Influence of <i>Nigella sativa</i> L. Oil Addition on Physicochemical and Sensory Properties of Freezer-Stored Ground Pork for Pâté by Elżbieta Górska-Horczyczak, Marta Brodowska-Trębacz, Monika Hanula, Ewelina Pogorzelska-Nowicka, Agnieszka Wierzbicka, Iwona Wojtasik-Kalinowska, Andrzej Półtorak

“…The quality parameters tested in the meat were colour (measured in the CIELab system), lipid oxidation products, the fatty acid profile, thrombogenicity (T1), atherogenicity (A1), and the ratio of hypocholesterolemia to hypercholesterolemia (h/H). After roasting the pâtés, their volatile compound profiles were studied and sensory tests were conducted. …”
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Trajectories of Energy Intake Distribution and Risk of Dyslipidemia: Findings from the China Health and Nutrition Survey (1991–2018) by Xiaoyun Song, Huijun Wang, Chang Su, Zhihong Wang, Wenwen Du, Feifei Huang, Jiguo Zhang, Xiaofang Jia, Hongru Jiang, Yifei Ouyang, Li Li, Jing Bai, Xiaofan Zhang, Gangqiang Ding, Bing Zhang

“…Compared with Group 1, Group 3 was associated with higher risk of dyslipidemia (RR = 1.48, 95% CI = 1.26, 1.75), hypercholesterolemia (RR = 1.96, 95% CI = 1.37, 2.81) and high low-density lipoproteins cholesterols (LDL-C) (RR = 2.41, 95% CI = 1.82, 3.20). …”
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Correction of hypertriglyceridemia in order to reduce the residual risk in atherosclerosis-related diseases. Expert Council Opinion by G. P. Arutyunov, S. A. Boytsov, M. I. Voevoda, O. M. Drapkina, V. V. Kukharchuk, A. I. Martynov, M. V. Shestakova, V. S. Gurevich, I. V. Sergienko, A. S. Alieva, N. M. Akhmedzhanov, M. G. Bubnova, A. S. Galyavich, I. G. Gordeev, M. V. Yezhov, Yu. A. Karpov, V. O. Konstantinov, S. V. Nedogoda, E. M. Nifontov, Y. A. Orlova, A. V. Panov, S. A. Saiganov, V. V. Skibitsky, E. I. Tarlovskaya, S. A. Urazgildeeva, Yu. Sh. Khalimov

“…Statins are the agents of choice to reduce the risk of cardiovascular disease in high-risk patients with hypercholesterolemia and HTG. Fenofibrate is used to correct HTG, and in case of intolerance to it or when the target level of TG is not reached, omega-3 ethers of polyunsaturated fatty acids in a dose of 2-4 g/day are recommended. …”
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Gemfibrozil Induces Anemia, Leukopenia and Reduces Hematopoietic Stem Cells via PPAR-α in Mice by Gabriel Rufino Estrela, Adriano Cleis Arruda, Heron Fernandes Vieira Torquato, Leandro Ceotto Freitas-Lima, Mauro Sérgio Perilhão, Frederick Wasinski, Alexandre Budu, Ricardo Ambrósio Fock, Edgar Julian Paredes-Gamero, Ronaldo Carvalho Araujo

“…Hypercholesterolemia, also called high cholesterol, is a form of hyperlipidemia, which may be a consequence of diet, obesity or diabetes. …”
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CARDIOVASCULAR RISK IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS BEFORE DISEASE-MODIFYING ANTIRHEUMATIC THERAPY (PRELIMINARY DATA OF THE REMARCА STUDY) by Yu. N. Gorbunova, D. S. Novikova, T. V. Popkova, E. I. Markelova, Yu. O. Korsakova, O. A. Fomicheva, D. S. Kolmakova, E. L. Luchikhina, D. E. Karateev, A. V. Smirnov, E. L. Nasonov

“…There was left ventricular hypertrophy in 22 (30.1%) patients, carotid atherosclerotic plaques in 26 (35.6%), coronary artery calcification in 30 (41.1%), hypertension in 38 (52.1%), abdominal obesity in 34 (46.6%), dyslipidemia in 40 (54.8%), hypercholesterolemia in 37 (50.7%), hypoalphalipoproteinemia in 21 (28.8%), hypertriglyceridemia in 12 (16.4%), low physical activity in 30 (41.1%), and smoking in 13 (17.8%). …”
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Simvastatin-hydroxyapatite coatings prevent biofilm formation and improve bone formation in implant-associated infections by Tiantong Sun, Jie Huang, Wang Zhang, Xuanqi Zheng, Hong Wang, Jing Liu, Huijie Leng, Wanqiong Yuan, Chunli Song

