The effects of a comprehensive community trial on cardiometabolic risk factors in adolescents: Isfahan healthy heart program by Roya Kelishadi, Noushin Mohammadifard, Nizal Sarrafzadegan, Fatemeh Nouri, Rezvan Pashmi, Ahmad Bahonar, Hossein Heidari, Sedigheh Asgary, Maryam Boshtam, Alireza Mardani

“…<br /><strong>RESULTS:</strong> The prevalence of hypercholesterolemia and hypertriglyceridemia declined<br />significantly in girls and boys in the IA (P &lt; 0.01). …”
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Effects of fish and krill oil on gene expression in peripheral blood mononuclear cells and circulating markers of inflammation: a randomised controlled trial by Amanda Rundblad, Kirsten B. Holven, Inge Bruheim, Mari C. Myhrstad, Stine M. Ulven

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Diabetes Mellitus Is a Strong Independent Negative Prognostic Factor in Patients with Brain Metastases Treated with Radiotherapy by Seong Jeong, Soniya Poudyal, Sabine Klagges, Thomas Kuhnt, Kirsten Papsdorf, Peter Hambsch, Johannes Wach, Erdem Güresir, Franziska Nägler, Alexander Rühle, Nils H. Nicolay, Clemens Seidel

“…Patient and survival data, including cerebrovascular risk factors (diabetes mellitus (DM), smoking, arterial hypertension, peripheral arterial occlusive disease, hypercholesterolemia and smoking) were recorded. Results: 203 patients were included. …”
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Preclinical toxicity assessment of a peptide-based antiPCSK9 vaccine in healthy mice by Amir Abbas Momtazi-Borojeni, Maciej Banach, Sayed Abbas Tabatabaei, Amirhossein Sahebkar

“…We have previously shown that active immunization using the antiPCSK9 vaccine could decrease hypercholesterolemia and impede the development of atherosclerotic lesions in the experimental model of atherosclerosis. …”
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Prevalence of anemia and its associated factors among patients with type 2 diabetes mellitus in a referral diabetic clinic in the north of Iran by Reyhane Hizomi Arani, Farima Fakhri, Mohammad Naeimi Tabiee, Fatemeh Talebi, Zahra Talebi, Negin Rashidi, Maryam Zahedi

“…The multivariable Model was adjusted for obesity, Hb A1c, T2DM duration, using glucose-lowering drugs (GLDs), chronic kidney disease (CKD), albuminuria, hypertriglyceridemia, and hypercholesterolemia.  Results The prevalence of anemia was 21.5% [95%CI: 17.6-25.7] among our total participants. …”
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Changes induced in mouse lipid metabolism by simultaneous impact of antisense oligonucleotide derivatives to <i>apoB</i>, <i>PCSK9</i>, and <i>apoCIII</i> mRNAs by S. I. Oshevski, Y. I. Ragino, E. V. Kashtanova, Y. V. Polonskaya, E. M. Stakhneva, V. P. Nikolin, N. A. Popova, N. A. Kolchanov, M. I. Voevoda

“…Development of new drugs able to decrease the level of “bad” cholesterol, in particular, based on antisense oligonucleotide derivatives (ASOs), remains relevant for the patients with familial hypercholesterolemia and/or intolerant to statins. The goal of the work was to assess the changes in the lipid metabolism caused by variants of joint impact of the ASOs targeted to the mRNAs of its key genes: apoB, PCSK9, and apoCIII. …”
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LATE TREATMENT WITH L-ARGININE INCREASES 8-ISOPROSTAGLANDIN F2Α AND OXIDIZED LDL IN HYPERCHOLESTEROLEMIC RABBITS by Motaharsadat Hosseini, Shaghayegh Haghjooy Javanmard, Mehdi Nematbakhsh

