Technology features of decellularization of human liver fragments as tissue-specific fine-grained matrix for cell-engineering liver construction by E. A. Nemets, L. A. Kirsanova, Ju. B. Basok, M. Ju. Schagidulin, E. A. Volkova, S. T. Metelsky, V. I. Sevastianov

“…The decellularization of mechanically grinded human liver fragments was carried out in three changes of buffer solution (pH = 7.4) containing 0.1% sodium dodecyl sulfate and increasing the concentration of Triton X100 (1%, 2% and 3%, respectively). …”
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Down-regulation of Notch1 gene promotes autophagy of human liver cancer cell line HepG2 by LI Chang-an, LIU Chun-xiu, XIE Xiao-juan, SUN Ai-ping

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Cyclin E1 in Murine and Human Liver Cancer: A Promising Target for Therapeutic Intervention during Tumour Progression by Roland Sonntag, Christian Penners, Marlene Kohlhepp, Ute Haas, Daniela Lambertz, Andreas Kroh, Thorsten Cramer, Fabio Ticconi, Ivan G. Costa, Frank Tacke, Nikolaus Gassler, Christian Trautwein, Christian Liedtke

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Development of an LC-MS/MS Method for Quantification of Sapitinib in Human Liver Microsomes: In Silico and In Vitro Metabolic Stability Evaluation by Mohamed W. Attwa, Haitham AlRabiah, Gamal A. E. Mostafa, Adnan A. Kadi

“…In the current study, a highly sensitive, rapid, and specific LC-MS/MS analytical method for the estimation of SPT in human liver microsomes (HLMs) was established with application to metabolic stability assessment. …”
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Post-transcriptional enhancement of FOXP3 protein plays a key role in tolerance after human liver transplantation by Li, Y, Zhao, X, Haga, H, Wood, K, Sakaguchi, S, Koshiba, T

Generation of An Induced Pluripotent Stem Cell Line from Human Liver Fibroblasts from A Patient with Combined Hepatocellular-Cholangiocarcinoma by Hyo-Suk Ahn, Jae-Sung Ryu, Jaeseo Lee, Seon Ju Mun, Yeon-Hwa Hong, Yongbo Shin, Kyung-Sook Chung, Myung Jin Son

“…Due to scarce availability of human liver tissue, induced pluripotent stem cells (iPSCs) are a useful alternative source to produce renewable liver cells. …”
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Hepatocyte-targeted siTAZ therapy lowers liver fibrosis in NASH diet-fed chimeric mice with hepatocyte-humanized livers by Xiaobo Wang, Mary P. Moore, Hongxue Shi, Yoshinari Miyata, Sara K. Donnelly, Daniel R. Radiloff, Ira Tabas

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AM-2201 Inhibits Multiple Cytochrome P450 and Uridine 5′-Diphospho-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes by Ju-Hyun Kim, Soon-Sang Kwon, Tae Yeon Kong, Jae Chul Cheong, Hee Seung Kim, Moon Kyo In, Hye Suk Lee

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Assessment of In Silico and In Vitro Selpercatinib Metabolic Stability in Human Liver Microsomes Using a Validated LC-MS/MS Method by Mohamed W. Attwa, Haitham AlRabiah, Gamal A.E. Mostafa, Ahmed H. Bakheit, Adnan A. Kadi

“…In the current experiment, a highly specific, sensitive, and fast liquid chromatography tandem mass spectrometry (LC-MS/MS) method for quantifying SLP in human liver microsomes (HLMs) was developed and applied to the metabolic stability evaluation of SLP. …”
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Expression of Interferons Lambda 3 and 4 Induces Identical Response in Human Liver Cell Lines Depending Exclusively on Canonical Signaling by Mariia Lunova, Jan Kubovciak, Barbora Smolková, Mariia Uzhytchak, Kyra Michalova, Alexandr Dejneka, Pavel Strnad, Oleg Lunov, Milan Jirsa

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Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells by Lisa Goedtke, Heike Sprenger, Ute Hofmann, Felix F. Schmidt, Helen S. Hammer, Ulrich M. Zanger, Oliver Poetz, Albrecht Seidel, Albert Braeuning, Stefanie Hessel-Pras

