High frequency of phenotypic deviations in <it>Physcomitrella patens</it> plants transformed with a gene-disruption library by Schulte Julia, Schlink Katja, Rensing Stefan A, Lucht Jan M, Holtorf Hauke, Hohe Annette, Guitton Marie-Christine, Granado José, Egener Tanja, Schween Gabriele, Zimmermann Susanne, Duwenig Elke, Rak Bodo, Reski Ralf

“…The resulting gene-disruption library was then used to transform Physcomitrella. Homologous recombination of the mutagenised cDNA with genomic coding sequences is expected to target insertion events preferentially to expressed genes. …”
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The Inability to Disassemble Rad51 Nucleoprotein Filaments Leads to Aberrant Mitosis and Cell Death by Tadas Andriuskevicius, Anton Dubenko, Svetlana Makovets

“…Homologous recombination relies on the formation of Rad51 nucleoprotein filaments which are responsible for the homology-based interactions between DNA strands. …”
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Shuffling the yeast genome using CRISPR/Cas9-generated DSBs that target the transposable Ty1 elements. by Lei Qi, Yang Sui, Xing-Xing Tang, Ryan J McGinty, Xiao-Zhuan Liang, Margaret Dominska, Ke Zhang, Sergei M Mirkin, Dao-Qiong Zheng, Thomas D Petes

“…Although homologous recombination between transposable elements can drive genomic evolution in yeast by facilitating chromosomal rearrangements, the details of the underlying mechanisms are not fully clarified. …”
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DMC1 attenuates RAD51-mediated recombination in Arabidopsis. by Olivier Da Ines, Jeanne Bazile, Maria E Gallego, Charles I White

“…DMC1 is meiosis-specific, while RAD51 is essential for both mitotic and meiotic homologous recombination. DMC1 is the main catalytically active strand-exchange protein during meiosis, while this activity of RAD51 is downregulated. …”
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Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes by Ward, T, McHugh, P, Durant, S

“…Furthermore, RAD51 foci accumulate as a consequence of FEN1 inhibition and the toxicity of FEN1 inhibitors increases in cells disrupted for the homologous recombination pathway, suggesting a role for homologous recombination in the resolution of damage induced by FEN1 inhibition. …”

DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phase. by Barber, L, Ward, T, Hartley, J, McHugh, P

“…Significantly, our analysis of ICL repair in cells synchronized for each cell cycle phase has revealed that homologous recombination does not play a major role in the direct repair of ICLs, even in G2, when a suitable template is readily available. …”

How clonal is Staphylococcus aureus? by Feil, E, Cooper, J, Grundmann, H, Robinson, D, Enright, M, Berendt, T, Peacock, S, Smith, J, Murphy, M, Spratt, BG, Moore, C, Day, N

“…However, phylogenetic analysis suggests that homologous recombination does contribute toward the evolution of this species over the long term. …”

PARP inhibitors in the treatment of metastatic breast cancer patients with germline BRCA1/2 mutations. Experience of treatment with talazoparib in clinical practice by M. A. Frolova, E. V. Glazkova, M. B. Stenina

“…BRCA1/2 proteins are involved in homologous recombination - DNA double-strand break repair mechanism. …”
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Synergistic Effect of Simultaneous versus Sequential Combined Treatment of Histone Deacetylase Inhibitor Valproic Acid with Etoposide on Melanoma Cells by Yueh-Ming Shyu, Lawrence Yu-Min Liu, Yung-Jen Chuang

“…Surprisingly, the enhanced homologous recombination activity and G2/M phase arrest resulted in the antagonistic effect in both cells under VPA pretreated sequential combined treatment. …”
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Integrative pan-cancer landscape of MMS22L and its potential role in hepatocellular carcinoma by Zhiting Guo, Fahui Liu, Qiming Gong

“…Methyl methanesulfonate-sensitivity protein 22-like (MMS22L) is crucial in protecting genome integrity during DNA replication by preventing DNA damage and maintaining efficient homologous recombination. However, the role of MMS22L in human cancers remains unclear. …”
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Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1 by Alice M Budden, Murat Eravci, Adam T Watson, Eduard Campillo-Funollet, Antony W Oliver, Karel Naiman, Antony M Carr

