Cell biobank as a necessary infrastructure for the development and implementation of mesenchymal stem cell-based therapy in the treatment of anthracycline-induced cardiotoxicity. L... by L. Yu. Grivtsova, O. E. Popovkina, N. N. Dukhova, O. A. Politiko, V. V. Yuzhakov, L. A. Lepekhina, S. Sh. Kalsina, S. A. Ivanov, A. D. Kaprin

“…MSCs differ from hematopoietic stem cells used as support for hematopoiesis in high-dose chemotherapy by the following features: pronounced trophic effect, immune tolerance, the ability to suppress alloreactivity and autoimmune disorders. …”
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Bispecific CD33/CD123 targeted chimeric antigen receptor T cells for the treatment of acute myeloid leukemia by Justin C. Boucher, Bishwas Shrestha, Paresh Vishwasrao, Mark Leick, Estelle V. Cervantes, Tayyebb Ghafoor, Kayla Reid, Kristen Spitler, Bin Yu, Brian C. Betts, Jose A. Guevara-Patino, Marcela V. Maus, Marco L. Davila

“…CD33 and CD123 are expressed on the surface of human acute myeloid leukemia blasts and other noncancerous tissues such as hematopoietic stem cells. On-target off-tumor toxicities may limit chimeric antigen receptor T cell therapies that target both CD33 and CD123. …”
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Inflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis by N. Zioni, A. Akhiad Bercovich, N. Chapal-Ilani, Tal Bacharach, N. Rappoport, A. Solomon, R. Avraham, E. Kopitman, Z. Porat, M. Sacma, G. Hartmut, M. Scheller, C. Muller-Tidow, D. Lipka, E. Shlush, M. Minden, N. Kaushansky, Liran I. Shlush

“…Abstract Both fatty bone marrow (FBM) and somatic mutations in hematopoietic stem cells (HSCs), also termed clonal hematopoiesis (CH) accumulate with human aging. …”
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Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells by Joan Sebastián Gallego-Murillo, Nurcan Yağcı, Eduardo Machado Pinho, Sebastian Aljoscha Wahl, Emile van den Akker, Marieke von Lindern

“…Only the first stage, when hematopoietic stem cells committed to erythroblasts, required holotransferrin supplementation. …”
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Co-culture of Umbilical Cord-derived Hematopoietic and Mesenchymal Stem Cells on Protein-Coated poly-L-Lactic Acid Nanoscaffolds by Maryam Islami, Masoud Soleimani, Monireh Ajami, Maryam Darvish

“…Background and purpose: Umbilical cord blood (UCB) is a source of Hematopoietic stem cells (HSCs) and has received a lot of attention due to its availability, renewal capacity, proliferation rate, and differentiation potential. …”
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Deciphering the Non-Coding RNA Landscape of Pediatric Acute Myeloid Leukemia by Jolien Vanhooren, Laurens Van Camp, Barbara Depreter, Martijn de Jong, Anne Uyttebroeck, An Van Damme, Laurence Dedeken, Marie-Françoise Dresse, Jutte van der Werff ten Bosch, Mattias Hofmans, Jan Philippé, Barbara De Moerloose, Tim Lammens

“…Here, we explored lncRNA (<i>n</i> = 30,168) and miRNA (<i>n</i> = 627) expression in pedAML subpopulations (leukemic stem cells (LSCs) and leukemic blasts (L-blasts)) and their normal counterparts (hematopoietic stem cells and control myeloblasts). The potential regulatory activity of differentially expressed lncRNAs in LSCs (unique or shared with the L-blast comparison) on miRNAs was assessed. …”
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The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice by Qing-Shuo Zhang, Matthew Deater, Kathryn Schubert, Laura Marquez-Loza, Carl Pelz, David A. Sinclair, Markus Grompe

“…Given that Sirt1 is important for the function of hematopoietic stem cells, we hypothesized that Sirt1 activation may improve hematopoiesis. …”
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In Vivo Lentiviral Gene Delivery of HLA-DR and Vaccination of Humanized Mice for Improving the Human T and B Cell Immune Reconstitution by Suresh Kumar, Johannes Koenig, Andreas Schneider, Fredrik Wermeling, Sanjaykumar Boddul, Sebastian J. Theobald, Miriam Vollmer, Doreen Kloos, Nico Lachmann, Frank Klawonn, Stefan Lienenklaus, Steven R. Talbot, André Bleich, Nadine Wenzel, Constantin von Kaisenberg, James Keck, Renata Stripecke

“…Humanized mouse models generated with human hematopoietic stem cells (HSCs) and reconstituting the human immune system (HIS-mice) are invigorating preclinical testing of vaccines and immunotherapies. …”
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Towards Tissue-Specific Stem Cell Therapy for the Intervertebral Disc: PPARδ Agonist Increases the Yield of Human Nucleus Pulposus Progenitor Cells in Expansion by Xingshuo Zhang, Julien Guerrero, Andreas S. Croft, Katharina A.C. Oswald, Christoph E. Albers, Sonja Häckel, Benjamin Gantenbein

“…The NPPCs were also identified to be positive for the angiopoietin-1 receptor (Tie2). Similar to hematopoietic stem cells, Tie2 might be involved in peroxisome proliferator-activated receptor delta (PPARδ) agonist-induced self-renewal regulation. …”
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Deciphering Master Gene Regulators and Associated Networks of Human Mesenchymal Stromal Cells by Elena Sánchez-Luis, Andrea Joaquín-García, Francisco J. Campos-Laborie, Fermín Sánchez-Guijo, Javier De las Rivas

