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121
Homologous Recombination Deficiency in Ovarian Cancer: from the Biological Rationale to Current Diagnostic Approaches
Published 2023-02-01Subjects: Get full text
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122
Mechanism of RBBP8‐mediated homologous recombination repair in gastric cancer synthetic lethal
Published 2023-09-01Subjects: Get full text
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123
Homologous Recombination Deficiency Unrelated to Platinum and PARP Inhibitor Response in Cell Line Libraries
Published 2024-02-01“…Abstract While large publicly available cancer cell line databases are invaluable for preclinical drug discovery and biomarker development, the association between homologous recombination deficiency (HRD) and drug sensitivity in these resources remains unclear. …”
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124
Somatic and germline aberrations in homologous recombination repair genes in Chinese prostate cancer patients
Published 2023-03-01“…Simple summarySomatic and germline aberrations in homologous recombinant repair (HHR) genes are associated with increased incidence and poor prognosis for prostate cancer. …”
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125
Landscape of homologous recombination deficiencies in solid tumours: analyses of two independent genomic datasets
Published 2022-01-01Subjects: “…Homologous recombination deficiency…”
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126
Prevalence and Prognostic Relevance of Homologous Recombination Repair Gene Mutations in Uterine Serous Carcinoma
Published 2022-11-01Subjects: Get full text
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127
TRIP13 Enhances Radioresistance of Lung Adenocarcinoma Cells through the Homologous Recombination Pathway
Published 2024-01-01Subjects: Get full text
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128
The homologous recombination machinery modulates the formation of RNA–DNA hybrids and associated chromosome instability
Published 2013-06-01“…These proteins normally promote DNA–DNA strand exchange in homologous recombination. We suggest they also directly promote the DNA–RNA strand exchange necessary for hybrid formation since we observed accumulation of Rad51p at a model hybrid-forming locus. …”
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129
Homologous Recombination Repair in Biliary Tract Cancers: A Prime Target for PARP Inhibition?
Published 2022-05-01Subjects: “…homologous recombination repair…”
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130
Role of Homologous Recombination Repair (HRR) Genes in Uterine Leiomyosarcomas: A Retrospective Analysis
Published 2022-04-01Subjects: Get full text
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131
Cruciform DNA Structures Act as Legible Templates for Accelerating Homologous Recombination in Transgenic Animals
Published 2022-04-01Subjects: Get full text
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132
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma
Published 2023-04-01“…Abstract Defects in homologous recombination repair (HRR) in tumors correlate with poor prognosis and metastases development. …”
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133
Analysis of Epigenetic Alterations in Homologous Recombination DNA Repair Genes in Male Breast Cancer
Published 2020-04-01Subjects: Get full text
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134
MND1 enables homologous recombination in somatic cells primarily outside the context of replication
Published 2023-07-01Subjects: Get full text
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135
Variation among <i>Metschnikowia pulcherrima</i> Isolates for Genetic Modification and Homologous Recombination
Published 2021-01-01Subjects: Get full text
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136
LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining
Published 2017“…We propose that LINC complexes serve a conserved role in DNA repair through both the inhibition of NHEJ and the promotion of homologous recombination at sites of chromosomal breaks.…”
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137
Investigation into the relationship between PARPs in DNA repair and synthetic lethality with homologous recombination deficiency
Published 2017“…Furthermore, inhibitors that target these enzymes are in clinical use for their ability to kill homologous recombination deficient tumour cells, through a mechanism of synthetic lethality. …”
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138
A role for human homologous recombination factors in suppressing microhomology-mediated end joining.
Published 2016“…DSB repair is usually facilitated by the classical non-homologous end joining (C-NHEJ), or homologous recombination (HR) pathways. However, a mutagenic alternative NHEJ pathway, microhomology-mediated end joining (MMEJ), can also be deployed. …”
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139
The landscape of recombination in African Americans: leveraging human population variation to investigate homologous recombination
Published 2013“…<p>Homologous recombination is a highly regulated and complex biological process required for sexual reproduction in humans and many other species. …”
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140
Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta.
Published 2012“…Cells deficient in pol η demonstrated increased homologous recombination (HR)-directed repair of double strand breaks created by IR. …”
Journal article