Multi-scale model of axonal and dendritic polarization by transcranial direct current stimulation in realistic head geometry by Aman S. Aberra, Ruochen Wang, Warren M. Grill, Angel V. Peterchev

“…Methods: We embedded layer-specific, morphologically-realistic cortical neuron models in a finite element model of the E-field in a human head and simulated steady-state polarization generated by conventional primary-motor-cortex–supraorbital (M1–SO) and 4 × 1 high-definition (HD) tDCS. …”
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Towards Photodynamic Image-Guided Surgery of Head and Neck Tumors: Photodynamic Priming Improves Delivery and Diagnostic Accuracy of Cetuximab-IRDye800CW by Chanda Bhandari, John Fakhry, Menitte Eroy, Jane Junghwa Song, Kimberley Samkoe, Tayyaba Hasan, Tayyaba Hasan, Kenneth Hoyt, Girgis Obaid

“…In this study, we demonstrate a proof-of-concept that PDP primes orthotopic FaDu human head and neck tumors in mice for P-IGS by increasing the delivery of Cet-IRDye800 by up to 138.6%, by expediting its interstitial accumulation by 10.5-fold, and by increasing its fractional tumor coverage by 49.5% at 1 h following Cet-IRDye800 administration. …”
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Temporal interference stimulation targets deep brain regions by modulating neural oscillations by Zeinab Esmaeilpour, Greg Kronberg, Davide Reato, Lucas C. Parra, Marom Bikson

“…The neuronal effects are replicated with a computational network model to explore the underlying mechanisms, and then coupled to a validated current-flow model of the human head. Results: Amplitude-modulated electric fields are stronger in deep brain regions, while unmodulated electric fields are maximal at the cortical regions. …”
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Localizing Clinical Patterns of Blast Traumatic Brain Injury Through Computational Modeling and Simulation by Scott T. Miller, Candice F. Cooper, Paul Elsbernd, Joseph Kerwin, Ricardo Mejia-Alvarez, Adam M. Willis, Adam M. Willis

“…In order to investigate the intracranial interface dynamics, we performed a novel set of computational simulations using a model human head simplified but containing models of gyri, sulci, cerebrospinal fluid (CSF), ventricles, and vasculature with high spatial resolution of the mechanical interfaces. …”
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Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice by Asami Hanazawa, Ryoji Ito, Ikumi Katano, Kenji Kawai, Motohito Goto, Hiroshi Suemizu, Yutaka Kawakami, Mamoru Ito, Takeshi Takahashi

“…Engraftment of HSC4 cells, a human head and neck squamous cell carcinoma-derived cell line producing various factors including IL-6, IL-1β, macrophage colony-stimulating factor (M-CSF), and vascular endothelial growth factor (VEGF), into HSC-NOG-hIL-6 Tg mice induced a significant number of TAM-like cells, but few were induced in HSC-NOG non-Tg mice. …”
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Sustained neuronal and microglial alterations are associated with diverse neurobehavioral dysfunction long after experimental brain injury by Rodney M. Ritzel, Yun Li, Junyun He, Niaz Khan, Sarah J. Doran, Alan I. Faden, Junfang Wu

“…In summary, the late neurobehavioral changes found after murine TBI are similar to those found chronically after moderate-severe human head injury. Importantly, such changes are associated with microglial dysfunction and changes in neuronal activity.…”
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Non‐invasive treatment of ischemia/reperfusion injury: Effective transmission of therapeutic near‐infrared light into the human brain through soft skin‐conforming silicone waveguid... by Paul T. Morse, Samuel Tuck, Mike Kerns, Dennis J. Goebel, Junmei Wan, Tom Waddell, Joseph M. Wider, Charlotte L. Hüttemann, Moh H. Malek, Icksoo Lee, Thomas H. Sanderson, Maik Hüttemann

