Adoptive transfer of allergen-expressing B cells prevents IgE-mediated allergy by Lisa Prickler, Ulrike Baranyi, Konstantinos Mengrelis, Anna Marianne Weijler, Verena Kainz, Bernhard Kratzer, Romy Steiner, Jasmin Mucha, Elisa Rudoph, Nina Pilat, Barbara Bohle, Herbert Strobl, Winfried Franz Pickl, Winfried Franz Pickl, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Birgit Linhart, Thomas Wekerle

“…We previously reported that the transfer of autologous hematopoietic stem cells (HSC) expressing the major timothy grass pollen allergen, Phl p 5, on their cell surface induced allergen-specific tolerance in mice. …”
Get full text

Dose-dependent effect of GFI1 expression in the reconstitution and the differentiation capacity of HSCs by Xiaoqing Xie, Xiaoqing Xie, Pradeep Kumar Patnana, Pradeep Kumar Patnana, Pradeep Kumar Patnana, Daria Frank, Daria Frank, Judith Schütte, Judith Schütte, Yahya Al-Matary, Axel Künstner, Hauke Busch, Helal Ahmed, Helal Ahmed, Longlong Liu, Daniel R. Engel, Ulrich Dührsen, Frank Rosenbauer, Nikolas Von Bubnoff, Georg Lenz, Cyrus Khandanpour, Cyrus Khandanpour, Cyrus Khandanpour

“…GFI1 is a transcriptional repressor and plays a pivotal role in regulating the differentiation of hematopoietic stem cells (HSCs) towards myeloid and lymphoid cells. …”
Get full text

Mesenchymal Stem/Stromal Cells Derived from Dental Tissues: A Comparative In Vitro Evaluation of Their Immunoregulatory Properties Against T cells by María del Pilar De la Rosa-Ruiz, Marco Antonio Álvarez-Pérez, Víctor Adrián Cortés-Morales, Alberto Monroy-García, Héctor Mayani, Gladis Fragoso-González, Sara Caballero-Chacón, Daniel Diaz, Fernando Candanedo-González, Juan José Montesinos

Get full text

Terapia celular em doenças pulmonares: existem perspectivas? Cell therapy in pulmonary diseases: are there perspectives? by João T. Ribeiro-Paes, Aldemir Bilaqui, Oswaldo T. Greco, Milton A. Ruiz, Luis B. C. Alves-de-Moraes, Carolina A. Faria, Talita Stessuk

“…On the other hand, based on the results obtained in experimental models, it is possible to postulate that cell therapy with hematopoietic stem cells (or from other sources) brings consistent application perspectives in several other human pulmonary diseases, especially in chronic obstructive pulmonary disease.…”
Get full text

TRISOMY 8 IN HIGH RISK MDS PATIENT by AC Chaves, TMCE Silva, RDB Dias, JVC Goes, RF Pinheiro, SMM Magalhães

“…Introduction: Myelodysplastic neoplasms (MDS) are a diverse group of clonal diseases affecting hematopoietic stem cells (HSCs). They are characterized by ineffective hematopoiesis, cytopenias, dysplasias, and the potential to progress to acute myeloid leukemia. …”
Get full text

The Molecular Subtype of Adult Acute Lymphoblastic Leukemia Samples Determines the Engraftment Site and Proliferation Kinetics in Patient-Derived Xenograft Models by Anna Richter, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Sandra Lange, Vivien Krebs, Bjoern Schneider, Johannes Lakner, Christoph Wittke, Christoph Kiefel, Irmela Jeremias, Hugo Murua Escobar, Brigitte Vollmar, Christian Junghanss

Get full text

RepID represses megakaryocytic differentiation by recruiting CRL4A-JARID1A at DAB2 promoter by Jae-Hyun Jo, Jong-Uk Park, Yeong-Mu Kim, Seon-Mi Ok, Dong-Kyu Kim, Dong-Hyun Jung, Hye-Ji Kim, Hyun-A Seong, Hyo Je Cho, Jihoon Nah, Sangjune Kim, Haiqing Fu, Christophe E. Redon, Mirit I. Aladjem, Sang-Min Jang

“…Abstract Background Megakaryocytes (MKs) are platelet precursors, which arise from hematopoietic stem cells (HSCs). While MK lineage commitment and differentiation are accompanied by changes in gene expression, many factors that modulate megakaryopoiesis remain to be uncovered. …”
Get full text

TRANSCRIPTOMIC PUZZLE IN MYELODYSPLASTIC NEOPLASMS: UNRAVELING THE DISCORDANCE BETWEEN CD34+ STEM CELLS AND PRIMARY BONE MARROW CELLS by HLR Junior, PG Gonçalves, DA Moreno, JVC Goes, RTG Oliveira, CV Montefusco-Pereira, MA Viana, TT Komoto, SMM Magalhães, RF Pinheiro

“…However, due to the complex nature of Myelodysplastic neoplasm (MDS), it is challenging to assess the impact and variations of DEGs between CD34+ HSC (hematopoietic stem cells) and primary bone marrow cells (PBMC) in MDS pathogenesis. …”
Get full text

