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241
PALB2 or BARD1 loss confers homologous recombination deficiency and PARP inhibitor sensitivity in prostate cancer
Published 2022-06-01“…We used functional approaches to directly test the impact of PALB2 and BARD1 loss on homologous recombination (HR) function and PARP inhibitor sensitivity in prostate cancer cell lines. …”
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242
Concordance between Three Homologous Recombination Deficiency (HRD) Assays in Patients with High-Grade Epithelial Ovarian Cancer
Published 2023-11-01Subjects: Get full text
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243
CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors
Published 2022-12-01Subjects: Get full text
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244
p53 null Fluorescent Yellow Direct Repeat (FYDR) mice have normal levels of homologous recombination
Published 2014“…In addition, p53 interacts with repair proteins involved in homologous recombination. Mitotic homologous recombination (HR) plays an essential role in the repair of double-strand breaks (DSBs) and broken replication forks. …”
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245
Redundancy between nucleases required for homologous recombination promotes PARP inhibitor resistance in the eukaryotic model organism Dictyostelium
Published 2017“…<p>ADP-ribosyltransferases (ARTs) promote repair of DNA single strand breaks (SSBs) and disruption of this pathway by Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) is toxic to cells with defects in homologous recombination (HR). Here we show that this relationship is conserved in the simple eukaryote <em>Dictyostelium</em> and exploit this organism to define mechanisms that drive resistance of HR-deficient cells to PARPi. …”
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246
Saccharomyces cerevisiae C1D is implicated in both non-homologous DNA end joining and homologous recombination.
Published 2002“…In addition, using a novel plasmid-based in vivo recombination assay, we show that yc1d mutant strains are also defective in homologous recombination. These results indicate that YC1D is implicated in both homologous recombination and NHEJ pathways for the repair of DNA double-strand breaks.…”
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247
DNA ADP-ribosylation stalls replication and is reversed by RecF-mediated homologous recombination and nucleotide excision repair
Published 2020“…Removal of ADPr from DNA requires the sequential activity of two DNA repair pathways, with RecF-mediated homologous recombination likely to transfer ADP-ribosylation from single- to double-stranded DNA (dsDNA) and subsequent nucleotide excision repair eliminating the lesion. …”
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248
A bimodal pattern of relatedness between the Salmonella Paratyphi A and Typhi genomes: convergence or divergence by homologous recombination?
Published 2007“…We developed a Bayesian changepoint model that uses variation in the degree of nucleotide divergence along two genomes to detect homologous recombination between these strains, and with other lineages of Salmonella enterica. …”
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249
Selections that isolate recombinant mitochondrial genomes in animals
Published 2015-08-01Subjects: Get full text
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250
A deep-learning-based genomic status estimating framework for homologous recombination deficiency detection from low-pass whole genome sequencing
Published 2024-02-01Subjects: “…Homologous recombination deficiency…”
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251
RecA filament sliding on DNA facilitates homology search
Published 2012-12-01Subjects: Get full text
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252
From DNA Sequences to Chemical Structures – Methods for Mining Microbial Genomic and Metagenomic Data Sets for New Natural Products
Published 2010-01-01Subjects: Get full text
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253
Somatic mutations in four novel genes contribute to homologous recombination deficiency in breast cancer: a real‐world clinical tumor sequencing study
Published 2024-03-01Subjects: “…homologous recombination…”
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254
Next-generation sequencing of homologous recombination genes could predict efficacy of platinum-based chemotherapy in non-small cell lung cancer
Published 2022-12-01Subjects: Get full text
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255
PARP inhibitor era in ovarian cancer treatment: a systematic review and meta-analysis of randomized controlled trials
Published 2024-02-01Subjects: Get full text
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256
Stable overexpression and targeted gene deletion of the causative agent of ash dieback Hymenoscyphus fraxineus
Published 2023-01-01Subjects: Get full text
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257
Correction: RecA filament sliding on DNA facilitates homology search
Published 2013-02-01Subjects: Get full text
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258
An asymmetric PCR-based, reliable and rapid single-tube native DNA engineering strategy
Published 2012-07-01Subjects: “…Intramolecular homologous recombination…”
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259
Analyzing Plant Gene Targeting Outcomes and Conversion Tracts with Nanopore Sequencing
Published 2021-09-01Subjects: Get full text
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260
High Expression of MRE11A Is Associated with Shorter Survival and a Higher Risk of Death in CRC Patients
Published 2023-06-01Subjects: Get full text
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