“…Statins have been commonly and safely used drugs for hypercholesterolemia for many years. Here, we report that simvastatin-hydroxyapatite-coated titanium alloy prevents biofilm-associated infections. …”
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Transportation of whey protein-derived peptides using Caco-2 cell model and identification of novel cholesterol-lowering peptides by Feifan Liu, Mingzhen Liu, Tao Zhang, Xuan Zhao, Xiaozhi Wang, Weimei Kong, Li Cui, Haibo Luo, Lili Guo, Yuxing Guo

“…Conclusion: This study not only provides theoretical support for the development of bioactive peptides that can be directly absorbed by the human body, but also provides new treatment ideas for hypercholesterolemia.…”
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The Influence of a Conjugated Pneumococcal Vaccination on Plasma Antibody Levels against Oxidized Low-Density Lipoprotein in Metabolic Disease Patients: A Single-Arm Pilot Clinical... by Ronit Shiri-Sverdlov, Inês Magro dos Reis, Yvonne Oligschlaeger, Tim Hendrikx, Dennis M. Meesters, Annick Vanclooster, Nele Vanhoutvin, Ger H. Koek, Marit Westerterp, Christoph J. Binder, David Cassiman, Tom Houben

“…The following patients were enrolled: four patients with familial partial lipodystrophy (all women, mean age 32 years old); three familial hypercholesterolemia patients (one girl, two boys; mean age 13 years); and two Niemann–Pick type B (NP-B) patients (two men, mean age 37.5 years old). …”
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Buckwheat and Cardiometabolic Health: A Systematic Review and Meta-Analysis by Erand Llanaj, Noushin Sadat Ahanchi, Helga Dizdari, Petek Eylul Taneri, Christa D. Niehot, Faina Wehrli, Farnaz Khatami, Hamidreza Raeisi-Dehkordi, Lum Kastrati, Arjola Bano, Marija Glisic, Taulant Muka

“…We selected 16 human studies based on 831 subjects with mild metabolic disturbances, such as hypercholesterolemia, diabetes and/or overweight. Eight studies, investigating primarily grain components, were included in the meta-analyses (<i>n</i> = 464). …”
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Protocol for a 20-year follow-up after a randomized controlled trial of a Mediterranean diet in pregnancy: maternal and offspring risk factors for cardiovascular disease by Hannibal Troensegaard, Janette Khoury, Ane C. Westerberg, Ane C. Westerberg, Serena Tonstad, Jeanine Roeters van Lennep, Marit B. Veierød, Per Ole Iversen, Per Ole Iversen, Kirsten B. Holven, Kirsten B. Holven, Kjetil Retterstøl, Kjetil Retterstøl

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Rate-Limiting Enzymes in Cardiometabolic Health and Aging in Humans by Laurence D. Parnell, Kira S. McCaffrey, Athena W. Brooks, Caren E. Smith, Chao-Qiang Lai, Jacob J. Christensen, Christopher D. Wiley, Jose M. Ordovas

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Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients by Verónica Alfaro‐Lara, Rocío Muñoz‐Hernández, Luis Giménez‐Miranda, Luis Beltrán‐Romero, Francisco Javier Castell‐Montsalve, Pablo Stiefel

“…In a multivariate stepwise binary logistic regression analysis (Wald Method) circulating endothelial microparticles remain significantly associated with pancreas fat content after adjusting for confounding factors, such as tobacco, diabetes mellitus, hypercholesterolemia, or metabolic syndrome. Our results reflect that in essential hypertension, pancreas fat content is superior to liver fat to study beta‐cell functionality and insulin resistance. …”
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The Essential Role of PRAK in Preserving Cardiac Function and Insulin Resistance in High-Fat Diet-Induced Diabetes by Jianfeng Du, Yu Tina Zhao, Hao Wang, Ling X. Zhang, Gangjian Qin, Shougang Zhuang, Marshall Kadin, Y. Eugene Chin, Paul Y. Liu, Ting C. Zhao

