Impact of Gold Nanoparticles on Testosterone Metabolism in Human Liver Microsomes by Kyoungju Choi, Hyun Joo

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Protocol for measuring mitochondrial size in mouse and human liver tissues by Balamurugan Ramatchandirin, Miho Iijima, Arisa Ikeda, Alexia Pearah, Sally Radovick, Fredric E. Wondisford, Hiromi Sesaki, Ling He

“…We describe the steps for tissue processing, antigen retrieval, mitochondrial staining using an integrating immunofluorescence assay, and computerized image analysis to measure each mitochondrial size in mouse and human liver tissues. This protocol reduces tissue sample volume and processing time for the preparation of primary cells.For complete details on the use and execution of this protocol, please refer to Pearah et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.…”
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Prenatal exposure of mice to the human liver carcinogen aflatoxin B by Thiantanawat, Apinya, Egner, Patricia A., Groopman, John D., Chawanthayatham, Supawadee, Wogan, Gerald N, Croy, Robert G, Essigmann, John M

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SYNTHESIS AND EFFECTS ON HUMAN LIVER GLYCOSIDASES OF 6-DEOXY-DMDP by Hughes, D, Fleet, G, Molyneaux, R, Winchester, B

Bio inspired heuristic computing scheme for the human liver nonlinear model by Zulqurnain Sabir, Salem Ben Said, Qasem Al-Mdallal

“…In this research, a bio-inspired heuristic computing approach has been developed to solve the nonlinear behavior of the human liver, which is categorized into the liver and blood. …”
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In Vivo and In Vitro Characterization of Primary Human Liver Macrophages and Their Inflammatory State by Andrea Zimmermann, René Hänsel, Kilian Gemünden, Victoria Kegel-Hübner, Jonas Babel, Hendrik Bläker, Madlen Matz-Soja, Daniel Seehofer, Georg Damm

Subjects: “…human liver…”
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Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy by John G. Jones

“…This review summarizes the applications and advances in human liver metabolic studies by in vivo MRS over the past 35 years and discusses future directions and opportunities that will be opened by the development of ultra-high field MR systems and by hyperpolarized stable isotope tracers.…”
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Inhibition of Human Liver Cytochrome P450 by Star Fruit Juice by Jiang-Wei Zhang, Yong Liu, Jie Cheng, Wei Li, Hong Ma, Hong-Tao Liu, Jie Sun, Li-Ming Wang, Yu-Qi He, Yun Wang, Zheng-Tao Wang, Ling Yang

“…The inhibitory effects of star fruit juice (0.5 to 5%, v/v) against the activities of seven CYP isoforms including CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4 and CPR were examined in human liver microsomes. To identify time-dependent inhibition, star fruit juice (2.5%, v/v) was preincubated with microsomes and a NADPH-generating system for 0-15 min, and then the extent of inhibition towards seven CYP isoforms were examined. …”
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Qualification of Human Liver Microsomes for Antibacterial Activity Screening of Drug Metabolites by Navid Jubaer

“…In this work, traditional biochemical tests and advanced proteomics-based identification techniques were used to identify two gram-negative bacteria in pooled human liver microsomes. Several decontamination procedures were assessed to eradicate these two bacteria from the microsomes without affecting its metabolic capacity, and organic extraction was found to be the most convenient and efficient approach to decontaminate microsomes and screen drug metabolites for antibacterial activity against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA).…”
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Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol by Pil Joung Cho, Sanjita Paudel, Doohyun Lee, Yun Ji Jin, GeunHyung Jo, Tae Cheon Jeong, Sangkyu Lee, Taeho Lee

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Immunological Aspects of AXL/GAS‐6 in the Context of Human Liver Regeneration by Gregor Ortmayr, Laura Brunnthaler, David Pereyra, Heidemarie Huber, Jonas Santol, Benedikt Rumpf, Sina Najarnia, Rory Smoot, Daphni Ammon, Thomas Sorz, Fabian Fritsch, Michael Schodl, Astrid Voill‐Glaninger, Barbara Weitmayr, Manuela Födinger, Martin Klimpfinger, Thomas Gruenberger, Alice Assinger, Wolfgang Mikulits, Patrick Starlinger

“…We aimed to assess the relevance of the AXL/GAS‐6‐pathway in human liver regeneration and, consequently, its association with clinical outcome after hepatic resection. …”
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Morphological Characteristics of Alveolar and Cystic Echinococcosis Lesions in Human Liver and Bone by Thomas F. E. Barth, Adriano Casulli

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Pathway-targeted pharmacogenomics of CYP1A2 in human liver by Kathrin eKlein, Stefan eWinter, Miia eTurpeinen, Matthias eSchwab, Matthias eSchwab, Ulrich M Zanger

“…Here we adopted a pathway-oriented approach using a large human liver bank (n=150) to elucidate whether variants in candidate genes of constitutive, ligand-inducible, and pathophysiological inhibitory regulatory pathways may explain different hepatic CYP1A2 phenotypes. …”
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The Influence of Interdisciplinary Work towards Advancing Knowledge on Human Liver Physiology by Blanca Delgado-Coello, Nalu Navarro-Alvarez, Jaime Mas-Oliva

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Building Implantable Human Liver Tissue from Pluripotent Stem Cells by David Hay

“…Therefore, developing renewable sources of human liver tissue is attractive. Pluripotent stem cell-derived liver tissue represents a potential alternative to cadaver derived hepatocytes and whole organ transplant. …”
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Advanced human liver models for the assessment of drug-induced liver injury by Seon Ju Mun, Jaeseo Lee, Yongbo Shin, Myung Jin Son

“…To resolve this issue, an increasing number of 3-dimensional human liver systems, including organoids, are being developed. …”
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Redox-Dependent Modulation of Human Liver Progenitor Cell Line Fate by Francesco Bellanti, Domenica Mangieri, Giorgia di Bello, Aurelio Lo Buglio, Giuseppe Pannone, Maria Carmela Pedicillo, Alberto Fersini, Michał Dobrakowski, Aleksandra Kasperczyk, Sławomir Kasperczyk, Gianluigi Vendemiale

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The mesenchymal transcription factor SNAI-1 instructs human liver specification by Orit Goldman, Victor Julian Valdes, Elena Ezhkova, Valerie Gouon-Evans

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Roles of Human Liver Cytochrome P450 Enzymes in Tenatoprazole Metabolism by Thien-Kim Le, Young Jin Park, Gun Su Cha, Fikri A. R. Hardiyanti Oktavia, Dong Hyun Kim, Chul-Ho Yun

“…It is known that tenatoprazole is metabolized to three major metabolites of 5′-hydroxy tenatoprazole, tenatoprazole sulfide, and tenatoprazole sulfone in human liver, primarily catalyzed by CYPs 2C19 and 3A4. …”
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Proteomic analysis of human liver cell line incubated with s-enantiomer of warfarin by Tay, Jacqueline Mei Shi.

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