Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation. by Hayretin Yumerefendi, Daniel J Dickinson, Hui Wang, Seth P Zimmerman, James E Bear, Bob Goldstein, Klaus Hahn, Brian Kuhlman

“…By inserting LANS into the C. elegans lin-1 locus using Cas9-triggered homologous recombination, we demonstrated control of cell fate via light-dependent manipulation of a native transcription factor. …”
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Prophage-like gene transfer agents promote Caulobacter crescentus survival and DNA repair during stationary phase by Kevin Gozzi, Ngat T. Tran, Joshua W. Modell, Tung B. K. Le, Michael T. Laub

“…Notably, we find that GTAs promote the survival of Caulobacter in stationary phase and following DNA damage by providing recipient cells a template for homologous recombination-based repair. This function may be broadly conserved in other GTA-producing organisms and explain the prevalence of this unusual HGT mechanism. …”
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DNA topoisomerase III localizes to centromeres and affects centromeric CENP-A levels in fission yeast. by Ulrika Norman-Axelsson, Mickaël Durand-Dubief, Punit Prasad, Karl Ekwall

“…This new role is independent of the established function of Top3 and Rqh1 in homologous recombination downstream of Rad51. Therefore, we hypothesize that the Top3-Rqh1 complex has an important role in controlling centromere DNA topology, which in turn affects the dynamics of CENP-A(Cnp1) nucleosomes.…”
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Dose Adjustment of Poly (ADP‑Ribose) Polymerase Inhibitors in Patients with Hepatic or Renal Impairment by Zhao D, Long X, Wang J

“…In recent years, five PARP inhibitors, olaparib, niraparib, rucaparib, talazoparib and veliparib, have been developed for the treatment of solid tumors, particularly in patients with breast-related cancer antigen (BRCA) 1/2 mutations, or those without a functional homologous recombination repair pathway. These novel treatments exhibit improved efficacy and toxicity when compared to conventional chemotherapy agents. …”
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Safety of bevacizumab and olaparib as frontline maintenance therapy in advanced ovarian cancer: expert review for clinical practice by Ignacio Romero, Eva Guerra, Ainhoa Madariaga, Luis Manso

“…Olaparib, a poly(ADP-ribose) polymerase inhibitor, in combination with the antiangiogenic agent bevacizumab, is approved as maintenance therapy for patients with newly diagnosed stage III or IV epithelial ovarian cancer who have homologous recombination deficient tumors with a deleterious or suspected deleterious BRCA mutation and/or genomic instability based on the long-lasting survival benefit observed in the PAOLA-1 trial. …”
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Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review by Vasiliki Panou, Oluf Dimitri Røe

“…More than 50% of the genes that are reported to predispose to MM are involved in DNA repair mechanisms, and the majority of them have a role in the homologous recombination pathway. Genetic alterations in tumor suppressor genes involved in chromatin, transcription and hypoxia regulation have also been described. …”
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A set of dual promoter vectors for high throughput cloning, screening, and protein expression in eukaryotic and prokaryotic systems from a single plasmid by Sinah Namita, Williams Charlotte A, Piper Robert C, Shields S

“…These plasmids also contain the essential elements for replication and selection in both cell types and have several advantages: they allow for cloning of genes by homologous recombination in yeast, protein expression can be determined before plasmid isolation and sequencing, and a GST-fusion tag is added to aid in soluble expression and purification. …”
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Male Germ Cell Telomeres and Chemical Pollutants by Gabriella Chieffi Baccari, Giuseppe Iurato, Alessandra Santillo, Brian Dale

“…Telomeres regulate the reproductive lifespan by mediating the synapsis and homologous recombination of chromosomes during gametogenesis. …”
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Recombination as an enforcement mechanism of prosocial behavior in cooperating bacteria by Isaiah Paolo A. Lee, Omar Tonsi Eldakar, J. Peter Gogarten, Cheryl P. Andam

“…We propose that homologous recombination provides such a mechanism in bacteria. …”
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Comprehensive Genomic Profiling-Guided Niraparib Treatment of Triple-Negative Breast Cancer in a Patient With Extensive Brain Metastasis: Case Report and Literature Review by Tai-Chung Lam

