Selective induction of DNA repair pathways in human B cells activated by CD4+ T cells. by Xiaosheng Wu, Renee C Tschumper, Albert Gutierrez, Stephen A Mihalcik, Grzegorz S Nowakowski, Diane F Jelinek

“…We first demonstrated that several DNA mismatch repair, homologous recombination, base excision repair, and ATR signaling genes were overexpressed in GC B cells relative to naïve and memory B cells, reflecting activation of a process we have termed somatic hyperrepair (SHR). …”
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Improving homology‐directed repair by small molecule agents for genetic engineering in unconventional yeast?—Learning from the engineering of mammalian systems by Min Lu, Sonja Billerbeck

“…In many unconventional yeasts, such as those promising new hosts for cell factory design but also human pathogenic yeasts and food spoilers, this progress has been limited by the fact that most yeasts favour non‐homologous end joining (NHEJ) over homologous recombination (HR) as a DNA repair mechanism, impairing genetic access to these hosts. …”
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Sequence features of <it>HLA-DRB1 </it>locus define putative basis for gene conversion and point mutations by von Salomé Jenny, Kukkonen Jyrki P

“…</p> <p>Conclusion</p> <p>The identified sequence features could putatively act in recombination allowing either less (CpG dinucleotides) or more specific DNA cleavage (complex sequences) or homologous recombination (complex sequences).</p>…”
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Multi-Gene Testing Overview with a Clinical Perspective in Metastatic Triple-Negative Breast Cancer by Martina Dameri, Lorenzo Ferrando, Gabriella Cirmena, Claudio Vernieri, Giancarlo Pruneri, Alberto Ballestrero, Gabriele Zoppoli

“…We make an overview of the clinical utility of multi-gene testing in mTNBC, and then, as immunotherapy is emerging as a possible targeted therapy for mTNBC, we also briefly report on the results of the latest clinical trials involving immune checkpoint inhibitors (ICIs) and TNBC, where NGS could play a role for the potential predictive utility of homologous recombination repair deficiency (HRD) and tumor mutational burden (TMB).…”
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Therapeutic Potential of PARP Inhibitors in the Treatment of Metastatic Castration-Resistant Prostate Cancer by Albert Jang, Oliver Sartor, Pedro C. Barata, Channing J. Paller

“…Up to 30% of patients with mCRPC have mutations in homologous recombination repair (HRR) genes. Poly (ADP-ribose) polymerase (PARP) inhibitors take advantage of HRR deficiency to kill tumor cells based on the concept of synthetic lethality. …”
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p53 Controls Meiotic Prophase Progression and Crossover Formation by Marina Marcet-Ortega, Andros Maldonado-Linares, Maria López-Panadés, Ignasi Roig

“…To avoid genomic instability, these DSBs need to be correctly repaired by homologous recombination. Surveillance mechanisms involving the DNA damage response (DDR) pathway ATM-CHK2-p53 can detect the persistence of unrepaired DBSs and activate the recombination-dependent arrest at the pachytene stage. …”
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Interrogating the Genomic Landscape of Uterine Leiomyosarcoma: A Potential for Patient Benefit by Genevieve V. Dall, Anne Hamilton, Gayanie Ratnayake, Clare Scott, Holly Barker

“…Recent identification of deficiencies in homologous recombination in a minority of these tumours, however, has provided a rationale for investigation of PARP inhibitors in this sub-set. …”
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Evolutionary diversification of an ancient gene family (<it>rhs</it>) through C-terminal displacement by Parkhill Julian, Thomas Gavin H, Jackson Andrew P, Thomson Nicholas R

“…Furthermore, we demonstrate that Rhs 'core' domains and variable C-termini are evolutionarily decoupled, and propose that <it>rhs </it>diversity is driven by homologous recombination with circular intermediates. Existing C-termini are displaced by laterally acquired alternatives, creating long arrays of dissociated 'tips' that characterize the appearance of <it>rhs </it>loci.…”
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Gene editing tools for mycoplasmas: references and future directions for efficient genome manipulation by Gang Zhao, Gang Zhao, Gang Zhao, Doukun Lu, Min Li, Min Li, Yujiong Wang, Yujiong Wang

“…This review summarizes several strategies for editing of mycoplasma genomes, including homologous recombination, transposons, clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system, and synthetic biology. …”
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Genome-wide analysis of DNA-PK-bound MRN cleavage products supports a sequential model of DSB repair pathway choice by Rajashree A. Deshpande, Alberto Marin-Gonzalez, Hannah K. Barnes, Phillip R. Woolley, Taekjip Ha, Tanya T. Paull

