GNE EXPRESSION ASSOCIATED WITH ISCHEMIA REPERFUSION IN HUMAN LIVER TRANSPLANTATION THE IMPACT OF ISCHEMIC PRECONDITIONING by Jassem, W, Fuggle, S, Thompson, R, Arno, M, Byrne, J, Nigel, H, Rela, M

Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo by Nikolaou, N, Arvaniti, A, Appanna, N, Sharp, A, Hughes, B, Digweed, D, Whitaker, M, Ross, RJ, Arlt, W, Penning, T, Morris, K, George, S, Keevil, B, Hodson, L, Gathercole, L, Tomlinson, JW

“…Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates endogenous glucocorticoids and catalyses an important step in bile acid synthesis. …”

An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection by Mukherji, A, Jühling, F, Simanjuntak, Y, Crouchet, E, Del Zompo, F, Teraoka, Y, Haller, A, Baltzinger, P, Paritala, S, Rasha, F, Fujiwara, N, Gadenne, C, Slovic, N, Oudot, MA, Durand, SC, Ponsolles, C, Schuster, C, Zhuang, X, Holmes, J, Yeh, M, Abe-Chayama, H, Heikenwälder, M, Sangiovanni, A, Iavarone, M, McKeating, JA

“…Here we unravel the rhythmic transcriptome and epigenome of human hepatocytes using male human liver chimeric mice. We identify a large number of rhythmically expressed protein coding genes in human hepatocytes of male chimeric mice, which includes key transcription factors, chromatin modifiers, and critical enzymes. …”

THE HUMAN LIVER AS A RESERVOIR OF INFECTION: THE EPIDEMIOLOGY AND CONTROL OF MALARIA CAUSED BY PLASMODIUM VIVAX by Baird, J

Single-cell RNA sequencing identifies a population of human liver-type ILC1s by Benjamin Krämer, Ansel P. Nalin, Feiyang Ma, Sarah Eickhoff, Philipp Lutz, Sonia Leonardelli, Felix Goeser, Claudia Finnemann, Gudrun Hack, Jan Raabe, Michael ToVinh, Sarah Ahmad, Christoph Hoffmeister, Kim M. Kaiser, Steffen Manekeller, Vittorio Branchi, Tobias Bald, Michael Hölzel, Robert Hüneburg, Hans Dieter Nischalke, Alexander Semaan, Bettina Langhans, Dominik J. Kaczmarek, Brooke Benner, Matthew R. Lordo, Jesse Kowalski, Adam Gerhardt, Jörg Timm, Marieta Toma, Raphael Mohr, Andreas Türler, Arthur Charpentier, Tobias van Bremen, Georg Feldmann, Arne Sattler, Katja Kotsch, Ali T. Abdallah, Christian P. Strassburg, Ulrich Spengler, William E. Carson, III, Bethany L. Mundy-Bosse, Matteo Pellegrini, Timothy E. O’Sullivan, Aharon G. Freud, Jacob Nattermann

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IL-17A in Human Liver: Significant Source of Inflammation and Trigger of Liver Fibrosis Initiation by Daria Kartasheva-Ebertz, Jesintha Gaston, Loriane Lair-Mehiri, Estelle Mottez, Tan-Phuc Buivan, Pierre-Philippe Massault, Olivier Scatton, Sebastien Gaujoux, Jean-Christophe Vaillant, Stanislas Pol, Sylvie Lagaye

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Corrigendum: Evaluation of herb–drug interaction between Danshen and rivaroxaban in rat and human liver microsomes by Xu Wang, Jingjing Fa, Yuanjin Zhang, Shengbo Huang, Jie Liu, Junqing Gao, Lina Xing, Lina Xing, Zongjun Liu, Zongjun Liu, Xin Wang

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Metabolism of Diterpenoids Derived from the Bark of <i>Cinnamomum cassia</i> in Human Liver Microsomes by Su Min Choi, Van Cong Pham, Sangkyu Lee, Jeong Ah Kim

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Inflammation Differentially Modulates the Biological Features of Adult Derived Human Liver Stem/Progenitor Cells by Hoda El-Kehdy, Mehdi Najar, Joery De Kock, Douaa Moussa Agha, Vera Rogiers, Makram Merimi, Laurence Lagneaux, Etienne M. Sokal, Mustapha Najimi

