Ovarian Cancer Immunotherapy and Personalized Medicine by Susan Morand, Monika Devanaboyina, Hannah Staats, Laura Stanbery, John Nemunaitis

“…These markers include tumor mutation burden, PD-L1, tumor-infiltrating lymphocytes, homologous recombination deficiency, and neoantigen intratumoral heterogeneity. …”
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BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling by Julius Rabl

“…BRCA1-A is recruited to DNA repair <i>foci</i>, edits ubiquitin signals on chromatin, and sequesters BRCA1 away from the site of damage, suppressing homologous recombination by limiting resection. BRISC forms a complex with metabolic enzyme SHMT2 and regulates the immune response, mitosis, and hematopoiesis. …”
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Disparity in the era of personalized medicine for epithelial ovarian cancer by Michael-John Devlin, Rowan E. Miller

“…The treatment of high-grade serous ovarian cancer and high-grade endometrioid ovarian cancer has seen significant improvements in recent years, with BRCA1/2 and homologous recombination status guiding a personalized approach which has resulted in improved patient outcomes. …”
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Chromatin diminution as a tool to study some biological problems by Andrey Grishanin

“…A hypothesis suggesting the role of non-coding DNA in homologous recombination in eukaryotes is proposed. Cyclops kolensis Lilljeborg, 1901 (Copepoda, Crustacea) is proposed as a model species for studying the mechanisms of transformation of the chromosomes and interphase nuclei structure of somatic line cells due to chromatin diminution. …”
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Development of PARP inhibitors in advanced prostate cancer by Maria Teresa Bourlon, Paola Valdez, Elena Castro

“…The relatively high prevalence of alterations in the homologous recombination repair (HRR) pathway described in advanced prostate cancer provides a unique opportunity to develop therapeutic strategies that take advantage of the decreased tumor ability to repair DNA damage. …”
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Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs by Roopa Thapar

“…Eukaryotes have evolved two major pathways, namely homologous recombination (HR) and non-homologous end joining (NHEJ) to repair DSBs. …”
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SUMO-mediated recruitment allows timely function of the Yen1 nuclease in mitotic cells. by Hugo Dorison, Ibtissam Talhaoui, Gerard Mazón

“…Yen1 plays a critical role in ensuring genome stability and unperturbed chromosome segregation by removing covalently linked DNA intermediates between sister chromatids that are formed by homologous recombination. Here we show how this important role of Yen1 depends on interactions mediated by non-covalent binding to SUMOylated partners. …”
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Playing the end game: DNA double-strand break repair pathway choice. by Chapman, R, Taylor, MR, Boulton, S

“…To preserve genome integrity, organisms have evolved several DSB repair mechanisms, of which nonhomologous end-joining (NHEJ) and homologous recombination (HR) represent the two most prominent. …”

The atspo11-1 mutation rescues atxrcc3 meiotic chromosome fragmentation. by Bleuyard, J, Gallego, M, White, C

“…Homologous recombination events occurring during meiotic prophase I ensure the proper segregation of homologous chromosomes at the first meiotic division. …”

DNA double-strand break repair pathways, chromosomal rearrangements and cancer. by Kasparek, T, Humphrey, T

“…Here we review the mechanisms by which non-homologous end joining (NHEJ) and homologous recombination (HR) repair pathways can both promote chromosomal rearrangements and also suppress them in response to such lesions, in accordance with their increasingly recognised tumour suppressor function. …”

p97/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response. by Ramadan, K

“…This newly identified pathway is essential to spatiotemporal protein turnover and regulates both main branches of DSB repair, homologous recombination and nonhomologous end joining. In this report, the function of the RNF8/Lys48 polyubiquitin chains/p97 pathway is discussed in the context of DSB repair and p97 chromatin-related functions.…”

Dual role of CDKs in DNA repair: to be, or not to be. by Yata, K, Esashi, F

“…Interestingly, there is increasing evidence that the catalytic activities of CDKs play critical roles in the DNA damage response, especially in the case of damage repaired by the homologous recombination (HR) pathway. In this review, we outline current knowledge of CDK regulation and its roles both in the unperturbed cell cycle and in DNA damage responses, and discuss the physiological roles of CDKs in HR repair.…”

Impact of recombination on bacterial evolution. by Didelot, X, Maiden, M

“…Here we focus on genetic exchange that has involved homologous recombination and illustrate how nucleotide sequence data have furthered our understanding of: (i) the frequency of recombination; (ii) the impact of recombination in different parts of the genome; and (iii) patterns of gene flow within bacterial populations. …”

DNA damage signaling and repair in Dictyostelium discoideum. by Hsu, D, Gaudet, P, Hudson, J, Pears, C, Lakin, N

“…DNA DSBs can be repaired by either homologous recombination (HR) or nonhomologous end-joining (NHEJ). …”

A failure of meiotic chromosome segregation in a fbh1Delta mutant correlates with persistent Rad51-DNA associations. by Sun, W, Lorenz, A, Osman, F, Whitby, M

“…The F-box DNA helicase Fbh1 constrains homologous recombination in vegetative cells, most likely through an ability to displace the Rad51 recombinase from DNA. …”

The chromatin remodeller ATRX: a repeat offender in human disease. by Clynes, D, Higgs, D, Gibbons, R

“…Exciting recent developments suggest that ATRX plays a variety of key roles at tandem repeat sequences within the genome, including the deposition of a histone variant, prevention of replication fork stalling, and the suppression of a homologous recombination-based pathway of telomere maintenance. …”

Genetic Dissection of Budding Yeast PCNA Mutations Responsible for the Regulated Recruitment of Srs2 Helicase by Li Fan, Wenqing Zhang, Josephine Rybchuk, Yu Luo, Wei Xiao

“…IMPORTANCE It is known that budding yeast PCNA sumoylation serves as a ligand to recruit a DNA helicase Srs2 through its tandem receptor motifs that prevent unwanted homologous recombination (HR) at replication forks, a process known as salvage HR. …”
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Development of a stable eukaryotic strain producing fully human monoclonal antibody on the basis of the human antibody against ectromelia virus by A. L. Matveev, Ya. A. Khlusevich, I. K. Baykov, I. V.  Babkin, E. P. Goncharova, V. V. Morozova, N. V. Tikunova

“…Then, CHO­S/FRT cells, which contain the FRT­site for homologous recombination and are able to produce green fluorescence protein GFP, were transfected with the constructed plasmid. …”
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Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo by Thomas J Etheridge, Desiree Villahermosa, Eduard Campillo-Funollet, Alex David Herbert, Anja Irmisch, Adam T Watson, Hung Q Dang, Mark A Osborne, Antony W Oliver, Antony M Carr, Johanne M Murray

“…This is consistent with a downstream function for ssDNA binding in regulating homologous recombination.…”
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Structural and DNA end resection study of the bacterial NurA-HerA complex by Jieyu Yang, Yiyang Sun, Ying Wang, Wanshan Hao, Kaiying Cheng

“…Abstract Background The nuclease NurA and the ATPase/translocase HerA play a vital role in repair of double-strand breaks (DSB) during the homologous recombination in archaea. A NurA-HerA complex is known to mediate DSB DNA end resection, leading to formation of a free 3′ end used to search for the homologous sequence. …”
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