Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study by Tomohiro Kawano, Yasufumi Gon, Manabu Sakaguchi, Hiroshi Yamagami, Soichiro Abe, Hiroyuki Hashimoto, Nobuyuki Ohara, Daisuke Takahashi, Yuko Abe, Tsutomu Takahashi, Shuhei Okazaki, Kenichi Todo, Hideki Mochizuki, Tsutomu Sasaki

“…Methods and Results Using data from 90 patients with acute ischemic stroke and active cancer who were registered in the SCAN (Ischemic Stroke in Patients With Cancer and Neoplasia) study, a prospective multicenter, observational study in Japan, we divided patients into 2 groups according to their median vWF antigen levels (high, n=46; or low, n=44). The high‐vWF group had a significantly higher initial National Institutes of Health Stroke Scale score (median, 7 [interquartile range, 3–11.25] versus 3 [interquartile range, 1–8.5]; P<0.05) and a significantly higher incidence of cryptogenic stroke (32 [70%] versus 16 [36%]; P<0.01) and venous thromboembolism (7 [15%] versus 0 [0%]; P<0.01), as well as multiple lesions (28 [62%] versus 12 [27%]; P<0.001), than the low‐vWF group. …”
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Association of tet methylcytosine dioxygenase 2 and 5-hydroxymethylcytosine in endometrioid adenocarcinoma and its clinical significance by Lei Kuang, Jingbo Zhang, Yanyu Li, Qing Wang, Jianwei Liu, Bei Zhang

“…TET2+5hmC+ (high TET2 and high 5hmC) association was significantly associated with well differentiation, myometrial invasion, negative lymph node metastasis, and tumor stage in EC. …”
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Imaging the subducting slab and mantle upwelling under the Japan islands revealed by double-difference tomography by Zhengshuai Zhang, Zhengshuai Zhang, Jianchang Zheng, Shuhao Wang, Cuiqin Li, Fangbin Liu

“…The subducting Pacific slab is imaged clearly as a high-velocity (high-V) faster than the surrounding mantle. Low-velocity (low-V) zones are imaged in the mantle wedge with significant along arc variations under the volcanic front. …”
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Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial by Thomas Olsen, Emma Stolt, Bente Øvrebø, Amany Elshorbagy, Elena C. Tore, Sindre Lee-Ødegård, Hannibal Troensegaard, Hanna Johannessen, Beate Doeland, Anna A. D. Vo, Anja F. Dahl, Karianne Svendsen, Magne Thoresen, Helga Refsum, Russell Rising, Kristýna Barvíková, Marleen van Greevenbroek, Viktor Kožich, Kjetil Retterstøl, Kathrine J. Vinknes

“…Methods N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5.6 g/day, control group) in sulfur amino acids. …”
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A Simple Semiempirical Short-Channel MOSFET Current-Voltage Model Continuous Across All Regions of Operation and Employing Only Physical Parameters by Khakifirooz, A., Nayfeh, Osama M., Antoniadis, Dimitri A.

“…Of these parameters, six are directly obtainable from standard device measurements: 1) gate capacitance in strong inversion conditions (typically at maximum voltage V[subscript GS] = V[subscript dd]); 2) subthreshold swing; 3) drain-induced barrier lowering (DIBL) coefficient; 4) current in weak inversion (typically I[subscript off] at V[subscript GS] = 0 V) and at high V[subscript DS]; 5) total resistance at V[subscript DS] = 0 V and V[subscript GS] = V[subscript dd] and 6), effective channel length. …”
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Electron velocity of 6 × 107 cm/s at 300 K in stress engineered InAlN/GaN nano-channel high-electron-mobility transistors by Arulkumaran, S., Ng, G. I., Manoj Kumar, C. M., Ranjan, K., Teo, K. L., Shoron, O. F., Rajan, S., Bin Dolmanan, S., Tripathy, S.

