Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver by Jo, J, Tan, A, Ussher, J, Sandalova, E, Tang, X, Tan-Garcia, A, To, N, Hong, M, Chia, A, Gill, US, Kennedy, P, Tan, K, Lee, K, De Libero, G, Gehring, A, Willberg, C, Klenerman, P, Bertoletti, A

“…In conclusion, the human liver harbors a network of immune cells able to modulate their immunological responses to different pathogen-associated molecules. …”

A gain of function p53 gene mutant promotes growth suppression in human liver cancer cells by Nor Adzimah Johdi, Siti Nurmi Nasir, A. Rahman A. Jamal

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Thymoquinone-loaded nanostructured lipid carrier reduces proliferation of human liver cancer cells, HepG2 by Mustafa Azmy, Nurfahima, Haron, Aminah Suhaila, Syed Alwi, Sharifah Sakinah

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JNK signaling pathways is required for mitochondrial dysfunction-induced iinsulin resistance in WRL-68 human liver cell by Abu Bakar, Mohamad Hafizi, Sarmidi, Mohamad Roji, Yaakob, Harisun, Cheng, Kian Kai, Zaman Huri, Hasniza

“…Therefore, the aim of this study was to investigate the therapeutic roles of JNK signaling pathways inhibition upon mitochondrial dysfunction-induced insulin resistance in WRL-68 human liver cells. We found that JNK inhibitor (SP600125) exhibits ameliorative properties in cells treated with rotenone, mitochondrial complex I inhibitor via enhancement of insulin stimulated-glucose uptake activity. …”

Preparation and Evaluation of Chitosan Coated PLGA Nanoparticles Encapsulating Ivosidenib with Enhanced Cytotoxicity Against Human Liver Cancer Cells by Alsulays BB, Aodah AH, Ahmed MM, Anwer MK

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The long noncoding RNA TINCR promotes self-renewal of human liver cancer stem cells through autophagy activation by Jing Shi, Cao Guo, Yang Li, Junli Ma

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Establishment of Human Leukocyte Antigen-Mismatched Immune Responses after Transplantation of Human Liver Bud in Humanized Mouse Models by Akihiro Mori, Soichiro Murata, Nao Tashiro, Tomomi Tadokoro, Satoshi Okamoto, Ryo Otsuka, Haruka Wada, Tomoki Murata, Takeshi Takahashi, Ken-ichiro Seino, Hideki Taniguchi

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Human liver single nuclear RNA sequencing implicates BMPR2, GDF15, arginine, and estrogen in portopulmonary hypertension by Arun Jose, Jean M. Elwing, Steven M. Kawut, Michael W. Pauciulo, Kenneth E. Sherman, William C. Nichols, Michael B. Fallon, Francis X. McCormack

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Reversible, Time-Dependent Inhibition of CYP3A-Mediated Metabolism of Midazolam and Tacrolimus by Telaprevir in Human Liver Microsomes by Brian Chapron, Linda Risler, Brian Phillips, Carol Collins, Kenneth Thummel, Danny Shen

“…To further explore the inhibitory mechanisms of telaprevir, we assessed whether telaprevir-mediated inhibition of the oxidation of midazolam and tacrolimus is time-dependent in human liver microsomes, and whether any observed time-dependency was irreversible or reversible in nature. …”
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Developing Biliary Atresia-like Model by Treating Human Liver Organoids with Polyinosinic:Polycytidylic Acid (Poly (I:C)) by Patrick Ho-Yu Chung, Rosana Ottakandathil Babu, Zhongluan Wu, Kenneth Kak-Yuen Wong, Paul Kwong-Hang Tam, Vincent Chi-Hang Lui

“…Background: We explored the feasibility of creating BA-like organoids by treating human liver organoids with Polyinosinic:Polycytidylic acid (Poly I:C). …”
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Exploring the Interactome of Cytochrome P450 2E1 in Human Liver Microsomes with Chemical Crosslinking Mass Spectrometry by Dmitri R. Davydov, Bikash Dangi, Guihua Yue, Deepak S. Ahire, Bhagwat Prasad, Victor G. Zgoda

