A non-coding CRHR2 SNP rs255105, a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction. by Orna Levran, Joel Correa da Rosa, Matthew Randesi, John Rotrosen, Miriam Adelson, Mary Jeanne Kreek

“…An analysis was performed to identify associations between variants in 11 stress-related genes, selected a priori, and heroin addiction. Two discovery samples of American subjects of European descent (EA, n = 601) and of African Americans (AA, n = 400) were analyzed separately. …”
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Integration of Molecular Inflammatory Interactome Analyses Reveals Dynamics of Circulating Cytokines and Extracellular Vesicle Long Non-Coding RNAs and mRNAs in Heroin Addicts During Acute and Protracted Withdrawal by Zunyue Zhang, Zunyue Zhang, Hongjin Wu, Hongjin Wu, Qingyan Peng, Qingyan Peng, Zhenrong Xie, Fengrong Chen, Fengrong Chen, Yuru Ma, Yuru Ma, Yizhi Zhang, Yizhi Zhang, Yong Zhou, Jiqing Yang, Jiqing Yang, Cheng Chen, Cheng Chen, Shaoyou Li, Shaoyou Li, Yongjin Zhang, Yongjin Zhang, Weiwei Tian, Yuan Wang, Yu Xu, Yu Xu, Huayou Luo, Huayou Luo, Mei Zhu, Yi-Qun Kuang, Juehua Yu, Juehua Yu, Kunhua Wang, Kunhua Wang, Kunhua Wang, Kunhua Wang

“…Heroin addiction and withdrawal influence multiple physiological functions, including immune responses, but the mechanism remains largely elusive. …”
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Acute Kidney Injury in Heroin Users by Ileana Adela VACAROIU, Daniela RADULESCU, Anca Ioana STANESCU

Subjects: “…heroin addiction…”
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ILLICIT DRUGS - EXTERNAL SIGNS OF DRUG ADDICTION by Teodora Kiryakova, Dobrina Karayasheva, Biliana Mileva, Alexandar Alexandrov

Subjects: “…heroin addiction…”
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Opioid Kullanım Bozukluğu Olan Ergende Pregabalin Kötüye Kullanımı by Ömer Kardaş, Burcu Kardaş

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Heroin-dependent patient satisfaction with methadone as a medication influences satisfaction with basic interventions delivered by staff to implement methadone maintenance treatmen... by Alcaraz S, Viladrich C, Trujols J, Siñol N, Pérez de los Cobos J

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Laser meridian massage decreased craving in men with opioid use disorder on methadone maintenance treatment by Wen-Long Hu, Meng-Chang Tsai, Chun-En Kuo, Chun-Ting Liu, Szu-Ying Wu, Tzu-Chan Wu, Yu-Chiang Hung

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Psychopathology of addiction: Can the SCL90-based five-dimensional structure differentiate Heroin Use Disorder from a non-substance-related addictive disorder such as Gambling Diso... by Angelo G. I. Maremmani, Denise Gazzarrini, Amelia Fiorin, Valeria Cingano, Graziano Bellio, Giulio Perugi, Icro Maremmani

Subjects: “…Heroin Addiction…”
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Increased Amplitude of Low-Frequency Fluctuation in Right Angular Gyrus and Left Superior Occipital Gyrus Negatively Correlated With Heroin Use by Jing Luo, Ru Yang, Wenhan Yang, Chunmei Duan, Yuan Deng, Jun Zhang, Jiyuan Chen, Jun Liu

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COMMUNICATIVE FEATURES OF PATIENTS WITH COMBINED ADDICTION ON HEROIN AND ALCOHOL by S. P. Elshansky, E. I. Osipova, D. V. Semenov, R. S. Bykov

Subjects: “…complicated by alcoholism heroin addiction…”
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Disrupted topological organization in whole-brain functional networks of heroin-dependent individuals: a resting-state FMRI study. by Guihua Jiang, Xue Wen, Yingwei Qiu, Ruibin Zhang, Junjing Wang, Meng Li, Xiaofen Ma, Junzhang Tian, Ruiwang Huang