“…To obtain a gene regulatory profile of human MSCs, we generated a compendium of more than two hundred cell samples with genome-wide expression data, including a homogeneous set of 93 samples of five related primary cell types: bone marrow mesenchymal stem cells (BM-MSC), hematopoietic stem cells (HSC), lymphocytes (LYM), fibroblasts (FIB), and osteoblasts (OSTB). …”
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Thymic macrophages consist of two populations with distinct localization and origin by Tyng-An Zhou, Hsuan-Po Hsu, Yueh-Hua Tu, Hui-Kuei Cheng, Chih-Yu Lin, Nien-Jung Chen, Jin-Wu Tsai, Ellen A Robey, Hsuan-Cheng Huang, Chia-Lin Hsu, Ivan L Dzhagalov

“…Timd4+ thymic macrophages are of embryonic origin, while Cx3cr1+ macrophages are derived from adult hematopoietic stem cells. Aging has a profound effect on the macrophages in the thymus. …”
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A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis by Pengfei Guo, Rebecca C Lim, Keshari Rajawasam, Tiffany Trinh, Hong Sun, Hui Zhang

“…Mouse Ezh2K20R/K20R mutants develop hepatosplenomegaly associated with high GFI1B expression, and Ezh2K20R/K20R mutant bone marrows expand hematopoietic stem cells and downstream hematopoietic populations. …”
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Conditioned Medium from Human Tonsil-Derived Mesenchymal Stem Cells Enhances Bone Marrow Engraftment via Endothelial Cell Restoration by Pleiotrophin by Yu-Hee Kim, Kyung-Ah Cho, Hyun-Ji Lee, Minhwa Park, Sang-Jin Shin, Joo-Won Park, So-Youn Woo, Kyung-Ha Ryu

“…Cotransplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) has been widely reported to promote HSC engraftment and enhance marrow stromal regeneration. …”
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Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model by Tarun K. Garg, Sarita Garg, Isabelle R. Miousse, Stephen Y. Wise, Alana D. Carpenter, Oluseyi O. Fatanmi, Frits van Rhee, Vijay K. Singh, Martin Hauer-Jensen

“…Flow cytometry was used to immunophenotype the bone marrow (BM) lymphoid cell populations, while clonogenic ability of hematopoietic stem cells (HSCs) was assessed by colony forming unit (CFU) assays on day 8 prior to irradiation and days 2, 7, 14, and 30 post-irradiation. …”
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An aging-related immune landscape in the hematopoietic immune system by Jianjie Lv, Chun Zhang, Xiuxing Liu, Chenyang Gu, Yidan Liu, Yuehan Gao, Zhaohao Huang, Qi Jiang, Binyao Chen, Daquan He, Tianfu Wang, Zhuping Xu, Wenru Su

“…Our research revealed that during the aging process, hematopoietic stem cells undergo significant changes in function and composition, and their polymorphism and differentiation abilities are downregulated. …”
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Deciphering cell states and genealogies of human hematopoiesis by Weng, Chen, Yu, Fulong, Yang, Dian, Poeschla, Michael, Liggett, L. Alexander, Jones, Matthew G., Qiu, Xiaojie, Wahlster, Lara, Caulier, Alexis, Hussmann, Jeffrey A., Schnell, Alexandra, Yost, Kathryn E., Koblan, Luke, Martin-Rufino, Jorge D., Min, Joseph, Hammond, Alessandro, Ssozi, Daniel, Bueno, Raphael, Mallidi, Hari, Kreso, Antonia, Escabi, Javier, Rideout, William M., Jacks, Tyler, Hormoz, Sahand, van Galen, Peter, Weissman, Jonathan S., Sankaran, Vijay G.

“…The human blood system is maintained through the differentiation and massive amplification of a limited number of long-lived hematopoietic stem cells (HSCs)1. Perturbations to this process underlie diverse diseases, but the clonal contributions to human hematopoiesis and how this changes with age remain incompletely understood. …”
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Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice by Chen, Qingfeng, Khoury, Maroun, Chen, Jianzhu

“…Adoptive transfer of human hematopoietic stem cells (HSCs) into mice lacking T, B and natural killer (NK) cells leads to development of human-blood lineage cells in the recipient mice (humanized mice). …”
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Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies by Schweighofer, C. D., Abruzzo, L., Frenzel, Lukas P., Wendtner, C. M., Leskov, Ilya B., Pallasch, Christian, Drake, Adam, Iliopoulou, Bettina P., Souza, A., Shen, C.-H., Hemann, Michael, Chen, Jianzhu

“…Although numerous mouse models of B-cell malignancy have been developed via the enforced expression of defined oncogenic lesions, the feasibility of generating lineage-defined human B-cell malignancies using mice reconstituted with modified human hematopoietic stem cells (HSCs) remains unclear. In fact, whether human cells can be transformed as readily as murine cells by simple oncogene combinations is a subject of considerable debate. …”
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Context-specific roles for paracrine IL-6 in lymphomagenesis by Gilbert, Luke Andrew, Hemann, Michael

“…Specifically, paracrine IL-6 signaling promotes the survival of transplanted hematopoietic stem cells following lethal irradiation, allowing for the persistence and expansion of progenitor cells bearing a cancer-promoting alteration. …”
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Developmental hematopoiesis: ontogeny, genetic programming and conservation. by Ciau-Uitz, A, Monteiro, R, Kirmizitas, A, Patient, R

“…Hematopoietic stem cells (HSCs) sustain blood production throughout life and are of pivotal importance in regenerative medicine. …”