Downregulation of rRNA transcription triggers cell differentiation. by Yuki Hayashi, Takao Kuroda, Hiroyuki Kishimoto, Changshan Wang, Atsushi Iwama, Keiji Kimura

“…Furthermore, TIF-IA knockdown in an ex vivo culture of mouse hematopoietic stem cells increased the percentage of myeloid cells and reduced the percentage of immature cells. …”
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A Novel Inducible Mouse Model of MLL-ENL-driven Mixed-lineage Acute Leukemia by Vaia Stavropoulou, Marwa Almosailleakh, Hélène Royo, Jean-François Spetz, Sabine Juge, Laurent Brault, Patrick Kopp, Michelina Iacovino, Michael Kyba, Alexandar Tzankov, Michael B. Stadler, Gianni Cazzaniga, Antoine H.F.M. Peters, Juerg Schwaller

“…The authors established a doxycycline (DOX)-inducible transgenic mouse model “iMLL-ENL” in which induction in long-term hematopoietic stem cells, lymphoid primed multipotent progenitor cells, multipotent progenitors (MPP4) but not in more committed myeloid granulocyte-macrophage progenitors led to a fully reversible acute leukemia expressing myeloid and B-cell markers. iMLL-ENL leukemic cells generally expressed lower MLL-ENL mRNA than those obtained after retroviral transduction. …”
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Deregulation of All-<i>Trans</i> Retinoic Acid Signaling and Development in Cancer by Geoffrey Brown

“…In adults, active RARγ maintains the pool of hematopoietic stem cells, whereas active RARα drives myeloid cell differentiation. …”
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Umbilical cord blood and cord tissue banking as somatic stem cell resources to support medical cell modalities by Tokiko Nagamura-Inoue, Fumitaka Nagamura

“…CB, a known source of hematopoietic stem cells for transplantation, has attracted attention as a new source of immune cells, including universal chimeric antigen receptor-T cell therapy (CAR-T) and, more recently, universal CAR-natural killer cells. …”
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Regulation of differentiation of MEG01 to megakaryocytes and platelet-like particles by Valproic acid through Notch3 mediated actin polymerization by Ankita Dhenge, Rutuja Kuhikar, Vaijayanti Kale, Lalita Limaye

“…Its role in self-renewal and proliferation of hematopoietic stem cells (HSCs) is well studied, but little is known about its involvement in regulating megakaryopoiesis and thrombopoiesis. …”
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Case report: Use of granulocyte-colony stimulating factor as an immunomodulatory therapy in a patient with neuromyelitis optica spectrum disorder and comorbid immunodeficiency by Gina S. Perez Giraldo, Edith L. Graham, Stephen VanHaerents, Roumen Balabanov

“…G-CSF is a polyfunctional cytokine that influences survival, proliferation, and differentiation of hematopoietic stem cells, and has immunomodulatory effects on the innate and adaptive immune systems.ObjectiveTo report a case of neuromyelitis optica spectrum disorder (NMOSD) with comorbid immunodeficiency and frequent infections.MethodsCase report and review of literature.ResultsA 23 years-old man presented with a focal onset seizure with impaired awareness at age 12. …”
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Determining Physical Mechanisms of Gene Expression Regulation from Single Cell Gene Expression Data. by Daphne Ezer, Victoria Moignard, Berthold Göttgens, Boris Adryan

“…We could identify two unique sub-populations within a seemingly homogenous group of hematopoietic stem cells. In addition, we could predict regulatory mechanisms controlling the expression levels of eighteen key hematopoietic transcription factors throughout differentiation. …”
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Differential CXCR4 expression on hematopoietic progenitor cells versus stem cells directs homing and engraftment by Sydney Felker, Archana Shrestha, Jeff Bailey, Devin M Pillis, Dylan Siniard, Punam Malik

“…HSPC transplantation improved engraftment of hematopoietic progenitor cells (HPC) but not of long-term repopulating hematopoietic stem cells (HSC). Mechanistically, HPC expressed higher functional levels of CXCR4 than HSC, conferring them a retention and homing advantage when transplanted i.b.m. …”
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Potential identity of multi-potential cancer stem-like subpopulation after radiation of cultured brain glioma by Kim Cheul H, Ko Mi H, Hur Beong I, Kang Mi K, Cha Seung H, Kang Soo K

“…Accordingly, subpopulations of radio-resistant cells in GBM have been shown to be very similar to hematopoietic stem cells (HSCs) in the circulating blood. This similarity may contribute to increased tumor growth and GBM recurrence.…”
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The development and improvement of immunodeficient mice and humanized immune system mouse models by Jiaxuan Chen, Shuzhen Liao, Zengzhi Xiao, Quanren Pan, Xi Wang, Kangyuan Shen, Shuting Wang, Lawei Yang, Fengbiao Guo, Hua-feng Liu, Qingjun Pan

