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The Development and Testing of a Patient Decision Aid for Individuals with Homologous Recombinant Proficient Ovarian Cancer Who Are Considering Niraparib Maintenance Therapy
Published 2024-03-01“…The aim of this study was to develop a decision aid for patients with homologous recombinant proficient (HRP) tumors, as the benefit–harm ratio of niraparib needs consideration. …”
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Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer
Published 2020-01-01Subjects: Get full text
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346
Germline Mutations in Other Homologous Recombination Repair-Related Genes Than <i>BRCA1/2</i>: Predictive or Prognostic Factors?
Published 2021-03-01Subjects: Get full text
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347
Prevalence of Homologous Recombination Deficiency in First-Line PARP Inhibitor Maintenance Clinical Trials and Further Implication of Personalized Treatment in Ovarian Cancer
Published 2023-06-01“…Among ovarian cancer patients with <i>BRCA</i> mutation or homologous recombination deficiency (HRD), the efficacy of Poly-ADP-ribose polymerase (PARP) inhibitors such as olaparib, niraparib, veliparib, and rucaparib has been proven in a number of clinical trials. …”
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Rosa26-GFP Direct Repeat (RaDR-GFP) Mice Reveal Tissue- and Age-Dependence of Homologous Recombination in Mammals In Vivo
Published 2014“…Homologous recombination (HR) is critical for the repair of double strand breaks and broken replication forks. …”
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Mph1 requires mismatch repair-independent and -dependent functions of MutSα to regulate crossover formation during homologous recombination repair
Published 2010“…In budding yeast the DNA helicase Mph1 prevents genome rearrangements during ectopic homologous recombination (HR) by suppressing the formation of crossovers (COs). …”
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Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition.
Published 2007“…These events required the homologous recombination (HR) genes rad32(+), rad50(+), nbs1(+), rhp51(+), rad22(+), rhp55(+), rhp54(+), and mus81(+). …”
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The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast.
Published 2014“…Here we identify roles for the DNA damage checkpoint pathway in facilitating homologous recombination (HR) repair and suppressing extensive LOH and chromosomal rearrangements in response to a DSB. …”
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Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells.
Published 1994“…We have obtained transgenic mice in which an erythropoietin-SV40 virus T antigen fusion gene is homologously recombined into the native Epo locus. This gene is expressed in a tissue-specific manner closely resembling that of the native Epo gene. …”
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PARP Inhibitors: A Major Therapeutic Option in Endocrine-Receptor Positive Breast Cancers
Published 2022-01-01Subjects: Get full text
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355
R-Loop Formation in Meiosis: Roles in Meiotic Transcription-Associated DNA Damage
Published 2022-08-01Subjects: Get full text
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356
An easy method to generate recombinant pseudorabies virus expressing the capsid protein of Porcine circovirus type 2d
Published 2023-05-01Subjects: Get full text
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357
Construction of an Unmarked Zymomonas mobilis Mutant Using a Site-Specific FLP Recombinase
Published 2012-01-01Subjects: Get full text
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358
Genetic and Biochemical Characterizations of aLhr1 Helicase in the Thermophilic Crenarchaeon <i>Sulfolobus acidocaldarius</i>
Published 2021-12-01Subjects: Get full text
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359
Effective sequential combined therapy with carboplatin and a CDC7 inhibitor in ovarian cancer
Published 2024-01-01Subjects: Get full text
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360
The deletion of omp19 gene of brucella abortus 2308 reduces its survival in mouse macrophage and in mice
Published 2020-07-01Subjects: Get full text
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