“…However, the unusually high v e at 300 K in the 3D TT-gate In0.17 Al 0.83N/GaN NC Fin-HEMT is attributed to the increase of in-plane tensile stress component by SiN passivation in the formed NC which is also verified by micro-photoluminescence (0.47 ± 0.02 GPa) and micro-Raman spectroscopy (0.39 ± 0.12 GPa) measurements. …”
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Use of anti-depressants and the risk of fracture of the hip or femur. by van den Brand, M, Pouwels, S, Samson, M, van Staa, T, Thio, B, Cooper, C, Leufkens, H, Egberts, A, Verhaar, H, de Vries, F

“…The risk of hip/femur fracture increased as the degree of 5-HTT inhibition of all anti-depressants increased from OR(adj) 1.64 [95% CI 1.14-2.35] for drugs with low 5-HTT inhibition to OR(adj) 2.31 [95% CI 1.94-2.76] for those with high 5-HTT inhibiting properties. CONCLUSION: Current use of both SSRIs and TCAs increase hip/femur fracture risk. …”

Folate and vitamin B12 status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK. by Clarke, R, Sherliker, P, Hin, H, Molloy, A, Nexo, E, Ueland, P, Emmens, K, Scott, J, Evans, J

“…The association of cognitive impairment with low B12 status was unaffected by high v. low folate status (&gt;30 nmol/l) (OR 1.50 (95 % CI 0.91, 2.46) v. 1.45 (95 % CI 1.19, 1.76)), respectively. …”

Donor-acceptor pairs in wide-bandgap semiconductors for quantum technology applications by Anil Bilgin, Ian N. Hammock, Jeremy Estes, Yu Jin, Hannes Bernien, Alexander A. High, Giulia Galli

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Risky business: a single-centre cross-sectional analysis of calculated cardiovascular risk in patients with primary aldosteronism and essential hypertension by Jun Yang, Stella May Gwini, Morag J Young, Peter J Fuller, Pravik Solanki, Renata Libianto, Genevieve Gabb, Jimmy Shen

“…We aimed to compare the calculated risks of CVD in patients who had hypertension with PA or EH using CVD risk calculators, hypothesising that they will fail to recognise the increased CVD risk in PA.Design Cross-sectional analysis.Setting An endocrine hypertension service in Victoria, Australia.Participants Patients who had hypertension without CVD referred for the investigation of hypertension.Outcome measures Calculated 5-year or 10-year CVD risk as predicted by the National Vascular Disease Prevention Alliance (NVDPA) algorithm, Framingham Risk Score, Pooled Cohort Equations and QRISK3.Results Those with PA (n=128) and EH (n=133), did not differ significantly in their calculated CVD risks with the NVDPA algorithm (moderate-to-high 5-year risk 36/100 vs 45/99, p=0.17); the Framingham Risk Score (median 10-year risk 7.72% (4.43%–12.95%) vs 6.84% (3.85%–10.50%), p=0.14); the Pooled Cohort Equations (median 10-year risk 9.45% (4.36%–15.37%) vs 7.90% (2.09%–14.73%), p=0.07); and QRISK3 (median 10-year risk 11.31% (7.22%–20.29%) vs 12.47% (5.10%–19.93%), p=0.51). …”
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Temperature fluctuation and acute myocardial infarction in Beijing: an extended analysis of temperature ranges and differences by Siqi Tang, Jia Fu, Yanbo Liu, Yakun Zhao, Yuxiong Chen, Yitao Han, Xinlong Zhao, Yijie Liu, Xiaofeng Jin, Zhongjie Fan

“…Extremely low (1st percentile) and high (5°C) DTDmean1 generated cumulative relative risk (CRR) of 2.73 (95% CI: 1.56–4.79) and 2.15 (95% CI: 1.54–3.01). …”
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Distributed Big Data Analytics Method for the Early Prediction of the Neonatal 5-Minute Apgar Score before or during Birth and Ranking the Risk Factors from a National Dataset by Toktam Khatibi, Ali Farahani, Mohammad Mehdi Sepehri, Mohammad Heidarzadeh

“…Our proposed stack ensemble outperforms the compared classifiers with an accuracy of 99.37 ± 1.06, precision of 99.37 ± 1.06, recall of 99.50 ± 0.61 and F-score of 99.41 ± 0.70 (for confidence interval of 95%) to predict low, moderate and high 5-min Apgar scores. Among the top predictors, fetal height around the baby’s head and fetal weight denote fetal growth status. …”
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Evaluation of dynamic serum thiol/disulfide homeostasis in locally advanced and metastatic gastric cancer by Mutlu Hizal, Mehmet A.N. Sendur, Burak Bilgin, Muhammed Bulent Akinci, Didem Sener Dede, Salim Neselioglu, Ozcan Erel, Bulent Yalcin

