Extended-release naltrexone versus standard oral naltrexone versus placebo for opioid use disorder: the NEAT three-arm RCT by John Strang, Michael Kelleher, Soraya Mayet, Ed Day, Jennifer Hellier, Sarah Byford, Caroline Murphy, Blair McLennan, James Shearer, Elizabeth Ryan, John Marsden

“…Background: People recovering from heroin addiction need better treatments than are currently offered. …”
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Educational and Behavioral Counseling in a Methadone Maintenance Treatment Program in China: A Randomized Controlled Trial by Pulin Liu, Pulin Liu, Ranran Song, Yao Zhang, Cheng Liu, Bingxi Cai, Xuebing Liu, Jiaoyuan Li, Xueqin Chen, Juntao Ke, Jiao Lou, Wei Chen, Beibei Zhu, Li Zou, Yang Yang, Ying Zhu, Yajie Gong, Rong Zhong, Xiaoping Miao

“…Patients in the control group received standard methadone maintenance treatment as usual (TAU).ResultsDuring the 16-week trial, the EBC group showed better treatment attendance (P = 0.022) and a greater increase in knowledge regarding heroin addiction (P = 0.001) and MMT (P = 0.005) than did the TAU group. …”
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Enemy within? The silent epidemic of substance dependency in GCC countries by Abdullah Al-Harthi, Samir S. Al-Adawi

“…To compound the problem, as 90% of GCC heroin addicts use it intravenously, sharing of contaminated needles causes infections of human immune deficiency virus and a high incidence of other infections.33 Similarly, the number of cases of heroin addiction is often directly related to the number of crimes.27 Despite stringent regulations to reduce the supply and demand, the habit proliferates. …”
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Acute effects of methadone on EEG power spectrum and event-related potentials among heroin dependents by Motlagh, Farid, Ibrahim, Fatimah, Rashid, Rusdi Abdul, Shafiabady, Niusha, Seghatoleslam, Tahereh, Habil, Hussain

“…Methadone as the most prevalent opioid substitution medication has been shown to influence the neurophysiological functions among heroin addicts. However, there is no firm conclusion on acute neuroelectrophysiological changes among methadone-treated subjects as well as the effectiveness of methadone in restoring brain electrical abnormalities among heroin addicts. …”

Evaluation of morphological changes of the liver caused by heroin abuse in forensic practice by Ilić Goran, Gligorijević Jasmina, Milosavljević Ivica, Karadžić Radovan

“…The aim of the study was to investigate histopathological, ultrastructural and morphometric features of the liver of heroin addicts in forensic samples of the liver. Methods. …”
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The relationship between personality traits and anxiety/depression levels in different drug abusers' groups by Tatalović Vorkapić Sanja, Dadić-Hero Elizabeta, Ružić Klementina

“…RESULTS: In the group of heroin addicts, higher levels of anxiety and depression were significantly correlated with higher levels of psychoticism, neuroticism, criminality and addiction. …”
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Assessment of mitochondrial DNA copy number in peripheral blood leukocyte of opiate abusers and healthy individuals by Kouros Divsalar, Sara Hesami, Majid Mahmoodi, Navidreza Giahi, Fatemeh Divsalar, Mohammad Pour-Ranjbar, Amin Honarmand

“…Heroin addicts had also higher mean of mtDNA copy number than those in healthy group (P=0.21). …”
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Significant association of DRD2 and ANKK1 genes with rural heroin dependence and relapse in men by Milena Lachowicz, Jolanta Chmielowiec, Krzysztof Chmielowiec, Aleksandra Suchanecka, Jolanta Masiak, Monika Michałowska-Sawczyn, Bożena Mroczek, Artur Mierzecki, Iwona Ciechanowicz, Anna Grzywacz

“…From this group, 2 homogenous subgroups of subjects were isolated and additionally analyzed: (1) a group of heroin addicted subjects (n=61), and (2) a group of heroin-addicted subjects with at least two relapses in the last two years (n=21). …”
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Addiction and autonomy: can addicted people consent to the prescription of their drug of addiction? by Foddy, B, Savulescu, J

“…It is often claimed that the autonomy of heroin addicts is compromised when they are choosing between taking their drug of addiction and abstaining. …”

The Association of Altered Gut Microbiota and Intestinal Mucosal Barrier Integrity in Mice With Heroin Dependence by Jiqing Yang, Jiqing Yang, Jiqing Yang, Jiqing Yang, Pu Xiong, Pu Xiong, Ling Bai, Zunyue Zhang, Zunyue Zhang, Yong Zhou, Yong Zhou, Cheng Chen, Cheng Chen, Zhenrong Xie, Zhenrong Xie, Yu Xu, Yu Xu, Minghui Chen, Minghui Chen, Huawei Wang, Mei Zhu, Mei Zhu, Juehua Yu, Juehua Yu, Kunhua Wang, Kunhua Wang, Kunhua Wang

