Antimicrobial and anticancer activities of Allium hirtifolium boiss hydromethanolic extract by Ismail, Salmiah

“…In this current study, the effectiveness of hydromethanolic Allium hirtifolium Boiss bulbs was studied against six different pathogenic bacteria including Staphylococcus aureus, Methicillin Resistant Staphylococcus aureus (MRSA), Methicillin Sensitive Staphylococcus aureus (MSSA), Salmonella typhimurium, Escherichia coli O157:H7 and Escherichia coli, one fungus (Candida albicans), three different types of viruses Herpes Simplex Virus Type 1 (HSV-1), Herpes Simplex Virus Type 2 (HSV-2) and Respiratory Syncytial Virus (RSV), one type of normal human fibroblast cell line (MRC-5) and four different types of cancer cell lines consist of human breast cancer cells (MCF-7), human cervical cancer cells (HeLa), human liver cancer cells (HepG-2) and human colon cancer cells (HT-29) by in vitro system. …”
Get full text

Synthesis, characterization and cytotoxicity evaluation of carboxylated carbon nanotubes functionalized with silibinin, betulinic acid and levodopa for drug delivery by Tan, Julia Meihua

“…In order to assess the cytotoxicity characteristic of the synthesized nanohybrids, human cancer cell lines HepG2 (human liver hepatocellular carcinoma cell lines) and A549 (human lung adenocarcinoma epithelial cell lines) were used in comparison to normal cell lines MRC-5 (human lung cell lines), 3T3 (mouse fibroblast cell lines) and PC12 (rat neuronal cell lines). …”
Get full text

Determination of chemical composition and potential anticancer activities of Allium atroviolaceum extract on selected cancer cell lines by Khazaei, Somayeh

“…The present study was carried out to determine the phytochemicals and the chemotherapeutic potentials of Allium atroviolaceum flower (FA) and bulb (BA) cruden extracts in selected reproductive cancer cell lines, human hormone dependent breast cancer (MCF7), human hormone independent breast cancer (MDA-MB-2341), human cervical cancer (HeLa), and human liver cancer (HepG2) and non-malignant murine fibroblast (3T3) cell lines. …”
Get full text

Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators by Shujing Xu, Lin Sun, Waleed A. Zalloum, Tianguang Huang, Xujie Zhang, Dang Ding, Xiaoyu Shao, Xiangyi Jiang, Fabao Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan

“…Finally, the experimental metabolic stability results of <b>F₂-7f</b> in human liver microsomes and human plasma moderately correlated with our computational prediction. …”
Get full text

Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity by Jihoon G. Yoon, Dong Geon Jang, Sung-Gyu Cho, Chaeyoung Lee, Shin Hye Noh, Soo Kyung Seo, Jung Woo Yu, Hyeon Woo Chung, KyeoRe Han, Soon Sung Kwon, Dai Hoon Han, Jaeseong Oh, In-Jin Jang, Sang-Hoon Kim, Young-Koo Jee, Hyun Lee, Dong Won Park, Jang Won Sohn, Ho Joo Yoon, Chul Hoon Kim, Jae Myun Lee, Sang-Heon Kim, Min Goo Lee

“…In vitro experiments using human liver-derived cell lines (HepG2 and SNU387 cells) revealed toxic synergism between INH and Cu, which were strongly augmented in cells with defective NAT2 and ATP7B activity, leading to increased mitochondrial reactive oxygen species generation, mitochondrial dysfunction, DNA damage, and apoptosis. …”
Get full text

Therapeutic potential of green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG) in SARS-CoV-2 infection: Major interactions with host/virus proteases by Biswanath Dinda, Subhajit Dinda, Manikarna Dinda

“…In vitro study on the mechanism of EGCG sulfonation indicates that sulfotransferases, SULT1A1 and SULT1A3 are responsible for sulfonation in human liver and small intestine, respectively. Some attempts including structural modifications, and nanoformulations of EGCG and addition of nutrients with EGCG have been made to improve the bioavailability of EGCG. …”
Get full text

Danger signals released during cold ischemia storage activate NLRP3 inflammasome in myeloid cells and influence early allograft function in liver transplantationResearch in context by Fernando Lucas-Ruiz, Sandra V. Mateo, Marta Jover-Aguilar, Felipe Alconchel, Laura Martínez-Alarcón, Carlos de Torre-Minguela, Daniel Vidal-Correoso, Francisco Villalba-López, Víctor López-López, Antonio Ríos-Zambudio, José A. Pons, Pablo Ramírez, Pablo Pelegrín, Alberto Baroja-Mazo

“…This study aimed to identify DAMPs released during cold ischemia storage of human liver and analyze their ability to activate the inflammasome in myeloid cells and the possible implications in terms of short-term outcomes of liver transplantation. …”
Get full text

