DNA damage remodels the MITF interactome to increase melanoma genomic instability by Binet, R, Lambert, J-P, Tomkova, M, Tischfield, S, Baggiolini, A, Picaud, S, Sarkar, S, Louphrasitthiphol, P, Dias, D, Carreira, S, Humphrey, TC, Fillipakopoulos, P, White, R, Goding, CR

“…Consequently, cells with high MITF levels accumulate stalled replication forks and display defects in homologous recombination-mediated repair associated with impaired MRN recruitment to DNA damage. …”

Activation of Xer-recombination at dif: structural basis of the FtsKγ–XerD interaction by Keller, A, Xin, Y, Boer, S, Reinhardt, J, Baker, R, Arciszewska, L, Lewis, P, Sherratt, D, Löwe, J, Grainge, I

“…This can produce a topological problem; a genetic crossover from homologous recombination results in dimerization of the chromosome. …”

Direct observation of end resection by RecBCD during double-stranded DNA break repair in vivo by Wiktor, J, van der Does, M, Büller, L, Sherratt, D, Dekker, C

“…We thus visualized and quantified DNA end resection by the RecBCD complex in live cells, recorded DNA-degradation linked to end resection and uncovered a general relationship between the length of end resection and the choice of the homologous recombination template.…”

Schizosaccharomyces pombe checkpoint response to DNA interstrand cross-links. by Lambert, S, Mason, S, Barber, L, Hartley, J, Pearce, J, Carr, A, McHugh, P

“…First we confirmed that the repair pathways acting on ICLs in this yeast are similar to those in the main organisms studied to date (Escherichia coli, budding yeast, and mammalian cells), principally nucleotide excision repair and homologous recombination. We also identified and disrupted the S. pombe homologue of the Saccharomyces cerevisiae SNM1/PSO2 ICL repair gene and found that this activity is required for normal resistance to cross-linking agents, but not other forms of DNA damage. …”

The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. by Prevo, R, Fokas, E, Reaper, P, Charlton, P, Pollard, JR, McKenna, W, Muschel, R, Brunner, T

“…Reduced cancer cell radiosurvival following treatment with VE-821 was also accompanied by increased DNA damage and inhibition of homologous recombination repair, as evidenced by persistence of γH2AX and 53BP1 foci and inhibition of Rad51 foci, respectively. …”

Epistasis, core-genome disharmony, and adaptation in recombining bacteria by Taylor, AJ, Yahara, K, Pascoe, B, Ko, S, Mageiros, L, Mourkas, E, Calland, JK, Puranen, S, Hitchings, MD, Jolley, KA, Kobras, CM, Bayliss, S, Williams, NJ, van Vliet, AHM, Parkhill, J, Maiden, MCJ, Corander, J, Hurst, LD, Falush, D, Keim, P, Didelot, X, Kelly, DJ, Sheppard, SK

“…Why then is homologous recombination common in the core of bacterial genomes? …”

Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction. by Croset, V, Rytz, R, Cummins, S, Budd, A, Brawand, D, Kaessmann, H, Gibson, T, Benton, R

“…Examination of IR gene structure and genomic distribution suggests both non-allelic homologous recombination and retroposition contributed to the expansion of this multigene family. …”

Involvement Of Azotobacter Vinelandii Hypothetical Protein Avin_16040 In Oryza Sativa Root Attachment by Pauline, Liew Woan Ying

“…To investigate the biological function of Avin_16040, a deletion mutant of the Avin_16040 gene was generated by homologous recombination.…”
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mRNA Expression and Methylation of the , , , , and Genes in Gastric Adenocarcinoma by Joel Del Bel Pádua, Carolline Fontes Alves Mariano, Alexandre Todorovic Fabro, Fermino Sanches Lizarte Neto, Rogério Lenotti Zuliani, Cláudia Tarcila Gomes Sares, José Sebastião dos Santos, Ajith Kumar Sankarankutty, Daniela Pretti da Cunha Tirapelli, Vanessa da Silva Silveira, Greice Andreotti de Molfetta, Wilson Araújo da Silva Júnior, Mariângela Ottoboni Brunaldi

“…Background: Immunohistochemical prognostic significance of the homologous recombination-related proteins RAD51, ATM, BRCA1, and BRCA2 is known in gastric adenocarcinoma, one of the deadliest cancers. …”
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SETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapy by Xiaobin Zheng, Jing Lin, Jiani Xiong, Yanfang Guan, Bin Lan, Yi Li, Xuan Gao, Zhaodong Fei, Lisha Chen, Lizhu Chen, Ling Chen, Gang Chen, Zengqing Guo, Xin Yi, Weiguo Cao, Xinghao Ai, Chengzhi Zhou, Xiaofeng Li, Jun Zhao, Xiangtao Yan, Qitao Yu, Lu Si, Yu Chen, Chuanben Chen

