Low dose PFDA induces DNA damage and DNA repair inhibition by promoting nuclear cGAS accumulation in ovarian epithelial cells by Yuheng Qin, Xiaoyu Yuan, Zhenyan Cui, Wenhan Chen, Sinan Xu, Kelie Chen, Fang Wang, Fang Zheng, Heng Ni, Han-Ming Shen, Yihua Wu, Dajing Xia

Subjects: Get full text

WHIRLY protein functions in plants by Rachel E. Taylor, Christopher E. West, Christine H. Foyer

Subjects: Get full text

Involvement of POLA2 in Double Strand Break Repair and Genotoxic Stress by Tuyen T. Dang, Julio C. Morales

Subjects: Get full text

USP14 Regulates DNA Damage Response and Is a Target for Radiosensitization in Non-Small Cell Lung Cancer by Arishya Sharma, Alexandru Almasan

Subjects: Get full text

Establishment, optimization, and application of genetic technology in Aspergillus spp. by Jing Gao, Huiqing Liu, Zhenzhen Zhang, Zhihong Liang, Zhihong Liang, Zhihong Liang

Subjects: Get full text

What role do biocontrol agents with Mg2+ play in the fate of antibiotic resistome and pathogenic bacteria in the phyllosphere? by Qiqi Zhi, Ge Tan, Shaolong Wu, Qianqian Ma, Jianqiang Fan, Yiqiang Chen, Jingjing Li, Zhengrong Hu, Yansong Xiao, Liangzhi Li, Zhenghua Liu, Zhaoyue Yang, Zhendong Yang, Delong Meng, Huaqun Yin, Qianjun Tang, Tianbo Liu

Subjects: Get full text

The Landscape and Therapeutic Targeting of <i>BRCA1</i>, <i>BRCA2</i> and Other DNA Damage Response Genes in Pancreatic Cancer by Ioannis A. Voutsadakis, Antonia Digklia

Subjects: Get full text

WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer by Amanpreet Kaur, Jun Yi Stanley Lim, Sugunavathi Sepramaniam, Siddhi Patnaik, Nathan Harmston, May Ann Lee, Enrico Petretto, David M Virshup, Babita Madan

Subjects: Get full text

Plasticity of repetitive sequences demonstrated by the complete mitochondrial genome of Eucalyptus camaldulensis by Yoshinori Fukasawa, Patrick Driguez, Salim Bougouffa, Karen Carty, Alexander Putra, Ming-Sin Cheung, Luca Ermini

Subjects: Get full text

Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants by Gemma F. Codner, Joffrey Mianné, Adam Caulder, Jorik Loeffler, Rachel Fell, Ruairidh King, Alasdair J. Allan, Matthew Mackenzie, Fran J. Pike, Christopher V. McCabe, Skevoulla Christou, Sam Joynson, Marie Hutchison, Michelle E. Stewart, Saumya Kumar, Michelle M. Simon, Loranne Agius, Quentin M. Anstee, Kirill E. Volynski, Dimitri M. Kullmann, Sara Wells, Lydia Teboul

Subjects: Get full text

Horizontal Gene Transfer, Dispersal and Haloarchaeal Speciation by R. Thane Papke, Paulina Corral, Nikhil Ram-Mohan, Rafael R. de la Haba, Cristina Sánchez-Porro, Andrea Makkay, Antonio Ventosa

Subjects: Get full text

Older age should not be a barrier to testing for somatic variants in homologous recombination DNA repair-related genes in patients with high-grade serous ovarian carcinoma by Omali Pitiyarachchi, Yeh Chen Lee, Hao-Wen Sim, Sivatharsny Srirangan, Cristina Mapagu, Judy Kirk, Paul R. Harnett, Rosemary L. Balleine, David D.L. Bowtell, Goli Samimi, Alison H. Brand, Deborah J. Marsh, Philip Beale, Lyndal Anderson, Natalie Bouantoun, Pamela Provan, Susan J. Ramus, Anna DeFazio, Michael Friedlander

“…Background: Somatic pathogenic variants (PVs) in homologous recombination DNA repair (HR)-related genes found in high-grade serous ovarian carcinomas (HGSC) are not well-characterised in older patients (≥70 years). …”
Get full text

ATR-binding lncRNA ScaRNA2 promotes cancer resistance through facilitating efficient DNA end resection during homologous recombination repair by Yuanyuan Chen, Hui Shen, Tingting Liu, Kun Cao, Zhijie Wan, Zhipeng Du, Hang Wang, Yue Yu, Shengzhe Ma, Edward Lu, Wei Zhang, Jianming Cai, Fu Gao, Yanyong Yang

