Lysine Methylation-Dependent Proteolysis by the Malignant Brain Tumor (MBT) Domain Proteins by Hong Sun, Hui Zhang

“…The lysine methylation-mediated proteolysis regulates embryonic development, maintains pluripotency and self-renewal of embryonic stem cells and other stem cells such as neural stem cells and hematopoietic stem cells, and controls other biological processes. …”
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Roles of IFN-γ and γδ T cells in protective immunity against blood-stage malaria by Shin-Ichi eInoue, Mamoru eNiikura, Shoichiro eMineo, Fumie eKobayashi

“…However, the effects of IFN-γ on hematopoietic stem cells and progenitor cells are unclear. …”
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Numerical areal density of CD34 and CD117 immunoreactive hematopoietic cells in human fetal and embryonic liver by Jelena Vladičić Mašić, Ivan Nikolić, Vera Todorović, Marko Jović, Vladimir Petrović, Srđan Mašić, Nikolina Dukić, Snežana Zečević

“…The liver, as the largest hematopoietic organ of intrauterine development, is the source of hematopoietic stem cells. The aim of the study was to identify and quantify hematopoietic cells in human fetal and embryonic liver showing the immunoreactivity of CD34 and CD117 molecules. …”
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Diverse and reprogrammable mechanisms of malignant cell transformation in lymphocytes: pathogenetic insights and translational implications by Mariusz A. Wasik, Patricia M. Kim, Reza Nejati

“…Finally, lymphomas can develop cell-lineage infidelity and in the extreme cases drastically rewire their cell activation mechanisms and engage receptors and signaling pathways physiologically active in hematopoietic stem cells or non-lymphoid cells. Such profound reprograming may involve partial cell dedifferentiation or transdifferentiation towards histocytes, dendritic, or mesodermal cells with various degree of cell maturation along these lineages. …”
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Scurvy: A treatable forgotten fatal differential diagnosis and potential etiology of leukemia and aplastic anemia in pediatric population by Harold L. Mashauri

“…Vitamin C plays a vital role in hematopoiesis by controlling regulation and prevent dysfunction of hematopoietic stem cells. Scurvy deficiency has been a silent growing clinical problem which needs a high index of suspicion for a clinician to pick it. …”
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Challenges and Advances in Chimeric Antigen Receptor Therapy for Acute Myeloid Leukemia by Jennifer Marvin-Peek, Bipin N. Savani, Oluwole O. Olalekan, Bhagirathbhai Dholaria

“…Since many AML CAR targets under investigation including CD33, CD117, and CD123 are also expressed on hematopoietic stem cells, CAR T-cell therapy can lead to severe and potentially lethal myeloablation. …”
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Transposable elements and the regulatory logic of hematopoietic differentiation by Najia, Mohamad Ali

“…De-repression of TEs in hematopoietic stem cells, enacted via modulation of TE chromatin silencing machinery, facilitates the development of natural killer (NK) cells during lymphoid differentiation. …”
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The roll of integrins in hematopoiesis by Eshghi, Shawdee

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Exploring the utility of multivariate analysis for cell culture process development by Neo, Kai Xian

“…The therapeutic use of hematopoietic stem cells (HSCs) in clinical applications is hindered by insufficient number of donor cells. …”
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Systematic experimental design for bioprocess characterization: elucidating transient effects of multi-cytokine contributions on erythroid differentiation by Lim, Mayasari, Shunjie, Chua, Panoskaltsis, Nicki, Mantalaris, Athanasios (Sakis)

“…In vitro differentiation of hematopoietic stem cells (HSCs) is a highly dynamic process whereby contributions of exogenous cytokines vary at each stage of differentiation. …”
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SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice by Willekens, C, Laplane, L, Dagher, T, Benlabiod, C, Papadopoulos, N, Lacout, C, Rameau, P, Catelain, C, Alfaro, A, Edmond, V, Signolle, N, Marchand, V, Droin, N, Hoogenboezem, R, Schneider, RK, Penson, A, Abdel-Wahab, O, Giraudier, S, Pasquier, F, Marty, C, Plo, I, Villeval, J-L, Constantinescu, SN, Porteu, F, Vainchenker, W, Solary, E

“…Srsf2P95H reduced the competitiveness of transplanted Jak2V617F hematopoietic stem cells while preventing their exhaustion. …”

Impact of isolated germline JAK2V617I mutation on human hematopoiesis. by Mead, A, Chowdhury, O, Pecquet, C, Dusa, A, Woll, P, Atkinson, D, Burns, A, Score, J, Rugless, M, Clifford, R, Moule, S, Bienz, N, Vyas, P, Cross, N, Gale, R, Henderson, S, Constantinescu, SN, Schuh, A, Jacobsen, SE

