Similarities between exogenously- and endogenously-induced envelope stress: the effects of a new antibacterial molecule, TPI1609-10. by Shmuel Yitzhaki, Jason E Rostron, Yan Xu, Marc C Rideout, R Nathan Authement, Steven B Barlow, Anca M Segall

“…SM10 was screened in vitro to bind branched Holliday junction intermediates of homologous recombination and tyrosine recombinase-mediated recombination; thus, the cellular targets of the small molecules were expected to include the RuvABC Holliday junction resolvasome and the XerCD complex involved in proper segregation of replicated chromosomes to daughter cells. …”
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Pan-cancer analysis of co-occurring mutations in RAD52 and the BRCA1-BRCA2-PALB2 axis in human cancers. by Abdulaziz B Hamid, Lauren E Frank, Renee A Bouley, Ruben C Petreaca

“…In human cells homologous recombination (HR) is critical for repair of DNA double strand breaks (DSBs) and rescue of stalled or collapsed replication forks. …”
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Role of the SaeRS two-component regulatory system in <it>Staphylococcus epidermidis </it>autolysis and biofilm formation by Francois Patrice, Fischer Adrien, Wu Yang, Liu Jingran, Yang Jinsong, Yu Fangyou, Ben Haijing, Hu Jian, Zhu Tao, Lou Qiang, Schrenzel Jacques, Qu Di

“…</p> <p>Results</p> <p>The <it>saeRS </it>genes of SE1457 were deleted by homologous recombination. The <it>saeRS </it>deletion mutant, SE1457<it>ΔsaeRS</it>, exhibited increased biofilm formation that was disturbed more severely (a 4-fold reduction) by DNase I treatment compared to SE1457 and the complementation strain SE1457<it>saec</it>. …”
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Combined anti-tumor efficacy of somatostatin fusion protein and vaccinia virus on tumor cells with high expression of somatostatin receptors by Jun Fan, Lili Deng, Ying Peng, Yuedi Ding

“…Here, a vaccinia VG9/(SST-14)2-HSA recombinant was constructed by replacing somatostatin fusion gene into TK locus of attenuated VG9 strain via homologous recombination. Results showed that vaccinia VG9/(SST-14)2-HSA possessed a combined anti-tumor effect on sstr-positive tumor cells in vitro. …”
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The alternation of halobenzoquinone disinfection byproduct on toxicogenomics of DNA damage and repair in uroepithelial cells by Xu Zhang, Lifang Liu, Jun Wang, Lanqian Liang, Xu Wang, Gaihua Wang, Ziqiao He, Xueting Cui, Haiying Du, Bo Pang, Jinhua Li

“…Toxicogenomic analysis indicated that HBQs interfered with DNA repair pathways, mainly affecting base excision repair, nucleotide excision repair and homologous recombination repair. These results have provided new insights into the underlying molecular mechanisms of HBQs-induced DNA damage, and contributed to the understanding of the relationship between exposure to DBPs and risks of developing bladder cancer.…”
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Checkpoint Kinase 1 (CHK1) Inhibition Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Proton Irradiation via Rad51 Downregulation by Changhoon Choi, Won Kyung Cho, Sohee Park, Sung-Won Shin, Won Park, Haeyoung Kim, Doo Ho Choi

“…Immunofluorescence revealed that proton-induced DNA double-strand breaks (DSBs) were further enhanced by PF-477736, which was linked to the downregulation of Rad51, essential for the homologous recombination repair of DSBs. Direct inactivation of Rad51 resulted in enhanced proton sensitization. …”
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PARPi Decreased Primary Ovarian Cancer Organoid Growth Through Early Apoptosis and Base Excision Repair Pathway by Qi Cao, Lanyang Li, Yuqing Zhao, Chen Wang, Yanghua Shi, Xiang Tao, Chunhui Cai, Xin-Xin Han

“…As therapeutic drugs approved for OC, poly ADP-ribose polymerase inhibitors (PARPi) lead to synthetic lethality by inhibiting single-strand DNA repair, particularly in homologous recombination-deficient cancers. However, even PARPi have distinct efficacies and are prone to have drug resistance, the molecular mechanisms underlying the PARPi resistance in OC remain unclear. …”
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Ovarian Cancer: Biomarkers and Targeted Therapy by Mihaela Raluca Radu, Alina Prădatu, Florentina Duică, Romeo Micu, Sanda Maria Creţoiu, Nicolae Suciu, Dragoş Creţoiu, Valentin Nicolae Varlas, Viorica Elena Rădoi

“…Currently, in gynecological malignancies, potential therapeutic targets include tumor-intrinsic signaling pathways, angiogenesis, homologous-recombination deficiency, hormone receptors, and immunologic factors. …”
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The StkSR Two-Component System Influences Colistin Resistance in <i>Acinetobacter baumannii</i> by Sarah K. Giles, Uwe H. Stroeher, Bhavya Papudeshi, Robert A. Edwards, Jessica AP. Carlson-Jones, Michael Roach, Melissa H. Brown

“…The <i>stkR</i> response regulator was deleted via homologous recombination and its progeny, Δ<i>stkR</i>, was phenotypically characterized. …”
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CtIP Regulates Mitotic Spindle Assembly by Modulating the TPX2-Aurora A Signaling Axis by Wonkyung Oh, Ting Ting Wu, Seo-Yeon Jeong, Ho Jin You, Jung-Hee Lee

