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781
A novel computational method identifies intra- and inter-species recombination events in Staphylococcus aureus and Streptococcus pneumoniae.
Published 2012-01-01“…Comparative sequence analysis frequently reveals evidences of homologous recombination occurring with different mechanisms and rates in different species, but the large-scale use of computational methods to identify recombination events is hampered by their high computational costs. …”
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Article -
782
Targeted recombination of homologous chromosomes using CRISPR‐Cas9
Published 2023-09-01“…Taken together, we suggest that targeted homologous recombination by CRISPR targeting may have specific genetic applications, such as generation of allelic combinations or chromosomal variations.…”
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Article -
783
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication
Published 2020“…The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA double-strand break (DSB) repair by homologous recombination and protects DNA replication forks from attrition. …”
Journal article -
784
How G4 ligands enhance the innate immune response in BRCA1/2- deficient cells and tumours
Published 2020“…The stabilisation of G-quadruplexes causes replication fork stalling resulting in DNA damage accumulation and subsequent activation of DNA damage repair pathways such as homologous recombination (Rodriguez et al., 2012). However, tumours lacking BRCA1 and BRCA2 expression, and consequently abrogation of homologous recombination, will accumulate this damage and will therefore be killed more efficiently. …”
Thesis -
785
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer.
Published 2017“…Emerging data demonstrate homologous recombination (HR) defects in castration-resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. …”
Journal article -
786
Fission yeast Cut8 is required for the repair of DNA double-strand breaks, ribosomal DNA maintenance, and cell survival in the absence of Rqh1 helicase.
Published 2007“…Here, we show that rad3 rqh1 mutants are normally committed to a lethal pathway of DNA repair requiring homologous recombination, but blocking this pathway by Rhp51 inactivation restores viability. …”
Journal article -
787
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin
Published 2022“…Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound state. …”
Journal article -
788
The role of DNA polymerase eta in determining cellular responses to chemo-radiation treatment
Published 2013“…These findings suggest that homologous recombination mediates S phase-dependent radioresistance associated with pol η-deficiency.…”
Thesis -
789
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790
Optimization of designing multiple genes encoding the same protein based on NSGA-II for efficient execution on GPUs
Published 2023-07-01“…In order to augment expression levels, we need to focus on both homologous recombination and codon adaptation, which are estimated by three objective functions, namely HD (Hamming distance), LRCS (length of repeated or common substring) and CAI (codon adaptation index). …”
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Article -
791
A Proximity Ligation Method to Detect Proteins Bound to Single-Stranded DNA after DNA End Resection at DNA Double-Strand Breaks
Published 2021-12-01“…After a DNA double-strand break, cells utilize either non-homologous end joining or homologous recombination to repair the broken DNA ends. Homologous recombination requires extensive nucleolytic processing of one of the DNA strands, resulting in long stretches of 3′ single-strand DNA overhangs. …”
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Article -
792
Evidence for a Xer/dif system for chromosome resolution in archaea.
Published 2010-10-01“…Homologous recombination events between circular chromosomes, occurring during or after replication, can generate dimers that need to be converted to monomers prior to their segregation at cell division. …”
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Article -
793
Use of an on/off tetracycline riboswitch to control protein production in Komagataella phaffii
Published 2023-11-01“…This protein is involved in non-homologous recombination and the control of its production paves the way for the development of strains exhibiting higher rates of homologous recombination.…”
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Article -
794
Investigating genomic instability features in hereditary cancers
Published 2020“…DNA damage causing double stranded breaks (DSBs) are efficiently repaired via non homologous end joining (NHEJ) or Homologous recombination (HR). Our focus is on mechanisms of damage response proteins, RAD51C and BRCA1 in HR, an error free repair that involves resolution of holiday junctions at sites of homologous recombination exchange of DNA. …”
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Final Year Project (FYP) -
795
Germline mutations in PALB2, BRCA1, and RAD51C, which regulate DNA recombination repair, in patients with gastric cancer
Published 2016“…Tumors that developed in patients with these mutations had a mutation signature associated with somatic homologous recombination deficiency. Our findings indicate that defects in homologous recombination increase risk for gastric cancer.…”
Journal article -
796
Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation.
Published 2012“…Chk1 phosphorylation was used to indicate ATR activity, γH2AX and 53BP1 foci as evidence of DNA damage and Rad51 foci for homologous recombination activity. Sensitivity to radiation (XRT) and gemcitabine was measured with clonogenic assays in vitro and tumor growth delay in vivo. …”
Journal article -
797
Structural maintenance of chromosomes (SMC) proteins promote homolog-independent recombination repair in meiosis crucial for germ cell genomic stability.
Published 2010-07-01“…In meiosis, programmed DNA breaks repaired by homologous recombination (HR) can be processed into inter-homolog crossovers that promote the accurate segregation of chromosomes. …”
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Article -
798
Rdh54 stabilizes Rad51 at displacement loop intermediates to regulate genetic exchange between chromosomes.
Published 2022-09-01“…Homologous recombination (HR) is a double-strand break DNA repair pathway that preserves chromosome structure. …”
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799
Expanding the Use of PARP Inhibitors as Monotherapy and in Combination in Triple-Negative Breast Cancer
Published 2021-12-01“…To better identify a patient subpopulation that will best respond to PARPi, several genomic biomarkers of homologous recombination deficiency have been tested. However, gene expression signatures associated with PARPi response can integrate different pathways in addition to homologous recombination deficiency and can be implemented in the clinic more readily. …”
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Article -
800
Role of Olaparib in the Management of Metastatic Castration-Resistant Prostate Cancer: A Japanese Clinician’s Perspective
Published 2022-08-01“…Genomic alterations in genes involved in DNA damage repair by homologous recombination repair may predict increased sensitivity to poly-ADP ribose polymerase (PARP) inhibitors. …”
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