“…Using the same IRL output energies IDWs performed superior in comparison to the fiberoptic delivery, leading to an up to 95% and 81% increased IRL transmission for 750 and 940 nm IRL, respectively, analyzed at a depth of 4 cm into the human head. We discuss the unique safety features and potential further improvements of the IDWs for future clinical implementation.…”
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Numerical Analysis of Transcranial Magnetic Stimulation Application in Patients With Orofacial Pain by David Vrba, Lukas Malena, Jakub Albrecht, Jitka Fricova, Martin Anders, Richard Rokyta, Dario Rodrigues, Jan Vrba

“…The research has yielded unique insight into ROIs (with average volume 904 mm³) in patients with orofacial pain and has also extended further possibilities of human head MRI image semi-automatic segmentation. According to the calculations performed, the average ROI volume that was stimulated by an electric field with an intensity of over 80 V/m was only 4.4%, with the maximum ROI volume being 20.5%. …”
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In vitro experiments of Pediculus humanus capitis (Phthiraptera: Pediculidae) resistance to permethrin and 6-paradol in East Jakarta: Detoxification enzyme activity and electron mi... by Rizal Subahar, Lisawati Susanto, Rachmanin Aidilla, Annisa Putri Aulia, Yulhasri Yulhasri, Rawina Winita, Nadar S. Lubis, Ika Puspa Sari

“…Background and Aim: Pediculus humanus capitis, the human head louse, remains a global health problem. This study evaluated the resistance of head lice to permethrin and 6-paradol mediated by in vitro detoxification enzyme activity experiments and to describe physical changes in the lice using scanning electron microscopy (SEM). …”
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Dynamic state-space estimation of the hemodynamic response with Near-Infrared Spectroscopy by Gagnon, Louis, 1984-

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Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder by Jie Wang, Qing Xue, Wenfeng Zhao, Huang Wang, Haixia Leng, Mao Peng, Xiukun Jin, Liucen Tan, Keming Gao, Hongxing Wang, Baoquan Min

“…Background Although 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown.Aims To investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA, delivered via the forehead and the mastoid electrodes in the human brain.Methods Actual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve, first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS software.Results The electric field distributions of the sagittal, coronal and axial planes showed that the bilateral frontal lobes, bilateral temporal lobes, hippocampus, cingulate, hypothalamus, thalamus, amygdala, cerebellum and brainstem were visibly stimulated by the 15 mA tACS procedure.Conclusions Brain-wide activation, including the cortex, subcortical structures, cerebellum and brainstem, is involved in the 15 mA tACS intervention for first-episode major depressive disorder. …”
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Behavioral phenotyping of cancer pain in domesticated cats with naturally occurring squamous cell carcinoma of the tongue: initial validation studies provide evidence for regional... by Yen-Hao Erik Lai, B. Duncan X. Lascelles, Michael W. Nolan

“…Feline oral squamous cell carcinoma (FOSCC) is a common and naturally occurring condition that recapitulates many features of human head and neck cancer (HNC). In both species, there is need for improved strategies to reduce pain caused by HNC and its treatment. …”
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A Systematic Review of the Usefulness of Glial Fibrillary Acidic Protein for Predicting Acute Intracranial Lesions following Head Trauma by Teemu M. Luoto, Rahul Raj, Jussi P. Posti, Andrew J. Gardner, Andrew J. Gardner, William J. Panenka, Grant L. Iverson

“…Eligibility criteria included: (i) population: human head and brain injuries of all severities and ages; (ii) intervention: blood-based GFAP measurement ≤24 h post-injury; and (iii) outcome: acute traumatic lesion on non-contrast head CT ≤24 h post-injury. …”
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Identification of potential target genes of honokiol in overcoming breast cancer resistance to tamoxifen by Adam Hermawan, Adam Hermawan, Adam Hermawan, Herwandhani Putri, Naufa Hanif, Nurul Fatimah, Heri Himawan Prasetio

