Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway by Yuanyuan Fu, Pengzhi Wan, Jie Zhang, Xue Li, Jia Xing, Yu Zou, Kaiyue Wang, Hui Peng, Hui Peng, Qizhuo Zhu, Liu Cao, Xiaoyue Zhai, Xiaoyue Zhai

“…In the present study, renal mesangial cells (MCs) were cultured on polyacrylamide hydrogels with different stiffness accurately detected by atomic force microscope (AFM), simulating the in vivo growth microenvironment of MCs in normal kidney and renal fibrosis. …”
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Structural Characterization and Optimization of a Miconazole Oral Gel by Andrada Pintea, Robert-Alexandru Vlad, Paula Antonoaea, Emöke Margit Rédai, Nicoleta Todoran, Enikő-Csilla Barabás, Adriana Ciurba

“…Because of their biocompatibility, hydrophilic nature, and capacity of absorbing large quantities of water, hydrogels are still one of the most promising pharmaceutical formulations in the pharmaceutical industry. …”
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Bibliometric analysis of stem cells for spinal cord injury: current status and emerging frontiers by Zhizhong Shang, Pingping Wanyan, Pingping Wanyan, Mingchuan Wang, Baolin Zhang, Xiaoqian Cui, Xin Wang, Xin Wang, Xin Wang

“…Meanwhile, future research directions are primarily concerned with the molecular mechanisms, safety, clinical trials, exosomes, scaffolds, hydrogels, and inflammatory responses of stem cell therapy for spinal cord injuries.Conclusion: In summary, this study provided a comprehensive analysis of the current research status and frontiers of stem cell therapy for spinal cord injury. …”
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Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis by Gavin Tjin, Eric S. White, Alen Faiz, Delphine Sicard, Daniel J. Tschumperlin, Annabelle Mahar, Eleanor P. W. Kable, Janette K. Burgess

“…Functional effects (collagen structure and tissue stiffness using atomic force microscopy) of LO inhibitors on collagen remodelling were examined in two models, collagen hydrogels and decellularized human lung matrices. LOXL1/LOXL2 gene expression and protein levels were increased in IPF versus non-IPF. …”
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Three-dimensional printing technologies for drug delivery applications: processes, materials, and effects by Mancilla-De-la-Cruz, Jessica, Rodriguez-Salvador, Marisela, An, Jia, Chua, Chee Kai

“…In this context, polymers, glasses, and hydrogels represent the most frequent materials used. 3D printing allows different forms of drug dosage. …”
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How bulk fluid renewal can affect in vitro drug release from PLGA implants: Importance of the experimental set-up by C. Bassand, L. Benabed, J. Freitag, J. Verin, F. Siepmann, J. Siepmann

“…A “standard experimental set-up”, in which the implants were directly exposed to well agitated phosphate buffer pH 7.4 was used, as well as set-ups, in which the implants were embedded within agarose hydrogels (mimicking living tissue). The gels were exposed to well agitated phosphate buffer pH 7.4. …”
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Cell-mimicking polyethylene glycol-diacrylate based nanolipogel for encapsulation and delivery of hydrophilic biomolecule by Wen Jie Melvin Liew, Yee Shan Wong, Atul N. Parikh, Subbu S. Venkatraman, Ye Cao, Bertrand Czarny, Bertrand Czarny

“…This is in contrast to conventional FRAP works on cells or bulk hydrogels, which is limited in our application. Our work showed that the mesh size of the NLGs can be controlled by using different Mw of PEGDA, such as using a smaller MW to achieve higher crosslinking density, which will lead to having smaller mesh size for the crosslinked nanogel, and the release of hydrophilic DFITC can be sustained while suppressing the initial burst release, up to 10-fold more for crosslinked PEGDA 575 NLGs. …”
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Protein-mediated gelation and nano-scale assembly of unfunctionalized hyaluronic acid and chondroitin sulfate [version 2; peer review: 2 approved, 1 approved with reservations] by Anthony Tabet, June Y. Park, Jarrod Shilts, Kamil Sokolowski, Vijay K. Rana, Marlous Kamp, Nina Warner, Dominique Hoogland, Oren A. Scherman

“…These systems are formed from unfunctionalized polysaccharides, which is an attractive and simpler method of forming HA hydrogels and CS nanoparticles than functional chemistry-based approaches such as chemically modifying the polymer backbones. …”
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Worldwide productivity and research trend of publications concerning electroactive materials and spinal cord injury: A bibliometric study by Sirui Liu, Lin Song, Lin Song, Weishu Dai, Mengdie Liu, Mengdie Liu, Huijing Zhang, Huijing Zhang, Xueyan Zhang, Hongyu Li, Xiu Liu, Yan Lv, Ying Hu

“…Analysis of qualitative data revealed that the role and mechanism of injectable conductive hydrogels in spinal cord healing after damage is a hot topic of current study, with the mechanism primarily focusing on the inhibition of oxidative stress (Nrf2) and apoptosis (Casepase 3).Conclusion: Our bibliometric analysis indicates that research on electroactive materials for spinal cord injury remains an active field of study. …”
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Comparative Drug Release Investigations for Diclofenac Sodium Drug (DS) by Chitosan-Based Grafted and Crosslinked Copolymers by Lalita Chopra, Kamal Kishor Thakur, Jasgurpreet Singh Chohan, Shubham Sharma, R. A. Ilyas, M. R. M. Asyraf, S. Z. S. Zakaria