“…We have previously demonstrated that adult-derived human liver stem/progenitor cells (ADHLSC) display significant features that support their clinical development. …”
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Evolving Cell-Based and Cell-Free Clinical Strategies for Treating Severe Human Liver Diseases by Viviana Cernigliaro, Rossella Peluso, Beatrice Zedda, Lorenzo Silengo, Emanuela Tolosano, Rinaldo Pellicano, Fiorella Altruda, Sharmila Fagoonee

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Author Correction: Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology by Lorna Ewart, Athanasia Apostolou, Skyler A. Briggs, Christopher V. Carman, Jake T. Chaff, Anthony R. Heng, Sushma Jadalannagari, Jeshina Janardhanan, Kyung-Jin Jang, Sannidhi R. Joshipura, Mahika M. Kadam, Marianne Kanellias, Ville J. Kujala, Gauri Kulkarni, Christopher Y. Le, Carolina Lucchesi, Dimitris V. Manatakis, Kairav K. Maniar, Meaghan E. Quinn, Joseph S. Ravan, Ann Catherine Rizos, John F. K. Sauld, Josiah D. Sliz, William Tien-Street, Dennis Ramos Trinidad, James Velez, Max Wendell, Onyi Irrechukwu, Prathap Kumar Mahalingaiah, Donald E. Ingber, Jack W. Scannell, Daniel Levner

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Estimating Drug Efficacy with a Diet-Induced NASH Model in Chimeric Mice with Humanized Livers by Keishi Kisoh, Go Sugahara, Yuko Ogawa, Suzue Furukawa, Yuji Ishida, Takeshi Okanoue, Michinori Kohara, Chise Tateno

Subjects: “…human liver chimeric mice…”
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A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer by Haojie Jin, Siying Wang, Esther A Zaal, Cun Wang, Haiqiu Wu, Astrid Bosma, Fleur Jochems, Nikita Isima, Guangzhi Jin, Cor Lieftink, Roderick Beijersbergen, Celia R Berkers, Wenxin Qin, Rene Bernards

“…Here we found that human liver cancer was dependent on extracellular glutamine. …”
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Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids by Bing Zhao, Chao Ni, Ran Gao, Yuyan Wang, Li Yang, Jinsong Wei, Ting Lv, Jianqing Liang, Qisheng Zhang, Wei Xu, Youhua Xie, Xiaoyue Wang, Zhenghong Yuan, Junbo Liang, Rong Zhang, Xinhua Lin

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Mechanism of action of novel piperazine containing a toxicant against human liver cancer cells by Nima Samie, Sekaran Muniandy, MS Kanthimathi, Batoul Sadat Haerian

“…The purpose of this study was to assess the cytotoxic potential of a novel piperazine derivative (PCC) against human liver cancer cells. SNU-475 and 423 human liver cancer cell lines were used to determine the IC50 of PCC using the standard MTT assay. …”
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Poly(ε-Caprolactone) Hollow Fiber Membranes for the Biofabrication of a Vascularized Human Liver Tissue by Simona Salerno, Franco Tasselli, Enrico Drioli, Loredana De Bartolo

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Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver by Volker Kinast, Stefan L. Leber, Richard J. P. Brown, Gabrielle Vieyres, Patrick Behrendt, Constanze Eßbach, Pavel Strnad, Florian W. R. Vondran, Markus Cornberg, Cora Wex, Thomas Pietschmann, Johannes Haybaeck, Daniel Todt, Eike Steinmann

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A Newly Developed Method-Based Xanthine Oxidoreductase Activities in Various Human Liver Diseases by Ken Sato, Atsushi Naganuma, Tamon Nagashima, Yosuke Arai, Yuka Mikami, Yuka Nakajima, Yuki Kanayama, Tatsuma Murakami, Sanae Uehara, Daisuke Uehara, Yuichi Yamazaki, Takayo Murase, Takashi Nakamura, Toshio Uraoka

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Single‐cell transcriptomics reveals conserved cell identities and fibrogenic phenotypes in zebrafish and human liver by Joshua K. Morrison, Charles DeRossi, Isaac L. Alter, Shikha Nayar, Mamta Giri, Chi Zhang, Judy H. Cho, Jaime Chu

“…Joint clustering with human liver scRNA‐seq data demonstrates high conservation of transcriptional profiles and human marker genes in zebrafish. …”
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Ultrastructural Features of Human Liver Specimens from Patients Who Died of Dengue Hemorrhagic Fever by Min Min Win, Komgrid Charngkaew, Nuntaya Punyadee, Khin Saw Aye, Ne Win, Urai Chaisri, Nusara Chomanee, Panisadee Avirutnan, Sutee Yoksan, Prida Malasit

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