“…Homologous recombination deficiency (HRD) is a common phenotypic alteration that is highly druggable with poly (ADP-ribose) polymerase inhibitors (PARPi). …”
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CRISPR/Cas tools for enhancing the biopreservation ability of lactic acid bacteria in aquatic products by Huina Dong, Huiying Wang, Shaoping Fu, Dawei Zhang, Dawei Zhang

“…The genome editing tools based on homologous recombination and base editor were described. Then, the research status of CRISPRi in transcriptional regulation was reviewed briefly. …”
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A simple and stable method of tagging <em>Agrobacterium fabrum</em> C58 for environmental monitoring by Meriam BOURI, Haifa Ben GHARSA, Ludovic VIAL, Céline LAVIRE, Bernard R. GLICK, Ali RHOUMA

“…A gentamicin resistant cassette (aacC1) was inserted, by homologous recombination, into a non-coding region of the A. fabrum C58 chromosome between the genes atu1182 and atu1183. …”
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Precision Medicine in Castration-Resistant Prostate Cancer: Advances, Challenges, and the Landscape of PARPi Therapy—A Narrative Review by George Dimitrov, Radoslav Mangaldzhiev, Chavdar Slavov, Elenko Popov

“…An increasing body of evidence underscores the importance of distinct alterations in homologous recombination repair (HRR) genes, revealing unique sensitivities to PARPis. …”
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Chromosome 22q11.2 microdeletion in monozygotic twins with discordant phenotype and deletion size by Halder Ashutosh, Jain Manish, Chaudhary Isha, Varma Binuja

“…We think early post zygotic events (mitotic non-allelic homologous recombination) could have been played a role in the alteration of 22q11.2 deletion size and, thus phenotypic variability in the monozygotic twins.…”
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Regulation Mechanisms of Meiotic Recombination Revealed from the Analysis of a Fission Yeast Recombination Hotspot <i>ade6-M26</i> by Kouji Hirota

“…DSBs caused by Spo11 are repaired by homologous recombination using homologous chromosomes as donors, resulting in crossovers/chiasmata, which ensure physical contact between homologous chromosomes. …”
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Enhancement of xylanase expression by Komagataella phaffii through pexophagy inhibition by Taiyu Liu, Yixin Zhao, Jianguo Zhang, Jining Zhang

“…Komagataella phaffii atg30Δ was constructed through homologous recombination that resulted in the inhibition of pexophagy. …”
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Design of a Replicative-Competent MGF110 (1L-5-6L) Deleted African Swine Fever Virus (Genotype II) by Nefedeva Mariia V., Malogolovkin Alexander S., Titov Ilya A.

“…In this work, we generated the ASFV deletion mutant virus Volgograd/D(1L-5-6L) with the six genes deletion in multigenic family 110 (MGF110) (1L-5-6L) and studied its characteristics in vitro. The homologous recombination method was used for the deletion in ASFV parental strain Volgograd/14с. …”
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Animal models for human contiguous gene syndromes and other genomic disorders by Katherina Walz, Patricia Fonseca, James R. Lupski

“…The DNA rearrangements result from nonallelic homologous recombination (NAHR) utilizing flanking low-copy repeats (LCRs) as recombination substrates. …”
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A Set of Plasmid-Based Modules for Easy Switching of C-Terminal Epitope Tags in <i>Saccharomyces cerevisiae</i> by Hiroki Hayashi, Tsutomu Kishi

“…The isolated modules contained DNA sequences for homologous recombination, various epitopes (13×Myc, 6×HA, GFP, Venus, YFP, mCherry, and CFP), and a transformation marker (<i>Candida glabrata LEU2</i>). …”
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Confined environment facilitates stacked conformations in Holliday Junction by Priya Agarwal, Sahil Hasan Kabir, Nibedita Pal

“…Holliday Junction (HJ) is an important intermediate in homologous recombination and is involved in DNA break repair. …”
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