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1141
Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation.
Published 2015-01-01“…By inserting LANS into the C. elegans lin-1 locus using Cas9-triggered homologous recombination, we demonstrated control of cell fate via light-dependent manipulation of a native transcription factor. …”
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1142
Prophage-like gene transfer agents promote Caulobacter crescentus survival and DNA repair during stationary phase
Published 2022-11-01“…Notably, we find that GTAs promote the survival of Caulobacter in stationary phase and following DNA damage by providing recipient cells a template for homologous recombination-based repair. This function may be broadly conserved in other GTA-producing organisms and explain the prevalence of this unusual HGT mechanism. …”
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1143
DNA topoisomerase III localizes to centromeres and affects centromeric CENP-A levels in fission yeast.
Published 2013-01-01“…This new role is independent of the established function of Top3 and Rqh1 in homologous recombination downstream of Rad51. Therefore, we hypothesize that the Top3-Rqh1 complex has an important role in controlling centromere DNA topology, which in turn affects the dynamics of CENP-A(Cnp1) nucleosomes.…”
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1144
Dose Adjustment of Poly (ADP‑Ribose) Polymerase Inhibitors in Patients with Hepatic or Renal Impairment
Published 2022-11-01“…In recent years, five PARP inhibitors, olaparib, niraparib, rucaparib, talazoparib and veliparib, have been developed for the treatment of solid tumors, particularly in patients with breast-related cancer antigen (BRCA) 1/2 mutations, or those without a functional homologous recombination repair pathway. These novel treatments exhibit improved efficacy and toxicity when compared to conventional chemotherapy agents. …”
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1145
Safety of bevacizumab and olaparib as frontline maintenance therapy in advanced ovarian cancer: expert review for clinical practice
Published 2024-01-01“…Olaparib, a poly(ADP-ribose) polymerase inhibitor, in combination with the antiangiogenic agent bevacizumab, is approved as maintenance therapy for patients with newly diagnosed stage III or IV epithelial ovarian cancer who have homologous recombination deficient tumors with a deleterious or suspected deleterious BRCA mutation and/or genomic instability based on the long-lasting survival benefit observed in the PAOLA-1 trial. …”
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1146
Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review
Published 2020-06-01“…More than 50% of the genes that are reported to predispose to MM are involved in DNA repair mechanisms, and the majority of them have a role in the homologous recombination pathway. Genetic alterations in tumor suppressor genes involved in chromatin, transcription and hypoxia regulation have also been described. …”
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1147
A set of dual promoter vectors for high throughput cloning, screening, and protein expression in eukaryotic and prokaryotic systems from a single plasmid
Published 2012-08-01“…These plasmids also contain the essential elements for replication and selection in both cell types and have several advantages: they allow for cloning of genes by homologous recombination in yeast, protein expression can be determined before plasmid isolation and sequencing, and a GST-fusion tag is added to aid in soluble expression and purification. …”
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1148
Male Germ Cell Telomeres and Chemical Pollutants
Published 2023-04-01“…Telomeres regulate the reproductive lifespan by mediating the synapsis and homologous recombination of chromosomes during gametogenesis. …”
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1149
Recombination as an enforcement mechanism of prosocial behavior in cooperating bacteria
Published 2023-08-01“…We propose that homologous recombination provides such a mechanism in bacteria. …”
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1150
Comprehensive Genomic Profiling-Guided Niraparib Treatment of Triple-Negative Breast Cancer in a Patient With Extensive Brain Metastasis: Case Report and Literature Review
Published 2021-02-01“…Homologous recombination deficiency (HRD) is a common phenotypic alteration that is highly druggable with poly (ADP-ribose) polymerase inhibitors (PARPi). …”
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1151
CRISPR/Cas tools for enhancing the biopreservation ability of lactic acid bacteria in aquatic products
Published 2022-12-01“…The genome editing tools based on homologous recombination and base editor were described. Then, the research status of CRISPRi in transcriptional regulation was reviewed briefly. …”
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1152
A simple and stable method of tagging <em>Agrobacterium fabrum</em> C58 for environmental monitoring
Published 2017-05-01“…A gentamicin resistant cassette (aacC1) was inserted, by homologous recombination, into a non-coding region of the A. fabrum C58 chromosome between the genes atu1182 and atu1183. …”
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1153
Precision Medicine in Castration-Resistant Prostate Cancer: Advances, Challenges, and the Landscape of PARPi Therapy—A Narrative Review
Published 2024-02-01“…An increasing body of evidence underscores the importance of distinct alterations in homologous recombination repair (HRR) genes, revealing unique sensitivities to PARPis. …”
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1154
Chromosome 22q11.2 microdeletion in monozygotic twins with discordant phenotype and deletion size
Published 2012-03-01“…We think early post zygotic events (mitotic non-allelic homologous recombination) could have been played a role in the alteration of 22q11.2 deletion size and, thus phenotypic variability in the monozygotic twins.…”
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1155
Regulation Mechanisms of Meiotic Recombination Revealed from the Analysis of a Fission Yeast Recombination Hotspot <i>ade6-M26</i>
Published 2022-11-01“…DSBs caused by Spo11 are repaired by homologous recombination using homologous chromosomes as donors, resulting in crossovers/chiasmata, which ensure physical contact between homologous chromosomes. …”
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1156
Enhancement of xylanase expression by Komagataella phaffii through pexophagy inhibition
Published 2019-01-01“…Komagataella phaffii atg30Δ was constructed through homologous recombination that resulted in the inhibition of pexophagy. …”
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1157
Design of a Replicative-Competent MGF110 (1L-5-6L) Deleted African Swine Fever Virus (Genotype II)
Published 2023-03-01“…In this work, we generated the ASFV deletion mutant virus Volgograd/D(1L-5-6L) with the six genes deletion in multigenic family 110 (MGF110) (1L-5-6L) and studied its characteristics in vitro. The homologous recombination method was used for the deletion in ASFV parental strain Volgograd/14с. …”
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1158
Animal models for human contiguous gene syndromes and other genomic disorders
Published 2004-01-01“…The DNA rearrangements result from nonallelic homologous recombination (NAHR) utilizing flanking low-copy repeats (LCRs) as recombination substrates. …”
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1159
A Set of Plasmid-Based Modules for Easy Switching of C-Terminal Epitope Tags in <i>Saccharomyces cerevisiae</i>
Published 2021-12-01“…The isolated modules contained DNA sequences for homologous recombination, various epitopes (13×Myc, 6×HA, GFP, Venus, YFP, mCherry, and CFP), and a transformation marker (<i>Candida glabrata LEU2</i>). …”
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1160
Confined environment facilitates stacked conformations in Holliday Junction
Published 2023-12-01“…Holliday Junction (HJ) is an important intermediate in homologous recombination and is involved in DNA break repair. …”
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