiesis. BMF and MDS can occur de novo or secondary to hematopoietic stress, including following bone marrow transplantation or myeloablative therapy. …”
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Role of the bone marrow vascular niche in chemotherapy for MLL-AF9-induced acute myeloid leukemia by Chang Xu, Ting Lu, Xue Lv, Tao Cheng, Hui Cheng

“…Leukemia stem cells in acute myeloid leukemia (AML) can persist within unique bone marrow niches similar to those of healthy hematopoietic stem cells and resist chemotherapy. In the context of AML, endothelial cells (ECs) are crucial components of these niches that appear to promote malignant expansion despite treatment. …”
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PIM1 Promotes Survival of Cardiomyocytes by Upregulating c-Kit Protein Expression by David E. Ebeid, Fareheh Firouzi, Carolina Y. Esquer, Julian M. Navarrete, Bingyan J. Wang, Natalie A. Gude, Mark A. Sussman

“…PIM1 (Proviral Insertion site in Murine leukemia virus (PIM) kinase 1) is a cardioprotective serine threonine kinase that promotes cardiomyocyte survival and antagonizes senescence through multiple concurrent molecular signaling cascades. In hematopoietic stem cells, PIM1 interacts with the receptor tyrosine kinase c-Kit upstream of the ERK (Extracellular signal-Regulated Kinase) and Akt signaling pathways involved in cell proliferation and survival. …”
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CRISPR/Cas systems usher in a new era of disease treatment and diagnosis by Ruiting Li, Qin Wang, Kaiqin She, Fang Lu, Yang Yang

“…Significant progress has been made in applying genome editing strategies to modify T cells and hematopoietic stem cells (HSCs) ex vivo and to treat a wide variety of diseases and disorders in vivo. …”
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The state of the art in the treatment of severe aplastic anemia: immunotherapy and hematopoietic cell transplantation in children and adults by Agnieszka Piekarska, Katarzyna Pawelec, Anna Szmigielska-Kapłon, Marek Ussowicz

“…Acquired aplastic anemia (AA) is an immune-mediated bone marrow (BM) failure where marrow disruption is driven by a cytotoxic T-cell–mediated autoimmune attack against hematopoietic stem cells. The key diagnostic challenge in children, but also in adults, is to exclude the possible underlying congenital condition and myelodysplasia. …”
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Hematinic Potential of Olive Leaf Extract: Evidence from an In Vivo Study in Mice and a Pilot Study in Healthy Human Volunteers by Shinji Kondo, Farhana Ferdousi, Jinchang Zhao, Sofya Suidasari, Miki Yokozawa, Ken Yamauchi, Ken-ichi Tominaga, Hiroko Isoda

“…In this regard, olive leaf extract, which is rich in bioactive phenolic compounds, has been reported to induce erythroid differentiation in human hematopoietic stem cells. Therefore, in the present study, we aimed to explore the potential hematinic properties of aqueous olive leaf extract (WOL) in vivo. …”
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Deciphering the Efficacy and Mechanism of <i>Astragalus membranaceus</i> on High Altitude Polycythemia by Integrating Network Pharmacology and In Vivo Experiments by Xiru Liu, Hao Zhang, Jinxiao Yan, Xiang Li, Jie Li, Jialu Hu, Xuequn Shang, Hui Yang

“…In the HAPC animal models, we found that AM inhibited the differentiation of hematopoietic stem cells into the erythroid lineage. It also suppressed the production of erythrocytes and hemoglobin in peripheral blood by reducing the expression of HIF-1α, EPO, VEGFA, and Gata-1 mRNA. …”
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The PI3K-Akt-mTOR Signaling Pathway in Human Acute Myeloid Leukemia (AML) Cells by Ina Nepstad, Kimberley Joanne Hatfield, Ida Sofie Grønningsæter, Håkon Reikvam

“…Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Malignant cell growth is characterized by disruption of normal intracellular signaling, caused by mutations or aberrant external signaling. …”
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BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1 by Yufeng Zhang, Min Yang, Sheng Zhang, Zhiqiang Yang, Yufan Zhu, Yi Wang, Zhe Chen, Xuan Lv, Zan Huang, Yuanlong Xie, Lin Cai

“…Osteoclasts are multinucleated giant cells derived from hematopoietic stem cells and play a major role in bone absorption. …”
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Human Immunodeficiency Virus and Clonal Hematopoiesis by Stamatia C. Vorri, Ilias Christodoulou, Styliani Karanika, Theodoros Karantanos

“…Clonal hematopoiesis (CH) is the acquisition of somatic mutations by the hematopoietic stem cells, rendering them survival and growth benefit, thus leading to their clonal dominance in the bone marrow. …”
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CD123 as a Biomarker in Hematolymphoid Malignancies: Principles of Detection and Targeted Therapies by Hanadi El Achi, Edouard Dupont, Shilpa Paul, Joseph D. Khoury

“…Importantly, CD123 expression is upregulated in leukemic stem cells relative to non-neoplastic hematopoietic stem cells, which makes it a useful diagnostic and therapeutic biomarker in hematologic malignancies. …”
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