Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis by Tracey Hurrell, Vlasia Kastrinou-Lampou, Achilleas Fardellas, Delilah F. G. Hendriks, Åsa Nordling, Inger Johansson, Audrey Baze, Céline Parmentier, Lysiane Richert, Magnus Ingelman-Sundberg

“…We developed a hetero-cellular spheroid system comprised of primary human hepatocytes (PHH) co-cultured with crude fractions of primary human liver non-parenchymal cells (NPC) from several matched or non-matched donors, to identify phenotypes with utility in investigating NASH pathogenesis and drug screening. …”
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Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology by Lorna Ewart, Athanasia Apostolou, Skyler A. Briggs, Christopher V. Carman, Jake T. Chaff, Anthony R. Heng, Sushma Jadalannagari, Jeshina Janardhanan, Kyung-Jin Jang, Sannidhi R. Joshipura, Mahika M. Kadam, Marianne Kanellias, Ville J. Kujala, Gauri Kulkarni, Christopher Y. Le, Carolina Lucchesi, Dimitris V. Manatakis, Kairav K. Maniar, Meaghan E. Quinn, Joseph S. Ravan, Ann Catherine Rizos, John F. K. Sauld, Josiah D. Sliz, William Tien-Street, Dennis Ramos Trinidad, James Velez, Max Wendell, Onyi Irrechukwu, Prathap Kumar Mahalingaiah, Donald E. Ingber, Jack W. Scannell, Daniel Levner

“…Ewart et al. assess the performance of a human Liver-Chip for predictive toxicology. They also perform an economic analysis to demonstrate its potential financial value for the pharmaceutical industry.…”
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Simultaneous staining of cytoplasmic iron and collagen matrix in human liver biopsy specimens by F Grizzi, G Ceva-Grimaldi, B Franceschini, M Roncalli, M Chiriva-Internati, N Dioguardi

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Human Liver Sinusoid on a Chip for Hepatitis B Virus Replication Study by Young Bok (Abraham) Kang, Siddhartha Rawat, Nicholas Duchemin, Michael Bouchard, Moses Noh

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In vitro inhibitory effects of kaempferitrin on human liver cytochrome P450 enzymes by Ning Zhang, Jing Liu, Zhixia Chen, Wenwen Dou

“…However, whether KF affects the activity of human liver cytochrome P450 (CYP) enzymes remains unclear. …”
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Key astroglial markers in human liver cirrhosis of different degree: immunohistochemical study by T. V. Shulyatnikova, V. O. Tumanskyi

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The Interleukin 33–T Helper 2 Cell Axis Promotes Human Liver Fibrosis by Isabella Lurje, Frank Tacke

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The Role of CTGF in Liver Fibrosis Induced in 3D Human Liver Spheroids by Sara Redenšek Trampuž, Sander van Riet, Åsa Nordling, Magnus Ingelman-Sundberg

“…Elevated levels of CTGF can be found in plasma from patients with liver fibrosis and in experimental animal models of liver fibrosis, but the exact role of CTGF in, e.g., diet-induced human liver fibrosis is not entirely known. To address this question, we utilized a 3D human liver co-culture spheroid model composed of hepatocytes and non-parenchymal cells, in which fibrosis is induced by TGF-β1, CTGF or free fatty acids (FFA). …”
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Use of 3D Human Liver Organoids to Predict Drug-Induced Phospholipidosis by Ji-Young Lee, Hyo-Jeong Han, Sang-Joon Lee, Eun-Ho Cho, Han-Byul Lee, Ju-Hyung Seok, Hee Seon Lim, Woo-Chan Son

Subjects: “…3D human liver organoids…”
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Molecular Idiosyncratic Toxicology of Drugs in the Human Liver Compared with Animals: Basic Considerations by Rolf Teschke

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Glycerol as a precursor for hepatic de novo glutathione synthesis in human liver by Eunsook S. Jin, Craig R. Malloy, Gaurav Sharma, Erin Finn, Kelly N.Z. Fuller, Yesenia Garcia Reyes, Mark A. Lovell, Sarkis C. Derderian, Jonathan A. Schoen, Thomas H. Inge, Melanie G. Cree