“…</p> <p class="abstract"><strong>&nbsp;&nbsp; </strong><strong>CONCLUSION:</strong> L-arginine therapy from the very beginning of hypercholesterolemia reduced oxidative stress and the consequential irreversible vascular damage, and may be useful for primary prevention.…”
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Anthropometric Measures and Risk of Cardiovascular Disease: Is there an Opportunity for Non-Traditional Anthropometric Assessment? A Review by Aurora Carrión-Martínez, Benjamin J R Buckley, Esteban Orenes-Piñero, Francisco Marín, Gregory Y. H Lip, José Miguel Rivera-Caravaca

“…Results: In patients from the general population, elevated subscapular and triceps skinfolds showed a positive relationship with the development of hypertension, diabetes mellitus, hypercholesterolemia, cardiovascular mortality, and all-cause mortality. …”
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Assessment of Indices of Vascular Involvement in Children with Idiopathic Nephrotic Syndrome: A Case-control Study by Alok khanna, Mukesh saini, Ashuma sachdeva, Jyotsna sen, kapil bhalla, Animesh debbarma, Yogesh verma, Preet lamba

“…Introduction: Nephrotic Syndrome (NS) is characterised by proteinuria, oedema, hypoalbuminaemia, and hypercholesterolemia. The latter is a risk factor for atherosclerosis, suggesting a higher risk of cardiovascular disease in children with NS. …”
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SYNTAX Scoring In Patients with Coronary Artery Disease and Its Effect on Mode of Revascularization , Single Center Experience. by Hilal B. Al Saffar, Saad M. Zedan

“…Risk factors prevalencewas DM (42.6%), high blood pressure (52.8 %), smoking (42.4%), hypercholesterolemia (43.4%) and prior MI (32.3%). Mean age of group A was 54.22±11.27 while group B was 62.37±7.47 (P value 0.0001) . …”
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Detecting the risk for fatty liver, MASH, and insulin resistance using different indexes and markers of liver damage in young adults from West Mexico by Leonardo Leal-Mercado, Arturo Panduro, Saúl Laguna-Meraz, Sonia Román

“…Additionally, 80.8% of the participants had one or more metabolic abnormalities; hypercholesterolemia (25%), hypertriglyceridemia (39.2%), hypoalphalipoproteinemia (64%), and IR (54.3%). …”
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The effect of pentosan polysulfate sodium for improving dyslipidaemia and knee pain in people with knee osteoarthritis: A pilot study by Xiaoqian Liu, Sonika Virk, Tatyana Fedorova, Win Min Oo, David J. Hunter

“…People with painful knee OA and a history of primary hypercholesterolemia were included. PPS was taken orally in a dosage of 10 ​mg/kg once every 4 days for 5 weeks for two cycles. …”
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Prognostic Value of Endothelial Progenitor Cells in Acute Myocardial Infarction Patients by Gongjie Ye, Xiaodan Chen, Yinchao Zhou, Jianqing Zhou, Yongfei Song, Xiaoyong Yang, Lei Yang

“…The study incorporated various variables, including cardiovascular risk factors such as body mass index, hypertension, diabetes, hypercholesterolemia, atherosclerotic burden, and medication history, as well as clinical characteristics such as APACHEⅡscore, central venous-arterial carbon dioxide difference (GAP), homocysteine, creatinine, C-reactive protein, HbAlc, and cardiac index. …”
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Antihypercholesterolemig properties of palm oil and curcuma longa extract as single and combination doses in rabbits / Nur Anis Albakry by Albakry, Nur Anis

“…In conclusion, the results provided the effectiveness of treatment with combination of PO and CL extract at reducing hypercholesterolemia in rabbits, comparable to effects of atorvastatin and potentially beneficial at prevention of hyperlipidemia and protection against cardiovascular disease.…”
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EFFICACY AND SAFETY OF INCLISIRAN BY BASELINE BODY MASS INDEX: A POST HOC POOLED ANALYSIS OF THE ORION-9, ORION-10 AND ORION-11 PHASE III RANDOMIZED CONTROLLED TRIALS by Lawrence A Leiter, David G Kallend, Wolfgang Koenig, Ulf Landmesser, Kausik K Ray, Gregory G Schwartz, R Scott Wright, YannTong Chiang, Lorena Garcia Conde Orozco, Frederick J Raal