Upregulation of microRNA-125b-5p alleviates acute liver failure by regulating the Keap1/Nrf2/HO-1 pathway by Ya-Chao Tao, Ya-Chao Tao, Yong-Hong Wang, Yong-Hong Wang, Meng-Lan Wang, Meng-Lan Wang, Wei Jiang, Wei Jiang, Dong-Bo Wu, Dong-Bo Wu, En-Qiang Chen, En-Qiang Chen, Hong Tang, Hong Tang

“…Regulation of miRNAs related to inflammation may serve as promising interventions for the treatment of liver failure.AimsTo explore the role and mechanism of miR-125b-5p in the development of liver failure.MethodsSix human liver tissues were categorized into HBV-non-ACLF and HBV-ACLF groups. …”
Get full text

Transcriptomic landscapes of effective and failed liver regeneration in humans by Patrick Starlinger, Laura Brunnthaler, Chantal McCabe, David Pereyra, Jonas Santol, Jessica Steadman, Matthias Hackl, Susanna Skalicky, Hubert Hackl, Raphael Gronauer, Daniel O’Brien, Renate Kain, Petra Hirsova, Gregory J. Gores, Chen Wang, Thomas Gruenberger, Rory L. Smoot, Alice Assinger

“…Conclusions: Exploring the landscape of early transcriptional changes of human liver regeneration, we observed that people with dysfunctional regeneration experience overwhelming intrahepatic inflammation. …”
Get full text

Type 2 innate lymphoid cells are protective against hepatic ischaemia/reperfusion injury by Qi Cao, Ruifeng Wang, Zhiguo Niu, Titi Chen, Farhana Azmi, Scott A. Read, Jianwei Chen, Vincent W.S. Lee, Chunze Zhou, Sohel Julovi, Qingsong Huang, Yuan Min Wang, Malcolm R. Starkey, Guoping Zheng, Stephen I. Alexander, Jacob George, Yiping Wang, David C.H. Harris

“…We propose that ILC2s have the potential to serve as a therapeutic tool for protecting against acute liver injury and lay the foundation for translation of ILC2 therapy to human liver disease.…”
Get full text

Effects of FER1L4-miR-106a-5p/miR-372-5p-E2F1 regulatory axis on drug resistance in liver cancer chemotherapy by Xu Wang, Yunfei Chen, Ke Dong, Yujing Ma, Qizhi Jin, Shujun Yin, Xiaoshi Zhu, Shan Wang

“…This study aimed at investigating the effects of Fer-1 like family member 4 (FER1L4) on chemotherapy resistance and liver cancer development by using clinically collected liver cancer tissues and commercially purchased human liver cancer cisplatin-resistant cell line HUH-7/DDP. …”
Get full text

The egg ribonuclease SjCP1412 accelerates liver fibrosis caused by Schistosoma japonicum infection involving damage-associated molecular patterns (DAMPs) by Qi-Feng Li, Yi-Xin Li, Ying-Ying Yang, Pan-Pan Dong, Cong-Jin Mei, Ju-Lu Lu, Jian-Feng Zhang, Hai-Yong Hua, Chun-Rong Xiong, Chuan-Xin Yu, Li-Jun Song, Kun Yang

“…In vitro, the rSjCP1412 protein induced the human liver cancer cell line Hep G2 and liver sinusoidal endothelial cells apoptosis and necrosis and the release of proinflammatory damage-associated molecular patterns (DAMPs). …”
Get full text

ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress by Yoon Seok Jung, Kamalakannan Radhakrishnan, Seddik Hammad, Sebastian Müller, Johannes Müller, Jung-Ran Noh, Jina kim, In-Kyu Lee, Sung Jin Cho, Don-Kyu Kim, Yong-Hoon Kim, Chul-Ho Lee, Steven Dooley, Hueng-Sik Choi

“…FGF23 is mainly expressed in hepatocytes in the human liver, and it is upregulated in ALD patients. …”
Get full text

Chemo-/Regio-Selective Synthesis of Novel Functionalized Spiro[pyrrolidine-2,3′-oxindoles] under Microwave Irradiation and Their Anticancer Activity by Richa Sharma, Lalit Yadav, Ali Adnan Nasim, Ravi Kant Yadav, Rui Hong Chen, Neha Kumari, Fan Ruiqi, Ashoke Sharon, Nawal Kishore Sahu, Sirish Kumar Ippagunta, Paolo Coghi, Vincent Kam Wai Wong, Sandeep Chaudhary

“…Out of the 23 synthesized spiro[pyrrolidine-2,3′-oxindoles], while five compounds (<b>4c</b>, <b>4f</b>, <b>4m</b>, <b>4q</b>, <b>4t</b>) (IC₅₀ = 34.99–47.92 µM; SI = 0.96–2.43) displayed significant in vitro anticancer activity against human lung (A549) cancer cell lines, six compounds (<b>4c</b>, <b>4f</b>, <b>4k</b>, <b>4m</b>, <b>4q</b>, <b>4t</b>) (IC₅₀ = 41.56–86.53 µM; SI = 0.49–0.99) displayed promising in vitro anticancer activity against human liver (HepG2) cancer cell lines. In the case of lung (A549) cancer cell lines, these compounds were recognized to be more efficient and selective than standard reference artemisinin (IC₅₀ = 100 µM) and chloroquine (IC₅₀ = 100 µM; SI: 0.03). …”
Get full text

