A suite of modular, all-synthetic suicide vectors for allelic exchange mutagenesis in multidrug resistant Acinetobacter strains by Alaska Pokhrel, Liping Li, Francesca L. Short, Ian T. Paulsen

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Efficient traceless modification of the P1 bacteriophage genome through homologous recombination with enrichment in double recombinants: A new perspective on the functional annotation of uncharacterized phage genes by Agnieszka Bednarek, Katarzyna Giermasińska-Buczek, Małgorzata Łobocka

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RAD51AP1 and RAD54L Can Underpin Two Distinct RAD51-Dependent Routes of DNA Damage Repair via Homologous Recombination by Platon Selemenakis, Platon Selemenakis, Neelam Sharma, Mollie E. Uhrig, Jeffrey Katz, Youngho Kwon, Patrick Sung, Claudia Wiese

Subjects: “…homologous recombination…”
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Transforming Growth Factor Beta and Epithelial to Mesenchymal Transition Alter Homologous Recombination Repair Gene Expression and Sensitize BRCA Wild-Type Ovarian Cancer Cells to Olaparib by Cai M. Roberts, Mehida Rojas-Alexandre, Ruth E. Hanna, Z. Ping Lin, Elena S. Ratner

“…We found that TGFβ and EMT resulted in the downregulation of genes responsible for homologous recombination (HR) and sensitized cells to olaparib. …”
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Improved detection of homologous recombination deficiency in Chinese patients with ovarian cancer: a novel non‐exonic single‐nucleotide polymorphism‐based next‐generation sequencing panel by Bing Wei, Jinxiang Zheng, Cai Jiang, He Zhang, Mingye Zhang, Taoran Cheng, Jun Li, Zhizhong Wang, Lijun Deng, Li Wang, Qingxin Xia, Jie Ma

“…As homologous recombination deficiency (HRD) is a biomarker to predict the efficiency of PARP inhibitor treatment, this study developed a non‐exonic single‐nucleotide polymorphism (SNP)‐based targeted next‐generation sequencing panel and comprehensively examined it both on standard and clinical ovarian cancer tissues. …”
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Relationship between polymorphisms in homologous recombination repair genes RAD51 G172T、XRCC2 & XRCC3 and risk of breast cancer: A meta-analysis by Jiayang Yu, Chun-Guang Wang

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Homologous recombination mRNAs (RAD21, RAD50 and BARD1) have a potentially poor prognostic role in ERBB2-low bladder cancer patients by Nada Albarakati, Hanin Al-Ghamdi, Batla Al-Sowayan, Alaa Alshareeda

“…This overexpression of the homologous recombination repair transcripts was associated with poor outcome in ERBB2-low tumors, not in ERBB2-high tumors. …”
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Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks by Bert van de Kooij, Alex Kruswick, Haico van Attikum, Michael B. Yaffe

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Single-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination. by Kenneth J Finn, Joachim J Li

“…Structural analyses of such re-replication induced gene amplifications (RRIGA) suggested that RRIGA could provide a new mechanism for generating copy number variation by non-allelic homologous recombination (NAHR). Here we elucidate this new mechanism and provide insight into why it is so efficient. …”
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Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks by van de Kooij, Bert, Kruswick, Alex, van Attikum, Haico, Yaffe, Michael B

“…DSB-Spectrum reporters distinguish between DSB-repair by error-free canonical non-homologous end-joining (c-NHEJ) versus homologous recombination (HR; reporter 1), mutagenic repair versus HR (reporter 2), and mutagenic end-joining versus single strand annealing (SSA) versus HR (reporter 3). …”
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Circulating Tumor DNA from Ascites as an alternative to tumor sampling for genomic profiling in ovarian cancer patients by Maria Kfoury, Reda El Hazzaz, Claire Sanson, Felix Blanc Durand, Judith Michels, Emeline Colomba Blameble, Roseline Tang, Audrey Le Formal, Elodie Lecerf, Sebastien Gouy, Amandine Maulard, Patricia Pautier, Etienne Rouleau, Alexandra Leary

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Effect of a Defective Clamp Loader Complex of DNA Polymerase III on Growth and SOS Response in <i>Pseudomonas aeruginosa</i> by Maria Concetta Spinnato, Alessandra Lo Sciuto, Jessica Mercolino, Massimiliano Lucidi, Livia Leoni, Giordano Rampioni, Paolo Visca, Francesco Imperi

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Characterisation of Ovarian Cancer Cell Line NIH-OVCAR3 and Implications of Genomic, Transcriptomic, Proteomic and Functional DNA Damage Response Biomarkers for Therapeutic Targeti... by Alice Bradbury, Rachel O’Donnell, Yvette Drew, Nicola J. Curtin, Sweta Sharma Saha

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Structural Insight into the Mechanism of PALB2 Interaction with MRG15 by Jennifer Redington, Jaigeeth Deveryshetty, Lakshmi Kanikkannan, Ian Miller, Sergey Korolev

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Biomarker-driven drug repurposing on biologically similar cancers with DNA-repair deficiencies by Seeya Awadhut Munj, Tasnimul Alam Taz, Suzan Arslanturk, Elisabeth I. Heath, Elisabeth I. Heath

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Extrachromosomal Circular DNA from TCGA Tumors Is Generated from Common Genomic Loci, Is Characterized by Self-Homology and DNA Motifs near Circle Breakpoints by Philip D. Tatman, Joshua C. Black

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Karyopherin α-2 Mediates MDC1 Nuclear Import through a Functional Nuclear Localization Signal in the tBRCT Domain of MDC1 by Kamalakannan Radhakrishnan, Seon-Joo Park, Seok Won Kim, Gurusamy Hariharasudhan, Seo-Yeon Jeong, In Youb Chang, Jung-Hee Lee

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PARP Inhibitors for Breast Cancer: Germline <em>BRCA1/2</em> and Beyond by Maria Clara Saad Menezes, Farah Raheem, Lida Mina, Brenda Ernst, Felipe Batalini

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Suppression of <i>SHROOM1</i> Improves In Vitro and In Vivo Gene Integration by Promoting Homology-Directed Repair by Zhihua Zhao, Hanshuo Zhang, Tuanlin Xiong, Junyi Wang, Di Yang, Dan Zhu, Juan Li, Ye Yang, Changhong Sun, Yuting Zhao, Jianzhong Jeff Xi

Subjects: “…homologous recombination…”
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Partial Reduction in <i>BRCA1</i> Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance by Sandra Classen, Elena Rahlf, Johannes Jungwirth, Nina Albers, Luca Philipp Hebestreit, Alexandra Zielinski, Lena Poole, Marco Groth, Philipp Koch, Thomas Liehr, Stefanie Kankel, Nils Cordes, Cordula Petersen, Kai Rothkamm, Helmut Pospiech, Kerstin Borgmann

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