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981
Telomere Checkpoint in Development and Aging
Published 2023-11-01“…Heterochromatin formation, transcriptional repression, the suppression of homologous recombination and chromosome end protection are all required for telomere stability. …”
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982
Ku stabilizes replication forks in the absence of Brc1.
Published 2015-01-01“…In brc1∆ pku80∆ cells, nuclear foci of Rad52 homologous recombination (HR) protein increase and Mus81-Eme1 Holliday junction resolvase becomes critical, indicating increased replication fork instability. …”
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983
Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity
Published 2015-04-01“…Emerging evidence indicate that TERRA transcripts form DNA-RNA hybrids at chromosome ends which can promote homologous recombination among telomeres, delaying cellular senescence and sustaining genome instability. …”
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984
BRCA1-Dependent Transcriptional Regulation: Implication in Tissue-Specific Tumor Suppression
Published 2018-12-01“…BRCA1 is best known for its functions in maintenance of genomic integrity including repairing DNA double-strand breaks through homologous recombination and suppressing DNA replication stress. …”
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985
Immunobiological Properties of <i>Francisella tularensis</i> 15/10 Strain with Deleted recA Gene
Published 2011-08-01“…Deletion of recA gene in Francisella tularensis 15/10 genome leads to the increase in its sensitivity to ultraviolet irradiation, reduction of the homologous recombination capacity, and a slight decline of virulence for mice. …”
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986
Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability.
Published 2013-01-01“…The SUMO conjugates in question are formed by the SUMO ligase Pli1, which is necessary for limiting spontaneous homologous recombination when Top1 is present. Surprisingly there is no requirement for Pli1 to limit recombination in the vicinity of a replication fork blocked at the programmed barrier RTS1. …”
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987
A-MYB and BRDT-dependent RNA Polymerase II pause release orchestrates transcriptional regulation in mammalian meiosis
Published 2023-03-01“…During spermatogenic meiosis, chromatin changes due to transcription, homologous recombination, and chromosome synapsis must be coordinated. …”
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988
The chloroplast genome of the marine microalga Tisochrysis lutea
Published 2019-01-01“…This is unlike land plant and green algal chloroplast genomes in which efficient copy correction by homologous recombination ensures identical long inverted repeats containing the rRNA operons. …”
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989
UGDR: a generic pipeline to detect recombined regions in polyploid and complex hybrid yeast genomes
Published 2022-12-01“…Abstract Motivation In eukaryotes, homologous recombination between the parental genomes frequently occurs during the evolutionary conserved process of meiosis, generating the genetic diversity transmitted by the gametes. …”
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990
The 22q11.2 Low Copy Repeats
Published 2022-11-01“…LCR22s are among the most complex loci in the human genome and are susceptible to nonallelic homologous recombination. This can lead to a variety of genomic disorders, including deletions, duplications, and translocations, of which the 22q11.2 deletion syndrome is the most common in humans. …”
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991
Belt and braces: Two escape ways to maintain the cassette reservoir of large chromosomal integrons.
Published 2024-04-01“…Through experimental evolution, we find that the integrase is rapidly inactivated and that the inverted SCI can recover its original orientation by homologous recombination between two insertion sequences (ISs) present in the array. …”
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992
DNA repair pathways as a novel therapeutic strategy in esophageal cancer: A review study
Published 2022-11-01“…There are two core pathways that repair double‐strand breaks, homologous recombination (HR) and non‐homologous end joining (NHEJ) and numerous proteins are recognized that affect the occurrence of HR and NHEJ. …”
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993
Coordinated Binding of Single-Stranded and Double-Stranded DNA by UvsX Recombinase.
Published 2013-01-01“…Homologous recombination is important for the error-free repair of DNA double-strand breaks and for replication fork restart. …”
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994
Targeting the BRCA1/2 deficient cancer with PARP inhibitors: Clinical outcomes and mechanistic insights
Published 2023-03-01“…BRCA1 and BRCA2 play a critical role in a variety of molecular processes related to DNA metabolism, including homologous recombination and mediating the replication stress response. …”
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995
Established and Evolving Roles of the Multifunctional Non-POU Domain-Containing Octamer-Binding Protein (NonO) and Splicing Factor Proline- and Glutamine-Rich (SFPQ)
Published 2024-01-01“…In this review, we focus on several other established roles of NonO and SFPQ, including their participation in the cell cycle, nonhomologous end-joining (NHEJ), homologous recombination (HR), telomere stability, childhood birth defects and cancer. …”
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996
Prophage-like gene transfer agents promote Caulobacter crescentus survival and DNA repair during stationary phase.
Published 2022-11-01“…Notably, we find that GTAs promote the survival of Caulobacter in stationary phase and following DNA damage by providing recipient cells a template for homologous recombination-based repair. This function may be broadly conserved in other GTA-producing organisms and explain the prevalence of this unusual HGT mechanism.…”
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997
Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures
Published 2022-10-01“…ERCC1-XPF is involved in nucleotide excision repair (NER), repair of DNA interstrand crosslinks (ICLs), and DNA double-strand break (DSB) repair via homologous recombination. In addition, ERCC1-XPF contributes to the processing of various alternative (i.e., non-B) DNA structures. …”
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998
Transcriptional Regulation of Aerobic Metabolism in Pichia pastoris Fermentation.
Published 2016-01-01“…In order to confirm the above results, we disrupted PAS_chr2-1_0582 by homologous recombination. Alcohol consumption was equivalent to one fifth of the normal control, and fewer peroxisomes were observed in Δ0582 strain following methanol induction. …”
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999
Emerging Roles of RAD52 in Genome Maintenance
Published 2019-07-01“…The maintenance of genome integrity is critical for cell survival. Homologous recombination (HR) is considered the major error-free repair pathway in combatting endogenously generated double-stranded lesions in DNA. …”
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1000
ATR Inhibitors in Platinum-Resistant Ovarian Cancer
Published 2022-11-01“…Ataxia telangiectasia and RAD3-Related Protein Kinase inhibitors (ATRi) have attracted attention as a promising class of targeted drugs that can regulate the cell cycle and influence homologous recombination (HR) repair. In recent years, many preclinical and clinical studies have demonstrated the efficacy of ATRis in PROC. …”
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