Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls. by Soemedi, R, Topf, A, Wilson, I, Darlay, R, Rahman, T, Glen, E, Hall, D, Huang, N, Bentham, J, Bhattacharya, S, Cosgrove, C, Brook, J, Granados-Riveron, J, Setchfield, K, Bu'lock, F, Thornborough, C, Devriendt, K, Breckpot, J, Hofbeck, M, Lathrop, M, Rauch, A, Blue, G, Winlaw, D, Hurles, M, Santibanez-Koref, M

“…Recurrent rearrangements of chromosome 1q21.1 that occur via non-allelic homologous recombination have been associated with variable phenotypes exhibiting incomplete penetrance, including congenital heart disease (CHD). …”

Investigating protein-protein interactions of the Bloom Syndrome complex by Belblidia, Z

“…</p> <p>BLM interacts with TOP3A, RMI1 and RMI2 to form the BTR complex, which functions to promote the restart of stalled forks and the dissolution of double Holliday junctions during homologous recombination repair to the prevent the formation of sister chromatid exchanges. …”

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity. by Tacconi, E, Lai, X, Folio, C, Porru, M, Zonderland, G, Badie, S, Michl, J, Sechi, I, Rogier, M, Matía García, V, Batra, A, Rueda, O, Bouwman, P, Jonkers, J, Ryan, A, Reina-San-Martin, B, Hui, J, Tang, N, Bruna, A, Biroccio, A, Tarsounas, M

“…Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly toxic to cells and mice lacking the FA protein FANCD2. …”

Contributions of tropodithietic acid and biofilm formation to the probiotic activity of Phaeobacter inhibens by Zhao, Wenjing, Dao, Christine, Abd Karim, Murni Marlina, Gomez-Chiarri, Marta, Rowley, David, Nelson, David R.

“…Results: Mutations in clpX (ATP-dependent ATPase) and exoP (an exopolysaccharide biosynthesis gene) were created by insertional mutagenesis using homologous recombination. Mutation of clpX resulted in the loss of TDA production, no decline in biofilm formation, and loss of the ability to inhibit the growth of Vibrio tubiashii and Vibrio anguillarum in co-colonization experiments. …”
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Contributions of tropodithietic acid and biofilm formation to the probiotic activity of Phaeobacter inhibens by Zhao, Wenjing, Dao, Christine, Karim, Murni, Gomez-Chiarri, Marta, Rowley, David, Nelson, David R.

“…Results:Mutations in clpX (ATP-dependent ATPase) and exoP (an exopolysaccharide biosynthesis gene) were created by insertional mutagenesis using homologous recombination. Mutation of clpX resulted in the loss of TDA production, no decline in biofilm formation, and loss of the ability to inhibit the growth of Vibrio tubiashii and Vibrio anguillarum in co-colonization experiments. …”
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Kertas kerja 3rd. congress of european microbiologists " microbes and maninterdepence and future challenges" 27 Jun - 03 Julai 2009 di Goteborg, Sweden by Kirnpal Kaur, Banga Singh

“…After undergoing homologous recombination, the wild apy gene was deleted from the construct. …”
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The Puzzling Fate of a Lupin Chromosome Revealed by Reciprocal Oligo-FISH and BAC-FISH Mapping by Wojciech Bielski, Michał Książkiewicz, Denisa Šimoníková, Eva Hřibová, Karolina Susek, Barbara Naganowska

“…The results highlighted changes in synteny within the Lang06 region between the lupin species, including putative translocations, inversions, and/or non-allelic homologous recombination, which would have accompanied the evolution and speciation.…”
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Correlation between large rearrangements and patient phenotypes in NF1 deletion syndrome: an update and review by Laurence Pacot, Milind Girish, Samantha Knight, Gill Spurlock, Vinod Varghese, Manuela Ye, Nick Thomas, Eric Pasmant, Meena Upadhyaya

“…The most frequent NF1 large deletion is 1.4 Mb, resulting from homologous recombination between two low copy repeats. This “type-1” deletion is associated with a severe clinical phenotype in NF1 patients, with several phenotypic manifestations including learning disability, a much earlier development of cutaneous neurofibromas, an increased tumour risk, and cardiovascular malformations. …”
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Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes by Jaigeeth Deveryshetty, Rahul Chadda, Jenna R. Mattice, Simrithaa Karunakaran, Michael J. Rau, Katherine Basore, Nilisha Pokhrel, Noah Englander, James A. J. Fitzpatrick, Brian Bothner, Edwin Antony

