Telomere Checkpoint in Development and Aging by Alla Kalmykova

“…Heterochromatin formation, transcriptional repression, the suppression of homologous recombination and chromosome end protection are all required for telomere stability. …”
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Ku stabilizes replication forks in the absence of Brc1. by Arancha Sánchez, Paul Russell

“…In brc1∆ pku80∆ cells, nuclear foci of Rad52 homologous recombination (HR) protein increase and Mus81-Eme1 Holliday junction resolvase becomes critical, indicating increased replication fork instability. …”
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Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity by Emilio eCusanelli, Pascal eChartrand

“…Emerging evidence indicate that TERRA transcripts form DNA-RNA hybrids at chromosome ends which can promote homologous recombination among telomeres, delaying cellular senescence and sustaining genome instability. …”
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BRCA1-Dependent Transcriptional Regulation: Implication in Tissue-Specific Tumor Suppression by Xiaowen Zhang, Rong Li

“…BRCA1 is best known for its functions in maintenance of genomic integrity including repairing DNA double-strand breaks through homologous recombination and suppressing DNA replication stress. …”
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Immunobiological Properties of <i>Francisella tularensis</i> 15/10 Strain with Deleted recA Gene by A. A. Lapin, A. N. Mokrievich, G. M. Vakhrameeva, T. I. Kombarova, I. V. Bakhteeva, I. A. Dyatlov, V. M. Pavlov

“…Deletion of recA gene in Francisella tularensis 15/10 genome leads to the increase in its sensitivity to ultraviolet irradiation, reduction of the homologous recombination capacity, and a slight decline of virulence for mice. …”
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Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability. by Roland Steinacher, Fekret Osman, Alexander Lorenz, Claire Bryer, Matthew C Whitby

“…The SUMO conjugates in question are formed by the SUMO ligase Pli1, which is necessary for limiting spontaneous homologous recombination when Top1 is present. Surprisingly there is no requirement for Pli1 to limit recombination in the vicinity of a replication fork blocked at the programmed barrier RTS1. …”
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A-MYB and BRDT-dependent RNA Polymerase II pause release orchestrates transcriptional regulation in mammalian meiosis by Adriana K. Alexander, Edward J. Rice, Jelena Lujic, Leah E. Simon, Stephanie Tanis, Gilad Barshad, Lina Zhu, Jyoti Lama, Paula E. Cohen, Charles G. Danko

“…During spermatogenic meiosis, chromatin changes due to transcription, homologous recombination, and chromosome synapsis must be coordinated. …”
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The chloroplast genome of the marine microalga Tisochrysis lutea by Alejandra B. Méndez-Leyva, Jingya Guo, Elisabeth A. Mudd, Jerry Wong, Jean-Marc Schwartz, Anil Day

“…This is unlike land plant and green algal chloroplast genomes in which efficient copy correction by homologous recombination ensures identical long inverted repeats containing the rRNA operons. …”
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UGDR: a generic pipeline to detect recombined regions in polyploid and complex hybrid yeast genomes by Amina Bedrat

“…Abstract Motivation In eukaryotes, homologous recombination between the parental genomes frequently occurs during the evolutionary conserved process of meiosis, generating the genetic diversity transmitted by the gametes. …”
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The 22q11.2 Low Copy Repeats by Lisanne Vervoort, Joris Robert Vermeesch

“…LCR22s are among the most complex loci in the human genome and are susceptible to nonallelic homologous recombination. This can lead to a variety of genomic disorders, including deletions, duplications, and translocations, of which the 22q11.2 deletion syndrome is the most common in humans. …”
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Belt and braces: Two escape ways to maintain the cassette reservoir of large chromosomal integrons. by Egill Richard, Baptiste Darracq, Eloi Littner, Gael A Millot, Valentin Conte, Thomas Cokelaer, Jan Engelstädter, Eduardo P C Rocha, Didier Mazel, Céline Loot

“…Through experimental evolution, we find that the integrase is rapidly inactivated and that the inverted SCI can recover its original orientation by homologous recombination between two insertion sequences (ISs) present in the array. …”
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DNA repair pathways as a novel therapeutic strategy in esophageal cancer: A review study by Mohammad Reza Kheyrandish, Seyed Mostafa Mir, Mehdi Sheikh Arabi

“…There are two core pathways that repair double‐strand breaks, homologous recombination (HR) and non‐homologous end joining (NHEJ) and numerous proteins are recognized that affect the occurrence of HR and NHEJ. …”
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Coordinated Binding of Single-Stranded and Double-Stranded DNA by UvsX Recombinase. by Robyn L Maher, Scott W Morrical

“…Homologous recombination is important for the error-free repair of DNA double-strand breaks and for replication fork restart. …”
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Targeting the BRCA1/2 deficient cancer with PARP inhibitors: Clinical outcomes and mechanistic insights by Ashwin Ragupathi, Manrose Singh, Alexis M. Perez, Dong Zhang

“…BRCA1 and BRCA2 play a critical role in a variety of molecular processes related to DNA metabolism, including homologous recombination and mediating the replication stress response. …”
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Established and Evolving Roles of the Multifunctional Non-POU Domain-Containing Octamer-Binding Protein (NonO) and Splicing Factor Proline- and Glutamine-Rich (SFPQ) by Danyang Yu, Ching-Jung Huang, Haley O. Tucker

“…In this review, we focus on several other established roles of NonO and SFPQ, including their participation in the cell cycle, nonhomologous end-joining (NHEJ), homologous recombination (HR), telomere stability, childhood birth defects and cancer. …”
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Prophage-like gene transfer agents promote Caulobacter crescentus survival and DNA repair during stationary phase. by Kevin Gozzi, Ngat T Tran, Joshua W Modell, Tung B K Le, Michael T Laub

“…Notably, we find that GTAs promote the survival of Caulobacter in stationary phase and following DNA damage by providing recipient cells a template for homologous recombination-based repair. This function may be broadly conserved in other GTA-producing organisms and explain the prevalence of this unusual HGT mechanism.…”
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Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures by Tonia T. Li, Karen M. Vasquez

“…ERCC1-XPF is involved in nucleotide excision repair (NER), repair of DNA interstrand crosslinks (ICLs), and DNA double-strand break (DSB) repair via homologous recombination. In addition, ERCC1-XPF contributes to the processing of various alternative (i.e., non-B) DNA structures. …”
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Transcriptional Regulation of Aerobic Metabolism in Pichia pastoris Fermentation. by Biao Zhang, Baizhi Li, Dai Chen, Jie Zong, Fei Sun, Huixin Qu, Chongyang Liang

“…In order to confirm the above results, we disrupted PAS_chr2-1_0582 by homologous recombination. Alcohol consumption was equivalent to one fifth of the normal control, and fewer peroxisomes were observed in Δ0582 strain following methanol induction. …”
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Emerging Roles of RAD52 in Genome Maintenance by Manisha Jalan, Kyrie S. Olsen, Simon N. Powell

“…The maintenance of genome integrity is critical for cell survival. Homologous recombination (HR) is considered the major error-free repair pathway in combatting endogenously generated double-stranded lesions in DNA. …”
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ATR Inhibitors in Platinum-Resistant Ovarian Cancer by Siyu Li, Tao Wang, Xichang Fei, Mingjun Zhang

“…Ataxia telangiectasia and RAD3-Related Protein Kinase inhibitors (ATRi) have attracted attention as a promising class of targeted drugs that can regulate the cell cycle and influence homologous recombination (HR) repair. In recent years, many preclinical and clinical studies have demonstrated the efficacy of ATRis in PROC. …”
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