Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain by Adriana Della Pietra, Georgii Krivoshein, Konstantin Ivanov, Raisa Giniatullina, Henna-Kaisa Jyrkkänen, Ville Leinonen, Marko Lehtonen, Arn M. J. M. van den Maagdenberg, Juha Savinainen, Rashid Giniatullin

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DNA Copy Number Changes at 8q11–24 in Metastasized Colorectal Cancer by T. E. Buffart, J. Coffa, M. A. J. A. Hermsen, B. Carvalho, J. R. M. van der Sijp, B. Ylstra, G. Pals, J. P. Schouten, G. A. Meijer

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Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma by Christian W. Thorball, Tiphaine Oudot-Mellakh, Nava Ehsan, Christian Hammer, Federico A. Santoni, Jonathan Niay, Dominique Costagliola, Cécile Goujard, Laurence Meyer, Sophia S. Wang, Shehnaz K. Hussain, Ioannis Theodorou, Matthias Cavassini, Andri Rauch, Manuel Battegay, Matthias Hoffmann, Patrick Schmid, Enos Bernasconi, Huldrych F. Günthard, Pejman Mohammadi, Paul J. McLaren, Charles S. Rabkin, Caroline Besson, Jacques Fellay

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Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas by Anaís Sánchez-Castillo, Kim G. Savelkouls, Alessandra Baldini, Judith Hounjet, Pierre Sonveaux, Paulien Verstraete, Kim De Keersmaecker, Barbara Dewaele, Benny Björkblom, Beatrice Melin, Wendy Y. Wu, Rickard L. Sjöberg, Kasper M. A. Rouschop, Martijn P. G. Broen, Marc Vooijs, Kim R. Kampen

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NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology by Ana I. Rojo, Marta Pajares, Patricia Rada, Angel Nuñez, Alejo J. Nevado-Holgado, Richard Killik, Fred Van Leuven, Elena Ribe, Simon Lovestone, Masayuki Yamamoto, Antonio Cuadrado

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LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility by Jae Yeon Hwang, Pengxin Chai, Shoaib Nawaz, Jungmin Choi, Francesc Lopez-Giraldez, Shabir Hussain, Kaya Bilguvar, Shrikant Mane, Richard P Lifton, Wasim Ahmad, Kai Zhang, Jean-Ju Chung

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Tumor mutation burden and circulating tumor DNA in combined CTLA-4 and PD-1 antibody therapy in metastatic melanoma – results of a prospective biomarker study by Andrea Forschner, Florian Battke, Dirk Hadaschik, Martin Schulze, Stephanie Weißgraeber, Chung-Ting Han, Maria Kopp, Maximilian Frick, Bernhard Klumpp, Nicola Tietze, Teresa Amaral, Peter Martus, Tobias Sinnberg, Thomas Eigentler, Ulrike Keim, Claus Garbe, Dennis Döcker, Saskia Biskup

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A systematic analysis of splicing variants identifies new diagnoses in the 100,000 Genomes Project by Alexander J. M. Blakes, Htoo A. Wai, Ian Davies, Hassan E. Moledina, April Ruiz, Tessy Thomas, David Bunyan, N. Simon Thomas, Christine P. Burren, Lynn Greenhalgh, Melissa Lees, Amanda Pichini, Sarah F. Smithson, Ana Lisa Taylor Tavares, Peter O’Donovan, Andrew G. L. Douglas, Genomics England Research Consortium, Splicing and Disease Working Group, Nicola Whiffin, Diana Baralle, Jenny Lord

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Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice by Yuvarani Masarapu, Egle Cekanaviciute, Zaneta Andrusivova, Jakub O. Westholm, Åsa Björklund, Robin Fallegger, Pau Badia-i-Mompel, Valery Boyko, Shubha Vasisht, Amanda Saravia-Butler, Samrawit Gebre, Enikő Lázár, Marta Graziano, Solène Frapard, Robert G. Hinshaw, Olaf Bergmann, Deanne M. Taylor, Douglas C. Wallace, Christer Sylvén, Konstantinos Meletis, Julio Saez-Rodriguez, Jonathan M. Galazka, Sylvain V. Costes, Stefania Giacomello