“…Abstract Homologous recombination (HR) is an essential double-stranded DNA break repair pathway. …”
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Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere by Piyusha Mongia, Naoko Toyofuku, Ziyi Pan, Ran Xu, Yakumo Kinoshita, Keitaro Oki, Hiroki Takahashi, Yoshitoshi Ogura, Tetsuya Hayashi, Takuro Nakagawa

“…Abstract Rad51 maintains genome integrity, whereas Rad52 causes non-canonical homologous recombination leading to gross chromosomal rearrangements (GCRs). …”
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Synthesis of Full-Length cDNA Infectious Clones of <i>Soybean Mosaic Virus</i> and Functional Identification of a Key Amino Acid in the Silencing Suppressor Hc-Pro by Wenhua Bao, Ting Yan, Xiaoyi Deng, Hada Wuriyanghan

“…In this study, both tag-free and reporter gene <i>green fluorescent protein</i> (<i>GFP</i>)-containing infectious clones for the SMV N1 strain were constructed by Gibson assembly and with the yeast homologous recombination system, respectively. Both infectious clones are suitable for agroinfiltration on the model host <i>N. benthamiana</i> and show strong infectivity for the natural host soybean and several other legume species. …”
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Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops by Jie Liu, Christopher Ede, William D Wright, Steven K Gore, Shirin S Jenkins, Bret D Freudenthal, M Todd Washington, Xavier Veaute, Wolf-Dietrich Heyer

“…Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity. …”
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Mapping and Analysis of Swi5 and Sfr1 Phosphorylation Sites by Andrea Sevcovicova, Jana Plava, Matej Gazdarica, Eva Szabova, Barbora Huraiova, Katarina Gaplovska-Kysela, Ingrid Cipakova, Lubos Cipak, Juraj Gregan

“…The evolutionarily conserved Swi5-Sfr1 complex plays an important role in homologous recombination, a process crucial for the maintenance of genomic integrity. …”
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OsMre11 Is Required for Mitosis during Rice Growth and Development by Miaomiao Shen, Yanshen Nie, Yueyue Chen, Xiufeng Zhang, Jie Zhao

“…Moreover, OsMre11 could form a complex with OsRad50 and OsNbs1, and they might function together in non-homologous end joining and homologous recombination repair pathways. These results indicated that <i>OsMre11</i> plays vital roles in DNA replication and damage repair of the mitotic cell cycle, which ensure the development and fertility of rice by maintaining genome stability.…”
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Expression Levels of RAD51 Inversely Correlate with Survival of Glioblastoma Patients by Christopher Morrison, Eric Weterings, Daruka Mahadevan, Abhay Sanan, Martin Weinand, Baldassarre Stea

“…Within this uniformly treated GBM population, RAD51, in the homologous recombination pathway, was overexpressed (vs. normal brain) and inversely correlated with OS. …”
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Mcm2 phosphorylation and the response to replicative stress by Stead Brent E, Brandl Christopher J, Sandre Matthew K, Davey Megan J

“…Deletions that decrease spontaneous DNA damage, increase homologous recombination or slow replication forks were isolated. …”
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Rad51 filaments assembled in the absence of the complex formed by the Rad51 paralogs Rad55 and Rad57 are outcompeted by translesion DNA polymerases on UV-induced ssDNA gaps. by Laurent Maloisel, Emilie Ma, Jamie Phipps, Alice Deshayes, Stefano Mattarocci, Stéphane Marcand, Karine Dubrana, Eric Coïc

“…Two error-free pathways can bypass the lesions: the template switching pathway, which uses the sister chromatid as a template, and the homologous recombination pathway (HR), which also can use the homologous chromosome as template. …”
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All three subunits of RecBCD enzyme are essential for DNA repair and low-temperature growth in the Antarctic Pseudomonas syringae Lz4W. by Theetha L Pavankumar, Anurag K Sinha, Malay K Ray

“…Generally, RecD associates with two other proteins (RecB and RecC) to produce RecBCD enzyme, which is involved in homologous recombination and DNA repair in many bacteria, including Escherichia coli. …”
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Methods of yeast genome editing by A. S. Rozanov, V. N. Shlyahtun, L. A. Tekutieva, O. M. Son, S. V. Sizova, S. E. Peltek

“…For a long time, yeast genome engineering was based on the yeasts’ system of homologous recombination. It was sufficient for several decades before the development of high­throughput methods. …”
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Role of RPA Phosphorylation in the ATR-Dependent G2 Cell Cycle Checkpoint by Shengqin Liu, Brendan M. Byrne, Thomas N. Byrne, Gregory G. Oakley

“…However, when DSBs are generated after DNA replication in the G2 phase of the cell cycle, a second DSB repair pathway, homologous recombination, can come into action. Both ATM and ATR are important for DSB-induced DSB repair and checkpoint responses. …”
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