Homologous Recombination Deficiency in Ovarian Cancer: from the Biological Rationale to Current Diagnostic Approaches by Alessandro Mangogna, Giada Munari, Francesco Pepe, Edoardo Maffii, Pierluigi Giampaolino, Giuseppe Ricci, Matteo Fassan, Umberto Malapelle, Stefania Biffi

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Mechanism of RBBP8‐mediated homologous recombination repair in gastric cancer synthetic lethal by Yang Yu, Shuxia Wang, Yanhua Yin, Guangsheng Wang

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Homologous Recombination Deficiency Unrelated to Platinum and PARP Inhibitor Response in Cell Line Libraries by Shiro Takamatsu, Kosuke Murakami, Noriomi Matsumura

“…Abstract While large publicly available cancer cell line databases are invaluable for preclinical drug discovery and biomarker development, the association between homologous recombination deficiency (HRD) and drug sensitivity in these resources remains unclear. …”
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Somatic and germline aberrations in homologous recombination repair genes in Chinese prostate cancer patients by Yixiao Liu, Yixiao Liu, Yixiao Liu, Bo Jin, Cheng Shen, Cheng Shen, Cheng Shen, Xianshu Gao, Xin Qi, Mingwei Ma, Hongzhen Li, Han Hao, Han Hao, Han Hao, Qi Tang, Qi Tang, Qi Tang, Kaiwei Yang, Kaiwei Yang, Kaiwei Yang, Yue Mi, Yue Mi, Yue Mi, Jie Guan, Xuero Feng, Zhisong He, Zhisong He, Zhisong He, Haixia Li, Wei Yu, Wei Yu, Wei Yu

“…Simple summarySomatic and germline aberrations in homologous recombinant repair (HHR) genes are associated with increased incidence and poor prognosis for prostate cancer. …”
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Landscape of homologous recombination deficiencies in solid tumours: analyses of two independent genomic datasets by Zhongwu Lai, Matthew Brosnan, Ethan S. Sokol, Mingchao Xie, Jonathan R. Dry, Elizabeth A. Harrington, J. Carl Barrett, Darren Hodgson

Subjects: “…Homologous recombination deficiency…”
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Prevalence and Prognostic Relevance of Homologous Recombination Repair Gene Mutations in Uterine Serous Carcinoma by Lin Dong, Tingting Wang, Ning Li, Hongwen Yao, Jianming Ying, Lingying Wu, Guangwen Yuan

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TRIP13 Enhances Radioresistance of Lung Adenocarcinoma Cells 
through the Homologous Recombination Pathway by Shutong GE, Runchuan GU, Xiongtao YANG, Changdan XU, Shijie WANG, Guangying ZHU

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The homologous recombination machinery modulates the formation of RNA–DNA hybrids and associated chromosome instability by Lamia Wahba, Steven K Gore, Douglas Koshland

“…These proteins normally promote DNA–DNA strand exchange in homologous recombination. We suggest they also directly promote the DNA–RNA strand exchange necessary for hybrid formation since we observed accumulation of Rad51p at a model hybrid-forming locus. …”
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Homologous Recombination Repair in Biliary Tract Cancers: A Prime Target for PARP Inhibition? by Chao Yin, Monika Kulasekaran, Tina Roy, Brennan Decker, Sonja Alexander, Mathew Margolis, Reena C. Jha, Gary M. Kupfer, Aiwu R. He

Subjects: “…homologous recombination repair…”
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Role of Homologous Recombination Repair (HRR) Genes in Uterine Leiomyosarcomas: A Retrospective Analysis by Francesca Ciccarone, Matteo Bruno, Elisa De Paolis, Alessia Piermattei, Maria De Bonis, Domenica Lorusso, Gian Franco Zannoni, Nicola Normanno, Angelo Minucci, Giovanni Scambia, Gabriella Ferrandina

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Cruciform DNA Structures Act as Legible Templates for Accelerating Homologous Recombination in Transgenic Animals by Huan Ou-Yang, Shiao-Hsuan Yang, Wei Chen, Shang-Hsun Yang, Abdulkadir Cidem, Li-Ying Sung, Chuan-Mu Chen

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Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma by Lara Planas‐Paz, Alicia Pliego‐Mendieta, Catherine Hagedorn, Domingo Aguilera‐Garcia, Martina Haberecker, Fabian Arnold, Marius Herzog, Lorenz Bankel, Roman Guggenberger, Sabrina Steiner, Yanjiang Chen, Abdullah Kahraman, Martin Zoche, Mark A Rubin, Holger Moch, Christian Britschgi, Chantal Pauli

“…Abstract Defects in homologous recombination repair (HRR) in tumors correlate with poor prognosis and metastases development. …”
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Analysis of Epigenetic Alterations in Homologous Recombination DNA Repair Genes in Male Breast Cancer by Saudade André, Sandra P. Nunes, Fernanda Silva, Rui Henrique, Ana Félix, Carmen Jerónimo

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MND1 enables homologous recombination in somatic cells primarily outside the context of replication by Lisa Koob, Anoek Friskes, Louise vanBergen, Femke M. Feringa, Bram van denBroek, Emma S. Koeleman, Ellis vanBeek, Michael Schubert, Vincent A. Blomen, Thijn R. Brummelkamp, Lenno Krenning, René H. Medema

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Variation among <i>Metschnikowia pulcherrima</i> Isolates for Genetic Modification and Homologous Recombination by Mauro Moreno-Beltrán, Deborah Gore-Lloyd, Christopher Chuck, Daniel Henk

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LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining by Lawrence, Katherine S., Tapley, Erin C., Cruz, Victor E., Li, Qianyan, Aung, Kayla, Hart, Kevin C., Starr, Daniel A., Engebrecht, JoAnne, Schwartz, Thomas

“…We propose that LINC complexes serve a conserved role in DNA repair through both the inhibition of NHEJ and the promotion of homologous recombination at sites of chromosomal breaks.…”
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Investigation into the relationship between PARPs in DNA repair and synthetic lethality with homologous recombination deficiency by Ronson, G

“…Furthermore, inhibitors that target these enzymes are in clinical use for their ability to kill homologous recombination deficient tumour cells, through a mechanism of synthetic lethality. …”

A role for human homologous recombination factors in suppressing microhomology-mediated end joining. by Ahrabi, S, Sarkar, S, Pfister, S, Pirovano, G, Higgins, G, Porter, A, Humphrey, T

“…DSB repair is usually facilitated by the classical non-homologous end joining (C-NHEJ), or homologous recombination (HR) pathways. However, a mutagenic alternative NHEJ pathway, microhomology-mediated end joining (MMEJ), can also be deployed. …”

The landscape of recombination in African Americans: leveraging human population variation to investigate homologous recombination by Hinch, A

“…<p>Homologous recombination is a highly regulated and complex biological process required for sexual reproduction in humans and many other species. …”

Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta. by Nicolay, N, Carter, R, Hatch, S, Schultz, N, Prevo, R, Mckenna, W, Helleday, T, Sharma, R

“…Cells deficient in pol η demonstrated increased homologous recombination (HR)-directed repair of double strand breaks created by IR. …”