A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo by Gerel Melig, Ikuo Nobuhisa, Kiyoka Saito, Ryota Tsukahara, Ayumi Itabashi, Yoshiakira Kanai, Masami Kanai-Azuma, Mitsujiro Osawa, Motohiko Oshima, Atsushi Iwama, Tetsuya Taga

“…Abstract Background During mouse embryonic development, definitive hematopoiesis is first detected around embryonic day (E) 10.5 in the aorta-gonad-mesonephros (AGM) region. Hematopoietic stem cells (HSCs) arise in the dorsal aorta’s intra-aortic hematopoietic cell clusters (IAHCs). …”
Get full text

Effect of erythropoietin on bone marrow mononuclear cells by A. P. Lykov, M. A. Surovtseva, O. V. Poveshchenko, A. M. Chernyavsky, A. V. Fomichev, N. A. Bondarenko, I. I. Kim

“…We have also revealed a correlation between the numbers of endothelial progenitor cells at different stages of differentiation, and numbers of hematopoietic stem cells in the total BM-MNCs pool. The number of CD34+/CD133+, CD34- / CD31+, CD45+/EpoR+, and CD34+/EpoR+ in BM-MNCs pool are dependent on the age of patients. …”
Get full text

The Multi-Kinase Inhibitor EC-70124 Is a Promising Candidate for the Treatment of FLT3-ITD-Positive Acute Myeloid Leukemia by Belen Lopez-Millan, Paula Costales, Francisco Gutiérrez-Agüera, Rafael Díaz de la Guardia, Heleia Roca-Ho, Meritxell Vinyoles, Alba Rubio-Gayarre, Rémi Safi, Julio Castaño, Paola Alejandra Romecín, Manuel Ramírez-Orellana, Eduardo Anguita, Irmela Jeremias, Lurdes Zamora, Juan Carlos Rodríguez-Manzaneque, Clara Bueno, Francisco Morís, Pablo Menendez

Get full text

Endothelial and hematopoietic hPSCs differentiation via a hematoendothelial progenitor by Alejandra Vargas-Valderrama, Anne-Charlotte Ponsen, Morgane Le Gall, Denis Clay, Sébastien Jacques, Tudor Manoliu, Valérie Rouffiac, Karine Ser-le-Roux, Cyril Quivoron, Fawzia Louache, Georges Uzan, Maria-Teresa Mitjavila-Garcia, Estelle Oberlin, Hind Guenou

“…Finally, the transcriptomic analyses confirmed the hematoendothelial, endothelial and hematopoietic identity of hPSC-EB-CD144+, hPSC-ECs and hPSC-BCs, respectively, and the similarities between hPSC-BC-CD144+CD45+, a subpopulation of hPSC-BCs, and human EL hematopoietic stem cells/hematopoietic progenitors. Conclusion The present work reports a hPSC differentiation protocol into functional hematopoietic and endothelial cells through a hematoendothelial population. …”
Get full text

CIRCULATING HEMATOPOIETIC STEM AND PROGENITOR CELLS AND ERYTHROBLASTS COUNTING IS INCREASED IN PATIENTS WITH SICKLE CELL ANEMIA by J Milhomens, A Godard, J Grenier, M De-Grandis, DT Covas, W El-Nemer, S Kashima

“…Subsequently, 1 million cells per sample were stained with an antibody panel targeting HSPC markers (anti-human CD10, CD34, CD38, CD45, CD45RA, CD90, and CD123) for the identification of various hematopoietic cell populations, including hematopoietic stem cells (HSCs), multipotent progenitors (MPPs), megakaryocyte/erythrocyte progenitors (MEPs), granulocyte/macrophage progenitors (GMPs), and common lymphoid and myeloid progenitors (CLPs and CMPs), as well as erythroblasts (CD34, CD71, CD105, CD117, CD123, CD235a) including burst-forming unit erythroid and colony-forming unit erythroid (BFU-e and CFU-e), proerythroblasts, early and late basophilic erythroblasts, polychromatic erythroblasts, and orthochromatic erythroblasts. …”
Get full text

ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition by Jian Tang, Jian Tang, Shinan Ma, Yujiu Gao, Fan Zeng, Ying Feng, Chong Guo, Lin Hu, Lingling Yang, Lingling Yang, Yanghui Chen, Qiufang Zhang, Yahong Yuan, Xingrong Guo, Xingrong Guo

Get full text

HEMATOLOGIC RECOVERY INDUCED BY ELTROMBOPAG IN PATIENT WITH APLASTIC ANEMIA AFTER TEMOZOLOMIDE by ACP Silva, JOR Cassiano, NN Kloster, CM Freitas, MM Garcia, RDA Conserva, CEF Gonçalves, VLP Figueiredo

“…It is also known that the most frequent mechanism related to acquired AA is an immune-mediated destruction of hematopoietic stem cells (HSCs) and bone marrow progenitor cells. …”
Get full text

Eco matters; In & Out by Editorial

“…In vitro maintenance of highly purified, transplantable hematopoietic stem cells. Blood. 1997;89(12):4337-47. Lv H, Li L, Sun M, Zhang Y, Chen L, Rong Y, Li Y. …”
Get full text