“…We describe existing humanized immune system mouse models based on immunodeficient mice in which human cells or tissues have been transplanted to establish a human immune system, including humanized-peripheral blood mononuclear cells (Hu-PBMCs), humanized hematopoietic stem cells (Hu-HSCs), and humanized bone marrow, liver, thymus (Hu-BLT) mouse models. …”
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Jam-a is highly expressed on human hematopoietic repopulating cells and associates with the key hematopoietic chemokine receptor cxcr4. by Watt, S, Chang, C, Hale, S, Cox, C, Blair, A, Kronsteiner, B, Grabowska, R, Zhang, Y, Cook, D, Khoo, C, Schrader, J, Buglass Kabuga, S, Martin-Rendon, E

“…Here, we demonstrate that another JAM family member, JAM-A, is most highly expressed on human hematopoietic stem cells with in vivo repopulating activity (p&lt;0.01 for JAM-Ahigh compared to JAM-AInt or Low cord blood CD34+ cells). …”

Hoxb4-YFP reporter mouse model: a novel tool for tracking HSC development and studying the role of Hoxb4 in hematopoiesis. by Hills, D, Gribi, R, Ure, J, Buza-Vidas, N, Luc, S, Jacobsen, SE, Medvinsky, A

“…Hoxb4 overexpression promotes dramatic expansion of bone marrow (BM) hematopoietic stem cells (HSCs) without leukemic transformation and induces development of definitive HSCs from early embryonic yolk sac and differentiating embryonic stem cells. …”

High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle. by Tipping, A, Pina, C, Castor, A, Hong, D, Rodrigues, N, Lazzari, L, May, G, Jacobsen, SE, Enver, T

“…Evidence suggests the transcription factor GATA-2 is a critical regulator of murine hematopoietic stem cells. Here, we explore the relation between GATA-2 and cell proliferation and show that inducing GATA-2 increases quiescence (G(0) residency) of murine and human hematopoietic cells. …”

Understanding the contribution of developmentally distinct neutrophils to the developing haemato-immune system by Park, Y

“…Neutrophils originate from at least two origins: yolk sac-derived erythromyeloid progenitors (EMPs) and aorta-derived hematopoietic stem cells (HSCs). In zebrafish, developmentally discrete neutrophil populations are associated with different functions. …”

Effective CRISPR/Cas9-mediated correction of a Fanconi anemia defect by error-prone end joining or templated repair by Van De Vrugt, HJ, Harmsen, T, Riepsaame, J, Alexantya, G, Van Mil, SE, De Vries, Y, Bin Ali, R, Huijbers, IJ, Dorsman, JC, Wolthuis, RMF, Riele, H

“…For FA patients, gene editing holds promise for therapeutic applications aimed at functionally restoring mutated genes in hematopoietic stem cells. However, intrinsic FA DNA repair defects may obstruct gene editing feasibility. …”

Endothelial progenitor cells in pathogenesis of new coronaviral infection by N. A. Kuzubova, O. N. Titova, E. S. Lebedeva, E. V. Volchkova

“…The results of studies carried out in 2020 indicate that SARS-Cov-2 infects both hematopoietic stem cells, transforming into EPCs, and directly circulating EPCs, causing inflammatory and procoagulant reactions that complicate the COVID-19 course. …”
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Immunosuppressive therapy in patients with aplastic anemia: a single-center retrospective study. by Hasan Jalaeikhoo, Ahmad Khajeh-Mehrizi

“…Aplastic anemia (AA) is a rare disease in which hematopoietic stem cells are severely diminished resulting in hypocellular bone marrow and pancytopenia. …”
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Nuclear Sirtuins and the Aging of the Immune System by Andrés Gámez-García, Berta N. Vazquez

“…In the immune system, sirtuins instruct cellular differentiation from hematopoietic precursors and promote leukocyte polarization and activation. In hematopoietic stem cells, sirtuins safeguard quiescence and stemness to prevent cellular exhaustion. …”
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The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression by Gloria Mas, Na Man, Yuichiro Nakata, Concepcion Martinez-Caja, Daniel Karl, Felipe Beckedorff, Francesco Tamiro, Chuan Chen, Stephanie Duffort, Hidehiro Itonaga, Adnan K. Mookhtiar, Kranthi Kunkalla, Alfredo M. Valencia, Clayton K. Collings, Cigall Kadoch, Francisco Vega, Scott C. Kogan, Lluis Morey, Daniel Bilbao, Stephen D. Nimer

“…During emergency hematopoiesis, hematopoietic stem cells (HSCs) rapidly proliferate to produce myeloid and lymphoid effector cells, a response that is critical against infection or tissue injury. …”
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Effects of Cyclosporine and Azacitidine on Some Hematologic and ‎Biochemical Parameters of Benzene-Induced Aplastic Anemia in Rats by ghanem taher, Huda F Hasn

“… Aplastic anemia, marked by deficiencies in hematopoietic stem cells, leads to peripheral blood pancytopenia and hypocellular bone ‎marrow. …”
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