FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia by Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

“…Although conditional deletion of Fbxo22 in hematopoietic cells did not significantly affect the function of hematopoietic stem cells, MLL-AF9-induced leukemogenesis was dramatically abrogated upon Fbxo22 deletion, together with remarkably reduced LSCs after serial transplantations. …”
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Remission of severe myasthenia gravis after autologous stem cell transplantation by Monica I. Schlatter, Soumya S. Yandamuri, Kevin C. O'Connor, Richard J. Nowak, Minh C. Pham, Abeer H. Obaid, Callee Redman, Marie Provost, Peter A. McSweeney, Michael L. Pearlman, Michael T. Tees, James D. Bowen, Richard A. Nash, George E. Georges

“…After mobilization of hematopoietic stem cells with rituximab, prednisone, and G‐CSF, the patient had HDIT consisting of carmustine, etoposide, cytarabine, melphalan, and rabbit antithymocyte globulin, followed by autologous HCT. …”
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HIV-1 Latency and Viral Reservoirs: Existing Reversal Approaches and Potential Technologies, Targets, and Pathways Involved in HIV Latency Studies by Sushant Khanal, Madison Schank, Mohamed El Gazzar, Jonathan P. Moorman, Zhi Q. Yao

“…Beyond the canonical resting memory CD4⁺ T cells, HIV reservoirs also exist within tissue macrophages, myeloid cells, brain microglial cells, gut epithelial cells, and hematopoietic stem cells (HSCs). Despite a lack of active viral production, latently HIV-infected subjects continue to exhibit aberrant cellular signaling and metabolic dysfunction, leading to minor to major cellular and systemic complications or comorbidities. …”
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Comprehensive evaluation of the effects of long-term cryopreservation on peripheral blood mononuclear cells using flow cytometry by Bo Li, Chunmei Yang, Gui Jia, Yansheng Liu, Na Wang, Fangfang Yang, Rui Su, Yulong Shang, Ying Han

“…Abstract Human peripheral blood mononuclear cells (PBMCs) originate from hematopoietic stem cells in the bone marrow, which mainly includes lymphocytes (T cells, B cells, and natural killer cells) and monocytes. …”
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Resident Self-Tissue of Proinflammatory Cytokines Rather Than Their Systemic Levels Correlates with Development of Myelofibrosis in <i>Gata1</i>^low Mice by Maria Zingariello, Paola Verachi, Francesca Gobbo, Fabrizio Martelli, Mario Falchi, Maria Mazzarini, Mauro Valeri, Giuseppe Sarli, Christian Marinaccio, Johanna Melo-Cardenas, John D. Crispino, Anna Rita Migliaccio

“…We assessed cytokine serum levels by Luminex-bead-assay and ELISA, frequency and cytokine content of stromal cells by flow cytometry, and immunohistochemistry and bone marrow (BM) localization of GFP-tagged hematopoietic stem cells (HSC) by confocal microscopy. Differences in serum levels of 32 inflammatory-cytokines between prefibrotic and fibrotic <i>Gata1</i>^low mice and their wild-type littermates were modest. …”
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Boar Sperm Cryopreservation Improvement Using Semen Extender Modification by Dextran and Pentaisomaltose by Ondrej Simonik, Filipa Bubenickova, Lucie Tumova, Michaela Frolikova, Vishma Pratap Sur, Jan Beran, Katerina Havlikova, Lenka Hackerova, Daniela Spevakova, Katerina Komrskova, Pavla Postlerova

“…In this paper, we demonstrate that pentaisomaltose, previously used for cryopreservation in hematopoietic stem cells, represents a promising compound for the elimination or reduction of glycerol in extenders for boar semen cryopreservation. …”
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Clinical applications of adipose-derived stromal vascular fraction in veterinary practice by Khan Sharun, Kaveri Jambagi, Rohit Kumar, Mudasir Bashir Gugjoo, Abhijit M. Pawde, Hardeep Singh Tuli, Kuldeep Dhama, Amarpal