“…Results ScaRNA2 was identified as the most enriched ATR-binding lncRNA and was found to be essential for homologous recombination (HR) mediated DNA damage repair. Furthermore, scaRNA2 knockdown abrogated the recruitment of ATR and its substrates in response to DNA damage. …”
Get full text

Genetic and pathogenic characterizations of a naturally occurring reassortant and homologous recombinant strain of the classical infectious bursal disease virus re-emerging in chickens in southern China by Weiwei Wang, Jun Shi, Yan Zhang, Yuanzheng Qiao, Wenbo Zuo, Zhiyuan Wang, Tingbin Nong, Shichen Hu, Yang Chen, Ruiyang Kong, Xiumiao He, Ping Wei

Get full text

A Novel Non-Allelic Homologous Recombination Event in a Parent with an 11;22 Reciprocal Translocation Leading to 22q11.2 Deletion Syndrome by Steven Pastor, Oanh Tran, Daniel E. McGinn, T. Blaine Crowley, Elaine H. Zackai, Donna M. McDonald-McGinn, Beverly S. Emanuel

“…Most individuals with 22q11.2 deletion syndrome (22q11.2DS) carry a de novo, hemizygous deletion approximately 3 Mbp in size occurring by non-allelic homologous recombination (NAHR) mediated by the LCR22s. The ability to fully delineate an individual’s 22q11.2 regional structure will likely be important for studies designed to assess an unaffected individual’s risk for generating rearrangements in germ cells, potentially leading to offspring with 22q11.2DS. …”
Get full text

Markerless bacterial artificial chromosome manipulation method by red proteins of phage λ mediated homologous recombination utilizing fluorescent proteins for both positive and counter selection by Tomoki Yoshikawa, Masayasu Misu, Takeshi Kurosu, Yuki Takamatsu, Satoko Sugimoto, Masayuki Shimojima, Hideki Ebihara, Masayuki Saijo

Get full text

Alterations in Homologous Recombination-Related Genes and Distinct Platinum Response in Metastatic Triple-Negative Breast Cancers: A Subgroup Analysis of the ProfiLER-01 Trial by Elise Bonnet, Véronique Haddad, Stanislas Quesada, Kim-Arthur Baffert, Audrey Lardy-Cléaud, Isabelle Treilleux, Daniel Pissaloux, Valéry Attignon, Qing Wang, Adrien Buisson, Pierre-Etienne Heudel, Thomas Bachelot, Armelle Dufresne, Lauriane Eberst, Philippe Toussaint, Valérie Bonadona, Christine Lasset, Alain Viari, Emilie Sohier, Sandrine Paindavoine, Valérie Combaret, David Pérol, Isabelle Ray-Coquard, Jean-Yves Blay, Olivier Trédan

Subjects: Get full text

A Homologous Recombination System to Generate Epitope-Tagged Target Genes in <i>Chaetomium thermophilum</i>: A Genetic Approach to Investigate Native Thermostable Proteins by Nikola Kellner, Sabine Griesel, Ed Hurt

Subjects: “…homologous recombination (HR)…”
Get full text

The Largest Chinese Cohort Study Indicates Homologous Recombination Pathway Gene Mutations as Another Major Genetic Risk Factor for Colorectal Cancer with Heterogeneous Clinical Phenotypes by Yun Xu, Kai Liu, Cong Li, Minghan Li, Fangqi Liu, Xiaoyan Zhou, Menghong Sun, Megha Ranganathan, Liying Zhang, Sheng Wang, Xin Hu, Ye Xu

“…Mismatch repair gene mutation was identified in 9.1% of patients, most prevalent across all high-risk groups. Homologous recombination (HR) gene mutations were detected in 6.5% of cases, penetrated in early-onset and extra-colonic cancer risk groups. …”
Get full text

Functional Homologous Recombination (HR) Screening Shows the Majority of <i>BRCA1/2</i>-Mutant Breast and Ovarian Cancer Cell Lines Are HR-Proficient by Titia G. Meijer, John W. M. Martens, Wendy J. C. Prager-van der Smissen, Nicole S. Verkaik, Corine M. Beaufort, Stanley van Herk, Teresa Robert-Finestra, Remco M. Hoogenboezem, Kirsten Ruigrok-Ritstier, Maarten W. Paul, Joost Gribnau, Eric M. J. Bindels, Roland Kanaar, Agnes Jager, Dik C. van Gent, Antoinette Hollestelle

Subjects: “…homologous recombination repair…”
Get full text