“…Conclusions: This is the first report of glycerol incorporation into glutathione through glycine or glutamate metabolism in human liver. This could represent a compensatory mechanism to increase glutathione in the setting of excess glycerol delivery to the liver.…”
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Noninvasive assessment of steatosis and viability of cold-stored human liver grafts by MRI by Young, LAJ, Ceresa, CDL, Mózes, FE, Ellis, J, Valkovič, L, Colling, R, Coussios, C-C, Friend, PJ, Rodgers, CT

“…Methods Six ex vivo human livers were scanned during static cold storage following normothermic machine perfusion. …”

Human liver memory CD8+ T cells use autophagy for tissue residence by Swadling, L, Pallett, LJ, Diniz, MO, Baker, JM, Amin, OE, Stegmann, KA, Burton, AR, Schmidt, NM, Jeffery-Smith, A, Zakeri, N, Suveizdyte, K, Froghi, F, Fusai, G, Rosenberg, WM, Davidson, BR, Schurich, A, Simon, AK, Maini, MK

“…By performing ex vivo staining of freshly isolated cells from human liver tissue, we find that an increased rate of basal autophagy is a hallmark of intrahepatic lymphocytes, particularly liver-resident CD8+ T cells. …”

Analysis of gene expression patterns associated with ischemic preconditioning in cadaveric human livers by Jassem, W, Byrne, J, Fuggle, S, Thompson, R, Heaton, N, Rela, M

Isolation of liver associated leukocytes (LAL) from human liver graft perfusates by Pastacaldi, S, Butler, P, Keshav, S, Burroughs, A, Rolles, K

The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes. by Sim, S.M., Back, D.J., Breckenridge, A.M.

“…We have examined the effect of a number of drugs which themselves undergo glucuronidation on AZT conjugation by human liver microsomes in vitro. 2. AZT glucuronidation followed Michaelis-Menten kinetics. …”

Effects of henna (Lawsoniainermis) on the apoptotic pathway of human liver carcinoma cell lines by Endrini, Susi, Rahmat, Asmah, Ismail, Patimah, Yap, Taufiq Yun Hin, Othman, Fauziah

“…This study was conducted to determine the effect of henna (extract and essential oil) on the apoptotic phenomena in a human liver cancer cell lines, HepG2. It was determined by using TUNEL assay to investigate their mechanism of action and the observations were done by using Fluoresence Microscope and Confocal Laser Scanning Microscope. …”
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Evaluation of Herb–Drug Interaction Between Danshen and Rivaroxaban in Rat and Human Liver Microsomes by Xu Wang, Jingjing Fa, Yuanjin Zhang, Shengbo Huang, Jie Liu, Junqing Gao, Lina Xing, Lina Xing, Zongjun Liu, Zongjun Liu, Xin Wang

“…In further inhibition kinetic study, we found that Danshen tablet is a mixed inhibitor in rivaroxaban metabolism in rat and human liver microsomes, with the Ki value at 0.72 and 0.25 mg/ml, respectively. …”
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CULTIVATION OF HUMAN LIVER CELLS AND ADIPOSE-DERIVED MESENCHYMAL STROMAL CELLS IN PERFUSION BIOREACTOR by Yu. В. Basok, A. M. Grigoryev, L. A. Kirsanova, N. P. Shmerko, К. M. Khizroev, V. I. Sevastianov

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In vitro characterization of 3D culture-based differentiation of human liver stem cells by Marta Tapparo, Marta Tapparo, Gabriele Saccu, Gabriele Saccu, Chiara Pasquino, Chiara Pasquino, Valentina Fonsato, Valentina Fonsato, Claudio Medana, Valentina Schiavo, Enrica Mecarelli, Monica Maccagno, Monica Maccagno, Lorenzo Silengo, Stefania Bruno, Giovanni Camussi, Maria Beatriz Herrera Sanchez, Maria Beatriz Herrera Sanchez

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