“…CtBP-interacting protein (CtIP) plays a critical role in controlling the homologous recombination-mediated DNA double-stranded break (DSB) repair pathway through DNA end resection, and recent studies suggest that it also plays a role in mitosis. …”
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Genomic features and its potential implication in bone oligometastatic NSCLC by Rongxin Liao, Guangming Yi, Lu Shen, Xiaoyue Zhang, Zaicheng Xu, Yuan Peng, Zhenzhou Yang

“…The signatures related to smoking, aging, homologous recombination deficiency and APOBEC were identified as the most important mutational processes in bone oligometastasis. …”
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An Aurora B-RPA signaling axis secures chromosome segregation fidelity by Poonam Roshan, Sahiti Kuppa, Jenna R. Mattice, Vikas Kaushik, Rahul Chadda, Nilisha Pokhrel, Brunda R. Tumala, Aparna Biswas, Brian Bothner, Edwin Antony, Sofia Origanti

“…Furthermore, phosphorylation impairs RPA binding to DSS1 that likely suppresses homologous recombination during mitosis by preventing recruitment of DSS1-BRCA2 to exposed ssDNA. …”
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Rapid Construction of an Infectious Clone of Fowl Adenovirus Serotype 4 Isolate by Minzhi Gong, Yating Wang, Shijia Liu, Boshuo Li, Enqi Du, Yupeng Gao

“…The FAdV4 infectious clone vector was introduced into the ccdB cm expression cassette to replace the IIIa gene using a λ-red homologous recombination technique, and then the ccdB cm expression cassette was excised by <i>Pme</i>I digestion and self-ligation to obtain the resulting plasmids as SC-Ad vectors.…”
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The Small GTPase CsRAC1 Is Important for Fungal Development and Pepper Anthracnose in by Noh-Hyun Lee, Teng Fu, Jong-Hwan Shin, Yong-Won Song, Dong-Cheol Jang, Kyoung Su Kim

“…Here, we generated a deletion mutant (ΔCsrac1) via homologous recombination to investigate the functional roles of CsRAC1. …”
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Research Advances of RAD51AP1 in Tumor Progression and Drug Resistance by Renwang LIU, Mingbiao LI, Zixuan HU, Zuoqing SONG, Jun CHEN

“…The genomic instability may lead to an initiation of cancer in many organisms. Homologous recombination repair (HRR) is vital in maintaining cellular genomic stability. …”
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Xrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes by Xuebi Cai, Jessica M. Stringer, Nadeen Zerafa, John Carroll, Karla J. Hutt

“…Recent studies have shown that DNA double-strand break repair occurs predominantly via the homologous recombination (HR) pathway in small non-growing meiotically arrested oocytes (primordial follicle stage). …”
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PD-1 inhibitor plus anlotinib for metastatic castration-resistant prostate cancer: a real-world study by Xin-Xing Du, Yan-Hao Dong, Han-Jing Zhu, Xiao-Chen Fei, Yi-Ming Gong, Bin-Bin Xia, Fan Wu, Jia-Yi Wang, Jia-Zhou Liu, Lian-Cheng Fan, Yan-Qing Wang, Liang Dong, Yin-Jie Zhu, Jia-Hua Pan, Bai-Jun Dong, Wei Xue

“…DNA-damage repair (DDR) pathways and homologous recombination repair (HRR) pathway defects indicated a comparatively longer PSA-progression-free survival (PSA-PFS; 2.5 months vs 1.2 months, P = 0.027; 3.3 months vs 1.2 months, P = 0.017; respectively). …”
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Endogenous retroviral solo-LTRs in human genome by Mingyue Chen, Xiaolong Huang, Chunlei Wang, Chunlei Wang, Chunlei Wang, Shibo Wang, Lei Jia, Lei Jia, Lin Li, Lin Li

“…HERVs account for 8% of human genome, and the majority of HERVs are solitary LTRs (solo-LTRs) due to homologous recombination. Multiple findings have showed that solo-LTRs could provide an enormous reservoir of transcriptional regulatory sequences involved in diverse biological processes, especially carcinogenesis and cancer development. …”
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The m6A RNA Demethylase ALKBH5 Promotes Radioresistance and Invasion Capability of Glioma Stem Cells by Aline Kowalski-Chauvel, Marie Géraldine Lacore, Florent Arnauduc, Caroline Delmas, Christine Toulas, Elizabeth Cohen-Jonathan-Moyal, Catherine Seva

“…We used patient-derived GBMSCs to demonstrate that high expression of the RNA demethylase, ALKBH5, increases radioresistance by regulating homologous recombination (HR). In cells downregulated for ALKBH5, we observed a decrease in GBMSC survival after irradiation likely due to a defect in DNA-damage repair. …”
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Application of multiple sgRNAs boosts efficiency of CRISPR/Cas9-mediated gene targeting in Arabidopsis by Jing Li, Dali Kong, Yongping Ke, Wenjie Zeng, Daisuke Miki

“…Abstract Background Precise gene targeting (GT) is a powerful tool for heritable precision genome engineering, enabling knock-in or replacement of the endogenous sequence via homologous recombination. We recently established a CRISPR/Cas9-mediated approach for heritable GT in Arabidopsis thaliana (Arabidopsis) and rice and reported that the double-strand breaks (DSBs) frequency of Cas9 influences the GT efficiency. …”
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