“…The gut microbiota is believed to play a significant role in psychological and gastrointestinal symptoms in heroin addicts. However, the underlying mechanism remains largely unknown. …”
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Influência dos factores sociodemográficos e familiares na evolução terapêutica de heroinodependentes no programa do tratamento combinado por etapas. by M David, M Geada, D Neto

“…In this study the authors evaluate the history of drug abuse, the familial and sociodemographic influence on the clinical evolution of 74 heroin-addicts, admitted sequentially to a therapeutic drug-free program named Sequential Combined Treatment (SCT), based on family and individual counselling, with a daily administration of naltrexone and with regular evaluation of drug abstinence, based on urinary analysis collected by family members. …”
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Methadone versus buprenorphine: data detected from Caltanissetta SER.T by Fabio Venturella, Giulia Cancellieri, Marco Giammanco, Anastasia Valentina Liga, Francesca Mortillaro, Annamaria Di Carlo

“…In last years, heroin-addicted have exponentially increased: this has made it necessary to identify a pharmacological strategy as effective as possible. …”
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Neural correlates of drug-related attentional bias in heroin dependence by Zhao, Q, Li, H, Hu, B, Li, Y, Gillebert, C, Mantini, D, Liu, Q

“…This study investigated the neural basis of AB in abstinent heroin addicts, combining event-related potential (ERP) analysis and source localization techniques. …”

Methadone induced torsades de pointes and ventricular fibrillation: A case review by Somayeh Khalesi, Hassan Shemirani, faezeh Dehghani-Tafti

“…[endif]--> <div><div><p class="abstract"><strong>BACKGROUND:</strong> Methadone is a synthetic opioid, which has been successfully used in treating heroin addiction and chronic pain syndrome in palliative care for more than 30 years. …”
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Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence by Qinglin Zhao, Hongqian Li, Bin Hu, Yonghui Li, Céline R. Gillebert, Céline R. Gillebert, Dante Mantini, Dante Mantini, Dante Mantini, Quanying Liu, Quanying Liu

“…Electroencephalography data were collected in 21 abstinent heroin addicts and 24 age- and gender-matched healthy controls (HCs) during a dot-probe task. …”
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ASSESSMENT OF TOXICITY DUE TO INTRAVENOUS ADMINISTRATION OF HEROIN CUT WITH CAFFEINE IN A CHRONIC CITALOPRAM CONSUMER. by Nunziata Barbera

“…This article presents the case of a 26 year old male heroin addict and chronic user of high doses of citalopram, who was found dead at his home. …”
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Adopção de heroinodependentes como estratégia de tratamento em ambulatório. by D Neto, L Sardinha, M David, S Cantante

“…The authors describe the ambulatory treatment of a young man, the son of a divorced mother, where they used a methodology called Combined Treatment of Heroin Addicts, which was done in stages. They used family sessions, with a concomitant hearing of the patient alone, combined with the use of an opioid antagonist, called naltrexone. …”
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Etapas de tratamento de doentes alcoólicos. by D Neto, M G Pereira

“…Based in a previous model of Sequential Combined Treatment of Heroin Addicted Patients with Naltrexone and Family Therapy, the authors outline some basic principles of a similar intervention designed for alcoholic patients and their families, which includes, when possible, a family integrated with an individual approach, an emphasis on normativity, on firmness and on self help groups. …”
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Forensic Aspects of a Fatal Intoxication Involving Acetaminophen, Citalopram and Trazodone: A Case Report by Giulio Mannocchi, Roberta Tittarelli, Flaminia Pantano, Francesca Vernich, Margherita Pallocci, Pierluigi Passalacqua, Michele Treglia, Luigi Tonino Marsella

“…We report the case of a young man, a former heroin addict, found dead at home by the Police Forces in an advanced state of decomposition. …”
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Descended Social Anxiety Disorder and Craving in Women Heroin Dependence Through Exercise Alerts Plasma Oxytocin Levels by Jing Song Wang, Jing Lin Liu, Jun Zhang, Jun Tan, Ting Huang, Chun Xia Lu, Xi Yang Peng, Yin Guo, Lan Zheng

“…Aerobic exercise combined with resistance training plus incremental load for 8 weeks can increase plasma OT levels and significantly reduce severity of SAD and cue-induced cravings in female heroin addicts.…”
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