“…BackgroundHonokiol (HON) inhibits epidermal growth factor receptor (EGFR) signaling and increases the activity of erlotinib, an EGFR inhibitor, in human head and neck cancers. In this study, using a bioinformatics approach and in vitro experiments, we assessed the target genes of HON against breast cancer resistance to tamoxifen (TAM).Materials and methodsMicroarray data were obtained from GSE67916 and GSE85871 datasets to identify differentially expressed genes (DEGs). …”
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CutFEM forward modeling for EEG source analysis by Tim Erdbrügger, Tim Erdbrügger, Andreas Westhoff, Malte Höltershinken, Malte Höltershinken, Jan-Ole Radecke, Jan-Ole Radecke, Yvonne Buschermöhle, Yvonne Buschermöhle, Alena Buyx, Fabrice Wallois, Sampsa Pursiainen, Joachim Gross, Joachim Gross, Rebekka Lencer, Rebekka Lencer, Rebekka Lencer, Rebekka Lencer, Christian Engwer, Carsten Wolters, Carsten Wolters

“…This so-called EEG forward problem is based on an accurate estimation of the volume conduction effects in the human head, represented by a partial differential equation which can be solved using the finite element method (FEM). …”
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The importance of modeling the human cerebral vasculature in blunt trauma by Dhananjay Radhakrishnan Subramaniam, Ginu Unnikrishnan, Aravind Sundaramurthy, Jose E. Rubio, Vivek Bhaskar Kote, Jaques Reifman

“…Abstract Background Multiple studies describing human head finite element (FE) models have established the importance of including the major cerebral vasculature to improve the accuracy of the model predictions. …”
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Non invasive brain stimulation : modeling and experimental analysis of transcranial magnetic stimulations and transcranial DC stimulation as a modality for neuropathology treatment by Wagner, Timothy A. (Timothy Andrew), 1974-

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Pemanfaatan Daun Sirsak (Annona muricata) sebagai Sampo Anti Kutu Kepala (Pediculus humanus capitis) by Fauzan Azmi Hasti Habibi Samosir, Dewi Masyithah Darlan, Luthfi Umam Hakim Nasution, Grestia Angraini Panggabean

“…Although small, head lice are very dangerous, because they live by sucking blood from the scalp and spread easily to various places, such as pillows, bolsters, up to the human head. One way to deal with head lice is to use synthetic pediculicides which are easy to get at pharmacies. …”
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Intracellular Amplifiers of Reactive Oxygen Species Affecting Mitochondria as Radiosensitizers by Hong-Gui Xu, Viktor Reshetnikov, Marit Wondrak, Lisa Eckhardt, Leoni A. Kunz-Schughart, Christina Janko, Rainer Tietze, Christoph Alexiou, Hannes Borchardt, Achim Aigner, Wenjie Gong, Michael Schmitt, Leopold Sellner, Steffen Daum, Hülya Gizem Özkan, Andriy Mokhir

“…We observed that 2c acts as a radiosensitizer in human head and neck squamous carcinoma cells. This is the first demonstration of a synergy between the radiotherapy and NAAF-based ROS amplifiers.…”
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Anti-Tumoral Effects of a (1<i>H</i>-Pyrrol-1-yl)Methyl-1<i>H</i>-Benzoimidazole Carbamate Ester Derivative on Head and Neck Squamous Carcinoma Cell Lines by Alice Nicolai, Valentina Noemi Madia, Antonella Messore, Daniela De Vita, Alessandro De Leo, Davide Ialongo, Valeria Tudino, Elisabetta Tortorella, Luigi Scipione, Samanta Taurone, Tiziano Pergolizzi, Marco Artico, Roberto Di Santo, Roberta Costi, Susanna Scarpa

“…We evaluated the antineoplastic properties of RDS 60 in two human head and neck squamous cell carcinoma (HNSCC) cell lines and we found that this compound significantly inhibited replication of both HNSCC cell lines without inducing any important cytotoxic effect on human dermal fibroblasts and human keratinocytes. …”
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