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881
Ovarian Cancer Immunotherapy and Personalized Medicine
Published 2021-06-01“…These markers include tumor mutation burden, PD-L1, tumor-infiltrating lymphocytes, homologous recombination deficiency, and neoantigen intratumoral heterogeneity. …”
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882
BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling
Published 2020-10-01“…BRCA1-A is recruited to DNA repair <i>foci</i>, edits ubiquitin signals on chromatin, and sequesters BRCA1 away from the site of damage, suppressing homologous recombination by limiting resection. BRISC forms a complex with metabolic enzyme SHMT2 and regulates the immune response, mitosis, and hematopoiesis. …”
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883
Disparity in the era of personalized medicine for epithelial ovarian cancer
Published 2023-01-01“…The treatment of high-grade serous ovarian cancer and high-grade endometrioid ovarian cancer has seen significant improvements in recent years, with BRCA1/2 and homologous recombination status guiding a personalized approach which has resulted in improved patient outcomes. …”
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884
Chromatin diminution as a tool to study some biological problems
Published 2024-02-01“…A hypothesis suggesting the role of non-coding DNA in homologous recombination in eukaryotes is proposed. Cyclops kolensis Lilljeborg, 1901 (Copepoda, Crustacea) is proposed as a model species for studying the mechanisms of transformation of the chromosomes and interphase nuclei structure of somatic line cells due to chromatin diminution. …”
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885
Development of PARP inhibitors in advanced prostate cancer
Published 2024-01-01“…The relatively high prevalence of alterations in the homologous recombination repair (HRR) pathway described in advanced prostate cancer provides a unique opportunity to develop therapeutic strategies that take advantage of the decreased tumor ability to repair DNA damage. …”
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886
Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs
Published 2018-10-01“…Eukaryotes have evolved two major pathways, namely homologous recombination (HR) and non-homologous end joining (NHEJ) to repair DSBs. …”
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887
SUMO-mediated recruitment allows timely function of the Yen1 nuclease in mitotic cells.
Published 2022-03-01“…Yen1 plays a critical role in ensuring genome stability and unperturbed chromosome segregation by removing covalently linked DNA intermediates between sister chromatids that are formed by homologous recombination. Here we show how this important role of Yen1 depends on interactions mediated by non-covalent binding to SUMOylated partners. …”
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888
Playing the end game: DNA double-strand break repair pathway choice.
Published 2012“…To preserve genome integrity, organisms have evolved several DSB repair mechanisms, of which nonhomologous end-joining (NHEJ) and homologous recombination (HR) represent the two most prominent. …”
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889
The atspo11-1 mutation rescues atxrcc3 meiotic chromosome fragmentation.
Published 2004“…Homologous recombination events occurring during meiotic prophase I ensure the proper segregation of homologous chromosomes at the first meiotic division. …”
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890
DNA double-strand break repair pathways, chromosomal rearrangements and cancer.
Published 2011“…Here we review the mechanisms by which non-homologous end joining (NHEJ) and homologous recombination (HR) repair pathways can both promote chromosomal rearrangements and also suppress them in response to such lesions, in accordance with their increasingly recognised tumour suppressor function. …”
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891
p97/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response.
Published 2012“…This newly identified pathway is essential to spatiotemporal protein turnover and regulates both main branches of DSB repair, homologous recombination and nonhomologous end joining. In this report, the function of the RNF8/Lys48 polyubiquitin chains/p97 pathway is discussed in the context of DSB repair and p97 chromatin-related functions.…”
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892
Dual role of CDKs in DNA repair: to be, or not to be.
Published 2009“…Interestingly, there is increasing evidence that the catalytic activities of CDKs play critical roles in the DNA damage response, especially in the case of damage repaired by the homologous recombination (HR) pathway. In this review, we outline current knowledge of CDK regulation and its roles both in the unperturbed cell cycle and in DNA damage responses, and discuss the physiological roles of CDKs in HR repair.…”
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893
Impact of recombination on bacterial evolution.
Published 2010“…Here we focus on genetic exchange that has involved homologous recombination and illustrate how nucleotide sequence data have furthered our understanding of: (i) the frequency of recombination; (ii) the impact of recombination in different parts of the genome; and (iii) patterns of gene flow within bacterial populations. …”
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894
DNA damage signaling and repair in Dictyostelium discoideum.
Published 2006“…DNA DSBs can be repaired by either homologous recombination (HR) or nonhomologous end-joining (NHEJ). …”
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895
A failure of meiotic chromosome segregation in a fbh1Delta mutant correlates with persistent Rad51-DNA associations.
Published 2011“…The F-box DNA helicase Fbh1 constrains homologous recombination in vegetative cells, most likely through an ability to displace the Rad51 recombinase from DNA. …”
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896
The chromatin remodeller ATRX: a repeat offender in human disease.
Published 2013“…Exciting recent developments suggest that ATRX plays a variety of key roles at tandem repeat sequences within the genome, including the deposition of a histone variant, prevention of replication fork stalling, and the suppression of a homologous recombination-based pathway of telomere maintenance. …”
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897
Genetic Dissection of Budding Yeast PCNA Mutations Responsible for the Regulated Recruitment of Srs2 Helicase
Published 2023-04-01“…IMPORTANCE It is known that budding yeast PCNA sumoylation serves as a ligand to recruit a DNA helicase Srs2 through its tandem receptor motifs that prevent unwanted homologous recombination (HR) at replication forks, a process known as salvage HR. …”
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898
Development of a stable eukaryotic strain producing fully human monoclonal antibody on the basis of the human antibody against ectromelia virus
Published 2018-01-01“…Then, CHOS/FRT cells, which contain the FRTsite for homologous recombination and are able to produce green fluorescence protein GFP, were transfected with the constructed plasmid. …”
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899
Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo
Published 2021-04-01“…This is consistent with a downstream function for ssDNA binding in regulating homologous recombination.…”
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900
Structural and DNA end resection study of the bacterial NurA-HerA complex
Published 2023-02-01“…Abstract Background The nuclease NurA and the ATPase/translocase HerA play a vital role in repair of double-strand breaks (DSB) during the homologous recombination in archaea. A NurA-HerA complex is known to mediate DSB DNA end resection, leading to formation of a free 3′ end used to search for the homologous sequence. …”
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