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1501
Investigating DNA double-strand break repair in Dictyostelium discoideum
Published 2011“…This work has demonstrated the regulatory role of Adprt1a in DSB repair by promoting non-homologous end joining (NHEJ), at the expense of homologous recombination (HR). This may be achieved by the enhanced association of the Ku70/Ku80 heterodimer, the DSB sensor that initiates NHEJ, with chromatin following DNA damage in a PAR-dependent manner. …”
Thesis -
1502
Evolutionary and molecular analysis of the emergent severe fever with thrombocytopenia syndrome virus.
Published 2013“…Our discovery of a mosaic L segment sequence, which is descended from two major circulating lineages of SFTSV in China, represents the first evidence that homologous recombination plays a role in SFTSV evolution. Selection analyses indicate that negative selection is predominant in SFTSV genes, yet differences in selective forces among genes are consistent between Phlebovirus species. …”
Journal article -
1503
Nested Russian doll-like genetic mobility drives rapid dissemination of the carbapenem resistance gene blaKPC
Published 2016“…We also identify a common insertion site for Tn4401 within various Tn2-like elements, suggesting that homologous recombination between Tn2-like elements has enhanced the spread of Tn4401 between different plasmid vectors. …”
Journal article -
1504
Study of DNA double strand break repair in Dictyostelium discoideum
Published 2012“…The homologous recombination (HR) pathway contributes to genome integrity by mediating double strand break (DSB) repair using a homologous DNA sequence as a template. …”
Thesis -
1505
KAT2-mediated acetylation switches the mode of PALB2 chromatin association to safeguard genome integrity
Published 2022“…The tumour suppressor PALB2 stimulates RAD51-mediated homologous recombination (HR) repair of DNA damage, whilst its steady-state association with active genes protects these loci from replication stress. …”
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1506
A study of the Bloom's syndrome protein
Published 1999“…Most characteristically, these cells show elevated levels of sister-chromatid exchanges which probably result from homologous recombination events. Since the cells are not hypersensitive to DNA damaging agents, the defect is unlikely to be in one of the common DNA repair pathways. …”
Thesis -
1507
A prototypical Fanconi anemia pathway in lower eukaryotes?
Published 2012“…Yeast cells require a combination of nucleotide excision repair, homologous recombination repair and postreplication repair/translesion DNA synthesis to remove ICLs. …”
Journal article -
1508
Stability by multimer resolution of pJHCMW1 is due to the Tn1331 resolvase and not to the Escherichia coli Xer system.
Published 2000“…The Escherichia coli Xer site-specific recombination system acts at sites such as ColE1 cer to resolve plasmid multimers formed by homologous recombination, thereby maintaining plasmids in a monomeric state and helping to ensure stable plasmid inheritance. …”
Journal article -
1509
Evidence for soft selective sweeps in the evolution of pneumococcal multidrug resistance and vaccine escape.
Published 2014“…The rapid diversification through homologous recombination seen in the global collection was similarly observed in the absence of vaccination in a set of isolates from the Maela refugee camp in Thailand, a collection that also allowed variation to be observed within carriage through longitudinal sampling. …”
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1510
Efficient second strand cleavage during Holliday junction resolution by RuvC requires both increased junction flexibility and an exposed 5' phosphate.
Published 2009“… BACKGROUND: Holliday junction (HJ) resolution is a critical step during homologous recombination. In Escherichia coli this job is performed by a member of the RNase H/Integrase superfamily called RuvC, whereas in Schizosaccharomyces pombe it has been attributed to the XPF family member Mus81-Eme1. …”
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1511
6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance.
Published 2010“…Familial breast and ovarian cancers are often defective in homologous recombination (HR) due to mutations in the BRCA1 or BRCA2 genes. …”
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1512
Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment.
Published 2010“…Replicating cells exposed to either severe acute hypoxia (16 hours with 0.02% O(2)) followed by reoxygenation or moderate chronic hypoxia (72 hours with 0.2% O(2)) treatments have decreased homologous recombination (HR) protein expression and function. …”
Journal article -
1513
Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks
Published 2012“…</p> <h4>Methods:</h4> <p>We tested effects of IGF-1R siRNA transfection on the repair of radiation-induced DSBs by immunoblotting and immunofluorescence for cH2AX, and pulsed-field gel electrophoresis. Homologous recombination (HR) was quantified by reporter assays, and cell cycle distribution by flow cytometry.…”
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1514
A large AZFc deletion removes DAZ3/DAZ4 and nearby genes from men in Y haplogroup N.
Published 2004“…Furthermore, the observed deletions cannot be derived from the GenBank reference sequence by a single recombination event; an origin by homologous recombination from such a sequence organization must be preceded by an inversion event. …”
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1515
Evolution and population structure of Salmonella enterica serovar Newport.
Published 2010“…Both mutation and homologous recombination are responsible for diversification within each of these lineages, but the relative frequencies differed with the lineage. …”
Journal article -
1516
Beyond the trinity of ATM, ATR, and DNA-PK: multiple kinases shape the DNA damage response in concert with RNA metabolism
Published 2019“…The importance of kinase signaling and RNA processing in the DDR is highlighted by the regulation of p53-binding protein (53BP1), a key regulator of DSB repair pathway choice between homologous recombination (HR) and non-homologous end joining (NHEJ). …”
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1517
Replication fork collapse and recombination-dependent replication restart at replication fork barriers
Published 2019“…Replication fork collapse is a poorly understood process that is thought to involve either replisome remodelling and/or disassembly paving the way for homologous recombination (HR) proteins to act and restart replication, by a process known as recombination dependent replication restart (RDR), which is essential for completing DNA synthesis. …”
Thesis -
1518
Rapid, DNA-induced subunit exchange by DNA gyrase
Published 2024“…This exchange does not require ATP, can occur in the presence of fluoroquinolones, and raises the possibility of non-homologous recombination solely through gyrase activity. The ability of gyrase to undergo subunit exchange also explains how gyrase heterodimers, containing a single active-site tyrosine, can carry out double-strand passage reactions.…”
Journal article -
1519
Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast
Published 2012“…Moreover, ICL-induced Rad51 chromatin loading is delayed when both Pso2 and components of the Mph1-Mgm101-MutSα and Exo1 pathway are inactivated, demonstrating that the homologous recombination stages of ICL repair are inhibited. …”
Journal article -
1520
Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration
Published 1999“…To differentiate the unique and overlapping functions of LFA-1 and Mac-1, LFA-1-deficient mice were developed by targeted homologous recombination in embryonic stem cells, and neutrophil function was compared in vitro and in vivo with Mac-1-deficient, CD18-deficient, and wild-type mice. …”
Journal article