“…Here, we studied ten PAHs, different in carcinogenicity classification, for their potential to activate AHR- and CAR-dependent luciferase reporter genes in human liver cells. The majority of investigated PAHs activated AHR, while non-carcinogenic PAHs tended to activate CAR. …”
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Correction: The Proteome of Human Liver Peroxisomes: Identification of Five New Peroxisomal Constituents by a Label-Free Quantitative Proteomics Survey

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Cytotoxic Effects and Intracellular Localization of Bin Toxin from <i>Lysinibacillus sphaericus</i> in Human Liver Cancer Cell Line by Simab Kanwal, Shalini Abeysinghe, Monrudee Srisaisup, Panadda Boonserm

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Environmental Toxin Biliatresone-Induced Biliary Atresia-like Abnormal Cilia and Bile Duct Cell Development of Human Liver Organoids by Yue Hai-Bing, Menon Sudheer Sivasankaran, Babu Rosana Ottakandathil, Wu Zhong-Luan, So Man-Ting, Chung (Patrick) Ho-Yu, Wong (Kenneth) Kak-Yuen, Tam (Paul) Kwong-Hang, Lui (Vincent) Chi-Hang

“…To validate the hypothesis that biliatresone exposure is a plausible BA disease mechanism in humans, we treated normal human liver organoids with biliatresone and addressed its adverse effects on organoid development, functions and cellular organization. …”
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An LC–MS/MS Analytical Method for Quantifying Tepotinib in Human Liver Microsomes: Application to In Vitro and In Silico Metabolic Stability Estimation by Mohamed W. Attwa, Gamal A. E. Mostafa, Haitham AlRabiah, Adnan A. Kadi

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Chemical Mixtures in Household Environments: In Silico Predictions and In Vitro Testing of Potential Joint Action on PPARγ in Human Liver Cells by Celeste K. Carberry, Toby Turla, Lauren E. Koval, Hadley Hartwell, Rebecca C. Fry, Julia E. Rager

“…To test this hypothesis, five commonly co-occurring chemicals (namely, benzyl cinnamate, butyl paraben, decanoic acid, eugenol, and sodium dodecyl sulfate) were tested individually and in combination for changes in the expression of <i>PPARγ</i> and its downstream target, insulin receptor (<i>INSR</i>), in human liver HepG2 cells. Results showed that these likely co-occurring chemicals in household environments increased both <i>PPARγ</i> and <i>INSR</i> expression more significantly when the exposures occurred as mixtures vs. as individual chemicals. …”
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The role of sinusoidal endothelial cells and TIMP1 in the regulation of fibrosis in a novel human liver 3D NASH model by Sander van Riet, Anais Julien, Andrea Atanasov, Åsa Nordling, Magnus Ingelman-Sundberg

“…Here, we present a novel human liver spheroid model that can be used to study the mechanisms underlying liver fibrosis formation and degradation. …”
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In Vitro Metabolism Study of Seongsanamide A in Human Liver Microsomes Using Non-Targeted Metabolomics and Feature-Based Molecular Networking by Zhexue Wu, Geum Jin Kim, So-Young Park, Jong Cheol Shon, Kwang-Hyeon Liu, Hyukjae Choi

“…The purpose of this study was to elucidate the in vitro metabolic pathway and potential for drug interactions of seongsanamide A in human liver microsomes using non-targeted metabolomics and feature-based molecular networking (FBMN) techniques. …”
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Perturbation of <i>TM6SF2</i> Expression Alters Lipid Metabolism in a Human Liver Cell Line by Asmita Pant, Yue Chen, Annapurna Kuppa, Xiaomeng Du, Brian D. Halligan, Elizabeth K. Speliotes

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Correction: The Proteome of Human Liver Peroxisomes: Identification of Five New Peroxisomal Constituents by a Label-Free Quantitative Proteomics Survey. by Thomas Gronemeyer, Sebastian Wiese, Rob Ofman, Christian Bunse, Magdalena Pawlas, Heiko Hayen, Martin Eisenacher, Christian Stephan, Helmut E. Meyer, Hans R. Waterham, Ralf Erdmann, Ronald J. Wanders, Bettina Warscheid

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