Never tear us a-PARP: Dealing with DNA lesions during mitosis by Pepijn M. Schoonen, Marcel A.T.M. van Vugt

“…Tumors defective in homologous recombination (HR) are highly sensitive to poly ADP-ribose polymerase (PARP) inhibition, however the cell biological mechanisms underlying this synthetic lethality remain elusive. …”
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RAD51 wrestles with SUMO by Younghoon Kee, Jung-Hee Lee, Ho Jin You

“…RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. …”
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Epigenomic Analysis of RAD51 ChIP-seq Data Reveals <i>cis</i>-regulatory Elements Associated with Autophagy in Cancer Cell Lines by Keunsoo Kang, Yoonjung Choi, Hyeonjin Moon, Chaelin You, Minjin Seo, Geunho Kwon, Jahyun Yun, Boram Beck, Kyuho Kang

“…RAD51 is a recombinase that plays a pivotal role in homologous recombination. Although the role of RAD51 in homologous recombination has been extensively studied, it is unclear whether RAD51 can be involved in gene regulation as a co-factor. …”
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The cost-effectiveness analysis of maintenance olaparib plus Bevacizumab in patients with advanced ovarian cancer: based on the final survival results from PAOLA-1 trial by Youwen Zhu, Kun Liu, Hui Cao, Hong Zhu

“…In light of these new data, the present study was conducted with the goal of evaluating the cost-effectiveness of olaparib plus bevacizumab for the treatment of the overall AOC patient population and for homologous recombination deficiency (HRD)-positive patients, patients with a breast cancer susceptibility gene (BRCA) mutations, homologous recombination proficiency (HRD)-positive, or patients not harboring BRCA mutations AOC from a US payers perspective. …”
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A BRCA2 germline mutation and high expression of immune checkpoints in a TNBC patient by Yuyi Han, Valentina Rovella, Artem Smirnov, Oreste Claudio Buonomo, Alessandro Mauriello, Tommaso Perretta, Yufang Shi, Jonathan Woodmsith, Julia Bischof, TOR CENTRE, Gerry Melino, Eleonora Candi, Francesca Bernassola

“…The BRCA2, TP53, and BAP1 gene mutations are highly predictive of a defective homologous recombination repair system and subsequent chromosomal instability in this patient. …”
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Impact of PARP inhibitor maintenance therapy in newly diagnosed advanced epithelial ovarian cancer: A meta-analysis. by Banghyun Lee, Suk-Joon Chang, Byung Su Kwon, Joo-Hyuk Son, Myong Cheol Lim, Yun Hwan Kim, Shin-Wha Lee, Chel Hun Choi, Kyung Jin Eoh, Jung-Yun Lee, Dong Hoon Suh, Yong Beom Kim

“…Furthermore, patients in the PARPi group with the BRCA1/2 mutation (BRCAm), BRCA wild type, homologous-recombination deficiency (HRD), or HRD without BRCAm, but not with homologous-recombination proficiency had a significantly better two-year PFS than the patients in the placebo group. …”
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The potential role of DEK over-expression in the radiation response of head and neck cancer by Hui Xiao, Bismarck Odei, Steven K. Clinton, Darrion L. Mitchell

“…Methods: Control and DEK over-expressing keratinocytes and an HPV positive head and neck cancer cell line respectively were irradiated with 2–10 ​Gy and the impact on cell survival, γ-H2AX (a marker of DNA damage) and RAD51 (homologous recombination) were analyzed via clonogenic assays, and immunofluorescence measurements respectively. …”
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Evaluating the Genotoxic and Cytotoxic Effects of Thymidine Analogs, 5-Ethynyl-2′-Deoxyuridine and 5-Bromo-2′-Deoxyurdine to Mammalian Cells by Jeremy S. Haskins, Cathy Su, Junko Maeda, Kade D. Walsh, Alexis H. Haskins, Allison J. Allum, Coral E. Froning, Takamitsu A. Kato

“…Cells with defective homologous recombination repair displayed a greater growth delay and severe inhibition of clonogenicity with EdU compared to wild type and other DNA repair-deficient cells. …”
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Synthesis of the Genome of Bacteriophage N4 by G. Yu. Fisunov, T. A. Semashko, D. V. Evsyutina, E. A. Tsoy, D. R. Kharrasov, K. S. Gumayunova, I. V. Tuchkov, K. A. Nikiforov, D. A. Rybal’chenko, V. V. Kutyrev, V. M. Govorun