“…Adipose tissue-derived stromal vascular fraction (AdSVF) comprises a heterogeneous cell population, including the multipotent mesenchymal stem cells, hematopoietic stem cells, immune cells, endothelial cells, fibroblasts, and pericytes. …”
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Stat1 is an inducible transcriptional repressor of neural stem cells self-renewal program during neuroinflammation by Jaime Imitola, Jaime Imitola, Ethan W. Hollingsworth, Fumihiro Watanabe, Marta Olah, Marta Olah, Wassim Elyaman, Wassim Elyaman, Sarah Starossom, Sarah Starossom, Pia Kivisäkk, Pia Kivisäkk, Samia J. Khoury, Samia J. Khoury

“…Interferons increase hematopoietic stem cells during infection by activating STAT1, but the mechanisms by which STAT1 regulates intrinsic programs in neural stem cells (NSCs) during neuroinflammation is less known. …”
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ACE Inhibition Modulates Myeloid Hematopoiesis after Acute Myocardial Infarction and Reduces Cardiac and Vascular Inflammation in Ischemic Heart Failure by Wolf-Stephan Rudi, Michael Molitor, Venkata Garlapati, Stefanie Finger, Johannes Wild, Thomas Münzel, Susanne H. Karbach, Philip Wenzel

“…This effect was accompanied by enhanced retention of hematopoietic stem cells, Lin⁻Sca1⁻c-Kit⁺CD34⁺CD16/32⁺ granulocyte–macrophage progenitors (GMP) and Lin⁻Sca1⁻c-Kit⁺CD150⁻CD48⁻ multipotent progenitors (MPP) in the bone marrow, with an upregulation of the niche factors Angiopoetin 1 and Kitl at 7 d post MI. …”
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Long term maintenance of myeloid leukemic stem cells cultured with unrelated human mesenchymal stromal cells by Sawa Ito, A. John Barrett, Amalia Dutra, Evgenia Pak, Samantha Miner, Keyvan Keyvanfar, Nancy F. Hensel, Katayoun Rezvani, Pawel Muranski, Paul Liu, J. Joseph Melenhorst, Andre Larochelle

“…Mesenchymal stromal cells (MSCs) support the growth and differentiation of normal hematopoietic stem cells (HSCs). Here we studied the ability of MSCs to support the growth and survival of leukemic stem cells (LSCs) in vitro. …”
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UM171 cooperates with PIM1 inhibitors to restrict HSC expansion markers and suppress leukemia progression by Anling Hu, Jian Gao, Krishnapriya M. Varier, Babu Gajendran, Fei Jiang, Wuling Liu, Chunlin Wang, Xiao Xiao, Yanmei Li, Eldad Zacksenhaus, Sajjad Ali, Yaacov Ben-David

“…Abstract The pyrimido-indole derivative UM171 promotes human Hematopoietic Stem Cells Expansion (HSCE), but its impact on leukemia is not known. …”
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Integrating Single-Cell Transcriptome and Network Analysis to Characterize the Therapeutic Response of Chronic Myeloid Leukemia by Jialu Ma, Nathan Pettit, John Talburt, Shanzhi Wang, Sherman M. Weissman, Mary Qu Yang

“…Compared to normal hematopoietic stem cells, a set of genes that were concordantly differentially expressed in various types of stem cells of CML patients was revealed. …”
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Research progress in the pathogenesis and prognosis of ZNF384 fusion subtype acute leukemia by LI Ying, TAN Yangxia, YIN Hongxin, JIANG Yanling, CHEN Li, MENG Guoyu

“…It is mainly believed that the fusion protein regulates the transcription and expression of downstream proteins through chromatin remodeling, and plays a potential role in the differentiation of hematopoietic stem cells, the proliferation and apoptosis of cancer cells and genome repair. …”
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JAK inhibition in a patient with a STAT1 gain-of-function variant reveals STAT1 dysregulation as a common feature of aplastic anemia by Rosenberg, Jacob M, Peters, Joshua M, Hughes, Travis, Lareau, Caleb A, Ludwig, Leif S, Massoth, Lucas R, Austin-Tse, Christina, Rehm, Heidi L, Bryson, Bryan, Chen, Yi-Bin, Regev, Aviv, Shalek, Alex K, Fortune, Sarah M, Sykes, David B

