A Risk Model Developed Based on Homologous Recombination Deficiency Predicts Overall Survival in Patients With Lower Grade Glioma by Hao Peng, Hao Peng, Yibiao Wang, Pengcheng Wang, Chuixue Huang, Zhaohui Liu, Changwu Wu, Changwu Wu

Subjects: “…homologous recombination deficiency…”
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Beyond BRCA1/2: Homologous Recombination Repair Genetic Profile in a Large Cohort of Apulian Ovarian Cancers by Antonella Turchiano, Daria Carmela Loconte, Rosalba De Nola, Francesca Arezzo, Giulia Chiarello, Antonino Pantaleo, Matteo Iacoviello, Rosanna Bagnulo, Annunziata De Luisi, Sonia Perrelli, Stefania Martino, Carlotta Ranieri, Antonella Garganese, Alessandro Stella, Cinzia Forleo, Vera Loizzi, Marco Marinaccio, Ettore Cicinelli, Gennaro Cormio, Nicoletta Resta

“…Background: Pathogenic variants in homologous recombination repair (HRR) genes other than <i>BRCA1/2</i> have been associated with a high risk of ovarian cancer (OC). …”
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Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families by Thibaut S. Matis, Nadia Zayed, Bouchra Labraki, Manon de Ladurantaye, Théophane A. Matis, José Camacho Valenzuela, Nancy Hamel, Adrienne Atayan, Barbara Rivera, Yuval Tabach, Patricia N. Tonin, Alexandre Orthwein, Anne-Marie Mes-Masson, Zaki El Haffaf, William D. Foulkes, Paz Polak

“…Abstract It was hypothesized that variants in underexplored homologous recombination repair (HR) genes could explain unsolved multiple-case breast cancer (BC) families. …”
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Prediction of homologous recombination deficiency from Oncomine Comprehensive Assay Plus correlating with SOPHiA DDM HRD Solution. by Jun Kang, Kiyong Na, Haeyoun Kang, Uiju Cho, Sun Young Kwon, Sohyun Hwang, Ahwon Lee

“…<h4>Objective</h4>Poly(ADP-ribose) polymerase (PARP) inhibitors are used for targeted therapy for ovarian cancer with homologous recombination deficiency (HRD). In this study, we aimed to develop a homologous recombination deficiency prediction model to predict the genomic integrity (GI) index of the SOPHiA DDM HRD Solution from the Oncomine Comprehensive Assay (OCA) Plus. …”
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PAK6 promotes homologous-recombination to enhance chemoresistance to oxaliplatin through ATR/CHK1 signaling in gastric cancer by Weicai Huang, Zhen Han, Zepang Sun, Hao Feng, Liying Zhao, Qingyu Yuan, Chuanli Chen, Shitong Yu, Yanfeng Hu, Jiang Yu, Hao Liu, Guoxin Li, Yuming Jiang

“…Functionally, PAK6 mediates cancer chemoresistance by enhancing homologous recombination (HR) to facilitate the DNA double-strand break repair. …”
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Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer by Yimeng Chen, Xue Wang, Feng Du, Jian Yue, Yiran Si, Xiaochen Zhao, Lina Cui, Bei Zhang, Ting Bei, Binghe Xu, Peng Yuan

Subjects: “…homologous recombination deficiency…”
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Loss of NFBD1/MDC1 disrupts homologous recombination repair and sensitizes nasopharyngeal carcinoma cells to PARP inhibitors by Zhihai Wang, Wenqi Zuo, Quan Zeng, Yi Qian, Yanshi Li, Chuan Liu, Jue Wang, Shixun Zhong, Youquan Bu, Guohua Hu

Subjects: “…PARP inhibitor; homologous recombination…”
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Mitomycin C in Homologous Recombination Deficient Metastatic Pancreatic Cancer after Disease Progression on Platinum-Based Chemotherapy and Olaparib by Gehan Botrus, Denise Roe, Gayle S. Jameson, Pedro Luiz Serrano Uson Junior, Ronald Lee Korn, Lana Caldwell, Taylor Bargenquast, Max Miller, Erkut Hasan Borazanci

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Breast cancer stem-like cells show dominant homologous recombination due to a larger S-G2 fraction. by Al-Assar, O, Mantoni, T, Lunardi, S, Kingham, G, Helleday, T, Brunner, T

“…Cyclin D and E protein levels supported the cell cycle profile and highlighted the possible involvement of homologous recombination (HR) repair in the radioresistant phenotype. …”