“…Aiming to elucidate the system-wide effects of the alcohol-induced increase in the content of cytochrome P450 2E1 (CYP2E1) on drug metabolism, we explored the array of its protein-protein interactions (interactome) in human liver microsomes (HLM) with chemical crosslinking mass spectrometry (CXMS). …”
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Molecular Analysis of Fetal and Adult Primary Human Liver Sinusoidal Endothelial Cells: A Comparison to Other Endothelial Cells by Muhammad Ahmer Jamil, Heike Singer, Rawya Al-Rifai, Nicole Nüsgen, Melanie Rath, Sascha Strauss, Ioanna Andreou, Johannes Oldenburg, Osman El-Maarri

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The Angiotensin II Receptor Blocker Losartan Sensitizes Human Liver Cancer Cells to Lenvatinib-Mediated Cytostatic and Angiostatic Effects by Hirotetsu Takagi, Kosuke Kaji, Norihisa Nishimura, Koji Ishida, Hiroyuki Ogawa, Hiroaki Takaya, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Akira Mitoro, Hitoshi Yoshiji

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Physcion inhibition of CYP2C9, 2D6 and 3A4 in human liver microsomes by Lu Liu, Sen Sun, Xiaohua Li

“…(Polygonaceae), possesses wide pharmacological activities.Objectives The effect of physcion on CYP450 activity was investigated to provide a theoretical basis for use.Materials and methods The experiments were conducted in pooled human liver microsomes (HLMs). The activity of CYP450 isoforms was evaluated with corresponding substrates and probe reactions. …”
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Expression of Integrin β1, Focal Adhesion Kinase, and PDZ-Binding Motif in Human Liver Cirrhosis and Simple Steatosis by Zahra Goli, Iraj Khodadadi, Jamshid Karimi, Sina Mohagheghi, Heidar Tavilani

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The Anti-Tumor Effect and Underlying Apoptotic Mechanism of Ginsenoside Rk1 and Rg5 in Human Liver Cancer Cells by Chen Chen, Qing Lv, Yang Li, Ying-Hua Jin

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Cyto-Genotoxic and Transcriptomic Alterations in Human Liver Cells by Tris (2-Ethylhexyl) Phosphate (TEHP): A Putative Hepatocarcinogen by Quaiser Saquib, Abdullah M. Al-Salem, Maqsood A. Siddiqui, Sabiha M. Ansari, Xiaowei Zhang, Abdulaziz A. Al-Khedhairy

“…Contemporarily, toxicological studies on TEHP in human cells are very limited and there are few studies on its genotoxicity and cell death mechanism in human liver cells (HepG2). Herein, we find that HepG2 cells exposed to TEHP (100, 200, 400 µM) for 72 h reduced cell survival to 19.68%, 49.83%, 58.91% and 29.08%, 47.7% and 57.90%, measured by MTT and NRU assays. …”
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Effects of Copper or Zinc Organometallics on Cytotoxicity, DNA Damage and Epigenetic Changes in the HC-04 Human Liver Cell Line by Daniel Desaulniers, Gu Zhou, Andrew Stalker, Cathy Cummings-Lorbetskie

“…The HC-04 non-cancer human liver cell line was used to investigate the concentration–response effects (24 h and 72 h exposure) on cell proliferation, DNA damage (γH2AX and DNA unwinding assays), and epigenetic effects (global genome changes in DNA methylation and histone modifications using flow cytometry). …”
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Metabolic Stability of Eight Airborne OrganoPhosphate Flame Retardants (OPFRs) in Human Liver, Skin Microsomes and Human Hepatocytes by Stefano Di Bona, Emanuele Artino, Francesca Buiarelli, Patrizia Di Filippo, Roberta Galarini, Stefano Lorenzetti, Franco Lucarelli, Gabriele Cruciani, Laura Goracci

“…Their metabolism was studied at different time points in three matrices: human liver microsomes, human hepatocytes and human skin microsomes. …”
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Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer by Po-Shuan Huang, Yang-Hsiang Lin, Hsiang-Cheng Chi, Yi-Hsin Tseng, Cheng Yi Chen, Tzu-Kang Lin, Chau-Ting Yeh, Kwang-Huei Lin

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