“…BACKGROUND: Idiopathic aplastic anemia is a potentially lethal disease, characterized by T cell-mediated autoimmune attack of bone marrow hematopoietic stem cells. Standard of care therapies (stem cell transplantation or immunosuppression) are effective but associated with a risk of serious toxicities. …”
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Graphene Multilayers as Gates for Multi-Week Sequential Release of Proteins from Surfaces by Hong, Jinkee, Shah, Nisarg J., DeMuth, Peter Charles, Lee, Jong Bum, Chen, Jianzhu, Hammond, Paula T., Drake, Adam

“…In vitro toxicity assays of the individual materials on proliferating hematopoietic stem cells (HSCs) indicated limited cytotoxic effects with HSCs able to survive for the full 10 days of normal culture in the presence of Poly1 and the GO sheets. …”
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Comparison of <i>SOX2</i> and <i>POU5F1</i> Gene Expression in Leukapheresis-Derived CD34+ Cells before and during Cell Culture by Małgorzata Świstowska, Paulina Gil-Kulik, Marcin Czop, Katarzyna Wieczorek, Arkadiusz Macheta, Alicja Petniak, Maria Cioch, Marek Hus, Mariusz Szuta, Mansur Rahnama-Hezavah, Bartosz J. Płachno, Janusz Kocki

“…Bone marrow is an abundant source of both hematopoietic as well as non-hematopoietic stem cells. Embryonic, fetal and stem cells located in tissues (adipose tissue, skin, myocardium and dental pulp) express core transcription factors, including the <i>SOX2</i>, <i>POU5F1</i> and <i>NANOG</i> gene responsible for regeneration, proliferation and differentiation into daughter cells. …”
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Effective and stable gene transduction in rhesus macaque iPSCs capable of T-lineage differentiation utilizing the piggyBac system by Masahiro Tanaka, Yoshihiro Iwamoto, Bo Wang, Eri Imai, Munehiro Yoshida, Shoichi Iriguchi, Shin Kaneko

“…These Rh-iPSCs can differentiate into hematopoietic stem cells and T cells that express transgenes. …”
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Correction of Fanconi Anemia Mutations Using Digital Genome Engineering by Christopher J. Sipe, Mitchell G. Kluesner, Samuel P. Bingea, Walker S. Lahr, Aneesha A. Andrew, Minjing Wang, Anthony P. DeFeo, Timothy L. Hinkel, Kanut Laoharawee, John E. Wagner, Margaret L. MacMillan, Gregory M. Vercellotti, Jakub Tolar, Mark J. Osborn, R. Scott McIvor, Beau R. Webber, Branden S. Moriarity

“…Successful engraftment of gene-corrected autologous hematopoietic stem cells (HSC) circumvents the need for an allogeneic HCT and has been achieved in other genetic diseases using targeted nucleases to induce site specific DSBs and the correction of mutated genes through homology-directed repair (HDR). …”
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Hemophagocytic lymphohistiocytosis syndrome secondary to systemic hydroa vacciniforme lymphoproliferative disorder: a case report and literature review by Sai YANG, Mohammad Hassan HEIDARI, Ruzeng XUE, Ying LUO, Rongyi CHEN, Yongfeng CHEN, Yunsheng LIANG

“…After 8 months of follow-up, the patient passed away while waiting for transplantation of allogeneic hematopoietic stem cells. Conclusions Systemic HVLPD is rare and requires vigilance for the development of secondary hemophagocytic syndrome. …”
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Coupling of a Major Allergen to the Surface of Immune Cells for Use in Prophylactic Cell Therapy for the Prevention of IgE-Mediated Allergy by Konstantinos Mengrelis, Gerhard Niederacher, Lisa Prickler, Verena Kainz, Anna Marianne Weijler, Elisa Rudolph, Victoria Stanek, Julia Eckl-Dorna, Ulrike Baranyi, Andreas Spittler, Margarete Focke-Tejkl, Barbara Bohle, Rudolf Valenta, Christian Friedrich Wilhelm Becker, Thomas Wekerle, Birgit Linhart

“…In proof-of-concept studies, our laboratory has previously shown that the transfer of autologous hematopoietic stem cells (HSC) or autologous B cells expressing a major grass pollen allergen, Phl p 5, induces robust tolerance in mice. …”
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