“…Arrested replication forks, when restarted by homologous recombination, result in error-prone DNA syntheses and non-allelic homologous recombination. …”
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Capripoxviruses, leporipoxviruses, and orthopoxviruses: Occurrences of recombination by Alexander Sprygin, Ali Mazloum, Antoinette van Schalkwyk, Shawn Babiuk

“…Orthopoxvirus replication is intimately tethered to high frequencies of homologous recombination between co-infecting viruses, duplicated sequences of the same virus, and plasmid DNA transfected into poxvirus-infected cells. …”
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Current trends and risks associated with the use of therapies based on genome editing by O. A. Rachinskaya, E. V. Melnikova, V. A. Merkulov

“…To date, multiple approaches to genome editing have been developed based on different genome-editing systems (GESs) and genome modifications that result in single- or double-strand DNA breaks, either in vivo or ex vivo, followed by homologous recombination or non-homologous end joining to restore the sequence. …”
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Genetic Engineering by DNA Recombineering by Papa, Louis John, Shoulders, Matthew D.

“…Recombineering inserts PCR products into DNA using homologous recombination. A pair of short homology arms (50 base pairs) on the ends of a PCR cassette target the cassette to its intended location. …”
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The Complexity and Diversity of the Pathogenicity Locus in Clostridium difficile Clade 5. by Elliott, B, Dingle, K, Didelot, X, Crook, D, Riley, T

“…Although the exact mechanism of each PaLoc acquisition is unclear, evidence of possible homologous recombination with other clades and between clade 5 lineages was found within the PaLoc and adjacent regions. …”

Evolutionary history of the Clostridium difficile pathogenicity locus. by Dingle, K, Elliott, B, Robinson, E, Griffiths, D, Eyre, D, Stoesser, N, Vaughan, A, Golubchik, T, Fawley, W, Wilcox, M, Peto, T, Walker, A, Riley, T, Crook, D, Didelot, X

“…Exchanges and losses of the PaLoc DNA have also occurred, via long homologous recombination events involving flanking chromosomal sequences. …”

Targeting BRCA2 deficiency with GSK3 inhibitors by Zonderland, G

“…<p>BRCA1 and BRCA2 tumour suppressors are essential for homologous recombination-mediated double-strand break repair and replication fork protection. …”

The repertoire of minimal mobile elements in the Neisseria species and evidence that these are involved in horizontal gene transfer in other bacteria. by Snyder, L, McGowan, S, Rogers, M, Duro, E, O'Farrell, E, Saunders, N

“…In the Neisseria spp., natural competence for transformation and homologous recombination generate antigenic variants through creation of mosaic genes (such as opas) and through recombination with silent cassettes (such as pilE/pilS) and gene-complement diversity through the horizontal exchange of whole genes or groups of genes, in minimal mobile elements (MMEs). …”

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer by Yeow, ZY, Lambrus, B, Marlow, R, Zhan, K, Durin, M-A, Evans, L, Scott, P, Phan, T, Park, E, Ruiz, L, Moralli, D, Knight, E, Badder, L, Novo, D, Haider, S, Green, C, Tutt, A, Lord, C, Chapman, J, Holland, A

“…The success of poly-ADP ribose polymerase inhibitors in the treatment of breast cancers that are deficient in homologous recombination exemplifies the utility of synthetically lethal genetic interactions in the treatment of breast cancers that are driven by genomic instability3. …”

Impairment of cell division of Trypanosoma cruzi epimastigotes by Michele A Zacks

“…The mechanisms that facilitate the adaptation of Trypanosoma cruzi to two distinct hosts, insect and vertebrate, are poorly understood, in part due to the limited ability to perform gene disruption studies by homologous recombination. This report describes a developmentally-defective phenotype that resulted from integration of a drug marker adjacent to the GAPDH gene in T. cruzi.…”
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