Suppressive effect of pseudolaric acid B on Echinococcus multilocularis involving regulation of TGF-β1 signaling in vitro and in vivo by Haijun Gao, Haijun Gao, Haijun Gao, Lele Huo, Xiaojin Mo, Bin Jiang, Yanping Luo, Bin Xu, Jingzhong Li, Xingming Ma, Tao Jing, Zheng Feng, Ting Zhang, Ting Zhang, Wei Hu, Wei Hu

“…The toxicity tests demonstrated that PAB displayed lower cytotoxicity to human liver and kidney cells (HL-7702 and HK-2 cell) with IC50 = 25.29 and 42.94 μg/ml than albendazole with IC50 = 3.71 and 21.22 μg/ml in vitro, and caused lower hepatoxicity and nephrotoxicity in mice than ABZ. …”
Get full text

Cachexia causes time‐dependent activation of the inflammasome in the liver by Rodrigo Xavier dasNeves, Alex S. Yamashita, Daniela M.R. Riccardi, Julia Köhn‐Gaone, Rodolfo G. Camargo, Nelson I. Neto, Daniela Caetano, Silvio P. Gomes, Felipe H. Santos, Joanna D.C.C. Lima, Miguel L. Batista Jr, José Cesar Rosa‐Neto, Paulo Sérgio Martins De Alcântara, Linda F. Maximiano, José P. Otoch, Giorgio Trinchieri, Janina E.E. Tirnitz‐Parker, Marília Seelaender

“…Conclusions The results show that cancer cachexia is associated with an increase in the number of myeloid cells in rodent and human liver and with modulation of hepatic inflammasome pathway. …”
Get full text

Extraction, Gene Regulation and Hypocholesterolemic Effects, and Antioxidative Activity of Thymoquinone Rich Fraction and Thymoquinone from Nigella Sativa (pdf incomplete) by Al-Naqeeb, Ghanya Naji

“…The present study involves thymoquinone rich fraction (TQRF) prepared from Nigella sativa seeds using supercritical fluid extraction (SFE) and commercial available thymoquinone (TQ) to investigate their regulatory effects on genes involved in cholesterol metabolism in vitro using Human liver cancer cells (HepG2 cells) and in vivo using Sprague-Dawley rats. …”
Get full text

Suppression Effect of Eurycomanone on the Growth of Human Hepatoma Cells (Hepg2) by Inducing P53-Mediated Apoptotic Pathway by Zakaria, Yusmazura

“…The findings showed that CE inhibited cell proliferation towards human malignant melanoma cell (HM3KO), human cervical cancer cell (Hela), human liver cancer cell (HepG2) and human ovarian carcinoma cell (CaOV3) with an IC50 of 60±0.25 μg/ml, 60±0.25 μg/ml, 45±0.15 μg/ml and 79±0.16 μg/ml respectively. …”
Get full text

A large scale multi-laboratory suspect screening of pesticide metabolites in human biomonitoring: From tentative annotations to verified occurrences by Carolin Huber, Rosalie Nijssen, Hans Mol, Jean Philippe Antignac, Martin Krauss, Werner Brack, Kevin Wagner, Laurent Debrauwer, Chiara Maria Vitale, Elliott James Price, Jana Klanova, Borja Garlito Molina, Nuria Leon, Olga Pardo, Sandra F. Fernández, Tamás Szigeti, Szilvia Középesy, Libor Šulc, Pavel Čupr, Inese Mārtiņsone, Läsma Akülova, Ilse Ottenbros, Roel Vermeulen, Jelle Vlaanderen, Mirjam Luijten, Arjen Lommen

“…The obtained tentative annotations (n = 498) were used for acquiring representative data-dependent tandem mass spectra (MS2) and verified by spectral comparison to reference spectra generated from commercially available reference standards or produced through human liver S9 in vitro incubation experiments. 14 parent pesticides and 71 metabolites (including 16 glucuronide and 11 sulfate conjugates) were detected. …”
Get full text

Disturbed Gut-Liver axis indicating oral exposure to polystyrene microplastic potentially increases the risk of insulin resistance by Chunzhen Shi, Xiaohong Han, Wei Guo, Qi Wu, Xiaoxi Yang, Yuanyuan Wang, Gang Tang, Shunhao Wang, Ziniu Wang, Yaquan Liu, Min Li, Meilin Lv, Yunhe Guo, Zikang Li, Junya Li, Jianbo Shi, Guangbo Qu, Guibin Jiang

“…Human uptake abundance of microplastics via various pathways, and they accumulate in human liver, kidney, gut and even placenta (especially with a diameter of 1 μm or less). …”
Get full text