“…Abstract Background SETD2 protects against genomic instability via maintenance of homologous recombination repair (HRR) and mismatch repair (MMR) in neoplastic cells. …”
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Is Reflex Germline <i>BRCA1/2</i> Testing Necessary in Women Diagnosed with Non-Mucinous High-Grade Epithelial Ovarian Cancer Aged 80 Years or Older? by Robert D. Morgan, George J. Burghel, Nicola Flaum, Michael Bulman, Philip Smith, Andrew R. Clamp, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Emma R. Woodward, Fiona Lalloo, Emma J. Crosbie, Richard J. Edmondson, Helene Schlecht, Gordon C. Jayson, D. Gareth R. Evans

“…A subgroup of women also underwent germline testing using a panel of homologous recombination repair (HRR) genes and/or tumour testing for homologous recombination deficiency (HRD) using Myriad’s myChoice® companion diagnostic. …”
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S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair by Adi Amar-Schwartz, Vered Ben Hur, Amina Jbara, Yuval Cohen, Georgina D Barnabas, Eliran Arbib, Zahava Siegfried, Bayan Mashahreh, Fouad Hassouna, Asaf Shilo, Mohammad Abu-Odeh, Michael Berger, Reuven Wiener, Rami Aqeilan, Tamar Geiger, Rotem Karni

“…In this study, we discovered a novel role for S6K1 in regulating DNA repair through the coordinated regulation of the cell cycle, homologous recombination (HR) DNA repair (HRR) and mismatch DNA repair (MMR) mechanisms. …”
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General Genetics Concepts / by Major, Jude, author 648645

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For the Better or for the Worse? The Effect of Manganese on the Activity of Eukaryotic DNA Polymerases by Eva Balint, Ildiko Unk

“…DNA polymerases constitute a versatile group of enzymes that not only perform the essential task of genome duplication but also participate in various genome maintenance pathways, such as base and nucleotide excision repair, non-homologous end-joining, homologous recombination, and translesion synthesis. Polymerases catalyze DNA synthesis via the stepwise addition of deoxynucleoside monophosphates to the 3′ primer end in a partially double-stranded DNA. …”
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Drosophila duplication hotspots are associated with late-replicating regions of the genome. by Margarida Cardoso-Moreira, J J Emerson, Andrew G Clark, Manyuan Long

“…However, unlike the duplication hotspots identified in mammalian genomes, Drosophila duplication hotspots are not associated with sequences of high sequence identity capable of mediating non-allelic homologous recombination. Instead, Drosophila duplication hotspots are associated with late-replicating regions of the genome, suggesting a link between DNA replication and duplication rates. …”
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Recombination and population mosaic of a multifunctional viral gene, adeno-associated virus cap. by Yasuhiro Takeuchi, Richard Myers, Olivier Danos

“…Homologous recombination is a dominant force in evolution and results in genetic mosaics. …”
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Bisulfite treatment and single-molecule real-time sequencing reveal D-loop length, position, and distribution by Shanaya Shital Shah, Stella R Hartono, Frédéric Chédin, Wolf-Dietrich Heyer

“…Displacement loops (D-loops) are signature intermediates formed during homologous recombination. Numerous factors regulate D-loop formation and disruption, thereby influencing crucial aspects of DNA repair, including donor choice and the possibility of crossover outcome. …”
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Development and Efficacy Evaluation of an SP01-adjuvanted Inactivated Escherichia Coli Mutant Vaccine Against Bovine Coliform Mastitis by Xinyu Li, Chongyu Tian, Hui Han, Bochang Shi, Huabin Li, Yuan Liu, Wei He, Chunhe Li, Min Li, Yuanqiang Zheng, Bo Li, Liyan Zhao, Naxin Zheng, Fang Yan, Zhongpeng Zhao

“…To extend the cross-protection of the Ch-O111-1 strain, we deleted the galE gene fragment of the Ch-O111-1 strain through homologous recombination between the Ch-O111-1 strain and pCVD442/ΔgalE plasmid, which was identified through conventional methods, including PCR, SDS-PAGE and sequencing. …”
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Role of PARP in TNBC: Mechanism of Inhibition, Clinical Applications, and Resistance by Desh Deepak Singh, Amna Parveen, Dharmendra Kumar Yadav

“…PARP (poly(ADP-ribose) polymerase) is a major protein and is involved in DNA repair pathways, base excision repair (BER) mechanisms, homologous recombination (HR), and nonhomologous end-joining (NEJ) deficiency-based repair mechanisms. …”
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Changes in Gene Expression in Canola Roots Induced by ACC-Deaminase-Containing Plant-Growth-Promoting Bacteria by Nikos Hontzeas, Saleema S. Saleh, Bernard R. Glick

“…The technique of RNA arbitrarily primed-polymerase chain reaction (RAP-PCR) was used to study changes in gene expression over time in canola roots treated with the 1-aminocyclopropane-1-carboxylate (ACC) deaminase-containing plant-growth-promoting bacterium Enterobacter cloacae UW4 and to compare the changes with those in a mutant of E. cloacae UW4 in which the ACC deaminase structural gene acdS was replaced by homologous recombination with acdS with an intentional knockout containing a tetracycline resistance gene. …”
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