“…As compared with wild-type mice, hyperglycemia and hypercholesterolemia were manifested in PRAK-knockout mice following high-fat diet intervention. …”
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Probiotics: mechanism of action, health benefits and their application in food industries by Anam Latif, Aamir Shehzad, Sobia Niazi, Asna Zahid, Waqas Ashraf, Muhammad Waheed Iqbal, Abdur Rehman, Tahreem Riaz, Rana Muhammad Aadil, Imran Mahmood Khan, Fatih Özogul, Fatih Özogul, João Miguel Rocha, João Miguel Rocha, João Miguel Rocha, Tuba Esatbeyoglu, Sameh A. Korma, Sameh A. Korma

“…Due to their capability to modulate gut microbiota and attenuate the immune system, probiotics could be used as an adjuvant in hypertension, hypercholesterolemia, cancer, and gastrointestinal diseases. …”
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Mitogen and Stress-Activated Kinases 1 and 2 Mediate Endothelial Dysfunction by Naveed Akbar, Calum Forteath, Muhammad S. Hussain, Kathleen Reyskens, Jill J. F. Belch, Chim C. Lang, Ify R. Mordi, U Bhalraam, J. Simon C. Arthur, Faisel Khan

“…MyD88 KO mice showed preserved endothelial function and reduced plasma cytokine expression, despite significant hypercholesterolemia. MSK1/2 kinases interact with MAPK-activated proteins 2/3 (MAPKAP2/3), which limit cytokine synthesis. …”
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Diagnostic value and prognostic significance of MRI findings in sudden sensorineural hearing loss by Jelena Todic, Nils Guinand, Vincent Lenoir, Pascal Senn, Minerva Becker

“…At least one cardiovascular risk factor (hypertension, diabetes, hypercholesterolemia, cardiopathy, and active smoking) existed in 167/266 (63%) patients. …”
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CLINICIANS’ SELF-REPORTED EFFICACY IN CARDIOVASCULAR PREVENTION PRACTICE IN THE SOUTHEASTERN UNITED STATES by Trevor Caldarera, Megha Penmetsa, Austin Seals, Edward H. Ip, Salim S. Virani, Michael D. Shapiro, Yashashwi Pokharel

“…PCPs expressed lower self-efficacy compared to specialists in interpreting and managing results of coronary artery calcium testing (24% vs. 69%), high-sensitivity C-reactive protein (20% vs. 46%), lipoprotein(a) (17% vs. 40%), familial hypercholesterolemia (45% vs 72%), and in prescribing ezetimibe (64% vs. 88%), proprotein convertase subtilisin/kexin type 9 inhibitors (18% vs. 70%), and icosapent ethyl (18% vs. 46%) (Figure). …”
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Hypolipemiant Actions and Possible Cardioprotective Effects of Valine and Leucine: An Experimental Study by Elena Cojocaru, Maria Magdalena Leon-Constantin, Carmen Ungureanu, Mioara Florentina Trandafirescu, Alexandra Maștaleru, Laura Mihaela Trandafir, Florin Dumitru Petrariu, Oana Viola Bădulescu, Nina Filip

“…<i>Material and methods:</i> We performed an experimental research in which we induced a hypercholesterolemia via a cholesterol-rich diet. Our aim was to demonstrate the antiatherogenic potential of two essential amino acids (valine and leucine). …”
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Generation of a Soluble Form of Human Endoglin Fused to Green Fluorescent Protein by Lidia Ruiz-Llorente, M. Cristina Vega, Francisco J. Fernández, Carmen Langa, Nicholas W. Morrell, Paul D. Upton, Carmelo Bernabeu

“…High levels of sEng have been reported in patients with preeclampsia, hypercholesterolemia, atherosclerosis and cancer. In addition, sEng is a marker of cardiovascular damage in patients with hypertension and diabetes, plays a pathogenic role in preeclampsia, and inhibits angiogenesis and tumor proliferation, migration, and invasion in cancer. …”
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Treatment strategies and treatment-related adverse events in MG according to the age of onset by João Moura, João Moura, Joana Fernandes, Maria João Lima, Ana Paula Sousa, Raquel Samões, Raquel Samões, Raquel Samões, Ana Martins Silva, Ana Martins Silva, Ana Martins Silva, Ernestina Santos, Ernestina Santos, Ernestina Santos

“…Steroid-related adverse effects motivating the switch to steroid-sparing agents (82.0%) were different between groups, with hypertension, hypercholesterolemia, diabetes mellitus and malignancies being more common in LOMG. …”
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