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1261
DNA damage remodels the MITF interactome to increase melanoma genomic instability
Published 2024“…Consequently, cells with high MITF levels accumulate stalled replication forks and display defects in homologous recombination-mediated repair associated with impaired MRN recruitment to DNA damage. …”
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1262
Activation of Xer-recombination at dif: structural basis of the FtsKγ–XerD interaction
Published 2016“…This can produce a topological problem; a genetic crossover from homologous recombination results in dimerization of the chromosome. …”
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1263
Direct observation of end resection by RecBCD during double-stranded DNA break repair in vivo
Published 2017“…We thus visualized and quantified DNA end resection by the RecBCD complex in live cells, recorded DNA-degradation linked to end resection and uncovered a general relationship between the length of end resection and the choice of the homologous recombination template.…”
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1264
Schizosaccharomyces pombe checkpoint response to DNA interstrand cross-links.
Published 2003“…First we confirmed that the repair pathways acting on ICLs in this yeast are similar to those in the main organisms studied to date (Escherichia coli, budding yeast, and mammalian cells), principally nucleotide excision repair and homologous recombination. We also identified and disrupted the S. pombe homologue of the Saccharomyces cerevisiae SNM1/PSO2 ICL repair gene and found that this activity is required for normal resistance to cross-linking agents, but not other forms of DNA damage. …”
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1265
The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy.
Published 2012“…Reduced cancer cell radiosurvival following treatment with VE-821 was also accompanied by increased DNA damage and inhibition of homologous recombination repair, as evidenced by persistence of γH2AX and 53BP1 foci and inhibition of Rad51 foci, respectively. …”
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1266
Epistasis, core-genome disharmony, and adaptation in recombining bacteria
Published 2024“…Why then is homologous recombination common in the core of bacterial genomes? …”
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1267
Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction.
Published 2010“…Examination of IR gene structure and genomic distribution suggests both non-allelic homologous recombination and retroposition contributed to the expansion of this multigene family. …”
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1268
Involvement Of Azotobacter Vinelandii Hypothetical Protein Avin_16040 In Oryza Sativa Root Attachment
Published 2013“…To investigate the biological function of Avin_16040, a deletion mutant of the Avin_16040 gene was generated by homologous recombination.…”
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1269
mRNA Expression and Methylation of the , , , , and Genes in Gastric Adenocarcinoma
Published 2024-01-01“…Background: Immunohistochemical prognostic significance of the homologous recombination-related proteins RAD51, ATM, BRCA1, and BRCA2 is known in gastric adenocarcinoma, one of the deadliest cancers. …”
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1270
SETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapy
Published 2023-07-01“…Abstract Background SETD2 protects against genomic instability via maintenance of homologous recombination repair (HRR) and mismatch repair (MMR) in neoplastic cells. …”
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1271
Is Reflex Germline <i>BRCA1/2</i> Testing Necessary in Women Diagnosed with Non-Mucinous High-Grade Epithelial Ovarian Cancer Aged 80 Years or Older?
Published 2023-01-01“…A subgroup of women also underwent germline testing using a panel of homologous recombination repair (HRR) genes and/or tumour testing for homologous recombination deficiency (HRD) using Myriad’s myChoice® companion diagnostic. …”
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1272
S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair
Published 2022-10-01“…In this study, we discovered a novel role for S6K1 in regulating DNA repair through the coordinated regulation of the cell cycle, homologous recombination (HR) DNA repair (HRR) and mismatch DNA repair (MMR) mechanisms. …”
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1273
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1274
For the Better or for the Worse? The Effect of Manganese on the Activity of Eukaryotic DNA Polymerases
Published 2023-12-01“…DNA polymerases constitute a versatile group of enzymes that not only perform the essential task of genome duplication but also participate in various genome maintenance pathways, such as base and nucleotide excision repair, non-homologous end-joining, homologous recombination, and translesion synthesis. Polymerases catalyze DNA synthesis via the stepwise addition of deoxynucleoside monophosphates to the 3′ primer end in a partially double-stranded DNA. …”
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1275
Drosophila duplication hotspots are associated with late-replicating regions of the genome.
Published 2011-11-01“…However, unlike the duplication hotspots identified in mammalian genomes, Drosophila duplication hotspots are not associated with sequences of high sequence identity capable of mediating non-allelic homologous recombination. Instead, Drosophila duplication hotspots are associated with late-replicating regions of the genome, suggesting a link between DNA replication and duplication rates. …”
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1276
Recombination and population mosaic of a multifunctional viral gene, adeno-associated virus cap.
Published 2008-01-01“…Homologous recombination is a dominant force in evolution and results in genetic mosaics. …”
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1277
Bisulfite treatment and single-molecule real-time sequencing reveal D-loop length, position, and distribution
Published 2020-11-01“…Displacement loops (D-loops) are signature intermediates formed during homologous recombination. Numerous factors regulate D-loop formation and disruption, thereby influencing crucial aspects of DNA repair, including donor choice and the possibility of crossover outcome. …”
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1278
Development and Efficacy Evaluation of an SP01-adjuvanted Inactivated Escherichia Coli Mutant Vaccine Against Bovine Coliform Mastitis
Published 2022-11-01“…To extend the cross-protection of the Ch-O111-1 strain, we deleted the galE gene fragment of the Ch-O111-1 strain through homologous recombination between the Ch-O111-1 strain and pCVD442/ΔgalE plasmid, which was identified through conventional methods, including PCR, SDS-PAGE and sequencing. …”
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1279
Role of PARP in TNBC: Mechanism of Inhibition, Clinical Applications, and Resistance
Published 2021-10-01“…PARP (poly(ADP-ribose) polymerase) is a major protein and is involved in DNA repair pathways, base excision repair (BER) mechanisms, homologous recombination (HR), and nonhomologous end-joining (NEJ) deficiency-based repair mechanisms. …”
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1280
Changes in Gene Expression in Canola Roots Induced by ACC-Deaminase-Containing Plant-Growth-Promoting Bacteria
Published 2004-08-01“…The technique of RNA arbitrarily primed-polymerase chain reaction (RAP-PCR) was used to study changes in gene expression over time in canola roots treated with the 1-aminocyclopropane-1-carboxylate (ACC) deaminase-containing plant-growth-promoting bacterium Enterobacter cloacae UW4 and to compare the changes with those in a mutant of E. cloacae UW4 in which the ACC deaminase structural gene acdS was replaced by homologous recombination with acdS with an intentional knockout containing a tetracycline resistance gene. …”
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