“…The native thiol (NT) and total thiol (TT) levels of patients' group were significantly lower compared with controls (p = 0.001 and p < 0.001). In the CEA high (≥5.4 ng/ml) group, DS/NT ratio were higher compared with CEA low (<5.4 ng/ml) group (p = 0.024). …”
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Metabolic signatures of β‐cell destruction in type 1 diabetes by Shinsuke Noso, Naru Babaya, Yoshihisa Hiromine, Yasunori Taketomo, Fumimaru Niwano, Sawa Yoshida, Hiroshi Ikegami

“…Reporter operating characteristics analysis, including all type 1 diabetes, type 2 diabetes and healthy controls, showed that high 3‐phenylpropionic acid (Pc <0.0001) and low hypotaurine (Pc <0.0001) were useful for identifying new‐onset type 1 diabetes, and high 5‐methylcytosine (Pc = 0.002) for the complete‐lack type 1 diabetes. …”
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Implementation of medication reconciliation at admission and discharge in Ministry of Defense Health Services hospitals: a multicentre study by Ahmed Kassem, Noura Alnowaiser, Yasser K Alotaibi, Dalia S Alghamdi, Mohammed Alhrasen, Alaa Alwagdani, Ayla Mohammad Tourkmani, Yasser Al Barakah

“…Our interventions were based on the High 5’s project medication reconciliation WHO, and Medications at Transitions and Clinical Handoffs toolkit for medication reconciliation by Agency for Healthcare Research and Quality. …”
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The role of surgeon volume on patient outcome in total knee arthroplasty: a systematic review of the literature by Lau Rick L, Perruccio Anthony V, Gandhi Rajiv, Mahomed Nizar N

“…</p> <p>Results</p> <p>Studies were variable in defining surgeon volume (‘low’: <3 to <52 total knee arthroplasty per year; ‘high’: >5 to >70 total knee arthroplasty per year). …”
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Radical surgery for stage IB2/IIA2 cervical cancer: A large retrospective study by Fang Zhou, Fang Zhou, Xuedong Tang, Zhuyan Shao, Zhuyan Shao, Xi Chen, Wen Gao, Chenyan Fang, Zejia Wang, Ping Zhang, Tao Zhu, Tao Zhu, Huarong Tang, Huarong Tang

“…No significant differences in non-hematological complications were detected between the RS and RS + adjuvant therapy groups.ConclusionsRS followed by adjuvant therapy is a feasible and effective treatment for IB2/IIA2 CC, with a high 5-year survival rate and an acceptable incidence of complications. …”
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Outlook for 615 Small Intestinal Neuroendocrine Tumor Patients: Recurrence Risk after Surgery and Disease-Specific Survival in Advanced Disease by Cecilie Slott, Seppo W. Langer, Stine Møller, Jesper Krogh, Marianne Klose, Carsten Palnæs Hansen, Andreas Kjaer, Pernille Holmager, Rajendra Singh Garbyal, Ulrich Knigge, Mikkel Andreassen

“…Conclusions: Recurrence rates remained high 5–10 years after surgery (group2) supporting long-term follow-up. …”
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Climate change impacts on the future of forests in Great Britain by Yu, J, Berry, P, Guillod, B, Hickler, T

“…We applied a tree-species-based dynamic model (LPJ-GUESS) at a high 5-km spatial resolution to project climate and CO2 impacts on tree species and thus forests in Great Britain. …”

Preventive and therapeutic efficacy of finasteride and dutasteride in TRAMP mice. by Alexander B Opoku-Acheampong, Dave Unis, Jamie N Henningson, Amanda P Beck, Brian L Lindshield

“…BACKGROUND:The prostate cancer prevention trial (PCPT) and Reduction by dutasteride of Prostate Cancer Events (REDUCE) trial found that 5α-reductase (5αR) inhibitors finasteride and dutasteride respectively, decreased prostate cancer prevalence but also increased the incidence of high-grade tumors. 5αR2 is the main isoenzyme in normal prostate tissue; however, most prostate tumors have high 5αR1 and low 5αR2 expression. Because finasteride inhibits only 5αR2, we hypothesized that it would not be as efficacious in preventing prostate cancer development and/or progression in C57BL/6 TRAMP x FVB mice as dutasteride, which inhibits both 5αR1 and 5αR2. …”
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