“…The hydrogels responding to pH synthesized by graft copolymerization only and then concurrent grafting and crosslinking of monomer <i>N</i>-isopropyl acrylamide (NIPAAM) and binary comonomers acrylamide, acrylic acid and acrylonitrile (AAm, AA and AN) onto chitosan support were explored for the percent upload and release study for anti-inflammatory diclofenac sodium drug (DS), w.r.t. time and pH. …”
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Substrate Stiffness Modulates the Growth, Phenotype, and Chemoresistance of Ovarian Cancer Cells by Yali Fan, Quanmei Sun, Xia Li, Xia Li, Jiantao Feng, Zhuo Ao, Xiang Li, Jiandong Wang

“…Here, we utilized polyacrylamide hydrogels with varying physical parameters simulating tumor and metastatic target tissues to investigate the effect of substrate stiffness on the growth, phenotype, and chemotherapeutic response of ovarian cancer cells (OCCs). …”
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Protein-mediated gelation and nano-scale assembly of unfunctionalized hyaluronic acid and chondroitin sulfate [version 3; peer review: 2 approved, 1 approved with reservations] by Anthony Tabet, June Y. Park, Jarrod Shilts, Kamil Sokolowski, Vijay K. Rana, Marlous Kamp, Nina Warner, Dominique Hoogland, Oren A. Scherman

“…These systems are formed from unfunctionalized polysaccharides, which is an attractive and simple method of forming HA hydrogels and CS nanoparticles. We also summarize the concentrations of HA and CS found in various mammalian brains, which could potentially be useful for biomimetic scaffold development. …”
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A conservative approach to perineal Fournier's gangrene by Giulio Milanese, Luigi Quaresima, Marco Dellabella, Alessandro Scalise, Giovanni Maria Di Benedetto, Giovanni Muzzonigro, Daniele Minardi

“…After debridement, all the patients were treated with advanced specific dressings consisting of plates and strips made of calcium alginate, hydrogels and polyurethane and twodimensional cavity foams. …”
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Flagellin is essential for initial attachment to mucosal surfaces by Clostridioides difficile by Ben Sidner, Armando Lerma, Baishakhi Biswas, Thi Van Thanh Do, Yafan Yu, Leslie A. Ronish, Hugh McCullough, Jennifer M. Auchtung, Kurt H. Piepenbrink

“…Our results show the importance of flagellin for specific adhesion to mucosal hydrogels and can help to explain prior observations of adhesive defects in flagellin and pilin mutants.…”
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Physiological cell bioprinting density in human bone-derived cell-laden scaffolds enhances matrix mineralization rate and stiffness under dynamic loading by Anke M. de Leeuw, Reto Graf, Pei Jin Lim, Jianhua Zhang, Gian Nutal Schädli, Sheila Peterhans, Marianne Rohrbach, Cecilia Giunta, Matthias Rüger, Matthias Rüger, Marina Rubert, Ralph Müller

“…Recently, we introduced a mineralized bone model based on 3D bioprinted cell-laden alginate-gelatin-graphene oxide hydrogels cultured under dynamic loading using commercially available human mesenchymal stem cells. …”
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ANTIOXIDANT POTENTIAL OF TEMULAWAK (CURCUMA XANTHORRHIZA) EXTRACT GEL AS A CANDIDATE FOR WOUND HEALING by Reghita Claudia Malau, Sri Wahyuni Nasution, Ali Napiah Nasution, Wahyu Widowati, Faradhina Salfa Nindya, Hanna Sari Widya Kusuma

“…To expedite the healing of chronic wounds, numerous studies have begun to utilize gels, including hydrogels or sol-gels, which incorporate a combination of antioxidant properties. …”
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Boosting tendon repair: interplay of cells, growth factors and scaffold-free and gel-based carriers by Zexing Yan, Heyong Yin, Michael Nerlich, Christian G. Pfeifer, Denitsa Docheva

“…The main results are summarizing and discussing the clear advantages of scaffold-free and hydrogels carriers that can be functionalized with cells alone or in combination with growth factors. …”
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Development of 3D printable graphene oxide based bio-ink for cell support and tissue engineering by Jianfeng Li, Jianfeng Li, Jianfeng Li, Xiao Liu, Jeremy M. Crook, Jeremy M. Crook, Jeremy M. Crook, Jeremy M. Crook, Gordon G. Wallace

“…As an emerging technology, 3D bioprinting enables tissue engineering through the ability to arrange biomaterials and cells in pre-ordered structures. Hydrogels, such as alginate (Alg), can be formulated as inks for 3D bioprinting. …”
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Development of Conjugated Kefiran-Chondroitin Sulphate Cryogels with Enhanced Properties for Biomedical Applications by Hajer Radhouani, Cristiana Gonçalves, F. Raquel Maia, Eduarda P. Oliveira, Rui L. Reis, Joaquim M. Oliveira

“…Hydrogels based on natural polysaccharides can have unique properties and be tailored for several applications, which may be mainly limited by the fragile structure and weak mechanical properties of this type of system. …”
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Electrospun Nanofibrous Mesh Based on PVA, Chitosan, and Usnic Acid for Applications in Wound Healing by Alexandra Elena Stoica (Oprea), Delia Albuleț, Alexandra Cătălina Bîrcă, Florin Iordache, Anton Ficai, Alexandru Mihai Grumezescu, Bogdan Ștefan Vasile, Ecaterina Andronescu, Florica Marinescu, Alina Maria Holban

“…On the one hand, PVA is a water-soluble synthetic polymer widely used for the preparation of hydrogels in the field of biomedicine owing to its biocompatibility, water solubility, nontoxicity, and considerable mechanical properties. …”
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