The role of <it>Candida albicans </it>homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity by White Theodore C, Potenski Catherine J, Zheng Xiuzhong, Hoot Samantha J, Klein Hannah L

“…This study addresses the role of the homologous recombination factors Rad54 and Rdh54 in cell growth, DNA damage and FLC resistance in <it>Candida albicans</it>.…”
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Transient Response of Olaparib on Pulmonary Artery Sarcoma Harboring Multiple Homologous Recombinant Repair Gene Alterations by Chiao-En Wu, Ca Tung Ng, Kien Thiam Tan

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Identification of novel prognostic model based on homologous recombination deficiency associated lncRNAs in lung adenocarcinoma by Xi Liu, Tao Wang, Zhipeng Ren, Changjiang Feng, Xiaodong Tian

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Modification of Homologous Recombination Deficiency Score Threshold and Association with Long-Term Survival in Epithelial Ovarian Cancer by Jeffrey A. How, Amir A. Jazaeri, Bryan Fellman, Molly S. Daniels, Suzanna Penn, Cara Solimeno, Ying Yuan, Kathleen Schmeler, Jerry S. Lanchbury, Kirsten Timms, Karen H. Lu, Melinda S. Yates

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Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes by Yang Liu, Shahneen Sandhu, Anupama Pasam, Catherine Mitchell, Ygal Haupt, Scott G Williams, Paul Neeson, Simon Keam, David Goode, Christina Guo, Damien Bolton, Benjamin Blyth, Heather Thorne, David Clouston, Nathan Lawrentschuk, Stephen Lade, Declan Murphy, Roslyn Wallace, Anna Sofia Trigos, Patricia Banks, Alexander Hakansson, Daniel Moon, Phil Darcy, Elena Castro, David Olmos

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Homologous Recombination Abnormalities Associated With Mutations as Predicted by Machine Learning of Targeted Next-Generation Sequencing Data by Maher Albitar, Hong Zhang, Andrew Pecora, Stanley Waintraub, Deena Graham, Mira Hellmann, Donna McNamara, Ahmad Charifa, Ivan De Dios, Wanlong Ma, Andre Goy

“…Background: Homologous recombination deficiency (HRD) is the hallmark of breast cancer gene 1/2 ( BRCA1/2 )-mutated tumors and the unique biomarker for predicting response to double-strand break (DSB)–inducing drugs. …”
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Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining by Klaudia Szymonowicz, Adam Krysztofiak, Jansje van der Linden, Ajvar Kern, Simon Deycmar, Sebastian Oeck, Anthony Squire, Benjamin Koska, Julian Hlouschek, Melanie Vüllings, Christian Neander, Jens T. Siveke, Johann Matschke, Martin Pruschy, Beate Timmermann, Verena Jendrossek

“…We compared the differences in DNA double strand break (DSB) repair and survival of cells compromised in non-homologous end joining (NHEJ), homologous recombination repair (HRR) or both, after irradiation with an equal dose of X-ray photons, entrance plateau (EP) protons, and mid spread-out Bragg peak (SOBP) protons. …”
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Germline mutations of homologous recombination genes and clinical outcomes in pancreatic cancer: a multicenter study in Taiwan by Siao Muk Cheng, Yung-Yeh Su, Nai-Jung Chiang, Chih-Jung Wang, Ying-Jui Chao, Chien-Jui Huang, Hui-Jen Tsai, Shang-Hung Chen, Chi-Yen Chang, Chia-Rung Tsai, Yi-Jie Li, Chia-Jui Yen, Shih-Chang Chuang, Jeffrey Shu-Ming Chang, Yan-Shen Shan, Daw-Yang Hwang, Li-Tzong Chen

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SUMO-Based Regulation of Nuclear Positioning to Spatially Regulate Homologous Recombination Activities at Replication Stress Sites by Kamila Schirmeisen, Sarah A. E. Lambert, Karol Kramarz

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Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report by Hiroshi Hongo, Takeo Kosaka, Eriko Aimono, Hiroshi Nishihara, Mototsugu Oya

