-
1521
Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls.
Published 2012“…Recurrent rearrangements of chromosome 1q21.1 that occur via non-allelic homologous recombination have been associated with variable phenotypes exhibiting incomplete penetrance, including congenital heart disease (CHD). …”
Journal article -
1522
Investigating protein-protein interactions of the Bloom Syndrome complex
Published 2021“…</p> <p>BLM interacts with TOP3A, RMI1 and RMI2 to form the BTR complex, which functions to promote the restart of stalled forks and the dissolution of double Holliday junctions during homologous recombination repair to the prevent the formation of sister chromatid exchanges. …”
Thesis -
1523
BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.
Published 2017“…Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly toxic to cells and mice lacking the FA protein FANCD2. …”
Journal article -
1524
Contributions of tropodithietic acid and biofilm formation to the probiotic activity of Phaeobacter inhibens
Published 2016“…Results: Mutations in clpX (ATP-dependent ATPase) and exoP (an exopolysaccharide biosynthesis gene) were created by insertional mutagenesis using homologous recombination. Mutation of clpX resulted in the loss of TDA production, no decline in biofilm formation, and loss of the ability to inhibit the growth of Vibrio tubiashii and Vibrio anguillarum in co-colonization experiments. …”
Get full text
Article -
1525
Contributions of tropodithietic acid and biofilm formation to the probiotic activity of Phaeobacter inhibens
Published 2016“…Results:Mutations in clpX (ATP-dependent ATPase) and exoP (an exopolysaccharide biosynthesis gene) were created by insertional mutagenesis using homologous recombination. Mutation of clpX resulted in the loss of TDA production, no decline in biofilm formation, and loss of the ability to inhibit the growth of Vibrio tubiashii and Vibrio anguillarum in co-colonization experiments. …”
Get full text
Article -
1526
Kertas kerja 3rd. congress of european microbiologists " microbes and maninterdepence and future challenges" 27 Jun - 03 Julai 2009 di Goteborg, Sweden
Published 2009“…After undergoing homologous recombination, the wild apy gene was deleted from the construct. …”
Get full text
Monograph -
1527
The Puzzling Fate of a Lupin Chromosome Revealed by Reciprocal Oligo-FISH and BAC-FISH Mapping
Published 2020-12-01“…The results highlighted changes in synteny within the Lang06 region between the lupin species, including putative translocations, inversions, and/or non-allelic homologous recombination, which would have accompanied the evolution and speciation.…”
Get full text
Article -
1528
Correlation between large rearrangements and patient phenotypes in NF1 deletion syndrome: an update and review
Published 2024-03-01“…The most frequent NF1 large deletion is 1.4 Mb, resulting from homologous recombination between two low copy repeats. This “type-1” deletion is associated with a severe clinical phenotype in NF1 patients, with several phenotypic manifestations including learning disability, a much earlier development of cutaneous neurofibromas, an increased tumour risk, and cardiovascular malformations. …”
Get full text
Article -
1529
Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes
Published 2023-10-01“…Abstract Homologous recombination (HR) is an essential double-stranded DNA break repair pathway. …”
Get full text
Article -
1530
Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere
Published 2023-05-01“…Abstract Rad51 maintains genome integrity, whereas Rad52 causes non-canonical homologous recombination leading to gross chromosomal rearrangements (GCRs). …”
Get full text
Article -
1531
Synthesis of Full-Length cDNA Infectious Clones of <i>Soybean Mosaic Virus</i> and Functional Identification of a Key Amino Acid in the Silencing Suppressor Hc-Pro
Published 2020-08-01“…In this study, both tag-free and reporter gene <i>green fluorescent protein</i> (<i>GFP</i>)-containing infectious clones for the SMV N1 strain were constructed by Gibson assembly and with the yeast homologous recombination system, respectively. Both infectious clones are suitable for agroinfiltration on the model host <i>N. benthamiana</i> and show strong infectivity for the natural host soybean and several other legume species. …”
Get full text
Article -
1532
Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops
Published 2017-05-01“…Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity. …”
Get full text
Article -
1533
Mapping and Analysis of Swi5 and Sfr1 Phosphorylation Sites
Published 2021-06-01“…The evolutionarily conserved Swi5-Sfr1 complex plays an important role in homologous recombination, a process crucial for the maintenance of genomic integrity. …”
Get full text
Article -
1534
OsMre11 Is Required for Mitosis during Rice Growth and Development
Published 2020-12-01“…Moreover, OsMre11 could form a complex with OsRad50 and OsNbs1, and they might function together in non-homologous end joining and homologous recombination repair pathways. These results indicated that <i>OsMre11</i> plays vital roles in DNA replication and damage repair of the mitotic cell cycle, which ensure the development and fertility of rice by maintaining genome stability.…”
Get full text
Article -
1535
Expression Levels of RAD51 Inversely Correlate with Survival of Glioblastoma Patients
Published 2021-10-01“…Within this uniformly treated GBM population, RAD51, in the homologous recombination pathway, was overexpressed (vs. normal brain) and inversely correlated with OS. …”
Get full text
Article -
1536
Mcm2 phosphorylation and the response to replicative stress
Published 2012-05-01“…Deletions that decrease spontaneous DNA damage, increase homologous recombination or slow replication forks were isolated. …”
Get full text
Article -
1537
Rad51 filaments assembled in the absence of the complex formed by the Rad51 paralogs Rad55 and Rad57 are outcompeted by translesion DNA polymerases on UV-induced ssDNA gaps.
Published 2023-02-01“…Two error-free pathways can bypass the lesions: the template switching pathway, which uses the sister chromatid as a template, and the homologous recombination pathway (HR), which also can use the homologous chromosome as template. …”
Get full text
Article -
1538
All three subunits of RecBCD enzyme are essential for DNA repair and low-temperature growth in the Antarctic Pseudomonas syringae Lz4W.
Published 2010-01-01“…Generally, RecD associates with two other proteins (RecB and RecC) to produce RecBCD enzyme, which is involved in homologous recombination and DNA repair in many bacteria, including Escherichia coli. …”
Get full text
Article -
1539
Methods of yeast genome editing
Published 2018-01-01“…For a long time, yeast genome engineering was based on the yeasts’ system of homologous recombination. It was sufficient for several decades before the development of highthroughput methods. …”
Get full text
Article -
1540
Role of RPA Phosphorylation in the ATR-Dependent G2 Cell Cycle Checkpoint
Published 2023-12-01“…However, when DSBs are generated after DNA replication in the G2 phase of the cell cycle, a second DSB repair pathway, homologous recombination, can come into action. Both ATM and ATR are important for DSB-induced DSB repair and checkpoint responses. …”
Get full text
Article