“…The aim of this analysis was to assess the efficacy and safety of inclisiran in patients with heterozygous familial hypercholesterolemia, atherosclerotic cardiovascular disease (ASCVD) or ASCVD risk equivalent across body mass index (BMI) strata. …”
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Postprandial Glycemic and Insulinemic Response by a Brewer’s Spent Grain Extract-Based Food Supplement in Subjects with Slightly Impaired Glucose Tolerance: A Monocentric, Randomiz... by Hammad Ullah, Cristina Esposito, Roberto Piccinocchi, Lorenza Francesca De Lellis, Cristina Santarcangelo, Alessandro Di Minno, Alessandra Baldi, Daniele Giuseppe Buccato, Ayesha Khan, Gaetano Piccinocchi, Roberto Sacchi, Maria Daglia

“…Dietary fiber exerts beneficial effects on human health reducing the risk factors of metabolic related diseases such as hyperglycemia, insulin resistance, and hypercholesterolemia. The aim of this study is to demonstrate the efficacy of a food supplement based on brewer’s spent grain (BSG) extract in the reduction of postprandial glycemia and insulinemia in normoglycemic subjects. …”
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Inverse Correlation of Cholesterol Efflux Capacity with Peripheral Plaque Volume Measured by 3D Ultrasound by Maria Noflatscher, Monika Hunjadi, Michael Schreinlechner, Philip Sommer, Daniela Lener, Markus Theurl, Rudolf Kirchmair, Axel Bauer, Andreas Ritsch, Peter Marschang

“…By causing cholesterol to build up in the artery wall, hypercholesterolemia is a major factor in the pathophysiology of atherosclerotic plaque development. …”
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Stiffness and Elasticity of Aorta Assessed Using Computed Tomography Angiography as a Marker of Cardiovascular Health—A Cross-Sectional Study by Wojciech Hajdusianek, Aleksandra Żórawik, Piotr Macek, Małgorzata Poręba, Rafał Poręba, Paweł Gać

“…The study group (SG) was composed of 96 patients (mean age 70.41 ± 8.32 years) with a BMI of 25.58 ± 3.12 kg/m²; 28.1% were smokers, 54.2% had hypertension, 11.4% had diabetes, and 67.7% had hypercholesterolemia. The SG was further divided into three subgroups (optimal (ALS7-H), intermediate (ALS7-I), and inadequate (ALS7-L)) based on the ALS7. …”
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Application and Comparison of Dermoscopy and Reflectance Confocal Microscopy in the Target Treatment of Genital Lichen Sclerosus: A Single-Arm Prospective Study by Chengbei Bao, Yan Zhao, Renwei Luo, Qiuyun Xu, Zequn Tong, Zhixun Xiao, Zheyu Zhuang, Wenjia Dai, Bohan Gu, Ting Gong, Bo Cheng, Chao Ji

“…Irregular papillae, spongiosis, and fiber structures improved at week 20, week 4, and week 6 (all P < 0.01). Transient hypercholesterolemia (11.54%), thrombocytosis (7.69%), and elevated alanine aminotransferase (7.69%) occurred during treatment. …”
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Platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trial by Jose Ignacio Martin, Leire Atilano, Josu Merino, Igor Gonzalez, Gotzon Iglesias, Luis Areizaga, Paola Bully, Gonzalo Grandes, Isabel Andia

“…After 12 months, 17 patients (70.83%) in the lidocaine group versus 19 patients (76%) in the PRP group had improved function (unadjusted odds ratio, 0.71; 95% CI, 0.13 to 3.84), and 19 patients (76%) in the lidocaine group versus 20 patients (90.91%) in the PRP group had improved pain above 25% (unadjusted odds ratio, 0.35; 95% CI, 0.06 to 2.51). Hypercholesterolemia and baseline vascularization influenced outcomes. …”
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