-
481
A suite of modular, all-synthetic suicide vectors for allelic exchange mutagenesis in multidrug resistant Acinetobacter strains
Published 2023-05-01Subjects: Get full text
Article -
482
-
483
RAD51AP1 and RAD54L Can Underpin Two Distinct RAD51-Dependent Routes of DNA Damage Repair via Homologous Recombination
Published 2022-05-01Subjects: “…homologous recombination…”
Get full text
Article -
484
Transforming Growth Factor Beta and Epithelial to Mesenchymal Transition Alter Homologous Recombination Repair Gene Expression and Sensitize BRCA Wild-Type Ovarian Cancer Cells to Olaparib
Published 2023-08-01“…We found that TGFβ and EMT resulted in the downregulation of genes responsible for homologous recombination (HR) and sensitized cells to olaparib. …”
Get full text
Article -
485
Improved detection of homologous recombination deficiency in Chinese patients with ovarian cancer: a novel non‐exonic single‐nucleotide polymorphism‐based next‐generation sequencing panel
Published 2023-08-01“…As homologous recombination deficiency (HRD) is a biomarker to predict the efficiency of PARP inhibitor treatment, this study developed a non‐exonic single‐nucleotide polymorphism (SNP)‐based targeted next‐generation sequencing panel and comprehensively examined it both on standard and clinical ovarian cancer tissues. …”
Get full text
Article -
486
-
487
Homologous recombination mRNAs (RAD21, RAD50 and BARD1) have a potentially poor prognostic role in ERBB2-low bladder cancer patients
Published 2023-07-01“…This overexpression of the homologous recombination repair transcripts was associated with poor outcome in ERBB2-low tumors, not in ERBB2-high tumors. …”
Get full text
Article -
488
-
489
Single-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination.
Published 2013-01-01“…Structural analyses of such re-replication induced gene amplifications (RRIGA) suggested that RRIGA could provide a new mechanism for generating copy number variation by non-allelic homologous recombination (NAHR). Here we elucidate this new mechanism and provide insight into why it is so efficient. …”
Get full text
Article -
490
Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks
Published 2023“…DSB-Spectrum reporters distinguish between DSB-repair by error-free canonical non-homologous end-joining (c-NHEJ) versus homologous recombination (HR; reporter 1), mutagenic repair versus HR (reporter 2), and mutagenic end-joining versus single strand annealing (SSA) versus HR (reporter 3). …”
Get full text
Article -
491
Circulating Tumor DNA from Ascites as an alternative to tumor sampling for genomic profiling in ovarian cancer patients
Published 2023-10-01Subjects: Get full text
Article -
492
Effect of a Defective Clamp Loader Complex of DNA Polymerase III on Growth and SOS Response in <i>Pseudomonas aeruginosa</i>
Published 2022-02-01Subjects: Get full text
Article -
493
-
494
Structural Insight into the Mechanism of PALB2 Interaction with MRG15
Published 2021-12-01Subjects: Get full text
Article -
495
Biomarker-driven drug repurposing on biologically similar cancers with DNA-repair deficiencies
Published 2022-12-01Subjects: Get full text
Article -
496
-
497
Karyopherin α-2 Mediates MDC1 Nuclear Import through a Functional Nuclear Localization Signal in the tBRCT Domain of MDC1
Published 2020-04-01Subjects: Get full text
Article -
498
PARP Inhibitors for Breast Cancer: Germline <em>BRCA1/2</em> and Beyond
Published 2022-09-01Subjects: Get full text
Article -
499
Suppression of <i>SHROOM1</i> Improves In Vitro and In Vivo Gene Integration by Promoting Homology-Directed Repair
Published 2020-08-01Subjects: “…homologous recombination…”
Get full text
Article -
500
Partial Reduction in <i>BRCA1</i> Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance
Published 2022-11-01Subjects: Get full text
Article