“…Neuroimaging studies have shown that heroin addiction is related to abnormalities in widespread local regions and in the functional connectivity of the brain. …”
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Genome-Wide Association of Heroin Dependence in Han Chinese. by Gursharan Kalsi, Jack Euesden, Jonathan R I Coleman, Francesca Ducci, Fazil Aliev, Stephen J Newhouse, Xiehe Liu, Xiaohong Ma, Yingcheng Wang, David A Collier, Philip Asherson, Tao Li, Gerome Breen

“…To date, genome-wide association studies (GWAS) for heroin addiction have been limited; moreover they have been restricted to examining samples of European and African-American origin due to difficulty of recruiting samples from other populations. …”
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Methadone maintenance treatment is more effective than compulsory detoxification in addressing gut microbiota dysbiosis caused by heroin abuse by Peng Yan, Peng Yan, Haotian Ma, Haotian Ma, Wenrong Tian, Wenrong Tian, Jincen Liu, Jincen Liu, Xinyue Yan, Xinyue Yan, Lei Ma, Lei Ma, Shuguang Wei, Shuguang Wei, Jie Zhu, Jie Zhu, Yongsheng Zhu, Yongsheng Zhu, Jianghua Lai, Jianghua Lai

“…IntroductionHeroin use disorder (HUD) is commonly accompanied by gut dysbiosis, but the roles of gut microbiota in HUD treatment, such as compulsory detoxification and methadone maintenance treatment (MMT), remain poorly understood.MethodsIn this study, we performed 16 s rDNA and whole metagenome sequencing to analyze the gut microbial profiles of HUD patients undergoing heroin addiction, heroin withdrawal (compulsory detoxification), and MMT.ResultsOur findings revealed that, compared to healthy controls, microbial diversity was significantly decreased in HUD patients who were in a state of heroin addiction and withdrawal, but not in those receiving MMT. …”
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Addressing the growing opioid and heroin abuse epidemic: a call for medical school curricula by Madison C. Ratycz, Thomas J. Papadimos, Allison A. Vanderbilt

“…This article proposes ways to include heroin and fentanyl education into medical school curricula and highlights the potential of simulation-based medical education to enable students to develop the skillset and emotional intelligence necessary to work with patients struggling with opioid and heroin addiction. This will result in future doctors who are better prepared to both prevent and recognize opioid and heroin addiction in patients, an important step in helping reduce the number of addicted patients and address the drug overdose epidemic.…”
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To the Roots: Me, My Brother, Heroin and Iboga by Sagit Mezamer

“…We were bound for Portugal, where my brother was about to undergo treatment for his heroin addiction. A visual essay following an Ibogaine treatment. …”
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A case of drug abuse by Matteo Pacini

“…Methadone maintenance is also considered gathering site where heroin addicts can effectively acquire knowledge on harm reduction and drug rehabilitation. …”
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The frequency of OPRK1 G36T and OPRM1 A118G opioid receptor gene polymorphisms in heroin-dependent individuals and non-dependent healthy subjects in Turkey by Gunnur Demircan, Tuğçe Toker Uğurlu, Gülizar Zengin, Ata Onur Kepenek, Selim Can Berk, Damla Saygin, Idea Nehir Ozliman, Figen Ateşci, Demet Akın

“…INTRODUCTION: Polymorphisms of the Mu opioid receptor (MOR) gene (OPRM1), which encodes for the primary action site of heroin, have also been found to be associated with heroin addiction. The aim of this study was to investigate the relationships between heroin addiction and G36T OPRK1 and A118G OPRM1 receptor gene polymorphisms in a male population in Turkey. …”
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Addiction to Internet, Modeling and Control by Atena Ghasemabadi

“…Results and discussion The epidemic model of heroin addiction was first introduced by White and Comiskey. …”
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Severe Osteomalacia Related to Long-Term Intravenous Drug Abuse by Leslie Gamache MD, Mark R. Burge MD

“…We present the clinical, biochemical, and imaging findings of a woman with vitamin D deficiency and severe osteomalacia related to intravenous heroin addiction. Results . A 54-year-old woman with a medical history significant for long-standing heroin abuse presented with complaints of bone pain, muscle cramping, and a left hip ulcer. …”
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Optimal control strategies for a heroin epidemic model with age-dependent susceptibility and recovery-age by Asaf Khan, Gul Zaman, Roman Ullah, Nawazish Naveed

“…Keeping in view some control measures for heroin addiction, a control problem for further analysis is presented. …”
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