Тransplastomic tobacco plants producing the hydrophilic domain of the sheep pox virus coat protein L1R by D. K. Beisenov, G. E. Stanbekova, B. K. Iskakov

“…It provides integration of the transgene into the trnG/trnfM region of the chloroplast tobacco genome by homologous recombination. Spectinomycin-resistant tobacco lines were obtained by biolistic gun-mediated genetic transformation. …”
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Molecular Determinant of DIDS Analogs Targeting RAD51 Activity by Denis Velic, Alexandre Demeyer, Thibaut Peterlini, Houda Benhelli-Mokrani, Monique Mathé-Allainmat, Jean-Yves Masson, Fabrice Fleury

“…RAD51 is the central protein in DNA repair by homologous recombination (HR), involved in several steps of this process. …”
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ZSCAN4 interacts with PARP1 to promote DNA repair in mouse embryonic stem cells by Li-Kuang Tsai, Min Peng, Chia-Chun Chang, Luan Wen, Lin Liu, Xiubin Liang, Y. Eugene Chen, Jie Xu, Li-Ying Sung

“…Abstract Background In eukaryotic cells, DNA double strand breaks (DSB) are primarily repaired by canonical non-homologous end joining (c-NHEJ), homologous recombination (HR) and alternative NHEJ (alt-NHEJ). …”
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Post-transcriptional regulation of BRCA2 through interactions with miR-19a and miR-19b by Elena Mogilyansky, Peter Clark, Kevin Quann, Honglei Zhou, Eric Londin, Yi Jing, Isidore Rigoutsos

“…Breast cancer type 2, early onset susceptibility gene (BRCA2) is a major component of the homologous recombination DNA repair pathway. It acts as a tumor suppressor whose function is often lost in cancers. …”
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KIAA1529 regulates RAD51 expression to confer PARP inhibitors resistance in ovarian cancer by Yuan Qiao, Xuechen Yu, Bo Zhou, Kai Zhang, Juyuan Huang, Jing Liao

“…The effects of KIAA1529 on PARPi resistance were evaluated by knocking down KIAA1529 expression in ovarian cancer cells and assessing cell viability by CCK8 assays, apoptosis by flow cytometry, and homologous recombination (HR) repair by immunofluorescence analysis. …”
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Complete Pathologic Response to PARP Inhibitor Olaparib in a Patient with Stage IVB Recurrent Endometrioid Endometrial Adenocarcinoma by Rosemary Noel Senguttuvan, Christina Wei, Mustafa Raoof, Thanh H. Dellinger, Edward Wenge Wang

“…There is a paucity of data regarding PARP inhibition in endometrial cancer given that mutations in homologous recombination genes are rare, and currently no FDA approval exists. …”
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Endogenous CRISPR/Cas systems for genome engineering in the acetogens Acetobacterium woodii and Clostridium autoethanogenum by Margaux Poulalier-Delavelle, Jonathan P. Baker, James Millard, Klaus Winzer, Nigel P. Minton

“…Expression of synthetic CRISPR arrays, consisting of the native leader sequence, direct repeats, and adequate spacer, along with an editing template for homologous recombination, successfully led to the creation of 300 bp and 354 bp in-frame deletions of pyrE and pheA, respectively. …”
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Comparison of suspected Lynch syndrome patients carrying BRCA and BRCA‐like variants with Lynch syndrome probands: Phenotypic characteristics and pedigree analyses by Yun Xu, Cong Li, Zhimin Wang, Fangqi Liu, Ye Xu

“…Increasing numbers of germline variants involved in homologous recombination have been identified in suspected LS patients. …”
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Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells by Clara Dobler, Tina Jost, Markus Hecht, Rainer Fietkau, Luitpold Distel

“…The integrity of homologous recombination (HR) was assessed in two HPV positive, two HPV negative HNSCC, and two healthy fibroblast cell cultures. …”
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Construction of a heat-resistant strain of Lentinus edodes by fungal Hsp20 protein overexpression and genetic transformation by Yun-Yan Ling, Zhi-Lin Ling, Rui-Lin Zhao, Rui-Lin Zhao

“…In this study, an overexpression vector pEHg-gdp-hsp20 for the heat shock protein 20 gene of A. bisporus was constructed using a homologous recombination method. This vector was transferred into dikaryotic and monokaryotic mycelia by the Agrobacterium tumefaciens-method. …”
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Two novel mutations in the MCM8 gene shared by two Chinese siblings with primary ovarian insufficiency and short stature by Fei Wang, Sheng Guo, Pin Li

“…Abstract Background Minichromosome maintenance complex component 8 (MCM8) is responsible for homologous recombination and DNA double‐strand breaks (DSBs) repair and is the cause of primary ovarian insufficiency (POI), which is seldom diagnosed in adolescents and children. …”
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Utilization of a <it>ts-sacB </it>selection system for the generation of a <it>Mycobacterium avium </it>serovar-8 specific glycopeptidolipid allelic exchange mutant by Belisle John T, Inamine Julia M, Eckstein Torsten M, Lee Sun-Hwa, Irani Vida R, Maslow Joel N