“…At the first stage, gene block cassettes of 5–7 pieces with sizes ranging from 7 to 10.5 thousand bp were generated via homologous recombination in yeast. The resulting cassettes were then amplified and used for in vitro assembly using 5’-3’ exonuclease and thermostable DNA polymerase. …”
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<i>pilE</i> G-Quadruplex Is Recognized and Preferentially Bound but Not Processed by the MutL Endonuclease from <i>Neisseria gonorrhoeae</i> Mismatch Repair Pathway by Viktoriia Yu. Savitskaya, Vadim V. Strekalovskikh, Viktoriia G. Snyga, Mayya V. Monakhova, Alexander M. Arutyunyan, Nina G. Dolinnaya, Elena A. Kubareva

“…The human pathogen <i>Neisseria gonorrhoeae</i> uses a homologous recombination to undergo antigenic variation and avoid an immune response. …”
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PARP Inhibitor Olaparib Causes No Potentiation of the Bleomycin Effect in VERO Cells, Even in the Presence of Pooled ATM, DNA-PK, and LigIV Inhibitors by Valentina Perini, Michelle Schacke, Pablo Liddle, Salomé Vilchez-Larrea, Deborah J. Keszenman, Laura Lafon-Hughes

“…On one hand, it is unknown whether any limiting factor of homologous recombination can be a synthetic PARP lethality partner. …”
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Role of PARP inhibitors beyond BRCA mutation and platinum sensitivity in epithelial ovarian cancer: a meta-analysis of hazard ratios from randomized clinical trials by Roli Purwar, Rakesh Ranjan, Manjusha Pal, Satyanshu K. Upadhyay, Tarun Kumar, Manoj Pandey

“…Abstract Background PARP inhibitors (PARPi) have a well-established role in platinum-sensitive ovarian cancer (PSOC), in BRCA mutant (BRCAm), and homologous recombination deficiency (HRD) population. However, their role in wild type and homologous recombination proficient population is still not clear. …”
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Genetic analysis : an integrated approach / by 531048 Sanders, Mark Frederick, Bowman, John L. 531049

UBQLN4 promotes non-homologous end joining by repressing DNA end-resection by Ron D. Jachimowicz, H. Christian Reinhardt

“…Ataxia-telangiectasia-mutated (ATM) promotes homologous recombination (HR)-mediated DNA double-strand break repair. …”
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No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine by Boni, M, Smith, G, Holmes, E, Vijaykrishna, D

“…Hao (2011) reported that the PB2 genes of three swine influenza A viruses were likely generated through homologous recombination between two closely related parental strains. …”

Recombination at mammalian telomeres: an alternative mechanism for telomere protection and elongation. by Tarsounas, M, West, S

“…In human cells, homologous recombination (HR) provides an accurate mechanism for the repair of DNA double-strand breaks caused by replication fork breakdown or DNA damaging agents. …”

RAD51: beyond the break by Wassing, IE, Esashi, F

“…As the primary catalyst of homologous recombination (HR) in vertebrates, RAD51 has been extensively studied in the context of repair of double-stranded DNA breaks (DSBs). …”

No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine. by Boni, M, Smith, G, Holmes, E, Vijaykrishna, D

“…Hao (2011) reported that the PB2 genes of three swine influenza A viruses were likely generated through homologous recombination between two closely related parental strains. …”

Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity by Elisa Gobbini, Jacopo Vertemara, Maria Pia Longhese

“…Homologous recombination is initiated by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs), which involves different nucleases including the Mre11-Rad50-Xrs2 (MRX) complex and the Exonuclease 1 (Exo1). …”
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CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway by Daniel Gómez-Cabello, George Pappas, Diana Aguilar-Morante, Christoffel Dinant, Jiri Bartek

“…This work shows that the interplay of RNAPII-generated nascent RNA, RNA:DNA hybrids and the resection factor CtIP guide DNA double strand break repair pathway choice towards error-free homologous recombination.…”
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