“…Through targeted sequencing of MPN-associated mutations, exome sequencing, and clonality analysis, we demonstrate that JAK2V617I is likely to be the sole driver mutation in JAK2V617I-positive individuals with thrombocytosis. Phenotypic hematopoietic stem cells (HSCs) were increased in the blood and bone marrow of JAK2V617I-positive individuals and were sustained at higher levels than controls after xenotransplantation. …”

The role of ephrinB2 in hematopoietic stem/progenitor cell differentiation from an arterial hemogenic endothelium by Chen, I

“…<p>During development, hematopoiesis develops in temporally distinct waves in the yolk sac (YS) and embryo proper, culminating in the emergence of definitive hematopoietic stem cells (HSCs) from the hemogenic endothelium (HE) of the dorsal aorta. …”

Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1 mutant myelodysplastic syndromes by Dolatshad, H, Repapi, E, Steeples, V, Roy, S, Scifo, L, Armstrong, R, Shaw, J, Yip, B, Taylor, S, Boultwood, J, Liberante, F, Llorian, M, Killick, S, Kusec, R, Mills, K, Savage, K, Smith, C, Pellagatti, A

“…We have performed a systematic analysis of cryptic splicing abnormalities from RNA-sequencing data on hematopoietic stem cells (HSCs) of SF3B1-mutant MDS cases with RS. …”

Clonality in the myelodysplastic syndromes. by Boultwood, J, Wainscoat, J

“…Clonality studies involving myeloid and lymphoid cells in MDS have yielded discrepant results with regard to the potential involvement of multipotent (lympho-myeloid) hematopoietic stem cells (HSCs). However, failure to detect a clonal marker in all cells of all lineages does not preclude multipotent-HSC involvement. …”

Conventional Co-Housing Modulates Murine Gut Microbiota and Hematopoietic Gene Expression by Jichun Chen, Shuling Zhang, Xingmin Feng, Zhijie Wu, Wendy Dubois, Vishal Thovarai, Sonia Ahluwalia, Shouguo Gao, Jinguo Chen, Tyler Peat, Shurjo K. Sen, Giorgio Trinchieri, Neal S. Young, Beverly A. Mock

“…Through single cell RNA sequencing of sorted KL (c-Kit⁺Lin⁻) cells, we imputed a decline in long-term hematopoietic stem cells and an increase in granulocyte-monocyte progenitors in CVT mice with up-regulation of genes associated with cell survival. …”
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TIE2 Induces Breast Cancer Cell Dormancy and Inhibits the Development of Osteolytic Bone Metastases by Florian Drescher, Patricia Juárez, Danna L. Arellano, Nicolás Serafín-Higuera, Felipe Olvera-Rodriguez, Samanta Jiménez, Alexei F. Licea-Navarro, Pierrick G.J. Fournier

“…The tyrosine kinase receptor TIE2 induces the dormancy of hematopoietic stem cells, and could also induce the dormancy of BCa cells. …”
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A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells by Megan M. Schmit, Ryan M. Baxley, Liangjun Wang, Peter Hinderlie, Marissa Kaufman, Emily Simon, Anjali Raju, Jeffrey S. Miller, Anja-Katrin Bielinsky

“…Significantly, MCM10+/− iPSCs displayed defects in NK cell differentiation, exhibiting reduced yields of hematopoietic stem cells (HSCs). Although MCM10+/− HSCs were able to give rise to lymphoid progenitors, these did not generate mature NK cells. …”
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The Management of Children with Cancer during the COVID-19 Pandemic: A Rapid Review by Matteo Amicucci, Angela Mastronuzzi, Italo Ciaralli, Federico Piccioni, Andreea Cristina Schiopu, Emanuela Tiozzo, Orsola Gawronski, Valentina Biagioli, Immacolata Dall’Oglio

“…The strategies included limiting the risk of contagion by restricting access to the wards and implementing hygiene measures, the identification of separate pathways for the management of patients suspected or confirmed to be infected with COVID-19, the postponement of people accessing the hospital for non-urgent or unnecessary tests or medical examinations, and the preventive screening of patients before chemotherapy treatment or transplantation of hematopoietic stem cells. It is necessary to identify key indicators in order to better evaluate the effectiveness of the interventions implemented over time. …”
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Metabolic Biomarkers Affecting Cell Proliferation and Prognosis in Polycythemia Vera by Ziqing Wang, Yan Lv, Erpeng Yang, Yujin Li, Dehao Wang, Guang Hu, Yumeng Li, Mingjing Wang, Weiyi Liu, Mingqian Sun, Xiaomei Hu

“…Polycythemia vera (PV) is a malignant clonal hematological disease of hematopoietic stem cells characterized by the proliferation of peripheral blood cells, and JAK2 mutation is one of the main causes of PV peripheral blood cell proliferation. …”
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