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201
The role of <it>Candida albicans </it>homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity
Published 2011-09-01“…This study addresses the role of the homologous recombination factors Rad54 and Rdh54 in cell growth, DNA damage and FLC resistance in <it>Candida albicans</it>.…”
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202
Transient Response of Olaparib on Pulmonary Artery Sarcoma Harboring Multiple Homologous Recombinant Repair Gene Alterations
Published 2021-04-01Subjects: Get full text
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203
Identification of novel prognostic model based on homologous recombination deficiency associated lncRNAs in lung adenocarcinoma
Published 2023-04-01Subjects: Get full text
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204
Modification of Homologous Recombination Deficiency Score Threshold and Association with Long-Term Survival in Epithelial Ovarian Cancer
Published 2021-02-01Subjects: Get full text
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205
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Homologous Recombination Abnormalities Associated With Mutations as Predicted by Machine Learning of Targeted Next-Generation Sequencing Data
Published 2023-09-01“…Background: Homologous recombination deficiency (HRD) is the hallmark of breast cancer gene 1/2 ( BRCA1/2 )-mutated tumors and the unique biomarker for predicting response to double-strand break (DSB)–inducing drugs. …”
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207
Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining
Published 2020-04-01“…We compared the differences in DNA double strand break (DSB) repair and survival of cells compromised in non-homologous end joining (NHEJ), homologous recombination repair (HRR) or both, after irradiation with an equal dose of X-ray photons, entrance plateau (EP) protons, and mid spread-out Bragg peak (SOBP) protons. …”
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208
Germline mutations of homologous recombination genes and clinical outcomes in pancreatic cancer: a multicenter study in Taiwan
Published 2024-02-01Subjects: Get full text
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209
SUMO-Based Regulation of Nuclear Positioning to Spatially Regulate Homologous Recombination Activities at Replication Stress Sites
Published 2021-12-01Subjects: Get full text
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210
Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report
Published 2020-01-01Subjects: Get full text
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211
Homologous recombination deficiency (HRD) can predict the therapeutic outcomes of immuno-neoadjuvant therapy in NSCLC patients
Published 2022-05-01Subjects: Get full text
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212
The Interaction of PI3K Inhibition with Homologous Recombination Repair in Triple Negative Breast Cancer Cells
Published 2019-12-01“…Additionally, dysregulation in the homologous recombination (HR)-dependent DNA-repair is associated with TNBC phenotype due to BRCA1/2 mutations or HR deficiency. …”
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213
Circulating Tumor DNA Testing for Homology Recombination Repair Genes in Prostate Cancer: From the Lab to the Clinic
Published 2021-05-01Subjects: Get full text
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214
pBFK, a new thermosensitive shuttle vector for Streptococcus pyogenes gene deletion by homologous recombination
Published 2023-06-01Subjects: Get full text
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215
A RAD51–ADP double filament structure unveils the mechanism of filament dynamics in homologous recombination
Published 2023-08-01“…Abstract ATP-dependent RAD51 recombinases play an essential role in eukaryotic homologous recombination by catalyzing a four-step process: 1) formation of a RAD51 single-filament assembly on ssDNA in the presence of ATP, 2) complementary DNA strand-exchange, 3) ATP hydrolysis transforming the RAD51 filament into an ADP-bound disassembly-competent state, and 4) RAD51 disassembly to provide access for DNA repairing enzymes. …”
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216
Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma
Published 2020“…In response to PARPi, CDK18 facilitates ATR activation by interacting with ATR and regulating ATR-Rad9/ATR-ETAA1 interactions; thereby promoting homologous recombination (HR) and PARPi resistance. CDK18 knockdown or ATR inhibition in GSCs suppressed HR and conferred PARPi sensitivity, with ATR inhibitors synergizing with PARPis or sensitizing GSCs. …”
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217
Clinicopathological features of homologous recombination deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum and survival
Published 2012“…Up to 50% of epithelial ovarian cancers (EOC) display defects in the homologous recombination (HR) pathway. We sought to determine the ramifications of the homologous recombination deficient (HRD) status on the clinicopathological features, chemotherapy response and survival outcomes of EOC patients. …”
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218
Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells
Published 2017“…Mutations in homologous recombination (HR) genes BRCA1 and BRCA2 predispose to tumorigenesis. …”
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The role of Helicobacter pylori ruvA, ruvB and ruvC genes in homologous recombination and mutation
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Targeting Homologous Recombination Deficiency in Ovarian Cancer with PARP Inhibitors: Synthetic Lethal Strategies That Impact Overall Survival
Published 2022-09-01Subjects: Get full text
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