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Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe
Published 2017-07-01Subjects: Get full text
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302
PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous Recombination
Published 2022-10-01“…PTEN has been implicated in the repair of DNA double-strand breaks (DSBs), particularly through homologous recombination (HR). However, other data fail to demonstrate a direct role of PTEN in DSB repair. …”
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Dbf4-dependent kinase promotes cell cycle controlled resection of DNA double-strand breaks and repair by homologous recombination
Published 2024-04-01“…Upon cell cycle-dependent activation, cyclin-dependent kinases (CDKs) phosphorylate resection proteins and thereby stimulate end resection and repair by homologous recombination (HR). However, inability of CDK phospho-mimetic mutants to bypass this cell cycle regulation, suggests that additional cell cycle regulators may be important. …”
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306
Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium.
Published 2016-01-01“…The DNA damage response analysis suggest that DNA repair pathways, including the homologous recombination and REV1- and POLD3-mediated error-prone translesion synthesis pathways, are critical for the cells to tolerate to DNA damage caused by trace amount of Cr(VI).…”
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Clinical Utility of Genomic Tests Evaluating Homologous Recombination Repair Deficiency (HRD) for Treatment Decisions in Early and Metastatic Breast Cancer
Published 2023-02-01“…Different approaches currently exist to analyze impairment of the homologous recombination pathway, e.g., the search for specific mutations in homologous recombination repair (HRR) genes, such as <i>BRCA1</i>/<i>2</i>; the use of genomic scars or mutational signatures; or the development of functional tests. …”
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309
2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis
Published 2023-01-01“…Rescue assay and CHIP assay further verified HMA can impair homologous recombination repair through the MYC-CHK1-RAD51 pathway. …”
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Defective Homologous Recombination Repair By Up‐Regulating Lnc‐HZ10/Ahr Loop in Human Trophoblast Cells Induced Miscarriage
Published 2024-04-01Subjects: Get full text
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312
Assessing the Phenotype of a Homologous Recombination Deficiency Using High Resolution Array-Based Comparative Genome Hybridization in Ovarian Cancer
Published 2023-12-01“…Ovarian cancer (OC) cells with homologous recombination deficiency (HRD) accumulate genomic scars (LST, TAI, and LOH) over a value of 42 in sum. …”
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The influence of the CTIP Polymorphism, Q418P, on Homologous Recombination and Predisposition to Radiation-Induced Tumorigenesis (mainly rAML) in Mice
Published 2016“…This gene is essential for embryonic development, double-strand break (DSB) resection in homologous recombination (HR) and tumor suppression. In the 129S2/SvHsd mouse strain, a nonsynonymous single nucleotide polymorphism (nsSNP) in Ctip, Q418P, has been identified. …”
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H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids
Published 2019“…Genotoxic DNA double-strand breaks (DSBs) can be repaired by error-free homologous recombination (HR) or mutagenic non-homologous end-joining1. …”
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316
Increased HRD score in cisplatin resistant penile cancer cells
Published 2022-12-01Subjects: Get full text
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317
BET Proteins as Attractive Targets for Cancer Therapeutics
Published 2021-10-01Subjects: Get full text
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318
The multistep path to replicative senescence onset: zooming on triggering and inhibitory events at telomeric DNA
Published 2023-09-01Subjects: Get full text
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319
The Role of Topoisomerase II in DNA Repair and Recombination in <i>Arabidopsis thaliana</i>
Published 2021-12-01Subjects: Get full text
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320
Alternative Lengthening of Telomeres and Mediated Telomere Synthesis
Published 2022-04-01Subjects: Get full text
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