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181
A Newly Assigned Role of CTCF in Cellular Response to Broken DNAs
Published 2021-02-01Subjects: Get full text
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182
Applications of Programmable Endonucleases in Sequence- and Ligation-Independent Seamless DNA Assembly
Published 2023-06-01Subjects: Get full text
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183
Mammalian Genome Recombineering: Yeast, Still a Helper Microorganism of Choice?
Published 2008-01-01Subjects: Get full text
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184
An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms
Published 2019-11-01Subjects: Get full text
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185
Germline RAD51B variants confer susceptibility to breast and ovarian cancers deficient in homologous recombination
Published 2021-10-01“…Furthermore, we demonstrate that tumors harboring biallelic RAD51B alteration are deficient in homologous recombination DNA repair deficiency (HRD), as evidenced by analysis of sequencing data and in vitro functional assays. …”
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186
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance
Published 2023-03-01Subjects: “…homologous recombination repair…”
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187
Mutational signatures reveal mutual exclusivity of homologous recombination and mismatch repair deficiencies in colorectal and stomach tumors
Published 2023-07-01“…However, little is known about microsatellite (in)stability and its interactions with other DNA repair mechanisms such as homologous recombination (HR) in different cancer types. Based on whole-genome/exome mutational signature analysis, we showed HR deficiency (HRd) and mismatch repair deficiency (MMRd) occur in a significantly mutually exclusive manner in stomach and colorectal adenocarcinomas. …”
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188
Signatures associated with homologous recombination deficiency and immune regulation to improve clinical outcomes in patients with lung adenocarcinoma
Published 2022-09-01“…Homologous recombination deficiency (HRD) was used to induce particular DNA aberration profiles and related transcriptome alterations. …”
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189
Potential value of the homologous recombination deficiency signature we developed in the prognosis and drug sensitivity of gastric cancer
Published 2022-11-01Subjects: “…homologous recombination deficiency…”
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190
Rationale for the Use of Homologous Recombination Proficient Molecular Profile as a Biomarker for Therapeutic Targeting in Ovarian Cancer
Published 2023-09-01Subjects: “…homologous recombination…”
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191
Functional analyses of rare germline BRCA1 variants by transcriptional activation and homologous recombination repair assays
Published 2023-04-01Subjects: Get full text
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192
How BRCA and homologous recombination deficiency change therapeutic strategies in ovarian cancer: a review of literature
Published 2024-03-01Subjects: Get full text
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193
Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State
Published 2013-03-01“…Additional mechanistic studies uncover a direct role of the homologous recombination (HR) pathway, a pathway essential for error-free repair of DNA DSBs, in reprogramming. …”
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194
Evaluating homologous recombination activity in tissues to predict the risk of hereditary breast and ovarian cancer and olaparib sensitivity
Published 2024-04-01“…Abstract Homologous recombination (HR) repairs DNA damage including DNA double-stranded breaks and alterations in HR-related genes results in HR deficiency. …”
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195
Mutational pattern off homologous recombination repair (HRR)‐related genes in upper tract urothelial carcinoma
Published 2023-07-01Subjects: “…homologous recombination repair (HRR)…”
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196
Toward More Comprehensive Homologous Recombination Deficiency Assays in Ovarian Cancer, Part 1: Technical Considerations
Published 2022-02-01Subjects: Get full text
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197
Oncogenic Impact of TONSL, a Homologous Recombination Repair Protein at the Replication Fork, in Cancer Stem Cells
Published 2023-05-01Subjects: Get full text
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198
The Prognostic and Therapeutic Potential of DNA Damage Repair Pathway Alterations and Homologous Recombination Deficiency in Lung Cancer
Published 2022-10-01Subjects: Get full text
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199
Toward More Comprehensive Homologous Recombination Deficiency Assays in Ovarian Cancer Part 2: Medical Perspectives
Published 2022-02-01Subjects: Get full text
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200
Relationship between homologous recombination deficiency and clinical features of breast cancer based on genomic scar score
Published 2023-06-01Subjects: Get full text
Article