Breast cancer stem-like cells show enhanced homologous recombination due to a larger S-G2 fraction by Al-Assar, O, Mantoni, T, Lunardi, S, Kingham, G, Helleday, T, Brunner, T

hMOB2 deficiency impairs homologous recombination-mediated DNA repair and sensitises cancer cells to PARP inhibitors by Gundogdu, R, Erdogan, MK, Ditsiou, A, Spanswick, V, Garcia-Gomez, JJ, Hartley, JA, Esashi, F, Hergovich, A, Gomez, V

“…Here, we uncover hMOB2 as a regulator of double-strand break (DSB) repair by homologous recombination (HR). hMOB2 supports the phosphorylation and accumulation of the RAD51 recombinase on resected single-strand DNA (ssDNA) overhangs. …”

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation by Luijsterburg, MS, Typas, D, Caron, M-C, Wiegant, WW, Van Den Heuvel, D, Boonen, RA, Couturier, AM, Mullenders, LH, Masson, J-Y, Van Attikum, H

“…This cascade involves the ubiquitylation of histone H2A by the RNF168 ligase and the subsequent recruitment of RIF1, which suppresses homologous recombination (HR) in G1 cells. The RIF1-dependent suppression is relieved in S/G2 cells, allowing PALB2-driven HR to occur. …”

Deciphering the expression patterns of homologous recombination-related lncRNAs identifies new molecular subtypes and emerging therapeutic opportunities in epithelial ovarian cancer by Tian Hua, Xiao-Chong Zhang, Wei Wang, Yun-Jie Tian, Shu-Bo Chen

Subjects: “…homologous recombination-related lncRNAs in ovarian cancer…”
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METTL3 promotes homologous recombination repair and modulates chemotherapeutic response in breast cancer by regulating the EGF/RAD51 axis by Enjie Li, Mingyue Xia, Yu Du, Kaili Long, Feng Ji, Feiyan Pan, Lingfeng He, Zhigang Hu, Zhigang Guo

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Wnt/β-Catenin-Pathway Alterations and Homologous Recombination Deficiency in Cholangiocarcinoma Cell Lines and Clinical Samples: Towards Specific Vulnerabilities by Alexander Scheiter, Frederik Hierl, Ingrid Winkel, Felix Keil, Margit Klier-Richter, Cédric Coulouarn, Florian Lüke, Arne Kandulski, Matthias Evert, Wolfgang Dietmaier, Diego F. Calvisi, Kirsten Utpatel

“…One parameter to investigate in CCA is homologous recombination deficiency (HRD). While mutations in homologous recombinational repair (HRR)-related genes have been detected, their predictive value remains undetermined. …”
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Yeast cells can partially revert chromosome segregation to repair late DNA double-strand breaks through homologous recombination by Jessel Ayra-Plasencia, Félix Machín

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E2F1 Promotes Progression of Bladder Cancer by Modulating RAD54L Involved in Homologous Recombination Repair by Jeong-Yeon Mun, Seung-Woo Baek, Won Young Park, Won-Tae Kim, Seon-Kyu Kim, Yun-Gil Roh, Mi-So Jeong, Gi-Eun Yang, Jong-Ho Lee, Jin Woong Chung, Yung Hyun Choi, In-Sun Chu, Sun-Hee Leem

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Micelle encapsulation zinc‐doped copper oxide nanocomposites reverse Olaparib resistance in ovarian cancer by disrupting homologous recombination repair by Jingyan Yi, Xin Luo, Jinshan Xing, Aharon Gedanken, Xiukun Lin, Chunxiang Zhang, Gan Qiao

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Pan-Cancer Analysis Identified Homologous Recombination Factor With OB-Fold (HROB) as a Potential Biomarker for Various Tumor Types by Xianming Liu, Cunchuan Wang

“…Background: By recruiting the MCM8–MCM9 helicase to DNA damage site, the Homologous Recombination Factor With OB-Fold (HROB) is involved in the repair of inter-strand crosslink and homologous recombination. …”
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The RAD51-FFPE Test; Calibration of a Functional Homologous Recombination Deficiency Test on Diagnostic Endometrial and Ovarian Tumor Blocks by Lise M. van Wijk, Claire J. H. Kramer, Sylvia Vermeulen, Natalja T. ter Haar, Marthe M. de Jonge, Judith R. Kroep, Cor D. de Kroon, Katja N. Gaarenstroom, Harry Vrieling, Tjalling Bosse, Maaike P. G. Vreeswijk

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