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Homologous recombination deficiency (HRD) can predict the therapeutic outcomes of immuno-neoadjuvant therapy in NSCLC patients by Zhen Zhou, Zhengping Ding, Jie Yuan, Shengping Shen, Hong Jian, Qiang Tan, Yunhai Yang, Zhiwei Chen, Qingquan Luo, Xinghua Cheng, Yongfeng Yu, Xiaomin Niu, Liqiang Qian, Xiaoke Chen, Linping Gu, Ruijun Liu, Shenglin Ma, Jia Huang, Tianxiang Chen, Ziming Li, Wenxiang Ji, Liwei Song, Lan Shen, Long Jiang, Zicheng Yu, Chao Zhang, Zaixian Tai, Changxi Wang, Rongrong Chen, David P. Carbone, Xuefeng Xia, Shun Lu

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The Interaction of PI3K Inhibition with Homologous Recombination Repair in Triple Negative Breast Cancer Cells by Gamze Guney Eskiler

“…Additionally, dysregulation in the homologous recombination (HR)-dependent DNA-repair is associated with TNBC phenotype due to BRCA1/2 mutations or HR deficiency. …”
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Circulating Tumor DNA Testing for Homology Recombination Repair Genes in Prostate Cancer: From the Lab to the Clinic by Alessia Cimadamore, Liang Cheng, Francesco Massari, Matteo Santoni, Laura Pepi, Carmine Franzese, Marina Scarpelli, Antonio Lopez-Beltran, Andrea Benedetto Galosi, Rodolfo Montironi

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pBFK, a new thermosensitive shuttle vector for Streptococcus pyogenes gene deletion by homologous recombination by S. Boukthir, P. Gaudu, A. Faili, S. Kayal

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A RAD51–ADP double filament structure unveils the mechanism of filament dynamics in homologous recombination by Shih-Chi Luo, Min-Chi Yeh, Yu-Hsiang Lien, Hsin-Yi Yeh, Huei-Lun Siao, I-Ping Tu, Peter Chi, Meng-Chiao Ho

“…Abstract ATP-dependent RAD51 recombinases play an essential role in eukaryotic homologous recombination by catalyzing a four-step process: 1) formation of a RAD51 single-filament assembly on ssDNA in the presence of ATP, 2) complementary DNA strand-exchange, 3) ATP hydrolysis transforming the RAD51 filament into an ADP-bound disassembly-competent state, and 4) RAD51 disassembly to provide access for DNA repairing enzymes. …”
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Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma by Stanciu, Monica, Lees, Jacqueline

“…In response to PARPi, CDK18 facilitates ATR activation by interacting with ATR and regulating ATR-Rad9/ATR-ETAA1 interactions; thereby promoting homologous recombination (HR) and PARPi resistance. CDK18 knockdown or ATR inhibition in GSCs suppressed HR and conferred PARPi sensitivity, with ATR inhibitors synergizing with PARPis or sensitizing GSCs. …”
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Clinicopathological features of homologous recombination deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum and survival by Mukhophadyay, Asima, Plummer, Elizabeth R, Elattar, Ahmed, San, SooHoo, Uzir, Bisha Fathamah, Quinn, Jennifer E, Edmondson, Richard J, Curtin, Nicola J, Harriet, Aneke, Maxwell, Perry, McCluggage, W Glenn

“…Up to 50% of epithelial ovarian cancers (EOC) display defects in the homologous recombination (HR) pathway. We sought to determine the ramifications of the homologous recombination deficient (HRD) status on the clinicopathological features, chemotherapy response and survival outcomes of EOC patients. …”
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Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells by Schoonen, P, Talens, F, Stok, C, Gogola, E, Heijink, A, Bouwman, P, Foijer, F, Tarsounas, M, Blatter, S, Jonkers, J, Rottenberg, S, van Vugt, M

“…Mutations in homologous recombination (HR) genes BRCA1 and BRCA2 predispose to tumorigenesis. …”

The role of Helicobacter pylori ruvA, ruvB and ruvC genes in homologous recombination and mutation by Moccia, C, Kulick, S, Didelot, X, Ellrott, K, Kraft, C, Suerbaum, S

Targeting Homologous Recombination Deficiency in Ovarian Cancer with PARP Inhibitors: Synthetic Lethal Strategies That Impact Overall Survival by Tao Xie, Kristie-Ann Dickson, Christine Yee, Yue Ma, Caroline E. Ford, Nikola A. Bowden, Deborah J. Marsh

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