“…</p> <p>Methods</p> <p>To be able to study the role of the GPL in <it>M. avium </it>pathogenesis, a <it>ts-sacB </it>selection system, not previously used in <it>M. avium</it>, was employed as a means to achieve homologous recombination for the rhamnosyltransferase (<it>rtfA</it>) gene of a pathogenic serovar 8 strain of <it>M. avium </it>to prevent addition of serovar-specific sugars to rhamnose of the fatty acyl-peptide backbone of GPL. …”
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A Genomic Approach to Unravel Host-Pathogen Interaction in Chelonians: The Example of Testudinid Herpesvirus 3. by Francesco C Origgi, Marco Tecilla, Paola Pilo, Fabio Aloisio, Patricia Otten, Lisandra Aguilar-Bultet, Ursula Sattler, Paola Roccabianca, Carlos H Romero, David C Bloom, Elliott R Jacobson

“…Our results revealed 1) the existence of at least two distinct TeHV3 genogroups apparently associated with different pathologies in tortoises and 2) the first evidence for a putative homologous recombination event having occurred in a chelonian herpesvirus. …”
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4058 Enhanced efficiency of large-scale clinical proteomic studies: when less is more by Stefani Thomas, Betty Friedrich, Michael Schnaubelt, Daniel W. Chan, Hui Zhang, Ruedi Aebersold

“…Additionally, the homologous recombination deficiency-associated enriched DNA repair and chromosome organization pathways were conserved in both data sets. …”
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Spatial Gene Expression Analysis Reveals Characteristic Gene Expression Patterns of De Novo Neuroendocrine Prostate Cancer Coexisting with Androgen Receptor Pathway Prostate Cancer by Ryuta Watanabe, Noriyoshi Miura, Mie Kurata, Riko Kitazawa, Tadahiko Kikugawa, Takashi Saika

“…TP53, RB1, or PTEN and upregulation of the homologous recombination repair genes at NEPC sites were not downregulated. …”
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Whole genome sequence analysis of Salmonella Typhi in Papua New Guinea reveals an established population of genotype 2.1.7 sensitive to antimicrobials. by Zoe Anne Dyson, Elisheba Malau, Paul F Horwood, Rebecca Ford, Valentine Siba, Mition Yoannes, William Pomat, Megan Passey, Louise M Judd, Danielle J Ingle, Deborah A Williamson, Gordon Dougan, Andrew R Greenhill, Kathryn E Holt

“…Genetic variation among this population was attributed to either single point mutations, or homologous recombination adjacent to repetitive ribosomal RNA operons.…”
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Genomic Instability in Somatic Hybridization between <i>Poncirus</i> and <i>Citrus</i> Species Aiming to Create New Rootstocks by Dominique Dambier, Pascal Barantin, Gabriel Boulard, Gilles Costantino, Pierre Mournet, Aude Perdereau, Raphaël Morillon, Patrick Ollitrault

“…Mitochondrial genomes were mostly inherited from the callus parent, but homologous recombination events were observed for one parental combination. …”
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NUSAP1 promotes pancreatic ductal adenocarcinoma progression by drives the epithelial-mesenchymal transition and reduces AMPK phosphorylation by Yuan Liu, Rong Tang, Qing-Cai Meng, Si Shi, Jin Xu, Xian-Jun Yu, Bo Zhang, Wei Wang

“…Genome heterogeneity analysis revealed that NUSAP1 is related to tumor mutation burden (TMB), loss of heterozygosity (LOH) and homologous recombination deficiency (HRD) in PDAC. NUSAP1 is correlated with the levels of infiltrating immune cells, such as B cells and CD8 T cells. …”
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Causal pathways linking polycystic ovary syndrome to distinct breast cancer subtypes through mediator factors: a multivariable mendelian randomization analysis by Runxiang Cao, Lanlan Chen, Yutong Liu, Xuyutian Wang, Ruolin Ma, Qian Zhao, Ye Du

“…We analyzed 13 PCOS-related traits and found that age at menopause may mediate PCOS-induced ER + BC (with -4.82% proportion) with a weak protective effect through the repair of DNA double-strand breaks by homologous recombination. This study helps to better comprehend the shared mechanisms contributing to the development of both PCOS and BC, and to screen high-risk populations for BC and take appropriate preventive measures.…”
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Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae by Nicola Manfrini, Michela Clerici, Maxime Wery, Chiara Vittoria Colombo, Marc Descrimes, Antonin Morillon, Fabrizio d'Adda di Fagagna, Maria Pia Longhese

“…Therefore, the conversion of the DSB ends from double-stranded to single-stranded DNA, which is necessary to initiate DSB repair by homologous recombination, is responsible for loss of transcription around a DSB in S. cerevisiae.…”
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