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LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity by Nellie Y. Loh, Senthil K. Vasan, Daniel B. Rosoff, Emile Roberts, Andrea D. van Dam, Manu Verma, Daniel Phillips, Agata Wesolowska-Andersen, Matt J. Neville, Raymond Noordam, David W. Ray, Jonathan H. Tobias, Celia L. Gregson, Fredrik Karpe, Constantinos Christodoulides

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A unique case of vision loss in a patient with hypotrichosis and juvenile macular dystrophy and primary ciliary dyskinesia by Kenneth C. Fan, Nimesh A. Patel, Nicolas A. Yannuzzi, Supalert Prakhunhungsit, Catherin I. Negron, Elisa Basora, Andrew A. Colin, Mustafa Tekin, Audina M. Berrocal

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The global prevalence of autism spectrum disorder: A three-level meta-analysis by Oksana I. Talantseva, Oksana I. Talantseva, Raisa S. Romanova, Ekaterina M. Shurdova, Tatiana A. Dolgorukova, Polina S. Sologub, Olga S. Titova, Daria F. Kleeva, Elena L. Grigorenko, Elena L. Grigorenko, Elena L. Grigorenko, Elena L. Grigorenko, Elena L. Grigorenko

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Snow crab (Chionoecetes opilio) hemocytes and hepatopancreas transcriptomes: identification, validation, and application of immune-relevant biomarkers of exposure to noise by Jennifer R. Hall, Sarah J. Lehnert, Emmanuel Gonzalez, Emmanuel Gonzalez, Emmanuel Gonzalez, Jacqueline M. Hanlon, Surendra Kumar, Corey J. Morris, Matthew L. Rise

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A scoping review on the links between sustainable development goal 14 and early childhood caries by Morenike Oluwatoyin Folayan, Imen Ayouni, Arthemon Nguweneza, Ola Barakat Al-Batayneh, Jorma I. Virtanen, Balgis Gaffar, Duangporn Duangthip, Ivy Guo Fang Sun, Nneka Kate Onyejaka, Hamideh Daryanavard, Tshepiso Mfolo, Carlos A. Feldens, Robert J. Schroth, Maha El Tantawi

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Exploring the neurological features of individuals with germline PTEN variants: A multicenter study by Andrew Dhawan, Sarah Baitamouni, Darren Liu, Robyn Busch, Patricia Klaas, Thomas W. Frazier, Siddharth Srivastava, Sumit Parikh, Gary E. Hsich, Neil R. Friedman, David M. Ritter, Antonio Y. Hardan, Julian A. Martinez‐Agosto, Mustafa Sahin, Charis Eng

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Epstein-Barr virus infection as potential indicator of the occurrence and clinical presentation of systemic lupus erythematosus by Ana Banko, Andja Cirkovic, Rada Miskovic, Rada Miskovic, Ivica Jeremic, Ivica Jeremic, Milka Grk, Milica Basaric, Ivana Lazarevic, Sanvila Raskovic, Sanvila Raskovic, Aleksa Despotovic, Danijela Miljanovic

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In vitro model of retinoblastoma derived tumor and stromal cells for tumor microenvironment (TME) studies by Emily Alefeld, André Haase, Dario Van Meenen, Bettina Budeus, Oliver Dräger, Natalia Miroschnikov, Saskia Ting, Deniz Kanber, Eva Biewald, Nikolaos Bechrakis, Nicole Dünker, Maike Anna Busch

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Knowledge-driven binning approach for rare variant association analysis: application to neuroimaging biomarkers in Alzheimer’s disease by Dokyoon Kim, Anna O. Basile, Lisa Bang, Emrin Horgusluoglu, Seunggeun Lee, Marylyn D. Ritchie, Andrew J. Saykin, Kwangsik Nho

“…Abstract Background Rapid advancement of next generation sequencing technologies such as whole genome sequencing (WGS) has facilitated the search for genetic factors that influence disease risk in the field of human genetics. To identify rare variants associated with human diseases or traits, an efficient genome-wide binning approach is needed. …”
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Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer by Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent Dufossé

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Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites by Qianxi Feng, Eric Nickels, Ivo S Muskens, Adam J de Smith, W James Gauderman, Amy C Yee, Charite Ricker, Thomas Mack, Andrew D Leavitt, Lucy A Godley, Joseph L Wiemels

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