“…Abstract The Mre11-Rad50-Nbs1 (MRN) complex recognizes and processes DNA double-strand breaks for homologous recombination by performing short-range removal of 5ʹ strands. …”
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Chromosome Instability in Fanconi Anemia: From Breaks to Phenotypic Consequences by Benilde García-de-Teresa, Alfredo Rodríguez, Sara Frias

“…This pathway regulates the repair of DNA interstrand crosslinks (ICLs) through homologous recombination. In FA proper repair of ICLs is impaired and accumulation of toxic DNA double strand breaks occurs. …”
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Size of gene specific inverted repeat--dependent gene deletion In Saccharomyces cerevisiae. by Chanyuen Lim, Annette Lin Luhe, Crystal Tear Jingying, Balaji Balagurunathan, Jinchuan Wu, Hua Zhao

“…The inherent instability of the inverted sequences in close proximity facilitates the self-excision of the entire mutagenesis cassette deposited in the genome and promotes homologous recombination resulting in a seamless deletion via a single transformation. …”
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Facing inevitable PARPis resistance: Mechanisms and therapeutic strategies for breast cancer treatment by Haixia Liu, Xiaohui Chen, Yimin Jia, Hengyi Chen, Xiaohui Wang, Guoxiang Liu, Yang Luo

“…Abstract BRCA1/2 gene mutations, which result in a dysfunction of homologous recombination repair, have been discovered in at least 5% of breast cancer (BC) patients with the increase in BC incidence in recent years. …”
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Resistance to DNA repair inhibitors in cancer by Joseph S. Baxter, Diana Zatreanu, Stephen J. Pettitt, Christopher J. Lord

“…This is exemplified by PARP inhibitors (PARPi) used to treat cancers with defects in the homologous recombination DDR pathway. A series of novel DDR targets are now also under pre‐clinical or clinical investigation, including inhibitors of ATR kinase, WRN helicase or the DNA polymerase/helicase Polθ (Pol‐Theta). …”
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Exploring the evolutionary dynamics of plasmids: the <it>Acinetobacter </it>pan-plasmidome by Vaneechoutte Mario, Mengoni Alessio, Papaleo Maria, Brilli Matteo, Bacci Giovanni, Fondi Marco, Dijkshoorn Lenie, Fani Renato

“…Additionally and/or alternatively, from a genome perspective, plasmids can provide a basis for genomic rearrangements <it>via </it>homologous recombination and so they can facilitate the loss or acquisition of genes during these events, which eventually may lead to horizontal gene transfer (HGT). …”
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Genetic manipulation and targeted protein degradation in mammalian systems: practical considerations, tips and tricks for discovery research by Stefano L. Giandomenico, Erin M. Schuman

“…Despite such apparent advantages, genetic manipulation (i.e., knock‐down, knock‐out, mutation, and tagging) in mammalian systems can be challenging due to problems with delivery, low rates of homologous recombination, and epigenetic silencing. The advent of CRISPR‐Cas9 in combination with the development of robust differentiation protocols that can efficiently generate a variety of different cell types in vitro has accelerated our ability to probe gene function in a more physiological setting. …”
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Construction and expression verification of mouse spermatogenic cell-specific expression vector AAV-Dazl-RFP-Flag by LI Ya-hui, LI Kai, LUO Yan-yun, LI Meng-zhen, MANG Xin-yu, SONG Wei, YANG Tao

“…Methods The Adeno-associated virus vector AAV-CMV-RFP-Flag was modified by homologous recombination to construct mouse permatogenic cell-specific expression vector AAV-Dazl-RFP-Flag. …”
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Molecular mechanisms of Holliday junction branch migration catalyzed by an asymmetric RuvB hexamer by Anthony D. Rish, Zhangfei Shen, Zhenhang Chen, Nan Zhang, Qingfei Zheng, Tian-Min Fu

“…Abstract The Holliday junction (HJ) is a DNA intermediate of homologous recombination, involved in many fundamental physiological processes. …”
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Mechanistic Insights on Localized to Metastatic Prostate Cancer Transition and Therapeutic Opportunities by Yu EM, Hwang MW, Aragon-Ching JB

“…Aberrant pathway activations of PI3K/AKT due to PTEN loss, epithelial–mesenchymal transition pathways, homologous recombination repair, and DNA repair pathway mechanisms of resistance and cross-talk lead to opportunities for therapeutic targeting in metastatic castration-resistant prostate cancer. …”
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Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer by Jae-Ho Lee, An-Na Bae, Soo-Jung Jung

“…<i>Background and Objectives</i>: RAD51 plays an essential role in DNA repair via homologous recombination. RAD51 facilitates strand transfer between interrupted sequences and their undamaged homologies. …”
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