-
841
Never tear us a-PARP: Dealing with DNA lesions during mitosis
Published 2018-01-01“…Tumors defective in homologous recombination (HR) are highly sensitive to poly ADP-ribose polymerase (PARP) inhibition, however the cell biological mechanisms underlying this synthetic lethality remain elusive. …”
Get full text
Article -
842
RAD51 wrestles with SUMO
Published 2022-12-01“…RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. …”
Get full text
Article -
843
Epigenomic Analysis of RAD51 ChIP-seq Data Reveals <i>cis</i>-regulatory Elements Associated with Autophagy in Cancer Cell Lines
Published 2021-05-01“…RAD51 is a recombinase that plays a pivotal role in homologous recombination. Although the role of RAD51 in homologous recombination has been extensively studied, it is unclear whether RAD51 can be involved in gene regulation as a co-factor. …”
Get full text
Article -
844
The cost-effectiveness analysis of maintenance olaparib plus Bevacizumab in patients with advanced ovarian cancer: based on the final survival results from PAOLA-1 trial
Published 2023-08-01“…In light of these new data, the present study was conducted with the goal of evaluating the cost-effectiveness of olaparib plus bevacizumab for the treatment of the overall AOC patient population and for homologous recombination deficiency (HRD)-positive patients, patients with a breast cancer susceptibility gene (BRCA) mutations, homologous recombination proficiency (HRD)-positive, or patients not harboring BRCA mutations AOC from a US payers perspective. …”
Get full text
Article -
845
A BRCA2 germline mutation and high expression of immune checkpoints in a TNBC patient
Published 2023-10-01“…The BRCA2, TP53, and BAP1 gene mutations are highly predictive of a defective homologous recombination repair system and subsequent chromosomal instability in this patient. …”
Get full text
Article -
846
Impact of PARP inhibitor maintenance therapy in newly diagnosed advanced epithelial ovarian cancer: A meta-analysis.
Published 2023-01-01“…Furthermore, patients in the PARPi group with the BRCA1/2 mutation (BRCAm), BRCA wild type, homologous-recombination deficiency (HRD), or HRD without BRCAm, but not with homologous-recombination proficiency had a significantly better two-year PFS than the patients in the placebo group. …”
Get full text
Article -
847
The potential role of DEK over-expression in the radiation response of head and neck cancer
Published 2021-03-01“…Methods: Control and DEK over-expressing keratinocytes and an HPV positive head and neck cancer cell line respectively were irradiated with 2–10 Gy and the impact on cell survival, γ-H2AX (a marker of DNA damage) and RAD51 (homologous recombination) were analyzed via clonogenic assays, and immunofluorescence measurements respectively. …”
Get full text
Article -
848
Evaluating the Genotoxic and Cytotoxic Effects of Thymidine Analogs, 5-Ethynyl-2′-Deoxyuridine and 5-Bromo-2′-Deoxyurdine to Mammalian Cells
Published 2020-09-01“…Cells with defective homologous recombination repair displayed a greater growth delay and severe inhibition of clonogenicity with EdU compared to wild type and other DNA repair-deficient cells. …”
Get full text
Article -
849
Synthesis of the Genome of Bacteriophage N4
Published 2024-04-01“…At the first stage, gene block cassettes of 5–7 pieces with sizes ranging from 7 to 10.5 thousand bp were generated via homologous recombination in yeast. The resulting cassettes were then amplified and used for in vitro assembly using 5’-3’ exonuclease and thermostable DNA polymerase. …”
Get full text
Article -
850
<i>pilE</i> G-Quadruplex Is Recognized and Preferentially Bound but Not Processed by the MutL Endonuclease from <i>Neisseria gonorrhoeae</i> Mismatch Repair Pathway
Published 2023-03-01“…The human pathogen <i>Neisseria gonorrhoeae</i> uses a homologous recombination to undergo antigenic variation and avoid an immune response. …”
Get full text
Article -
851
PARP Inhibitor Olaparib Causes No Potentiation of the Bleomycin Effect in VERO Cells, Even in the Presence of Pooled ATM, DNA-PK, and LigIV Inhibitors
Published 2020-11-01“…On one hand, it is unknown whether any limiting factor of homologous recombination can be a synthetic PARP lethality partner. …”
Get full text
Article -
852
Role of PARP inhibitors beyond BRCA mutation and platinum sensitivity in epithelial ovarian cancer: a meta-analysis of hazard ratios from randomized clinical trials
Published 2023-05-01“…Abstract Background PARP inhibitors (PARPi) have a well-established role in platinum-sensitive ovarian cancer (PSOC), in BRCA mutant (BRCAm), and homologous recombination deficiency (HRD) population. However, their role in wild type and homologous recombination proficient population is still not clear. …”
Get full text
Article -
853
-
854
UBQLN4 promotes non-homologous end joining by repressing DNA end-resection
Published 2019-03-01“…Ataxia-telangiectasia-mutated (ATM) promotes homologous recombination (HR)-mediated DNA double-strand break repair. …”
Get full text
Article -
855
No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine
Published 2012“…Hao (2011) reported that the PB2 genes of three swine influenza A viruses were likely generated through homologous recombination between two closely related parental strains. …”
Journal article -
856
Recombination at mammalian telomeres: an alternative mechanism for telomere protection and elongation.
Published 2005“…In human cells, homologous recombination (HR) provides an accurate mechanism for the repair of DNA double-strand breaks caused by replication fork breakdown or DNA damaging agents. …”
Journal article -
857
RAD51: beyond the break
Published 2020“…As the primary catalyst of homologous recombination (HR) in vertebrates, RAD51 has been extensively studied in the context of repair of double-stranded DNA breaks (DSBs). …”
Journal article -
858
No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine.
Published 2012“…Hao (2011) reported that the PB2 genes of three swine influenza A viruses were likely generated through homologous recombination between two closely related parental strains. …”
Journal article -
859
Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity
Published 2018-09-01“…Homologous recombination is initiated by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs), which involves different nucleases including the Mre11-Rad50-Xrs2 (MRX) complex and the Exonuclease 1 (Exo1). …”
Get full text
Article -
860
CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway
Published 2022-09-01“…This work shows that the interplay of RNAPII-generated nascent RNA, RNA:DNA hybrids and the resection factor CtIP guide DNA double strand break repair pathway choice towards error-free homologous recombination.…”
Get full text
Article