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1581
Тransplastomic tobacco plants producing the hydrophilic domain of the sheep pox virus coat protein L1R
Published 2020-12-01“…It provides integration of the transgene into the trnG/trnfM region of the chloroplast tobacco genome by homologous recombination. Spectinomycin-resistant tobacco lines were obtained by biolistic gun-mediated genetic transformation. …”
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1582
Molecular Determinant of DIDS Analogs Targeting RAD51 Activity
Published 2021-09-01“…RAD51 is the central protein in DNA repair by homologous recombination (HR), involved in several steps of this process. …”
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1583
ZSCAN4 interacts with PARP1 to promote DNA repair in mouse embryonic stem cells
Published 2023-10-01“…Abstract Background In eukaryotic cells, DNA double strand breaks (DSB) are primarily repaired by canonical non-homologous end joining (c-NHEJ), homologous recombination (HR) and alternative NHEJ (alt-NHEJ). …”
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1584
Post-transcriptional regulation of BRCA2 through interactions with miR-19a and miR-19b
Published 2016-08-01“…Breast cancer type 2, early onset susceptibility gene (BRCA2) is a major component of the homologous recombination DNA repair pathway. It acts as a tumor suppressor whose function is often lost in cancers. …”
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1585
KIAA1529 regulates RAD51 expression to confer PARP inhibitors resistance in ovarian cancer
Published 2022-10-01“…The effects of KIAA1529 on PARPi resistance were evaluated by knocking down KIAA1529 expression in ovarian cancer cells and assessing cell viability by CCK8 assays, apoptosis by flow cytometry, and homologous recombination (HR) repair by immunofluorescence analysis. …”
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1586
Complete Pathologic Response to PARP Inhibitor Olaparib in a Patient with Stage IVB Recurrent Endometrioid Endometrial Adenocarcinoma
Published 2023-06-01“…There is a paucity of data regarding PARP inhibition in endometrial cancer given that mutations in homologous recombination genes are rare, and currently no FDA approval exists. …”
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1587
Endogenous CRISPR/Cas systems for genome engineering in the acetogens Acetobacterium woodii and Clostridium autoethanogenum
Published 2023-06-01“…Expression of synthetic CRISPR arrays, consisting of the native leader sequence, direct repeats, and adequate spacer, along with an editing template for homologous recombination, successfully led to the creation of 300 bp and 354 bp in-frame deletions of pyrE and pheA, respectively. …”
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1588
Comparison of suspected Lynch syndrome patients carrying BRCA and BRCA‐like variants with Lynch syndrome probands: Phenotypic characteristics and pedigree analyses
Published 2020-08-01“…Increasing numbers of germline variants involved in homologous recombination have been identified in suspected LS patients. …”
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1589
Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells
Published 2020-09-01“…The integrity of homologous recombination (HR) was assessed in two HPV positive, two HPV negative HNSCC, and two healthy fibroblast cell cultures. …”
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1590
Construction of a heat-resistant strain of Lentinus edodes by fungal Hsp20 protein overexpression and genetic transformation
Published 2022-11-01“…In this study, an overexpression vector pEHg-gdp-hsp20 for the heat shock protein 20 gene of A. bisporus was constructed using a homologous recombination method. This vector was transferred into dikaryotic and monokaryotic mycelia by the Agrobacterium tumefaciens-method. …”
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1591
Two novel mutations in the MCM8 gene shared by two Chinese siblings with primary ovarian insufficiency and short stature
Published 2020-09-01“…Abstract Background Minichromosome maintenance complex component 8 (MCM8) is responsible for homologous recombination and DNA double‐strand breaks (DSBs) repair and is the cause of primary ovarian insufficiency (POI), which is seldom diagnosed in adolescents and children. …”
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1592
Utilization of a <it>ts-sacB </it>selection system for the generation of a <it>Mycobacterium avium </it>serovar-8 specific glycopeptidolipid allelic exchange mutant
Published 2004-09-01“…</p> <p>Methods</p> <p>To be able to study the role of the GPL in <it>M. avium </it>pathogenesis, a <it>ts-sacB </it>selection system, not previously used in <it>M. avium</it>, was employed as a means to achieve homologous recombination for the rhamnosyltransferase (<it>rtfA</it>) gene of a pathogenic serovar 8 strain of <it>M. avium </it>to prevent addition of serovar-specific sugars to rhamnose of the fatty acyl-peptide backbone of GPL. …”
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1593
A Genomic Approach to Unravel Host-Pathogen Interaction in Chelonians: The Example of Testudinid Herpesvirus 3.
Published 2015-01-01“…Our results revealed 1) the existence of at least two distinct TeHV3 genogroups apparently associated with different pathologies in tortoises and 2) the first evidence for a putative homologous recombination event having occurred in a chelonian herpesvirus. …”
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1594
4058 Enhanced efficiency of large-scale clinical proteomic studies: when less is more
Published 2020-06-01“…Additionally, the homologous recombination deficiency-associated enriched DNA repair and chromosome organization pathways were conserved in both data sets. …”
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1595
Spatial Gene Expression Analysis Reveals Characteristic Gene Expression Patterns of De Novo Neuroendocrine Prostate Cancer Coexisting with Androgen Receptor Pathway Prostate Cancer
Published 2023-05-01“…TP53, RB1, or PTEN and upregulation of the homologous recombination repair genes at NEPC sites were not downregulated. …”
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1596
Whole genome sequence analysis of Salmonella Typhi in Papua New Guinea reveals an established population of genotype 2.1.7 sensitive to antimicrobials.
Published 2022-03-01“…Genetic variation among this population was attributed to either single point mutations, or homologous recombination adjacent to repetitive ribosomal RNA operons.…”
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1597
Genomic Instability in Somatic Hybridization between <i>Poncirus</i> and <i>Citrus</i> Species Aiming to Create New Rootstocks
Published 2022-01-01“…Mitochondrial genomes were mostly inherited from the callus parent, but homologous recombination events were observed for one parental combination. …”
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1598
NUSAP1 promotes pancreatic ductal adenocarcinoma progression by drives the epithelial-mesenchymal transition and reduces AMPK phosphorylation
Published 2024-01-01“…Genome heterogeneity analysis revealed that NUSAP1 is related to tumor mutation burden (TMB), loss of heterozygosity (LOH) and homologous recombination deficiency (HRD) in PDAC. NUSAP1 is correlated with the levels of infiltrating immune cells, such as B cells and CD8 T cells. …”
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1599
Causal pathways linking polycystic ovary syndrome to distinct breast cancer subtypes through mediator factors: a multivariable mendelian randomization analysis
Published 2023-11-01“…We analyzed 13 PCOS-related traits and found that age at menopause may mediate PCOS-induced ER + BC (with -4.82% proportion) with a weak protective effect through the repair of DNA double-strand breaks by homologous recombination. This study helps to better comprehend the shared mechanisms contributing to the development of both PCOS and BC, and to screen high-risk populations for BC and take appropriate preventive measures.…”
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1600
Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae
Published 2015-07-01“…Therefore, the conversion of the DSB ends from double-stranded to single-stranded DNA, which is necessary to initiate DSB repair by homologous recombination, is responsible for loss of transcription around a DSB in S. cerevisiae.…”
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